-
1
-
-
3543035771
-
Biology and therapeutic advances for pediatric osteosarcoma
-
Marina N, Gebhardt M, Teot L and Gorlick R. Biology and therapeutic advances for pediatric osteosarcoma. Oncologist 2004, 9: 422-441.
-
(2004)
Oncologist
, vol.9
, pp. 422-441
-
-
Marina, N.1
Gebhardt, M.2
Teot, L.3
Gorlick, R.4
-
2
-
-
0036467661
-
Prognostic factors in high-grade osteosarcoma of the extremities or trunk: An analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols
-
Bielack SS, Kempf-Bielack B, Delling G, Exner GU, Flege S, Helmke K and Kotz R, et al. Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols. J Clin Oncol 2002, 20: 776-90.
-
(2002)
J Clin Oncol
, vol.20
, pp. 776-790
-
-
Bielack, S.S.1
Kempf-Bielack, B.2
Delling, G.3
Exner, G.U.4
Flege, S.5
Helmke, K.6
Kotz, R.7
-
3
-
-
0037182139
-
Rapamycin blocks tumor progression: Unlinking immunosuppression from antitumor efficacy
-
Luan FL, Hojo M, Maluccio M, Yamaji K and Suthanthiran M. Rapamycin blocks tumor progression: unlinking immunosuppression from antitumor efficacy. Transplantation 2002, 73: 1565-1572.
-
(2002)
Transplantation
, vol.73
, pp. 1565-1572
-
-
Luan, F.L.1
Hojo, M.2
Maluccio, M.3
Yamaji, K.4
Suthanthiran, M.5
-
4
-
-
16844366544
-
Rapamycin inhibits ezrinmediated metastatic behavior in a murine model of osteosarcoma
-
Wan X, Mendoza A, Khanna C and Helman LJ. Rapamycin inhibits ezrinmediated metastatic behavior in a murine model of osteosarcoma. Cancer Res 2005, 65: 2406-2411.
-
(2005)
Cancer Res
, vol.65
, pp. 2406-2411
-
-
Wan, X.1
Mendoza, A.2
Khanna, C.3
Helman, L.J.4
-
5
-
-
33750858427
-
Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways
-
Liu L, Li F, Cardelli JA, Martin KA, Blenis J and Huang S. Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways. Oncogene 2006, 25: 7029-7040.
-
(2006)
Oncogene
, vol.25
, pp. 7029-7040
-
-
Liu, L.1
Li, F.2
Cardelli, J.A.3
Martin, K.A.4
Blenis, J.5
Huang, S.6
-
6
-
-
84865029396
-
Rapamycin inhibits proliferation of hemangioma endothelial cells by reducing HIF-1 dependent expression of VEGF
-
Medici D and Olsen BR. Rapamycin inhibits proliferation of hemangioma endothelial cells by reducing HIF-1 dependent expression of VEGF. PLoS One 2012, 7: e42913.
-
(2012)
PLoS One
, vol.7
-
-
Medici, D.1
Olsen, B.R.2
-
7
-
-
84855556875
-
Phase II study of the mammalian target of rapamycin inhibitor ridaforolimus in patients with advanced bone and soft tissue sarcomas
-
Chawla SP, Staddon AP, Baker LH, Schuetze SM, Tolcher AW, D'Amato GZ and Blay JY, et al. Phase II study of the mammalian target of rapamycin inhibitor ridaforolimus in patients with advanced bone and soft tissue sarcomas. J Clin Oncol 2012, 30: 78-84.
-
(2012)
J Clin Oncol
, vol.30
, pp. 78-84
-
-
Chawla, S.P.1
Staddon, A.P.2
Baker, L.H.3
Schuetze, S.M.4
Tolcher, A.W.5
D'Amato, G.Z.6
Blay, J.Y.7
-
8
-
-
79960761944
-
An emerging role for TOR signaling in mammalian tissue and stem cell physiology
-
Russell RC, Fang C and Guan KL. An emerging role for TOR signaling in mammalian tissue and stem cell physiology. Development 2011, 138: 3343-3356.
-
(2011)
Development
, vol.138
, pp. 3343-3356
-
-
Russell, R.C.1
Fang, C.2
Guan, K.L.3
-
9
-
-
39749100492
-
TOR regulation of AGC kinase in yeast and mammals
-
Jacinto E and Lorberg A. TOR regulation of AGC kinase in yeast and mammals. Biochem J 2008, 410: 19-37.
