-
1
-
-
33746377894
-
Protein misfolding, functional amyloid, and human disease
-
F. Chiti, and C.M. Dobson Protein misfolding, functional amyloid, and human disease Annu. Rev. Biochem. 75 2006 333 366
-
(2006)
Annu. Rev. Biochem.
, vol.75
, pp. 333-366
-
-
Chiti, F.1
Dobson, C.M.2
-
2
-
-
79961211353
-
Nanomechanics of functional and pathological amyloid materials
-
T.P.J. Knowles, and M.J. Buehler Nanomechanics of functional and pathological amyloid materials Nat. Nanotechnol. 6 2011 469 479
-
(2011)
Nat. Nanotechnol.
, vol.6
, pp. 469-479
-
-
Knowles, T.P.J.1
Buehler, M.J.2
-
3
-
-
84858374665
-
The amyloid state of proteins in human diseases
-
D. Eisenberg, and M. Jucker The amyloid state of proteins in human diseases Cell 148 2012 1188 1203
-
(2012)
Cell
, vol.148
, pp. 1188-1203
-
-
Eisenberg, D.1
Jucker, M.2
-
5
-
-
38949139507
-
Conformational equilibria in monomeric α-synuclein at the single-molecule level
-
M. Sandal, and F. Valle B. Samorì Conformational equilibria in monomeric α-synuclein at the single-molecule level PLoS Biol. 6 2008 e6
-
(2008)
PLoS Biol.
, vol.6
, pp. 6
-
-
Sandal, M.1
Valle, F.2
Samorì, B.3
-
6
-
-
59649095836
-
Pathogenic mutations shift the equilibria of α-synuclein single molecules towards structured conformers
-
M. Brucale, and M. Sandal B. Samorì Pathogenic mutations shift the equilibria of α-synuclein single molecules towards structured conformers ChemBioChem 10 2009 176 183
-
(2009)
ChemBioChem
, vol.10
, pp. 176-183
-
-
Brucale, M.1
Sandal, M.2
Samorì, B.3
-
7
-
-
84856698027
-
Common features at the start of the neurodegeneration cascade
-
R. Hervás, and J. Oroz M. Carrión-Vázquez Common features at the start of the neurodegeneration cascade PLoS Biol. 10 2012 e1001335
-
(2012)
PLoS Biol.
, vol.10
, pp. 1001335
-
-
Hervás, R.1
Oroz, J.2
Carrión-Vázquez, M.3
-
8
-
-
69549122277
-
On the remarkable mechanostability of scaffoldins and the mechanical clamp motif
-
A. Valbuena, and J. Oroz M. Carrión-Vázquez On the remarkable mechanostability of scaffoldins and the mechanical clamp motif Proc. Natl. Acad. Sci. USA 106 2009 13791 13796
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 13791-13796
-
-
Valbuena, A.1
Oroz, J.2
Carrión-Vázquez, M.3
-
10
-
-
0036708168
-
Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: The emerging role of oligomeric assemblies
-
M.D. Kirkitadze, G. Bitan, and D.B. Teplow Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: the emerging role of oligomeric assemblies J. Neurosci. Res. 69 2002 567 577
-
(2002)
J. Neurosci. Res.
, vol.69
, pp. 567-577
-
-
Kirkitadze, M.D.1
Bitan, G.2
Teplow, D.B.3
-
11
-
-
84858978818
-
Protein misfolded oligomers: Experimental approaches, mechanism of formation, and structure-toxicity relationships
-
F. Bemporad, and F. Chiti Protein misfolded oligomers: experimental approaches, mechanism of formation, and structure-toxicity relationships Chem. Biol. 19 2012 315 327
-
(2012)
Chem. Biol.
, vol.19
, pp. 315-327
-
-
Bemporad, F.1
Chiti, F.2
-
12
-
-
84857642949
-
The toxic Aβ oligomer and Alzheimer's disease: An emperor in need of clothes
-
I. Benilova, E. Karran, and B. De Strooper The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes Nat. Neurosci. 15 2012 349 357
-
(2012)
Nat. Neurosci.
