Dietary nitrate supplementation improves team sport-specific intense intermittent exercise performance

European Journal of Applied Physiology

Volumn 113, Issue 7, 2013, Pages 1673-1684

  Wylie, Lee J ^a   Mohr, Magni ^a   Krustrup, Peter ^a   Jackman, Sarah R ^a   Ermιdis, Georgios ^a   Kelly, James ^a   Black, Matthew I ^a   Bailey, Stephen J ^a   Vanhatalo, Anni ^a   Jones, Andrew M ^a  

^a UNIVERSITY OF EXETER   (United Kingdom)

Author keywords

Ergogenic aids; Nitric oxide; Repeated high intensity exercise; Team sports

Indexed keywords

EID: 84879202331     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-013-2589-8     Document Type: Article

References (71)

1. Allen DG, Lamb GD, Westerblad H (2008) Skeletal muscle fatigue: cellular mechanisms. Physiol Rev 88:287-332
2. Allen JD, Stabler T, Kenjale A, Ham KL, Robbins JL, Duscha BD, Dobrosielski DA, Annex BH (2010) Plasma nitrite flux predicts exercise performance in peripheral arterial disease after 3 months of exercise training. Free Radic Biol Med 49:1138-1144
3. Atkins SJ (2006) Performance of the Yo-Yo intermittent recovery test by elite professional and semiprofessional rugby league players. J Strength Cond Res 20:222-225
4. 2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans. J Appl Physiol 107:1144-1155
5. Bailey SJ, Fulford J, Vanhatalo A, Winyard PG, Blackwell JR, DiMenna FJ, Wilkerson DP, Benjamin N, Jones AM (2010) Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans. J Appl Physiol 109:135-148
6. Bailey SJ, Vanhatalo A, Winyard PG, Jones AM (2011) The nitrate-nitrite-nitric oxide pathway: its role in human exercise physiology. Eur J Sport Sci 12:309-320
7. Bangsbo J, Mohr M (2012) Fitness testing in football. Bangsbosport ISBN 978-87-994880-0-1, Copenhagen, Denmark
8. Bangsbo J, Krustrup P, González-Alonso J, Saltin B (2001) ATP production and efficiency of human skeletal muscle during intense exercise: effect of previous exercise. Am J Physiol Endocrinol Metab 280:E956-E964
9. Bangsbo J, Iaia FM, Krustrup P (2007) Metabolic response and fatigue in soccer. Int J Sports Physiol Perform 2:111-127
10. Bangsbo J, Iaia FM, Krustrup P (2008) The Yo-Yo intermittent recovery test: a useful tool for evaluation of physical performance in intermittent sports. Sports Med 38:37-51
11. Behnke BJ, McDonough P, Padilla DJ, Musch TI, Poole DC (2003) Oxygen exchange profile in rat muscles of contrasting fibre types. J Physiol 549:597-605
12. Bescós R, Ferrer-Roca V, Galilea PA, Roig A, Drobnic F, Sureda A, Martorell M, Cordova A, Tur JA, Pons A (2012) Sodium nitrate supplementation does not enhance performance of endurance athletes. Med Sci Sports Exerc 44:2400-2409
13. Bond H, Morton L, Braakhuis AJ (2012) Dietary nitrate supplementation improves rowing performance in well-trained rowers. Int J Sport Nutr Exerc Metab 22:251-256
14. Bradley PS, Mohr M, Bendiksen M, Randers MB, Flindt M, Barnes C, Hood P, Gomez A, Andersen JL, Di Mascio M, Bangsbo J, Krustrup P (2011) Sub-maximal and maximal Yo-Yo intermittent endurance test level 2: heart rate response, reproducibility and application to elite soccer. Eur J Appl Physiol 111:969-978
15. Burnley M, Jones AM (2007) Oxygen uptake kinetics as determinant of sports performance. Eur J Sport Sci 7:63-79
16. Cermak NM, Gibala MJ, van Loon LJ (2012a) Nitrate supplementation's improvement of 10-km time-trial performance in trained cyclists. Int J Sport Nutr Exerc Metab 22:64-71
