Higher endogenous nitrite levels are associated with superior exercise capacity in highly trained athletes

Nitric Oxide - Biology and Chemistry

Volumn 27, Issue 2, 2012, Pages 75-81

  Totzeck, Matthias ^a   Hendgen Cotta, Ulrike B ^a   Rammos, Christos ^a   Frommke, Lisa Marie ^a   Knackstedt, Christian ^b   Predel, Hans Georg ^c   Kelm, Malte ^a   Rassaf, Tienush ^a  

^a UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^c GERMAN SPORT UNIVERSITY COLOGNE   (Germany)

Author keywords

Endothelial function; Exercise capacity; Nitrite

Indexed keywords

LACTIC ACID; NITRATE; NITRITE;

ADULT; ARTICLE; ATHLETE; BICYCLE; BLOOD LEVEL; CONTROLLED STUDY; CORRELATIONAL STUDY; EXERCISE TEST; EXERCISE TOLERANCE; EXHAUSTION; FLOW; FLOW MEDIATED VASODILATION; HEART RATE; HUMAN; HUMAN EXPERIMENT; LACTATE ANAEROBIC THRESHOLD; MALE; METABOLIC PARAMETERS; NORMAL HUMAN; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM; VASODILATATION; VENOUS BLOOD;

ADULT; ANALYSIS OF VARIANCE; ATHLETES; ATHLETIC PERFORMANCE; ENDOTHELIUM, VASCULAR; EXERCISE TEST; HEART RATE; HUMANS; LACTIC ACID; LINEAR MODELS; MALE; NITRATES; NITRITES;

EID: 84861782134     PISSN: 10898603     EISSN: 10898611     Source Type: Journal    
DOI: 10.1016/j.niox.2012.05.003     Document Type: Article

References (40)

