Caffeine intake improves intense intermittent exercise performance and reduces muscle interstitial potassium accumulation

Journal of Applied Physiology

Volumn 111, Issue 5, 2011, Pages 1372-1379

  Mohr, Magni ^a,b   Nielsen, Jens Jung ^a   Bangsbo, Jens ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF EXETER   (United Kingdom)

Author keywords

Fatigue; Free fatty acids; Muscle ion kinetics; Potassium; Repeated exercise

Indexed keywords

AMMONIA; CAFFEINE; FATTY ACID; POTASSIUM; SODIUM;

ADULT; ARTICLE; BLOOD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; EXERCISE; EXERCISE TEST; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; KNEE; LEG; MALE; METABOLISM; METHODOLOGY; MICRODIALYSIS; MUSCLE FATIGUE; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; SKELETAL MUSCLE;

ADULT; AMMONIA; BLOOD GLUCOSE; CAFFEINE; DOUBLE-BLIND METHOD; EXERCISE; EXERCISE TEST; FATTY ACIDS, NONESTERIFIED; FEMALE; HUMANS; KNEE JOINT; LEG; MALE; MICRODIALYSIS; MUSCLE FATIGUE; MUSCLE, SKELETAL; POTASSIUM; SODIUM; YOUNG ADULT;

EID: 81355153481     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01028.2010     Document Type: Article

References (49)

