Mammalian target of rapamycin inhibition in macrophages of asymptomatic HIV + persons reverses the decrease in TLR-4-mediated TNF-α release through prolongation of MAPK pathway activation

Journal of Immunology

Volumn 187, Issue 11, 2011, Pages 6052-6058

  Li, Xin ^a   Han, Xinbing ^a   Llano, Juliana ^a   Bole, Medhavi ^a   Zhou, Xiuqin ^a   Swan, Katharine ^a   Anandaiah, Asha ^a   Nelson, Benjamin ^a   Patel, Naimish R ^a   Reinach, Peter S ^b   Koziel, Henry ^a   Tachado, Souvenir D ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON REGULATORY FACTOR 3; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE; INTERLEUKIN 10; JANUS KINASE 1; JANUS KINASE 2; LIPID A; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHATIDYLINOSITOL 3 KINASE; RAPAMYCIN; S6 KINASE; SHORT HAIRPIN RNA; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CYTOKINE RELEASE; DENDRITIC CELL; DOWN REGULATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE SILENCING; HOST RESISTANCE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INNATE IMMUNITY; MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; UPREGULATION;

BLOTTING, WESTERN; ENZYME ACTIVATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE KNOCKDOWN TECHNIQUES; HIV INFECTIONS; HUMANS; IMMUNOPRECIPITATION; MACROPHAGES; MAP KINASE SIGNALING SYSTEM; TOLL-LIKE RECEPTOR 4; TOR SERINE-THREONINE KINASES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 82755189234     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1101532     Document Type: Article

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