1. A.C. Guyton, J.E. Hall, Textbook of Medical Physiology, Saunders Elsevier, Philadelphia, 2011.
2. D.R. Bassett Jr., and E.T. Howley Limiting factors for maximum oxygen uptake and determinants of endurance performance Med. Sci. Sports Exercse 32 2000 70 84 (Pubitemid 30056961)
3. S. Moncada, and A. Higgs The l-arginine-nitric oxide pathway N. Engl. J. Med. 329 1993 2002 2012 (Pubitemid 24015045)
4. F. Murad, U. Forstermann, M. Nakane, H. Schmidt, J. Pollock, H. Sheng, T. Matsumoto, T. Warner, J. Mitchell, and R. Tracey The nitric oxide-cyclic GMP signal transduction pathway in vascular smooth muscle preparations and other tissues Jpn. J. Pharmacol. 58 Suppl 2 1992 150P 157P
5. L.J. Ignarro, and C.A. Gruetter Requirement of thiols for activation of coronary arterial guanylate cyclase by glyceryl trinitrate and sodium nitrite: possible involvement of S-nitrosothiols Biochim. Biophys. Acta 631 1980 221 231 (Pubitemid 10018147)
6. T. Lauer, M. Preik, T. Rassaf, B.E. Strauer, A. Deussen, M. Feelisch, and M. Kelm Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action Proc. Natl. Acad. Sci. USA 98 2001 12814 12819 (Pubitemid 33020027)
7. T. Rassaf, T. Lauer, C. Heiss, J. Balzer, S. Mangold, T. Leyendecker, J. Rottler, C. Drexhage, C. Meyer, and M. Kelm Nitric oxide synthase-derived plasma nitrite predicts exercise capacity Br. J. Sports Med. 41 2007 669 673 (Pubitemid 47518440) discussion 673.
8. T. Rassaf, C. Heiss, S. Mangold, T. Leyendecker, E.S. Kehmeier, M. Kelm, and T. Lauer Vascular formation of nitrite after exercise is abolished in patients with cardiovascular risk factors and coronary artery disease J. Am. Coll. Cardiol. 55 2010 1502 1503
9. T. Lauer, C. Heiss, J. Balzer, E. Kehmeier, S. Mangold, T. Leyendecker, J. Rottler, C. Meyer, M.W. Merx, M. Kelm, and T. Rassaf Age-dependent endothelial dysfunction is associated with failure to increase plasma nitrite in response to exercise Basic Res. Cardiol. 103 2008 291 297
10. Z. Huang, S. Shiva, D.B. Kim-Shapiro, R.P. Patel, L.A. Ringwood, C.E. Irby, K.T. Huang, C. Ho, N. Hogg, A.N. Schechter, and M.T. Gladwin Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control J. Clin. Invest. 115 2005 2099 2107 (Pubitemid 41134151)
11. K. Cosby, K.S. Partovi, J.H. Crawford, R.P. Patel, C.D. Reiter, S. Martyr, B.K. Yang, M.A. Waclawiw, G. Zalos, X. Xu, K.T. Huang, H. Shields, D.B. Kim-Shapiro, A.N. Schechter, R.O. Cannon 3rd, and M.T. Gladwin Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation Nat. Med. 9 2003 1498 1505 (Pubitemid 38004777)
12. M.T. Gladwin, J.H. Shelhamer, A.N. Schechter, M.E. Pease-Fye, M.A. Waclawiw, J.A. Panza, F.P. Ognibene, and R.O. Cannon 3rd Role of circulating nitrite and S-nitrosohemoglobin in the regulation of regional blood flow in humans Proc. Natl. Acad. Sci. USA 97 2000 11482 11487
13. T. Rassaf, U. Flogel, C. Drexhage, U. Hendgen-Cotta, M. Kelm, and J. Schrader Nitrite reductase function of deoxymyoglobin: oxygen sensor and regulator of cardiac energetics and function Circ. Res. 100 2007 1749 1754 (Pubitemid 46987867)
14. J.L. Zweier, P. Wang, A. Samouilov, and P. Kuppusamy Enzyme-independent formation of nitric oxide in biological tissues Nat. Med. 1 1995 804 809
15. S. Basu, N.A. Azarova, M.D. Font, S.B. King, N. Hogg, M.T. Gladwin, S. Shiva, and D.B. Kim-Shapiro Nitrite reductase activity of cytochrome c J. Biol. Chem. 283 2008 32590 32597
16. A.F. Vanin, L.M. Bevers, A. Slama-Schwok, and E.E. van Faassen Nitric oxide synthase reduces nitrite to NO under anoxia Cell. Mol. Life Sci. 64 2007 96 103 (Pubitemid 46159448)
17. F.J. Larsen, B. Ekblom, K. Sahlin, J.O. Lundberg, and E. Weitzberg Effects of dietary nitrate on blood pressure in healthy volunteers N. Engl. J. Med. 355 2006 2792 2793 (Pubitemid 46021534)
18. J.O. Lundberg, E. Weitzberg, J.A. Cole, and N. Benjamin Nitrate, bacteria and human health Nat. Rev. Microbiol. 2 2004 593 602 (Pubitemid 39200033)
19. F.J. Larsen, T.A. Schiffer, S. Borniquel, K. Sahlin, B. Ekblom, J.O. Lundberg, and E. Weitzberg Dietary inorganic nitrate improves mitochondrial efficiency in humans Cell. Metab. 13 2011 149 159
20. K.E. Lansley, P.G. Winyard, S.J. Bailey, A. Vanhatalo, D.P. Wilkerson, J.R. Blackwell, M. Gilchrist, N. Benjamin, and A.M. Jones Acute dietary nitrate supplementation improves cycling time trial performance Med. Sci. Sports Exercise 43 2011 1125 1131
21. A. Vanhatalo, S.J. Bailey, J.R. Blackwell, F.J. Dimenna, T.G. Pavey, D.P. Wilkerson, N. Benjamin, P.G. Winyard, and A.M. Jones Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderate-intensity and incremental exercise Am. J. Physiol. Regul. Integr. Comp. Physiol. 299 2010 R1121 R1131
