Arsenic speciation in the blood of arsenite-treated F344 rats

Chemical Research in Toxicology

Volumn 26, Issue 6, 2013, Pages 952-962

  Chen, Baowei ^a   Lu, Xiufen ^a   Shen, Shengwen ^a   Arnold, Lora L ^b   Cohen, Samuel M ^b   Le, X Chris ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID; ARSENIC; ARSENIC ACID; ARSENIC TRIOXIDE; CACODYLIC ACID; DIMETHYLMONOTHIOARSINIC ACID; HEMOGLOBIN; HYDROGEN PEROXIDE; METHANEARSONIC ACID; MONOMETHYLMONOTHIOARSONIC ACID; ORGANOARSENIC DERIVATIVE; THIOARSENICAL; TRIMETHYLARSINE OXIDE; UNCLASSIFIED DRUG; ARSENOUS ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANION EXCHANGE CHROMATOGRAPHY; ARSENIC POISONING; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; ERYTHROCYTE; FEMALE; GEL PERMEATION CHROMATOGRAPHY; METABOLISM; NONHUMAN; OXIDATION; RAT; TANDEM MASS SPECTROMETRY; TOXICOKINETICS; ANIMAL; BLOOD; CHEMISTRY; DIET; FISCHER 344 RAT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ANIMALIA; RATTUS;

ANIMALS; ARSENIC; ARSENITES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIET; FEMALE; RATS; RATS, INBRED F344; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84879184081     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx400123q     Document Type: Article

References (62)

1. NRC (1999) Arsenic in the Drinking Water, National Research Council, National Academy Press, Washington, DC.
2. NRC (2001) Arsenic in the Drinking Water (Update), National Research Council, National Academy Press, Washington, DC.
3. Chen, C. J., Chuang, Y. C., Lin, T. M., and Wu, H. Y. (1985) Malignant neoplasms among residents of a blackfoot disease endemic area in Taiwan-High-arsenic Artesian well water and cancers Cancer Res. 45, 5895-5899
4. Smith, A. H., Goycolea, M., Haque, R., and Biggs, M. L. (1998) Marked increase in bladder and lung cancer mortality in a region of Northern Chile due to arsenic in drinking water Am. J. Epidemiol. 147, 660-669
5. Lee, M. Y., Jung, B. I., Chung, S. M., Bae, O. N., Lee, J. Y., Park, J. D., Yang, J. S., Lee, H., and Chung, J. H. (2003) Arsenic-induced dysfunction in relaxation of blood vessels Environ. Health Perspect. 111, 513-517
6. Tseng, C. H., Tseng, C. P., Chiou, H. Y., Hsueh, Y. M., Chong, C. K., and Chen, C. J. (2002) Epidemiologic evidence of diabetogenic effect of arsenic Toxicol. Lett. 133, 69-76
7. Yokohira, M., Arnold, L. L., Pennington, K. L., Suzuki, S., Kakiuchi-Kiyota, S., Herbin-Davis, K., Thomas, D. J., and Cohen, S. M. (2011) Effect of sodium arsenite dose administered in the drinking water on the urinary bladder epithelium of female arsenic (+3 oxidation state) methyltransferase knockout mice Toxicol. Sci. 121, 257-266
8. Chatterjee, A. and Chatterji, U. (2011) All-trans retinoic acid protects against arsenic-induced uterine toxicity in female Sprague-Dawley rats Toxicol. Appl. Pharmacol. 257, 250-263
9. Tokar, E. J., Benbrahim-Tallaa, L., Ward, J. M., Lunn, R., Sams, R. L., and Waalkes, M. P. (2010) Cancer in experimental animals exposed to arsenic and arsenic compounds Crit. Rev. Toxicol. 40, 912-927
10. Cohen, S. M., Arnold, L. L., Uzvolgyi, E., Cano, M., St. John, M., Yamamoto, S., Lu, X., and Le, X. C. (2002) Possible role of dimethylarsinous acid in dimethylarsinic acid-induced urothelial toxicity and regeneration in the rat Chem. Res. Toxicol. 15, 1150-1157
11. Wei, M., Wanibuchi, H., Morimura, K., Iwai, S., Yoshida, K., Endo, G., Nakae, D., and Fukushima, S. (2002) Carcinogenicity of dimethylarsinic acid in male F344 rats and genetic alterations in induced urinary bladder tumors Carcinogenesis 23, 1387-1397
12. Byron, W. R., Bierbower, G. W., Brouwer, J. B., and Hansen, W. H. (1967) Pathologic changes in rats and dogs from two-year feeding of sodium arsenite or sodium arsenate Toxicol. Appl. Pharmacol. 10, 132-147