-
(2008)
Biochem J
, vol.410
, pp. 19-37
-
-
Jacinto, E.1
Lorberg, A.2
-
10
-
-
77953727786
-
Activation of autophagy and Akt/CREB signaling play an equivalent role in the neuroprotective effect of rapamycin in neonatal hypoxia-ischemia
-
Carloni S, Girelli S, Scopa C, Buonocore G, Longini M and Balduini W. Activation of autophagy and Akt/CREB signaling play an equivalent role in the neuroprotective effect of rapamycin in neonatal hypoxia-ischemia. Autophagy 2010, 6: 366-377.
-
(2010)
Autophagy
, vol.6
, pp. 366-377
-
-
Carloni, S.1
Girelli, S.2
Scopa, C.3
Buonocore, G.4
Longini, M.5
Balduini, W.6
-
11
-
-
84863889307
-
Calcium/calmodulin-dependent protein kinase IV limits organ damage in hepatic ischemia-reperfusion injury through induction of autophagy
-
Evankovich J, Zhang R, Cardinal JS, Zhang L, Chen J, Huang H and Beer-Stolz D, et al. Calcium/calmodulin-dependent protein kinase IV limits organ damage in hepatic ischemia-reperfusion injury through induction of autophagy. Am J Physiol Gastrointest Liver Physiol 2012, 303: 189-198.
-
(2012)
Am J Physiol Gastrointest Liver Physiol
, vol.303
, pp. 189-198
-
-
Evankovich, J.1
Zhang, R.2
Cardinal, J.S.3
Zhang, L.4
Chen, J.5
Huang, H.6
Beer-Stolz, D.7
-
12
-
-
82755189234
-
Mammalian target of rapamycin inhibition in macrophages of asymptomatic HIV- persons reverses the decrease in TLR-4-mediated IFN-α release through prolongation of MAPK pathway activation
-
Li X, Han X, Llano J, Bole M, Zhou X, Swan K and Anandaiah A, et al. Mammalian target of rapamycin inhibition in macrophages of asymptomatic HIV- persons reverses the decrease in TLR-4-mediated IFN-α release through prolongation of MAPK pathway activation. J Immunol 2011, 187: 6052-6058.
-
(2011)
J Immunol
, vol.187
, pp. 6052-6058
-
-
Li, X.1
Han, X.2
Llano, J.3
Bole, M.4
Zhou, X.5
Swan, K.6
Anandaiah, A.7
-
13
-
-
34347391261
-
CREB - A real culprit in oncogenesis
-
Siu YT and Jin DY. CREB - a real culprit in oncogenesis. FEBS J 2007, 274: 3224-3232.
-
(2007)
FEBS J
, vol.274
, pp. 3224-3232
-
-
Siu, Y.T.1
Jin, D.Y.2
-
14
-
-
80053524655
-
Roles and regulation of the transcription factor CREB in pancreatic b-cells
-
Dalle S, Quoyer J, Varin E and Costes S. Roles and regulation of the transcription factor CREB in pancreatic b-cells. Curr Mol Pharmacol 2011, 4: 187-195.
-
(2011)
Curr Mol Pharmacol
, vol.4
, pp. 187-195
-
-
Dalle, S.1
Quoyer, J.2
Varin, E.3
Costes, S.4
-
15
-
-
84868474450
-
Born to be alive: A role for the BCL-2 family in melanoma tumor cell survival, apoptosis, and treatment
-
Anvekar RA, Asciolla JJ, Missert DJ and Chipuk JE. Born to be alive: a role for the BCL-2 family in melanoma tumor cell survival, apoptosis, and treatment. Front Oncol 2011, 1: 34.
-
(2011)
Front Oncol
, vol.1
, pp. 34
-
-
Anvekar, R.A.1
Asciolla, J.J.2
Missert, D.J.3
Chipuk, J.E.4
-
16
-
-
0037699954
-
The biology of VEGF and its receptors
-
Ferrara N, Gerber HP and LeCouter J. The biology of VEGF and its receptors. Nat Med 2003, 9: 669-676.
-
(2003)
Nat Med
, vol.9
, pp. 669-676
-
-
Ferrara, N.1
Gerber, H.P.2
Lecouter, J.3
-
17
-
-
34547635236
-
CAMP-responsive element-binding protein regulates vascular endothelial growth factor expression: Implication in human prostate cancer bone metastasis
-
Wu D, Zhau H, Huang WC, Iqbal S, Habib FK, Sartor O and Cvitanovic L, et al. cAMP-responsive element-binding protein regulates vascular endothelial growth factor expression: implication in human prostate cancer bone metastasis. Oncogene 2007, 26: 5070-5077.