17. Cermak NM, Res P, Stinkens R, Lundberg JO, Gibala MJ, van Loon L JC (2012b) No improvement in endurance performance following a single dose of beetroot juice. Int J Sport Nutr Exerc Metab 22:470-478
18. Christensen PM, Nyberg M, Bangsbo J (2013) Influence of nitrate supplementation on VO(2) kinetics and endurance of elite cyclists. Scand J Med Sci Sports 23:e21-e31
19. Colliander EB, Dudley GA, Tesch PA (1988) Skeletal muscle fiber type composition and performance during repeated bouts of maximal, concentric contractions. Eur J Appl Physiol Occup Physiol 58:81-86
20. Cosby K, Partovi KS, Crawford JH, Patel RP, Reiter CD, Martyr S, Yang BK, Waclawiw MA, Zalos G, Xu X, Huang KT, Shields H, Kim-Shapiro DB, Schechter AN, Cannon RO 3rd, Gladwin MT (2003) Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat Med 9:1498-1505
21. Dreissigacker U, Wendt M, Wittke T, Tsikas D, Maassen N (2010) Positive correlation between plasma nitrite and performance during high-intensive exercise but not oxidative stress in healthy men. Nitric Oxide 23:128-135
22. Ferguson SK, Hirai DM, Copp SW, Holdsworth CT, Allen JD, Jones AM, Musch TI, Poole DC (2013) Impact of dietary nitrate supplementation via beetroot juice on exercising muscle vascular control in rats. J Physiol 591:547-557
23. Gladwin MT, Shelhamer JH, Schechter AN, Pease-Fye ME, Waclawiw MA, Panza JA, Ognibene FP, Cannon RO 3rd (2000) Role of circulating nitrite and S-nitrosohemoglobin in the regulation of regional blood flow in humans. Proc Natl Acad Sci USA 97:11482-11487
24. Govoni M, Jansson EA, Weitzberg E, Lundberg JO (2008) The increase in plasma nitrite after a dietary nitrate load is markedly attenuated by an antibacterial mouthwash. Nitric Oxide 19:333-337
25. Greenhaff PL, Nevill ME, Soderlund K, Bodin K, Boobis LH, Williams C, Hultman E (1994) The metabolic responses of human type I and II muscle fibres during maximal treadmill sprinting. J Physiol 478:149-155
26. i and contractile force in mouse fast-twitch muscle. J Physiol 590:3575-3583
27. 31 P-MRS study. J Appl Physiol 86:1367-1373
28. Hord NG, Tang Y, Bryan NS (2009) Food sources of nitrates and nitrites: the physiologic context for potential health benefits. Am J Clin Nutr 90:1-10
29. + pump alpha1-subunit and NHE1 expression as well as short-term work capacity in humans. Am J Physiol Regul Integr Comp Physiol 294:R966-R974
30. Ingebrigtsen J, Bendiksen M, Randers MB, Castagna C, Krustrup P, Holtermann A (2012) Yo-Yo IR2 testing of elite and sub-elite soccer players: performance, heart rate response and correlations to other interval tests. J Sports Sci 30:1337-1345
31. Kapil V, Milsom AB, Okorie M, Maleki-Toyserkani S, Akram F, Rehman F, Arghandawi S, Pearl V, Benjamin N, Loukogeorgakis S, Macallister R, Hobbs AJ, Webb AJ, Ahluwalia A (2010) Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO. Hypertension 56:274-281
32. Kenjale AA, Ham KL, Stabler T, Robbins JL, Johnson JL, Vanbruggen M, Privette G, Yim E, Kraus WE, Allen JD (2011) Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. J Appl Physiol 110:1582-1591
33. Krustrup P, Mohr M, Amstrup T, Rysgaard T, Johansen J, Steensberg A, Pedersen PK, Bangsbo J (2003) The Yo-Yo intermittent recovery test: physiological response, reliability, and validity. Med Sci Sports Exerc 35:697-705
34. Krustrup P, Söderlund K, Mohr M, Bangsbo J (2004) The slow component of oxygen uptake during intense, sub-maximal exercise in man is associated with additional fibre recruitment. Pflugers Arch 447:855-866