, vol.15
, pp. 349-357
-
-
Benilova, I.1
Karran, E.2
De Strooper, B.3
-
13
-
-
0034612284
-
Unfolding proteins by external forces and temperature: The importance of topology and energetics
-
E. Paci, and M. Karplus Unfolding proteins by external forces and temperature: the importance of topology and energetics Proc. Natl. Acad. Sci. USA 97 2000 6521 6526
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 6521-6526
-
-
Paci, E.1
Karplus, M.2
-
14
-
-
0034691149
-
Native topology determines force-induced unfolding pathways in globular proteins
-
D.K. Klimov, and D. Thirumalai Native topology determines force-induced unfolding pathways in globular proteins Proc. Natl. Acad. Sci. USA 97 2000 7254 7259
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 7254-7259
-
-
Klimov, D.K.1
Thirumalai, D.2
-
15
-
-
0042508741
-
Pulling geometry defines the mechanical resistance of a β-sheet protein
-
D.J. Brockwell, and E. Paci S.E. Radford Pulling geometry defines the mechanical resistance of a β-sheet protein Nat. Struct. Biol. 10 2003 731 737
-
(2003)
Nat. Struct. Biol.
, vol.10
, pp. 731-737
-
-
Brockwell, D.J.1
Paci, E.2
Radford, S.E.3
-
17
-
-
77955790562
-
Comparing the folding free-energy landscapes of Aβ42 variants with different aggregation properties
-
S. Mitternacht, and I. Staneva A. Irbäck Comparing the folding free-energy landscapes of Aβ42 variants with different aggregation properties Proteins 78 2010 2600 2608
-
(2010)
Proteins
, vol.78
, pp. 2600-2608
-
-
Mitternacht, S.1
Staneva, I.2
Irbäck, A.3
-
18
-
-
84864415168
-
Distinct phases of free α-synuclein - A Monte Carlo study
-
S.A. Jónsson, S. Mohanty, and A. Irbäck Distinct phases of free α-synuclein - a Monte Carlo study Proteins 80 2012 2169 2177
-
(2012)
Proteins
, vol.80
, pp. 2169-2177
-
-
Jónsson, S.A.1
Mohanty, S.2
Irbäck, A.3
-
19
-
-
0037168655
-
A structural model for Alzheimer's β-amyloid fibrils based on experimental constraints from solid state NMR
-
A.T. Petkova, and Y. Ishii R. Tycko A structural model for Alzheimer's β-amyloid fibrils based on experimental constraints from solid state NMR Proc. Natl. Acad. Sci. USA 99 2002 16742 16747
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 16742-16747
-
-
Petkova, A.T.1
Ishii, Y.2
Tycko, R.3
-
20
-
-
28444442999
-
3D structure of Alzheimer's amyloid-β(1-42) fibrils
-
T. Lührs, and C. Ritter R. Riek 3D structure of Alzheimer's amyloid-β(1-42) fibrils Proc. Natl. Acad. Sci. USA 102 2005 17342 17347
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 17342-17347
-
-
Lührs, T.1
Ritter, C.2
Riek, R.3
-
22
-
-
17944368176
-
The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation
-
C. Nilsberth, and A. Westlind-Danielsson L. Lannfelt The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation Nat. Neurosci. 4 2001 887 893
-
(2001)
Nat. Neurosci.
, vol.4
, pp. 887-893
-
-
Nilsberth, C.1
Westlind-Danielsson, A.2
Lannfelt, L.3
-
25
-
-
0031001349
-
Dynamic strength of molecular adhesion bonds
-
E. Evans, and K. Ritchie Dynamic strength of molecular adhesion bonds Biophys. J. 72 1997 1541 1555
-
(1997)
Biophys. J.
, vol.72
, pp. 1541-1555
-
-
Evans, E.1
Ritchie, K.2
-
26
-
-
34247894045
-
Use of the Metropolis algorithm to simulate the dynamics of protein chains
-
G. Tiana, L. Sutto, and R.A. Broglia Use of the Metropolis algorithm to simulate the dynamics of protein chains Physica A 380 2007 241 249
-
(2007)
Physica A
, vol.380
, pp. 241-249
-
-
Tiana, G.1
Sutto, L.2
Broglia, R.A.3
-
27
-
-
69449096819
-
Methods for Monte Carlo simulations of biomacromolecules
-
A. Vitalis, and R.V. Pappu Methods for Monte Carlo simulations of biomacromolecules Annu. Rep. Comput. Chem. 5 2009 49 76
-
(2009)
Annu. Rep. Comput. Chem.