13. Simeonova, P. P., Wang, S., Toriuma, W., Kommineni, V., Matheson, J., Unimye, N., Kayama, F., Harki, D., Ding, M., Vallyathan, V., and Luster, M. I. (2000) Arsenic mediates cell proliferation and gene expression in the bladder epithelium: association with activating protein-1 transactivation Cancer Res. 60, 3445-3453
14. Suzuki, S., Arnold, L. L., Ohnishi, T., and Cohen, S. M. (2008) Effects of inorganic arsenic on the rat and mouse urinary bladder Toxicol. Sci. 106, 350-363
15. Buchet, J. P., Lauwerys, R., and Roels, H. (1981) Comparison of the urinary excretion of arsenic metabolites after a single oral dose of sodium arsenite, monomethylarsonate, or dimethylarsinate in man Int. Arch. Occup. Environ. Health 48, 71-79
16. Lerman, S. and Clarkson, T. W. (1983) The metabolism of arsenite and arsenate by the rat Fundam. Appl. Toxicol. 3, 309-314
17. Xu, Y. Y., Wang, Y., Zheng, Q. M., Li, B., Li, X., Jin, Y. P., Lv, X. Q., Qu, G., and Sun, G. F. (2008) Clinical manifestations and arsenic methylation after a rare subacute arsenic poisoning accident Toxicol. Sci. 103, 278-284
18. Suzuki, K. T., Mandal, B. K., Katagiri, A., Sakuma, Y., Kawakami, A., Ogra, Y., Yamaguchi, K., Sei, Y., Yamanaka, K., Anzai, K., Ohmichi, M., Takayama, H., and Aimi, N. (2004) Dimethylthioarsenicals as arsenic metabolites and their chemical preparations Chem. Res. Toxicol. 17, 914-921
19. Raml, R., Rumpler, A., Goessler, W., Vahter, M., Li, L., Ochi, T., and Francesconi, K. A. (2007) Thio-dimethylarsinate is a common metabolite in urine samples from arsenic-exposed women in Bangladesh Toxicol. Appl. Pharmacol. 222, 374-380
20. Naranmandura, H., Suzuki, N., Iwata, K., Hirano, S., and Suzuki, K. T. (2007) Arsenic metabolism and thioarsenicals in hamsters and rats Chem. Res. Toxicol. 20, 616-624
21. Cohen, S. M., Arnold, L. L., Eldan, M., Lewis, A. S., and Beck, B. D. (2006) Methylated arsenicals: The implications of metabolism and carcinogenicity studies in rodents to human risk assessment Crit. Rev. Toxicol. 36, 99-133
22. Chen, B. W., Hua, N., Lu, M. L., and Le, X. C. (2009) Metabolism, toxicity, and biomonitoring of arsenic species Prog. Chem. 21, 474-482
23. Ito, K., Goessler, W., Gurleyuk, H., Wels, B., Palmer, C. D., Verostek, M. F., and Parsons, P. J. (2011) An interlaboratory study of arsenic speciation analysis of whole blood J. Anal. At. Spectrom. 26, 1740-1745
24. Lu, M. L., Wang, H. L., Li, X. F., Lu, X. F., Cullen, W. R., Arnold, L. L., Cohen, S. M., and Le, X. C. (2004) Evidence of hemoglobin binding to arsenic as a basis for the accumulation of arsenic in rat blood Chem. Res. Toxicol. 17, 1733-1742
25. Lu, M. L., Wang, H. L., Li, X. F., Arnold, L. L., Cohen, S. M., and Le, X. C. (2007) Binding of dimethylarsinous acid to Cys-13 alpha of rat hemoglobin is responsible for the retention of arsenic in rat blood Chem. Res. Toxicol. 20, 27-37
26. Yoshino, Y., Yuan, B., Miyashita, S., Iriyama, N., Horikoshi, A., Shikino, O., Toyoda, H., and Kaise, T. (2009) Speciation of arsenic trioxide metabolites in blood cells and plasma of a patient with acute promyelocytic leukemia Anal. Bioanal. Chem. 393, 689-697
27. Jiang, G., Gong, Z., Li, X. F., Cullen, W. R., and Le, X. C. (2003) Interaction of trivalent arsenicals with metallothionein Chem. Res. Toxicol. 16, 873-880
28. Naranmandura, H. and Suzuki, K. T. (2008) Identification of the major arsenic-binding protein in rat plasma as the ternary dimethylarsinous- hemoglobin-haptoglobin complex Chem. Res. Toxicol. 21, 678-685
29. Chen, B. W., Arnold, L. L., Cohen, S. M., Thomas, D. J., and Le, X. C. (2011) Mouse arsenic (+3 oxidation state) methyltransferase genotype affects metabolism and tissue dosimetry of arsenicals after arsenite administration in drinking water Toxicol. Sci. 124, 320-326
30. Mok, W. M. and Wai, C. M. (1994) Mobilization of Arsenic in Contaminated River Waters, in Arsenic in the Environment. Part I: Cycling and Characterization, Wiley, New York.