-
(2007)
Oncogene
, vol.26
, pp. 5070-5077
-
-
Wu, D.1
Zhau, H.2
Huang, W.C.3
Iqbal, S.4
Habib, F.K.5
Sartor, O.6
Cvitanovic, L.7
-
18
-
-
79952717399
-
Insulin regulates GLUT1-mediated glucose transport in MG-63 human osteosarcoma cells
-
Cifuentes M, Garcia MA, Arrabal PM, Martinez F, Yanez MJ, Jara N and Weil B, et al. Insulin regulates GLUT1-mediated glucose transport in MG-63 human osteosarcoma cells. J Cell Physiol 2011, 226: 1425-1432.
-
(2011)
J Cell Physiol
, vol.226
, pp. 1425-1432
-
-
Cifuentes, M.1
Garcia, M.A.2
Arrabal, P.M.3
Martinez, F.4
Yanez, M.J.5
Jara, N.6
Weil, B.7
-
19
-
-
51349164790
-
Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
-
Carracedo A, Teruya-Feldstein J, Rojo F, Salmena L, Alimonti A, Eqia A and Sasaki AT, et al. Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. J Clin Invest 2008, 118: 3065-3074.
-
(2008)
J Clin Invest
, vol.118
, pp. 3065-3074
-
-
Carracedo, A.1
Teruya-Feldstein, J.2
Rojo, F.3
Salmena, L.4
Alimonti, A.5
Eqia, A.6
Sasaki, A.T.7
-
20
-
-
0035949699
-
AKT plays a central role in tumorigenesis
-
Testa JR and Bellascosa A. AKT plays a central role in tumorigenesis. Proc Natl Acad Sci USA 2001, 98: 10983-10985.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 10983-10985
-
-
Testa, J.R.1
Bellascosa, A.2
-
21
-
-
54749095517
-
Enhancing mammalian target of rapamycin (mTOR)-targeted cancer therapy by preventing mTOR/Raptor inhibition-initiated, mTOR/Rictor-indepenedent Akt activation
-
Wang X, Yue P, Kim YA, Fu H, Khuri FR and Sun SY. Enhancing mammalian target of rapamycin (mTOR)-targeted cancer therapy by preventing mTOR/Raptor inhibition-initiated, mTOR/Rictor-indepenedent Akt activation. Cancer Res 2008, 68: 7409-7418.
-
(2008)
Cancer Res
, vol.68
, pp. 7409-7418
-
-
Wang, X.1
Yue, P.2
Kim, Y.A.3
Fu, H.4
Khuri, F.R.5
Sun, S.Y.6
-
22
-
-
83755178091
-
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of a-ketoglutarate to citrate to support cell growth and viability
-
Wise DR, Ward PS, Shay JE, Cross JR, Gruber JJ, Sachdeva UM and Platt JM, et al. Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of a-ketoglutarate to citrate to support cell growth and viability. Proc Natl Acad Sci USA 2011, 108: 19611-19616.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 19611-19616
-
-
Wise, D.R.1
Ward, P.S.2
Shay, J.E.3
Cross, J.R.4
Gruber, J.J.5
Sachdeva, U.M.6
Platt, J.M.7
-
23
-
-
33746637660
-
Current development of mTOR inhibitors as anticancer agents
-
Faivre S, Kroemer G and Raymond E. Current development of mTOR inhibitors as anticancer agents. Nat Rev Drug Discov 2006, 5: 671-688.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 671-688
-
-
Faivre, S.1
Kroemer, G.2
Raymond, E.3
-
24
-
-
45149094559
-
Mammalian target of rapamycin contributes to the acquired apoptotic resistance of human mesothelioma multicellular spheroids
-
Barbone D, Yang TM, Morgan JR, Gaudino G and Broaddus C. Mammalian target of rapamycin contributes to the acquired apoptotic resistance of human mesothelioma multicellular spheroids. J Biol Chem 2008, 283: 13021-13030.