, vol.5
, pp. 49-76
-
-
Vitalis, A.1
Pappu, R.V.2
-
28
-
-
0035826575
-
Monte Carlo update for chain molecules: Biased Gaussian steps in torsional space
-
G. Favrin, A. Irbäck, and F. Sjunnesson Monte Carlo update for chain molecules: biased Gaussian steps in torsional space J. Chem. Phys. 114 2001 8154 8158
-
(2001)
J. Chem. Phys.
, vol.114
, pp. 8154-8158
-
-
Favrin, G.1
Irbäck, A.2
Sjunnesson, F.3
-
29
-
-
79958710594
-
Monte Carlo study of the formation and conformational properties of dimers of Aβ42 variants
-
S. Mitternacht, and I. Staneva A. Irbäck Monte Carlo study of the formation and conformational properties of dimers of Aβ42 variants J. Mol. Biol. 410 2011 357 367
-
(2011)
J. Mol. Biol.
, vol.410
, pp. 357-367
-
-
Mitternacht, S.1
Staneva, I.2
Irbäck, A.3
-
30
-
-
10744219665
-
35 oxidation state affects the mechanism of amyloid formation
-
35 oxidation state affects the mechanism of amyloid formation J. Am. Chem. Soc. 126 2004 1992 2005
-
(2004)
J. Am. Chem. Soc.
, vol.126
, pp. 1992-2005
-
-
Hou, L.1
Shao, H.2
Zagorski, M.G.3
-
31
-
-
34247234602
-
The Alzheimer's peptides Aβ40 and 42 adopt distinct conformations in water: A combined MD/NMR study
-
N.G. Sgourakis, and Y. Yan A.E. García The Alzheimer's peptides Aβ40 and 42 adopt distinct conformations in water: a combined MD/NMR study J. Mol. Biol. 368 2007 1448 1457
-
(2007)
J. Mol. Biol.
, vol.368
, pp. 1448-1457
-
-
Sgourakis, N.G.1
Yan, Y.2
García, A.E.3
-
32
-
-
0035815115
-
Conformational properties of α-synuclein in its free and lipid-associated states
-
D. Eliezer, and E. Kutluay G. Browne Conformational properties of α-synuclein in its free and lipid-associated states J. Mol. Biol. 307 2001 1061 1073
-
(2001)
J. Mol. Biol.
, vol.307
, pp. 1061-1073
-
-
Eliezer, D.1
Kutluay, E.2
Browne, G.3
-
33
-
-
34948829554
-
Correlation of amyloid fibril β-structure with the unfolded state of α-synuclein
-
H.-Y. Kim, and H. Heise M. Zweckstetter Correlation of amyloid fibril β-structure with the unfolded state of α-synuclein ChemBioChem 8 2007 1671 1674
-
(2007)
ChemBioChem
, vol.8
, pp. 1671-1674
-
-
Kim, H.-Y.1
Heise, H.2
Zweckstetter, M.3
-
34
-
-
42649142233
-
Characterization of conformational and dynamic properties of natively unfolded human and mouse α-synuclein ensembles by NMR: Implication for aggregation
-
K.-P. Wu, and S. Kim J. Baum Characterization of conformational and dynamic properties of natively unfolded human and mouse α-synuclein ensembles by NMR: implication for aggregation J. Mol. Biol. 378 2008 1104 1115
-
(2008)
J. Mol. Biol.
, vol.378
, pp. 1104-1115
-
-
Wu, K.-P.1
Kim, S.2
Baum, J.3
-
35
-
-
0029619259
-
Knowledge-based protein secondary structure assignment
-
D. Frishman, and P. Argos Knowledge-based protein secondary structure assignment Proteins 23 1995 566 579
-
(1995)
Proteins
, vol.23
, pp. 566-579
-
-
Frishman, D.1
Argos, P.2
-
36
-
-
0003742069
-
-
Department of Biochemistry and Molecular Biology, University College London London, UK
-
S.J. Hubbard, and J.M. Thornton NACCESS Computer Program 1993 Department of Biochemistry and Molecular Biology, University College London London, UK
-
(1993)
NACCESS Computer Program
-
-
Hubbard, S.J.1
Thornton, J.M.2
-
39
-
-
34748906517
-
Mechanical unbinding of Aβ peptides from amyloid fibrils
-
E.P. Raman, and T. Takeda D.K. Klimov Mechanical unbinding of Aβ peptides from amyloid fibrils J. Mol. Biol. 373 2007 785 800
-
(2007)