31. Nordstrom, D. K. (2002) Public health-worldwide occurrences of arsenic in ground water Science 296, 2143-2145
32. Yan-Chu, H. (1994) Arsenic Distribution in Soils, in Arsenic in the Environment. Part I: Cycling and Characterization, Wiley, New York.
33. Chen, Y. C., Guo, Y. L. L., Su, H. J. J., Hsueh, Y. M., Smith, T. J., Lee, M. S., Chao, S. C., Lee, J. Y. Y., and Christiani, D. C. (2003) Arsenic methylation and skin cancer risk in southwestern Taiwan J. Occup. Environ. Med. 45, 241-248
34. Abernathy, C. O., Chappell, W. R., Meek, M. E., Gibb, H., and Guo, H. R. (1996) Is ingested inorganic arsenic a "threshold" carcinogen? Fundam. Appl. Toxicol. 29, 168-175
35. Kitchin, K. T. (2001) Recent advances in arsenic carcinogenesis: modes of action, animal model systems, and methylated arsenic metabolites Toxicol. Appl. Pharmacol. 172, 249-261
36. Cohen, S. M., Ohnishi, T., Arnold, L. L., and Le, X. C. (2007) Arsenic-induced bladder cancer in an animal model Toxicol. Appl. Pharmacol. 222, 258-263
37. Chilakapati, J., Wallace, K., Ren, H. Z., Fricke, M., Bailey, K., Ward, W., Creed, J., and Kitchin, K. (2010) Genome-wide analysis of BEAS-2B cells exposed to trivalent arsenicals and dimethylthioarsinic acid Toxicology 268, 31-39
38. Lin, S., Shi, Q., Nix, F. B., Styblo, M., Beck, M. A., Herbin-Davis, K. M., Hall, L. L., Simeonsson, J. B., and Thomas, D. J. (2002) A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol J. Biol. Chem. 277, 10795-10803
39. Thomas, D. J., Waters, S. B., and Styblo, M. (2004) Elucidating the pathway for arsenic methylation Toxicol. Appl. Pharmacol. 198, 319-326
40. Waters, S. B., Devesa, V., Del Razo, L. M., Styblo, M., and Thomas, D. J. (2004) Endogenous reductants support the catalytic function of recombinant rat cyt19, an arsenic methyltransferase Chem. Res. Toxicol. 17, 404-409
41. Styblo, M., Del Razo, L. M., LeCluyse, E. L., Hamilton, G. A., Wang, C., Cullen, W. R., and Thomas, D. J. (1999) Metabolism of arsenic in primary cultures of human and rat hepatocytes Chem. Res. Toxicol. 12, 560-565
42. Wang, A., Wolf, D. C., Sen, B., Knapp, G. W., Holladay, S. D., Huckle, W. R., Caceci, T., and Robertson, J. L. (2009) Dimethylarsinic acid in drinking water changed the morphology of urinary bladder but not the expression of DNA repair genes of bladder transitional epithelium in F344 rats Toxicol. Pathol. 37, 425-437
43. Adair, B. M., Moore, T., Conklin, S. D., Creed, J. T., Wolf, D. C., and Thomas, D. J. (2007) Tissue distribution and urinary excretion of dimethylated arsenic and its metabolites in dimethylarsinic acid-or arsenate-treated rats Toxicol. Appl. Pharmacol. 222, 235-242
44. Vahter, M. (1994) Species-differences in the metabolism of arsenic compounds Appl. Organomet. Chem. 8, 175-182
45. Wanibuchi, H., Salim, E. I., Kinoshita, A., Shen, J., Wei, M., Morimura, K., Yoshida, K., Kuroda, K., Endo, G., and Fukushima, S. (2004) Understanding arsenic carcinogenicity by the use of animal models Toxicol. Appl. Pharmacol. 198, 366-376
46. Shen, J., Wanibuchi, H., Waalkes, M. P., Salim, E. I., Kinoshita, A., Yoshida, K., Endo, G., and Fukushima, S. (2006) A comparative study of the sub-chronic toxic effects of three organic arsenical compounds on the urothelium in F344 rats; gender-based differences in response Toxicol. Appl. Pharmacol. 210, 171-180