35. Krustrup P, Mohr M, Steensberg A, Bencke J, Kjaer M, Bangsbo J (2006) Muscle and blood metabolites during a soccer game: implications for sprint performance. Med Sci Sports Exerc 38:1165-1174
36. Krustrup P, Söderlund K, Relu MU, Ferguson RA, Bangsbo J (2009) Heterogeneous recruitment of quadriceps muscle portions and fibre types during moderate intensity knee-extensor exercise: effect of thigh occlusion. Scand J Med Sci Sports 19:576-584
37. Lansley KE, Winyard PG, Bailey SJ, Vanhatalo A, Wilkerson DP, Blackwell JR, Gilchrist M, Benjamin N, Jones AM (2011a) Acute dietary nitrate supplementation improves cycling time trial performance. Med Sci Sports Exerc 43:1125-1131
38. 2 cost of walking and running: a placebo-controlled study. J Appl Physiol 110:591-600
39. Larsen FJ, Weitzberg E, Lundberg JO, Ekblom B (2007) Effects of dietary nitrate on oxygen cost during exercise. Acta Physiol (Oxf) 91:59-66
40. Larsen FJ, Weitzberg E, Lundberg JO, Ekblom B (2010) Dietary nitrate reduces maximal oxygen consumption while maintaining work performance in maximal exercise. Free Radic Biol Med 48:342-347
41. Larsen FJ, Schiffer TA, Borniquel S, Sahlin K, Ekblom B, Lundberg JO, Weitzberg E (2011) Dietary inorganic nitrate improves mitochondrial efficiency in humans. Cell Metab 13:149-159
42. Liu TH, Wu CL, Chiang CW, Lo YW, Tseng HF, Chang CK (2009) No effect of short-term arginine supplementation on nitric oxide production, metabolism and performance in intermittent exercise in athletes. J Nutr Biochem 20:462-468
43. Lundberg JO, Weitzberg E (2010) NO-synthase independent NO generation in mammals. Biochem Biophys Res Commu 396:39-45
44. Lundberg JO, Carlström M, Larsen FJ, Weitzberg E (2011) Roles of dietary inorganic nitrate in cardiovascular health and disease. Cardiovasc Res 89:525-532
45. Masschelein E, Van Thienen R, Wang X, Van Schepdael A, Thomis M, Hespel P (2012) Dietary nitrate improves muscle but not cerebral oxygenation status during exercise in hypoxia. J Appl Physiol 113:736-745
46. McDonough P, Behnke BJ, Padilla DJ, Musch TI, Poole DC (2005) Control of microvascular oxygen pressures in rat muscles comprised of different fibre types. J Physiol 563:903-913
47. + pump inactivation: implications for fatigue. J Appl Physiol 104:288-295
48. Merry TL, Lynch GS, McConell GK (2010) Downstream mechanisms of nitric oxide-mediated skeletal muscle glucose uptake during contraction. Am J Physiol Regul Integr Comp Physiol 299:R1656-R1665
49. Mohr M, Krustrup P, Bangsbo J (2003) Match performance of high standard soccer players with special reference to development of fatigue. J Sports Sci 21:519-528
50. Mohr M, Krustrup P, Nielsen JJ, Nybo L, Rasmussen MK, Juel C, Bangsbo J (2007) Effect of two different intense training regimens on skeletal muscle ion transport proteins and fatigue development. Am J Physiol Regul Integr Comp Physiol 292:R1594-R1602
51. Mohr M, Nordsborg N, Nielsen JJ, Pedersen LD, Fischer C, Krustrup P, Bangsbo J (2004) Potassium kinetics in human muscle interstitium during repeated intense exercise in relation to fatigue. Pflugers Arch 448:452-456
52. Mohr M, Nielsen JJ, Bangsbo J (2011) Caffeine intake improves intense intermittent exercise performance and reduces muscle interstitial potassium accumulation. J Appl Physiol 111:1372-1379
53. Murphy M, Eliot K, Heuertz RM, Weiss E (2012) Whole beetroot consumption acutely improves running performance. J Acad Nutr Diet 112:548-552