J. Mol. Biol.
, vol.373
, pp. 785-800
-
-
Raman, E.P.1
Takeda, T.2
Klimov, D.K.3
-
40
-
-
84874620335
-
SOD1 exhibits allosteric frustration to facilitate metal binding affinity
-
A. Das, and S.S. Plotkin SOD1 exhibits allosteric frustration to facilitate metal binding affinity Proc. Natl. Acad. Sci. USA 110 2013 3871 3876
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 3871-3876
-
-
Das, A.1
Plotkin, S.S.2
-
41
-
-
0029904487
-
NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded
-
P.H. Weinreb, and W. Zhen P.T. Lansbury NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded Biochemistry 35 1996 13709 13715
-
(1996)
Biochemistry
, vol.35
, pp. 13709-13715
-
-
Weinreb, P.H.1
Zhen, W.2
Lansbury, P.T.3
-
42
-
-
42449111198
-
Stabilization of a β-hairpin in monomeric Alzheimer's amyloid-β peptide inhibits amyloid formation
-
W. Hoyer, and C. Grönwall T. Härd Stabilization of a β-hairpin in monomeric Alzheimer's amyloid-β peptide inhibits amyloid formation Proc. Natl. Acad. Sci. USA 105 2008 5099 5104
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 5099-5104
-
-
Hoyer, W.1
Grönwall, C.2
Härd, T.3
-
43
-
-
84864695671
-
1-40 peptide probed by molecular dynamics simulations
-
1-40 peptide probed by molecular dynamics simulations Biophys. J. 103 2012 550 557
-
(2012)
Biophys. J.
, vol.103
, pp. 550-557
-
-
Wu, C.1
Scott, J.2
Shea, J.-E.3
-
44
-
-
84868258529
-
Explicit solvent molecular dynamics simulations of Aβ peptide interacting with ibuprofen ligands
-
C. Lockhart, S. Kim, and D.K. Klimov Explicit solvent molecular dynamics simulations of Aβ peptide interacting with ibuprofen ligands J. Phys. Chem. B 116 2012 12922 12932
-
(2012)
J. Phys. Chem. B
, vol.116
, pp. 12922-12932
-
-
Lockhart, C.1
Kim, S.2
Klimov, D.K.3
-
45
-
-
84864482811
-
Morin inhibits the early stages of amyloid β-peptide aggregation by altering tertiary and quaternary interactions to produce "off-pathway" structures
-
J.A. Lemkul, and D.R. Bevan Morin inhibits the early stages of amyloid β-peptide aggregation by altering tertiary and quaternary interactions to produce "off-pathway" structures Biochemistry 51 2012 5990 6009
-
(2012)
Biochemistry
, vol.51
, pp. 5990-6009
-
-
Lemkul, J.A.1
Bevan, D.R.2
-
47
-
-
84863528795
-
Amyloid peptide Aβ40 inhibits aggregation of Aβ42: Evidence from molecular dynamics simulations
-
M.H. Viet, and M.S. Li Amyloid peptide Aβ40 inhibits aggregation of Aβ42: evidence from molecular dynamics simulations J. Chem. Phys. 136 2012 245105
-
(2012)
J. Chem. Phys.
, vol.136
, pp. 245105
-
-
Viet, M.H.1
Li, M.S.2
-
48
-
-
84861217855
-
Impact of chemical heterogeneity on protein self-assembly in water
-
S.-H. Chong, and S. Ham Impact of chemical heterogeneity on protein self-assembly in water Proc. Natl. Acad. Sci. USA 109 2012 7636 7641
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 7636-7641
-
-
Chong, S.-H.1
Ham, S.2
-
49
-
-
84859605341
-
Dimer formation enhances structural differences between amyloid β-protein (1-40) and (1-42): An explicit-solvent molecular dynamics study
-
B. Barz, and B. Urbanc Dimer formation enhances structural differences between amyloid β-protein (1-40) and (1-42): an explicit-solvent molecular dynamics study PLoS ONE 7 2011 e34345
-
(2011)
PLoS ONE
, vol.7
, pp. 34345
-
-
Barz, B.1
Urbanc, B.2
-
50
-
-
79955486832
-
Characterizing the structural behavior of selected Aβ-42 monomers with different solubilities
-
C. Velez-Vega, and F.A. Escobedo Characterizing the structural behavior of selected Aβ-42 monomers with different solubilities J. Phys. Chem. B 115 2011 4900 4910
-
(2011)
J. Phys. Chem. B
, vol.115
, pp. 4900-4910
-
-
Velez-Vega, C.1
Escobedo, F.A.2
|