22. K.E. Lansley, P.G. Winyard, J. Fulford, A. Vanhatalo, S.J. Bailey, J.R. Blackwell, F.J. Dimenna, M. Gilchrist, N. Benjamin, and A.M. Jones Dietary nitrate supplementation reduces the O2 cost of walking and running: a placebo-controlled study J. Appl. Physiol. 110 2011 591 600
23. S.J. Bailey, J. Fulford, A. Vanhatalo, P.G. Winyard, J.R. Blackwell, F.J. DiMenna, D.P. Wilkerson, N. Benjamin, and A.M. Jones Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans J. Appl. Physiol. 109 2010 135 148
24. S.J. Bailey, P. Winyard, A. Vanhatalo, J.R. Blackwell, F.J. Dimenna, D.P. Wilkerson, J. Tarr, N. Benjamin, and A.M. Jones Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans J. Appl. Physiol. 107 2009 1144 1155
25. J.D. Allen, E.M. Miller, E. Schwark, J.L. Robbins, B.D. Duscha, and B.H. Annex Plasma nitrite response and arterial reactivity differentiate vascular health and performance Nitric Oxide 20 2009 231 237
26. F.J. Larsen, E. Weitzberg, J.O. Lundberg, and B. Ekblom Effects of dietary nitrate on oxygen cost during exercise Acta Physiol. (Oxf) 191 2007 59 66 (Pubitemid 47221195)
27. C. Heiss, A. Dejam, P. Kleinbongard, T. Schewe, H. Sies, and M. Kelm Vascular effects of cocoa rich in flavan-3-ols JAMA 290 2003 1030 1031 (Pubitemid 37430442)
28. C. Heiss, S. Jahn, M. Taylor, W.M. Real, F.S. Angeli, M.L. Wong, N. Amabile, M. Prasad, T. Rassaf, J.I. Ottaviani, S. Mihardja, C.L. Keen, M.L. Springer, A. Boyle, W. Grossman, S.A. Glantz, H. Schroeter, and Y. Yeghiazarians Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease J. Am. Coll. Cardiol. 56 2010 218 224
29. T. Rassaf, C. Heiss, U. Hendgen-Cotta, J. Balzer, S. Matern, P. Kleinbongard, A. Lee, T. Lauer, and M. Kelm Plasma nitrite reserve and endothelial function in the human forearm circulation Free Radical Biol. Med. 41 2006 295 301 (Pubitemid 43928502)
30. C. Meyer, C. Heiss, C. Drexhage, E.S. Kehmeier, J. Balzer, A. Muhlfeld, M.W. Merx, T. Lauer, H. Kuhl, J. Floege, M. Kelm, and T. Rassaf Hemodialysis-induced release of hemoglobin limits nitric oxide bioavailability and impairs vascular function J. Am. Coll. Cardiol. 55 2010 454 459
31. H.J. Trappe, and H. Lollgen Guidelines for ergometry. German Society of Cardiology-Heart and Cardiovascular Research Zeitschrift fur Kardiologie 89 2000 821 831
32. T. Rassaf, M. Feelisch, and M. Kelm Circulating NO pool: Assessment of nitrite and nitroso species in blood and tissues Free Radical Biol. Med. 36 2004 413 422 (Pubitemid 38224513)
33. N.S. Bryan, T. Rassaf, R.E. Maloney, C.M. Rodriguez, F. Saijo, J.R. Rodriguez, and M. Feelisch Cellular targets and mechanisms of nitros(yl)ation: an insight into their nature and kinetics in vivo Proc. Natl. Acad. Sci. USA 101 2004 4308 4313 (Pubitemid 38405925)
34. T. Rassaf, M. Preik, P. Kleinbongard, T. Lauer, C. Heiss, B.E. Strauer, M. Feelisch, and M. Kelm Evidence for in vivo transport of bioactive nitric oxide in human plasma J. Clin. Invest. 109 2002 1241 1248 (Pubitemid 34496602)
35. P. Kleinbongard, A. Dejam, T. Lauer, T. Rassaf, A. Schindler, O. Picker, T. Scheeren, A. Gîdecke, J. Schrader, R. Schulz, G. Heusch, G.A. Schaub, N.S. Bryan, M. Feelisch, and M. Kelm Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals Free Radical Biol. Med. 35 2003 790 796 (Pubitemid 37329482)
36. J.O. Lundberg, E. Weitzberg, and M.T. Gladwin The nitrate-nitrite-nitric oxide pathway in physiology and therapeuticsm Nat. Rev. Drug Discovery 7 2008 156 167 (Pubitemid 351194063)
37. J.O. Lundberg, M.T. Gladwin, A. Ahluwalia, N. Benjamin, N.S. Bryan, A. Butler, P. Cabrales, A. Fago, M. Feelisch, P.C. Ford, B.A. Freeman, M. Frenneaux, J. Friedman, M. Kelm, C.G. Kevil, D.B. Kim-Shapiro, A.V. Kozlov, J.R. Lancaster Jr., D.J. Lefer, K. McColl, K. McCurry, R.P. Patel, J. Petersson, T. Rassaf, V.P. Reutov, G.B. Richter-Addo, A. Schechter, S. Shiva, K. Tsuchiya, E.E. van Faassen, A.J. Webb, B.S. Zuckerbraun, J.L. Zweier, and E. Weitzberg Nitrate and nitrite in biology, nutrition and therapeutics Nat. Chem. Biol. 5 2009 865 869
38. S. Shiva, X. Wang, L.A. Ringwood, X. Xu, S. Yuditskaya, V. Annavajjhala, H. Miyajima, N. Hogg, Z.L. Harris, and M.T. Gladwin Ceruloplasmin is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis Nat. Chem. Biol. 2 2006 486 493 (Pubitemid 44266311)
39. F.J. Larsen, E. Weitzberg, J.O. Lundberg, and B. Ekblom Dietary nitrate reduces maximal oxygen consumption while maintaining work performance in maximal exercise Free. Radical Biol. Med. 48 2010 342 347
40. V. Kapil, A.B. Milsom, M. Okorie, S. Maleki-Toyserkani, F. Akram, F. Rehman, S. Arghandawi, V. Pearl, N. Benjamin, S. Loukogeorgakis, R. Macallister, A.J. Hobbs, A.J. Webb, and A. Ahluwalia Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO Hypertension 56 2010 274 281