Mouse arsenic (+3 oxidation state) methyltransferase genotype affects metabolism and tissue dosimetry of arsenicals after arsenite administration in drinking water

Toxicological Sciences

Volumn 124, Issue 2, 2011, Pages 320-326

  Chen, Baowei ^a   Arnold, Lora L ^b   Cohen, Samuel M ^b   Thomas, David J ^c   Le, X Chris ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Arsenic(III) methyltransferase; As3mt; Biotransformation and toxicokinetics; Dosimetry; Inorganic arsenic; Knockouts; Metabolism; Methylation; Mouse; Risk assessment

Indexed keywords

ARSENIC (+3 OXIDATION STATE) METHYLTRANSFERASE; ARSENIC TRIOXIDE; DRINKING WATER; METHYLTRANSFERASE; ORGANOARSENIC DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BLOOD LEVEL; FEMALE; GENOTYPE; MALE; METHYLATION; MICROFLORA; MOUSE; NONHUMAN; PHENOTYPE;

ANIMALS; ARSENITES; BIOTRANSFORMATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRINKING WATER; ERYTHROCYTES; FEMALE; GENOTYPE; METHYLATION; METHYLTRANSFERASES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; TISSUE DISTRIBUTION; WATER POLLUTANTS, CHEMICAL;

EID: 81855168354     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr246     Document Type: Article

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