47. Shen, J., Wanibuchi, H., Salim, E. I., Wei, M., Kinoshita, A., Yoshida, K., Endo, G., and Fukushima, S. (2003) Liver tumorigenicity of trimethylarsine oxide in male Fischer 344 rats-association with oxidative DNA damage and enhanced cell proliferation Carcinogenesis 24, 1827-1835
48. Raml, R., Goessler, W., and Francesconi, K. A. (2006) Improved chromatographic separation of thio-arsenic compounds by reversed-phase high performance liquid chromatography-inductively coupled plasma mass spectrometry J. Chromatogr., A 1128, 164-170
49. Hansen, H. R., Pickford, R., Thomas-Oates, J., Jaspars, M., and Feldmann, J. (2004) 2-Dimethylarsinothioyl acetic acid identified in a biological sample: the first occurrence of a mammalian arsinothioyl metabolite Angew. Chem., Int. Ed. 43, 337-340
50. Suzuki, S., Arnold, L. L., Pennington, K. L., Chen, B. W., Naranmandura, H., Le, X. C., and Cohen, S. M. (2010) Dietary administration of sodium arsenite to rats: Relations between dose and urinary concentrations of methylated and thio-metabolites and effects on the rat urinary bladder epithelium Toxicol. Appl. Pharmacol. 244, 99-105
51. Ochi, T., Kita, K., Suzuki, T., Rumpler, A., Goessler, W., and Francesconi, K. A. (2008) Cytotoxic, genotoxic and cell-cycle disruptive effects of thio-dimethylarsinate in cultured human cells and the role of glutathione Toxicol. Appl. Pharmacol. 228, 59-67
52. Naranmandura, H., Ogra, Y., Iwata, K., Lee, J., Suzuki, K. T., Weinfeld, M., and Le, X. C. (2009) Evidence for toxicity differences between inorganic arsenite and thioarsenicals in human bladder cancer cells Toxicol. Appl. Pharmacol. 238, 133-140
53. Naranmandura, H., Bu, N., Suzuki, K. T., Lou, Y., and Ogra, Y. (2010) Distribution and speciation of arsenic after intravenous administration of monomethylmonothioarsonic acid in rats Chemosphere 81, 206-213
54. Bartel, M., Ebert, F., Leffers, L., Karst, U., and Schwerdtle, T. (2011) Toxicological characterization of the inorganic and arganic arsenic metabolite thio-DMA in cultured human lung cells J. Toxicol. 2011, 373141
55. Suzuki, K. T., Iwata, K., Naranmandura, H., and Suzuki, N. (2007) Metabolic differences between two dimethylthioarsenicals in rats Toxicol. Appl. Pharmacol. 218, 166-173
56. Mondal, B., Chatterjee, D., and Bhattacharyya, M. (2012) Structure-function alteration of hemoglobin in arsenicosis patients: a probable pathway to exert toxicity J. Appl. Toxicol. 32, 581-589
57. Zhang, X. R., Cornelis, R., De Kimpe, J., Mees, L., and Lameire, N. (1998) Study of arsenic-protein binding in serum of patients on continuous ambulatory peritoneal dialysis Clin. Chem. 44, 141-147
58. Zhang, X. R., Cornelis, R., Mees, L., Vanholder, R., and Lameire, N. (1998) Chemical speciation of arsenic in serum of uraemic patients Analyst 123, 13-17
59. Naranmandura, H. and Suzuki, K. T. (2008) Formation of dimethylthioarsenicals in red blood cells Toxicol. Appl. Pharmacol. 227, 390-399
60. Wang, Z., Zhang, H., Li, X. F., and Le, X. C. (2007) Study of interactions between arsenicals and thioredoxins (human and E. coli) using mass spectrometry Rapid Commun. Mass Spectrom. 21, 3658-3666
61. Yan, H.., Wang, N., Weinfeld, M., Cullen, W. R., and Le, X. C. (2009) Identification of arsenic-binding proteins in human cells by affinity chromatography and mass spectrometry Anal. Chem. 81, 4144-4152
62. Lu, M., Wang, H., Li, X.-F., and Le, X. C. (2008) Identification of reactive cysteines in a protein using arsenic labeling and collision-induced dissociation tandem mass spectrometry J. Proteome Res. 7, 3080-3090