-
(2008)
J Biol Chem
, vol.283
, pp. 13021-13030
-
-
Barbone, D.1
Yang, T.M.2
Morgan, J.R.3
Gaudino, G.4
Broaddus, C.5
-
25
-
-
79953217107
-
Rapamycin-mediated mTOR inhibition attenuates surviving and sensitizes glioblastoma cells to radiation therapy
-
Anandharaj A, Cinghu S and Park WY. Rapamycin-mediated mTOR inhibition attenuates surviving and sensitizes glioblastoma cells to radiation therapy. Acta Biochim Biophys Sin 2011, 43: 292-300.
-
(2011)
Acta Biochim Biophys Sin
, vol.43
, pp. 292-300
-
-
Anandharaj, A.1
Cinghu, S.2
Park, W.Y.3
-
26
-
-
6044259204
-
Targeting mammalian target of rapamycin synergistically enhances chemotherapy-induced cytotxicity in breast cancer cells
-
Mondesire WH, Jian W, Zhang H, Ensor J, Hung MC, Mills GB and Meric-Bernstam F. Targeting mammalian target of rapamycin synergistically enhances chemotherapy-induced cytotxicity in breast cancer cells. Caner Res 2004, 10: 7031-7042.
-
(2004)
Caner Res
, vol.10
, pp. 7031-7042
-
-
Mondesire, W.H.1
Jian, W.2
Zhang, H.3
Ensor, J.4
Hung, M.C.5
Mills, G.B.6
Meric-Bernstam, F.7
-
27
-
-
68149170611
-
Cross-talk between PKA and Akt protects endothelial cells from apoptosis in the late ischemic preconditioning
-
Bellis A, Castaldo D, Trimarco V, Monti MG, Chivasso P, Sadoshima J and Trimarco B, et al. Cross-talk between PKA and Akt protects endothelial cells from apoptosis in the late ischemic preconditioning. Arterioscler Thromb Vasc Biol 2009, 29: 1207-1212.
-
(2009)
Arterioscler Thromb Vasc Biol
, vol.29
, pp. 1207-1212
-
-
Bellis, A.1
Castaldo, D.2
Trimarco, V.3
Monti, M.G.4
Chivasso, P.5
Sadoshima, J.6
Trimarco, B.7
-
28
-
-
33947233409
-
MEK/ ERK signaling contributes to the maintenance of human embryonic stem cell self-renewal
-
Li J, Wang G, Wang C, Zhao Y, Zhang H, Tan Z and Song Z, et al. MEK/ ERK signaling contributes to the maintenance of human embryonic stem cell self-renewal. Differentiation 2007, 75: 299-307.
-
(2007)
Differentiation
, vol.75
, pp. 299-307
-
-
Li, J.1
Wang, G.2
Wang, C.3
Zhao, Y.4
Zhang, H.5
Tan, Z.6
Song, Z.7
-
29
-
-
33750616041
-
ERK1/2 MAP kinases in cell survival and apoptosis
-
Lu Z and Xu S. ERK1/2 MAP kinases in cell survival and apoptosis. IUBMB Life 2000, 58: 621-631.
-
(2000)
IUBMB Life
, vol.58
, pp. 621-631
-
-
Lu, Z.1
Xu, S.2
-
30
-
-
0034648063
-
Neuroprotection by MAPK/ERK kinase inhibition with U0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured neurons
-
Satoh T, Nakatsuka D, Watanabe Y, Nagata I, Kikuchi H and Namura S. Neuroprotection by MAPK/ERK kinase inhibition with U0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured neurons. Neurosci Lett 2000, 288: 163-166.
-
(2000)
Neurosci Lett
, vol.288
, pp. 163-166
-
-
Satoh, T.1
Nakatsuka, D.2
Watanabe, Y.3
Nagata, I.4
Kikuchi, H.5
Namura, S.6
-
31
-
-
79451469849
-
Oroxylin A increases BDNF production by activation of MAPK-CREB pathway in rat primary cortical neuronal culture
-
Jeon SJ, Rhee SY, Seo JE, Bak HR, Lee Sh, Ryu JH and Cheong JH, et al. Oroxylin A increases BDNF production by activation of MAPK-CREB pathway in rat primary cortical neuronal culture. Neurosci Res 2011, 69: 214-222.
-
(2011)
Neurosci Res
, vol.69
, pp. 214-222
-
-
Jeon, S.J.1
Rhee, S.Y.2
Seo, J.E.3
Bak, H.R.4
Sh, L.5
Ryu, J.H.6
Cheong, J.H.7
-
32
-
-
77958031723
-
The rapamycin-sensitive phosphoproteome reveals that TOR controls protein kinase A toward some but not all substrates
-
TOR
-
Soulard A, Cremonesi A, Moes S, Schutz F, Jeno P and Hall MN. The rapamycin-sensitive phosphoproteome reveals that TOR controls protein kinase A toward some but not all substrates. Mol Biol Cell 2011, 21: 3475-3486.
