메뉴 건너뛰기




Volumn 114, Issue 8, 2013, Pages 1940-1954

Mechanisms of ceramide-induced COX-2-dependent apoptosis in human ovarian cancer OVCAR-3 cells partially overlapped with resveratrol

Author keywords

APOPTOSIS; CERAMIDE; COX 2; p38 KINASE; p53; RESVERATROL

Indexed keywords

CASPASE 3; CASPASE 7; CERAMIDE; CYCLOOXYGENASE 2; CYTOCHALASIN D; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN P53; RESVERATROL; SMALL INTERFERING RNA;

EID: 84879132154     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24539     Document Type: Article
Times cited : (42)

References (62)
  • 1
    • 0033812743 scopus 로고    scopus 로고
    • Indomethacin-induced apoptosis in esophageal adenocarcinoma cells involves upregulation of Bax and translocation of mitochondrial cytochrome C independent of COX-2 expression
    • Aggarwal S, Taneja N, Lin L, Orringer MB, Rehemtulla A, Beer DG,. 2000. Indomethacin-induced apoptosis in esophageal adenocarcinoma cells involves upregulation of Bax and translocation of mitochondrial cytochrome C independent of COX-2 expression. Neoplasia 2: 346-356.
    • (2000) Neoplasia , vol.2 , pp. 346-356
    • Aggarwal, S.1    Taneja, N.2    Lin, L.3    Orringer, M.B.4    Rehemtulla, A.5    Beer, D.G.6
  • 2
    • 0036523088 scopus 로고    scopus 로고
    • Caspase-3-dependent proteolytic cleavage of protein kinase Cdelta is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl
    • Anantharam V, Kitazawa M, Wagner J, Kaul S, Kanthasamy AG,. 2002. Caspase-3-dependent proteolytic cleavage of protein kinase Cdelta is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl. J Neurosci 22: 1738-1751.
    • (2002) J Neurosci , vol.22 , pp. 1738-1751
    • Anantharam, V.1    Kitazawa, M.2    Wagner, J.3    Kaul, S.4    Kanthasamy, A.G.5
  • 3
    • 0032032270 scopus 로고    scopus 로고
    • Bcr-Abl exerts its antiapoptotic effect against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome C and activation of caspase-3
    • Amarante-Mendes GP, Naekyung Kim C, Liu L, Huang Y, Perkins CL, Green DR, Bhalla K,. 1998. Bcr-Abl exerts its antiapoptotic effect against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome C and activation of caspase-3. Blood 91: 1700-1705.
    • (1998) Blood , vol.91 , pp. 1700-1705
    • Amarante-Mendes, G.P.1    Naekyung Kim, C.2    Liu, L.3    Huang, Y.4    Perkins, C.L.5    Green, D.R.6    Bhalla, K.7
  • 4
    • 33745602539 scopus 로고    scopus 로고
    • Diagnosis and management of epithelial ovarian cancer
    • Bhoola S, Hoskins WJ,. 2006. Diagnosis and management of epithelial ovarian cancer. Obstet Gynecol 107: 1399-1410.
    • (2006) Obstet Gynecol , vol.107 , pp. 1399-1410
    • Bhoola, S.1    Hoskins, W.J.2
  • 9
    • 14944379632 scopus 로고    scopus 로고
    • Cyclooxygenase-2 interacts with p53 and interferes with p53-dependent transcription and apoptosis
    • Corcoran CA, He Q, Huang Y, Sheikh MS,. 2005. Cyclooxygenase-2 interacts with p53 and interferes with p53-dependent transcription and apoptosis. Oncogene 24: 1634-1640.
    • (2005) Oncogene , vol.24 , pp. 1634-1640
    • Corcoran, C.A.1    He, Q.2    Huang, Y.3    Sheikh, M.S.4
  • 11
    • 0034532451 scopus 로고    scopus 로고
    • Thyroxine promotes association of mitogen-activated protein kinase and nuclear thyroid hormone receptor (TR) and causes serine phosphorylation of TR
    • Davis PJ, Shih A, Lin HY, Martino LJ, Davis FB,. 2000. Thyroxine promotes association of mitogen-activated protein kinase and nuclear thyroid hormone receptor (TR) and causes serine phosphorylation of TR. J Biol Chem 275: 38032-38039.
    • (2000) J Biol Chem , vol.275 , pp. 38032-38039
    • Davis, P.J.1    Shih, A.2    Lin, H.Y.3    Martino, L.J.4    Davis, F.B.5
  • 14
    • 1442350426 scopus 로고    scopus 로고
    • Dysregulated post-transcriptional control of COX-2 gene expression in cancer
    • Dixon DA,. 2004. Dysregulated post-transcriptional control of COX-2 gene expression in cancer. Curr Pharm Des 10: 635-646.
    • (2004) Curr Pharm des , vol.10 , pp. 635-646