54. + homeostasis and excitability in contracting muscles: implications for fatigue. Appl Physiol Nutr Metab 32:974-984
55. Nielsen JJ, Kristensen M, Hellsten Y, Bangsbo J, Juel C (2003) Localization and function of ATP-sensitive potassium channels in human skeletal muscle. Am J Physiol Regul Integr Comp Physiol 284:R558-R563
56. Nordsborg N, Mohr M, Pedersen LD, Nielsen JJ, Langberg H, Bangsbo J (2003) Muscle interstitial potassium kinetics during intense exhaustive exercise: effect of previous arm exercise. Am J Physiol Regul Integr Comp Physiol 285:R143-R148
57. Paganini AT, Foley JM, Meyer RA (1997) Linear dependence of muscle phosphocreatine kinetics on oxidative capacity. Am J Physiol 272:C501-C510
58. Peacock O, Tjønna AE, James P, Wisløff U, Welde B, Böhlke N, Smith A, Stokes K, Cook C, Sandbakk O (2012) Dietary nitrate does not enhance running performance in elite cross-country skiers. Med Sci Sports Exerc 44:2213-2219
59. Poveda JJ, Riestra A, Salas E, Cagigas ML, López-somoza C, Amado JA, Berrazueta JR (1997) Contribution of nitric oxide to exercise-induced changes in healthy volunteers: effects of acute exercise and long-term physical training. Eur J Clin Invest 27:967-971
60. Rampinini E, Sassi A, Azzalin A, Castagna C, Menaspà P, Carlomagno D, Impellizzeri FM (2010) Physiological determinants of Yo-Yo intermittent recovery tests in male soccer players. Eur J Appl Physiol 108:401-409
61. 2 consumption in trained human skeletal muscle. J Appl Physiol 87:325-331
62. Sobko T, Marcus C, Govoni M, Kamiya S (2010) Dietary nitrate in Japanese traditional foods lowers diastolic blood pressure in healthy volunteers. Nitric Oxide 22:136-140
63. Stamler JS, Meissner G (2001) Physiology of nitric oxide in skeletal muscle. Physiol Rev 81:209-237
64. Totzeck M, Hendgen-Cotta UB, Rammos C, Frommke LM, Knackstedt C, Predel HG, Kelm M, Rassaf T (2012) Higher endogenous nitrite levels are associated with superior exercise capacity in highly trained athletes. Nitric Oxide 27:75-81
65. Tsintzas K, Williams C (1998) Human muscle glycogen metabolism during exercise. Effect of carbohydrate supplementation. Sports Med 25:7-23
66. Vanhatalo A, Bailey SJ, Blackwell JR, DiMenna FJ, Pavey TG, Wilkerson DP, Benjamin N, Winyard PG, Jones AM (2010a) Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderate-intensity and incremental exercise. Am J Physiol Regul Integr Comp Physiol 299:R1121-R1131
67. Vanhatalo A, Fulford J, DiMenna FJ, Jones AM (2010b) Influence of hyperoxia on muscle metabolic responses and the power-duration relationship during severe-intensity exercise in humans: a 31P magnetic resonance spectroscopy study. Exp Physiol 95:528-540
68. Vanhatalo A, Fulford J, Bailey SJ, Blackwell JR, Winyard PG, Jones AM (2011) Dietary nitrate reduces muscle metabolic perturbation and improves exercise tolerance in hypoxia. J Physiol 589:5517-5528
69. Veale JP, Pearce AJ, Carlson JS (2010) The Yo-Yo intermittent recovery test (level 1) to discriminate elite junior Australian football players. J Sci Med Sport 13:329-331
70. Vernillo G, Silvestri A, Torre AL (2012) The Yo-Yo intermittent recovery test in junior basketball players according to performance level and age group. J Strength Cond Res 26:2490-2494
71. Wilkerson DP, Hayward GM, Bailey SJ, Vanhatalo A, Blackwell JR, Jones AM (2012) Influence of acute dietary nitrate supplementation on 50 mile time trial performance in well-trained cyclists. Eur J Appl Physiol 112:4127-4134