1. Allen DG, Westerblad H. The effects of caffeine on intracellular calcium, force and the rate of relaxation of mouse skeletal muscle. J Physiol 487: 331-342, 1995.
2. Allen DG, Lamb GD, Westerblad H. Impaired calcium release during fatigue. J Appl Physiol 104: 296-305, 2008.
3. Andersen P, Adams RP, Sjøgaard G, Thorboe A, Saltin B. Dynamic knee extension as model for study of isolated exercising muscle in humans. J Appl Physiol 59: 1647-1653, 1985. (Pubitemid 16197435)
4. Astorino TA, Rohmann RL, Firth K. Effect of caffeine ingestion on one-repetition maximum muscular strength. Eur J Appl Physiol 102: 127-132, 2008. (Pubitemid 350142377)
5. Bangsbo J, Jacobsen K, Nordberg N, Christensen NJ, Graham T. Acute and habitual caffeine ingestion and metabolic responses to steadystate exercise. J Appl Physiol 72:1297-303, 1992.
6. Bangsbo J, Madsen K, Kiens B, Richter EA. Effect of muscle acidity on muscle metabolism and fatigue during intense exercise in man. J Physiol 495: 587-596, 1996. (Pubitemid 26331838)
7. Bangsbo J, Iaia FM, Krustrup P. The Yo-Yo intermittent recovery test: a useful tool for evaluation of physical performance in intermittent sports. Sports Med 38: 37-51, 2008. (Pubitemid 350261958)
8. Bell DG, Jacobs I, Ellerington K. Effect of caffeine and ephedrine ingestion on anaerobic exercise performance. Med Sci Sports Exerc 33: 1399-1403, 2001. (Pubitemid 32729860)
9. Bruce CR, Anderson ME, Fraser SF, Stepto NK, Klein R, Hopkins WG, Hawley JA. Enhancement of 2000-m rowing performance after caffeine ingestion. Med Sci Sports Exerc 32: 1958-1963, 2000.
10. Cairns SP, Hing WA, Slack JR, Mills RG, Loiselle DS. Different effects of raised [K]o on membrane potential and contraction in mouse fast-and slow-twitch muscle. Am J Physiol Cell Physiol 273: C598-C611, 1997.
11. Carr A, Dawson B, Schneiker K, Goodman C, Lay B. Effect of caffeine supplementation on repeated sprint running performance. J Sports Med Phys Fitness 48: 472-478, 2008.
12. Collomp K, Caillaud C, Audran M, Chanal JL, Prefaut C. Effect of acute or chronic administration of caffeine on performance and on catecholamines during maximal cycle ergometer exercise. C R Seances Soc Biol Fil 184: 87-92, 1990. (Pubitemid 20365860)
13. Costill DL, Dalsky GP, Fink WJ. Effects of caffeine ingestion on metabolism and exercise performance. Med Sci Sports Exerc 10: 155-158, 1978. (Pubitemid 9080718)
14. Crowe MJ, Leicht AS, Spinks WL. Physiological and cognitive responses to caffeine during repeated, high-intensity exercise. Int J Sport Nutr Exerc Metab 16: 528-544, 2006. (Pubitemid 44520665)
15. Davis JK, Green JM. Caffeine and anaerobic performance: ergogenic value and mechanisms of action. Sports Med 39: 813-832, 2009.
16. Doherty M. The effects of caffeine on the maximal accumulated oxygen deficit and short-term running performance. Int J Sport Nutr 8: 95-104, 1998.
17. Doherty M, Smith PM, Davison RC, Hughes MG. Caffeine is ergogenic after supplementation of oral creatine monohydrate. Med Sci Sports Exerc 34: 1785-1792, 2002. (Pubitemid 35283496)
18. Foskett A, Ali A, Gant N. Caffeine enhances cognitive function and skill performance during simulated soccer activity. Int J Sport Nutr Exerc Metab 19: 410-423, 2009.
19. Fitts RH. Cellular mechanisms of muscle fatigue. Physiol Rev 74: 49-94, 1994. (Pubitemid 24045674)
20. Glaister M, Howatson G, Abraham CS, Lockey RA, Goodwin JE, Foley P, McInnes G. Caffeine supplementation and multiple sprint running performance. Med Sci Sports Exerc 40: 1835-1840, 2008.
21. Goldstein ER, Ziegenfuss T, Kalman D, Kreider R, Campbell B, Wilborn C, Taylor L, Willoughby D, Stout J, Graves BS, Wildman R, Ivy JL, Spano M, Smith AE, Antonio J. International Society of Sports Nutrition position stand: caffeine and performance. J Int Soc Sports Nutr 7: 5, 2010.
22. Graham TE, Spriet LL. Performance and metabolic responses to a high caffeine dose during prolonged exercise. J Appl Physiol 71: 2292-2298, 1991.
23. Graham TE, Helge JW, MacLean DA, Kiens B, Richter EA. Caffeine ingestion does not alter carbohydrate or fat metabolism in human skeletal muscle during exercise. J Physiol 529: 837-847, 2000. (Pubitemid 32051082)
24. Greer F, McLean C, Graham TE. Caffeine, performance, and metabolism during repeated Wingate exercise tests. J Appl Physiol 85: 1502-1508, 1998. (Pubitemid 28465083)
25. Hellsten Y, Nielsen JJ, Lykkesfeldt J, Bruhn M, Silveira L, Pilegaard H, Bangsbo J. Antioxidant supplementation enhances the exercise-induced increase in mitochondrial uncoupling protein 3 and endothelial nitric oxide synthase mRNA content in human skeletal muscle. Free Radic Biol Med 43: 353-361, 2007. (Pubitemid 46977622)
