Exploring the mechanism of a regulatory SNP of KLK3 by molecular dynamics simulation

Journal of Biomolecular Structure and Dynamics

Volumn 31, Issue 4, 2013, Pages 426-440

  Zhang, Zhiyi ^a,b   Liu, Ming ^a,c,d   Li, Beiping ^a   Wang, Yuelan ^a   Yue, Junjie ^a   Liang, Long ^a   Sun, Jianzhong ^b  

^a BEIJING INSTITUTE OF BIOTECHNOLOGY   (China)

^b BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^c EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^d Genor Biopharma Co Ltd   (China)

Author keywords

AR; Hydrophobic; KLK3; Molecular dynamics simulation; Protein DNA binding; Recognition helix; Relative motion; RSNP

Indexed keywords

ADENINE; ANDROGEN RECEPTOR; CYTOSINE; GUANINE; HOMODIMER; METHYL GROUP; THYMINE;

ARTICLE; COMPLEX FORMATION; EQUILIBRIUM CONSTANT; GENE; HUMAN; HYDROPHOBICITY; KLK3 GENE; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INTERACTION; REGULATORY MECHANISM; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTION REGULATION;

BASE SEQUENCE; BINDING SITES; HUMANS; HYDROGEN BONDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; KALLIKREINS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; NUCLEIC ACID CONFORMATION; OLIGODEOXYRIBONUCLEOTIDES; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSTATE-SPECIFIC ANTIGEN; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ANDROGEN; SEQUENCE HOMOLOGY, NUCLEIC ACID;

EID: 84879227620     PISSN: 07391102     EISSN: 15380254     Source Type: Journal    
DOI: 10.1080/07391102.2012.703067     Document Type: Article

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