-
(2011)
Mol Biol Cell
, vol.21
, pp. 3475-3486
-
-
Soulard, A.1
Cremonesi, A.2
Moes, S.3
Schutz, F.4
Jeno, P.5
Hall, M.N.6
-
33
-
-
0035413602
-
Physiological substrates of cAMP-dependent protein kinase
-
Shabb JB. Physiological substrates of cAMP-dependent protein kinase. Chem Rev 2001, 101: 2381-2411.
-
(2001)
Chem Rev
, vol.101
, pp. 2381-2411
-
-
Shabb, J.B.1
-
34
-
-
69249240179
-
Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis
-
Huber A, Bodenmiller B, Uotila A, Stahl M, Wanka S, Gerrits B and Aebersold R, et al. Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis. Genes Dev 2009, 23: 1929-1943.
-
(2009)
Genes Dev
, vol.23
, pp. 1929-1943
-
-
Huber, A.1
Bodenmiller, B.2
Uotila, A.3
Stahl, M.4
Wanka, S.5
Gerrits, B.6
Aebersold, R.7
-
35
-
-
1042291164
-
Down-regulation of MEK/ERK signaling by E-cadherin-dependent PI3K/ Akt pathway in differentiating intestinal epithelial cells
-
Laprise P, Lanqlois MJ, Boucher MJ, Jobin C and Rivard N. Down-regulation of MEK/ERK signaling by E-cadherin-dependent PI3K/ Akt pathway in differentiating intestinal epithelial cells. J Cell Physiol 2004, 199: 32-39.
-
(2004)
J Cell Physiol
, vol.199
, pp. 32-39
-
-
Laprise, P.1
Lanqlois, M.J.2
Boucher, M.J.3
Jobin, C.4
Rivard, N.5
-
36
-
-
78649831949
-
Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cell
-
Sunayam J, Matscuda K, Sato A, Tachibana K, Suzuki K, Narita Y and Shibui S, et al. Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cell. Stem Cells 2010, 28: 1930-1939.
-
(2010)
Stem Cells
, vol.28
, pp. 1930-1939
-
-
Sunayam, J.1
Matscuda, K.2
Sato, A.3
Tachibana, K.4
Suzuki, K.5
Narita, Y.6
Shibui, S.7
-
37
-
-
34547645033
-
Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human cancer
-
Ma L, Teruya-Feldstein J, Bonner P, Bernardi R, Franz DN, Witte D and Cordon-Cardo C, et al. Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human cancer. Cancer Res 2007, 67: 7162-7112.
-
(2007)
Cancer Res
, vol.67
, pp. 7162-7112
-
-
Ma, L.1
Teruya-Feldstein, J.2
Bonner, P.3
Bernardi, R.4
Franz, D.N.5
Witte, D.6
Cordon-Cardo, C.7
-
38
-
-
65549167833
-
Targeting the mTOR signaling network for cancer therapy
-
Meric-Bernstam F and Gonzalez-Angulo AM. Targeting the mTOR signaling network for cancer therapy. J Clin Oncol 2009, 17: 2278-2287.
-
(2009)
J Clin Oncol
, vol.17
, pp. 2278-2287
-
-
Meric-Bernstam, F.1
Gonzalez-Angulo, A.M.2
-
39
-
-
67649411967
-
Antagonism of the mammalian target of rapamycin selectively mediates metabolic effects of epidermal growth factor receptor inhibition and protects human malignant glioma cells from hypoxia-induced cell death
-
Ronellenfitsch MW, Brucker DP, Burger MC, Wolking S, Trstschler F, Rieger J and Wick W, et al. Antagonism of the mammalian target of rapamycin selectively mediates metabolic effects of epidermal growth factor receptor inhibition and protects human malignant glioma cells from hypoxia-induced cell death. Brain 2009, 132: 1509-1522.
-
(2009)
Brain
, vol.132
, pp. 1509-1522
-
-
Ronellenfitsch, M.W.1
Brucker, D.P.2
Burger, M.C.3
Wolking, S.4
Trstschler, F.5
Rieger, J.6
Wick, W.7
|