26. Hornery DJ, Farrow D, Mujika I, Young WB. Caffeine, carbohydrate, and cooling use during prolonged simulated tennis. Int J Sports Physiol Perform 2: 423-438, 2007.
27. Juel C, Pilegaard H, Nielsen JJ, Bangsbo J. Interstitial K in human skeletal muscle during and after dynamic graded exercise determined by microdialysis. Am J Physiol Regul Integr Comp Physiol 278: R400-R406, 2000. (Pubitemid 30129630)
28. Kalmar JM, Cafarelli E. Caffeine: a valuable tool to study central fatigue in humans? Exerc Sport Sci Rev 32: 143-147, 2004. (Pubitemid 39362877)
29. Karelis AD, Péronnet F, Gardiner PF. Glucose infusion attenuates muscle fatigue in rat plantaris muscle during prolonged indirect stimulation in situ. Exp Physiol 87: 585-592, 2002. (Pubitemid 35012232)
30. Krustrup P, Mohr M, Amstrup T, Rysgaard T, Johansen J, Steensberg A, Pedersen PK, Bangsbo J. The yo-yo intermittent recovery test: physiological response, reliability, and validity. Med Sci Sports Exerc 35: 697-705, 2003. (Pubitemid 36417863)
31. Krustrup P, Mohr M, Nybo L, Jensen JM, Nielsen JJ, Bangsbo J. The Yo-Yo IR2 test: physiological response, reliability, and application to elite soccer. Med Sci Sports Exerc 38: 1666-1673, 2006. (Pubitemid 44373787)
32. Lindinger MI, Graham TE, Spriet LL. Caffeine attenuates the exerciseinduced increase in plasma [K] in humans. J Appl Physiol 74: 1149-1155, 1993. (Pubitemid 23118564)
33. Marcil M, Karelis AD, Péronnet F, Gardiner PF. Glucose infusion attenuates fatigue without sparing glycogen in rat soleus muscle during prolonged electrical stimulation in situ. Eur J Appl Physiol 93: 569-574, 2005. (Pubitemid 40450237)
34. McKenna MJ, Bangsbo J, Renaud JM. Muscle K, Na, and Cl disturbances and Na-K pump inactivation: implications for fatigue. J Appl Physiol 104: 288-295, 2008.
35. McNaughton LR, Lovell RJ, Siegler J, Midgley AW, Moore L, Bentley DJ. The effects of caffeine ingestion on time trial cycling performance. Int J Sports Physiol Perform 3: 157-163, 2008.
36. Mohr M, Nordsborg N, Nielsen JJ, Pedersen LD, Fischer C, Krustrup P, Bangsbo J. Potassium kinetics in human muscle interstitium during repeated intense exercise in relation to fatigue. Pflügers Arch 448: 452-456, 2004. (Pubitemid 39006010)
37. Mohr M, Krustrup P, Nielsen JJ, Nybo L, Rasmussen MK, Juel C, Bangsbo J. Effect of two different intense training regimens on skeletal muscle ion transport proteins and fatigue development. Am J Physiol Regul Integr Comp Physiol 292: R1594-R1602, 2007. (Pubitemid 46557824)
38. Nielsen JJ, Mohr M, Klarskov C, Kristensen M, Krustrup P, Juel C, Bangsbo J. Effects of high-intensity intermittent training on potassium kinetics and performance in human skeletal muscle. J Physiol 554: 857-870, 2004. (Pubitemid 38219897)
39. Nordsborg N, Mohr M, Pedersen LD, Nielsen JJ, Langberg H, Bangsbo J. Muscle interstitial potassium kinetics during intense exhaustive exercise: effect of previous arm exercise. Am J Physiol Regul Integr Comp Physiol 285: R143-R148, 2003. (Pubitemid 36736511)
40. Pruscino CL, Ross ML, Gregory JR, Savage B, Flanagan TR. Effects of sodium bicarbonate, caffeine, and their combination on repeated 200-m freestyle performance. Int J Sport Nutr Exerc Metab 18: 116-130, 2008.
41. Sejersted OM, Sjøgaard G. Dynamics and consequences of potassium shifts in skeletal muscle and heart during exercise. Physiol Rev 80: 1411-1481, 2000.
42. Sjøgaard G. Water and electrolyte fluxes during exercise and their relation to muscle fatigue. Acta Physiol Scand Suppl 556: 129-136, 1986. (Pubitemid 17227028)
43. Spriet LL, MacLean DA, Dyck DJ, Hultman E, Cederblad G, Graham TE. Caffeine ingestion and muscle metabolism during prolonged exercise in humans. Am J Physiol Endocrinol Metab 262: E891-E898, 1992.
44. Stuart GR, Hopkins WG, Cook C, Cairns SP. Multiple effects of caffeine on simulated high-intensity team-sport performance. Med Sci Sports Exerc 37: 1998-2005, 2005. (Pubitemid 41691845)
45. Tarnopolsky MA. Caffeine and endurance performance. Sports Med 18: 109-125, 1994.
46. Van Thuyne W, Delbeke FT. Distribution of caffeine levels in urine in different sports in relation to doping control before and after the removal of caffeine from the WADA doping list. Int J Sports Med 27: 745-750, 2006. (Pubitemid 44369573)
47. Wiles JD, Coleman D, Tegerdine M, Swaine IL. The effects of caffeine ingestion on performance time, speed and power during a laboratory-based 1 km cycling time-trial. J Sports Sci 24: 1165-1171, 2006. (Pubitemid 44575117)
48. Williams JH, Signorile JF, Barnes WS, Henrich TW. Caffeine, maximal power output and fatigue. Br J Sports Med 22: 132-134, 1988.
49. Williams AD, Cribb PJ, Cooke MB, Hayes A. The effect of ephedra and caffeine on maximal strength and power in resistance-trained athletes. J Strength Cond Res 22: 464-470, 2008.