    • Dixon, D.A.1
  • 15
    • 46749138342 scopus 로고    scopus 로고
    • Integrin-dependent phagocytosis: Spreading from microadhesion to new concepts
    • Dupuy AG, Caron E,. 2008. Integrin-dependent phagocytosis: Spreading from microadhesion to new concepts. J Cell Sci 121: 1773-1783.
    • (2008) J Cell Sci , vol.121 , pp. 1773-1783
    • Dupuy, A.G.1    Caron, E.2
  • 16
    • 0043075955 scopus 로고    scopus 로고
    • Rofecoxib (Vioxx), a specific cyclooxygenase-2 inhibitor, is chemopreventive in a mouse model of colon cancer
    • Evans JF,. 2003. Rofecoxib (Vioxx), a specific cyclooxygenase-2 inhibitor, is chemopreventive in a mouse model of colon cancer. Am J Clin Oncol 26: S62-S65.
    • (2003) Am J Clin Oncol , vol.26
    • Evans, J.F.1
  • 17
    • 9444257007 scopus 로고    scopus 로고
    • Internal organisation of the nucleus: Assembly of compartments by macromolecular crowding and the nuclear matrix model
    • Hancock R,. 2004. Internal organisation of the nucleus: Assembly of compartments by macromolecular crowding and the nuclear matrix model. Biol Cell 96: 595-601.
    • (2004) Biol Cell , vol.96 , pp. 595-601
    • Hancock, R.1
  • 18
    • 0027762512 scopus 로고
    • Sphingolipid breakdown products: Anti-proliferative and tumor-suppressor lipids
    • Hannun YA, Linardic CM,. 1993. Sphingolipid breakdown products: Anti-proliferative and tumor-suppressor lipids. Biochim Biophys Acta 1154: 223-236.
    • (1993) Biochim Biophys Acta , vol.1154 , pp. 223-236
    • Hannun, Y.A.1    Linardic, C.M.2
  • 19
  • 20
    • 33845317647 scopus 로고    scopus 로고
    • The internalization and degradation of human copper transporter 1 following cisplatin exposure
    • Holzer AK, Howell SB,. 2006. The internalization and degradation of human copper transporter 1 following cisplatin exposure. Cancer Res 66: 10944-10952.
    • (2006) Cancer Res , vol.66 , pp. 10944-10952
    • Holzer, A.K.1    Howell, S.B.2
  • 21
    • 79961098183 scopus 로고    scopus 로고
    • Regulation of p53 and cell proliferation by resveratrol and its derivatives in breast cancer cells: An in silico and biochemical approach targeting integrin alphavbeta3
    • Hsieh TC, Wong C, Bennett DJ, Wu JM,. 2011. Regulation of p53 and cell proliferation by resveratrol and its derivatives in breast cancer cells: An in silico and biochemical approach targeting integrin alphavbeta3. Int J Cancer 129: 2732-2743.
    • (2011) Int J Cancer , vol.129 , pp. 2732-2743
    • Hsieh, T.C.1    Wong, C.2    Bennett, D.J.3    Wu, J.M.4
  • 23
    • 0242574299 scopus 로고    scopus 로고
    • Differential regulation of cyclooxygenase-2 expression by phytosphingosine derivatives, NAPS and TAPS, and its role in the NAPS or TAPS-mediated apoptosis
    • Kim HJ, Shin W, Park CS, Kim HO, Kim TY,. 2003. Differential regulation of cyclooxygenase-2 expression by phytosphingosine derivatives, NAPS and TAPS, and its role in the NAPS or TAPS-mediated apoptosis. J Invest Dermatol 121: 1126-1134.
    • (2003) J Invest Dermatol , vol.121 , pp. 1126-1134
    • Kim, H.J.1    Shin, W.2    Park, C.S.3    Kim, H.O.4    Kim, T.Y.5
  • 24
    • 0035909511 scopus 로고    scopus 로고
    • Inhibition of human brain tumor cell growth by the anti-inflammatory drug, flurbiprofen
    • King JG Jr, Khalili K,. 2001. Inhibition of human brain tumor cell growth by the anti-inflammatory drug, flurbiprofen. Oncogene 20: 6864-6870.
    • (2001) Oncogene , vol.20 , pp. 6864-6870
    • King, Jr.J.G.1    Khalili, K.2
  • 25
    • 0033022440 scopus 로고    scopus 로고
    • Thyroid hormone induces activation of mitogen-activated protein kinase in cultured cells
    • Lin HY, Davis FB, Gordinier JK, Martino LJ, Davis PJ,. 1999a. Thyroid hormone induces activation of mitogen-activated protein kinase in cultured cells. Am J Physiol 276: C1014-C1024.
    • (1999) Am J Physiol , vol.276
    • Lin, H.Y.1    Davis, F.B.2    Gordinier, J.K.3    Martino, L.J.4    Davis, P.J.5
  • 26
    • 0040316990 scopus 로고    scopus 로고
    • Thyroid hormone promotes the phosphorylation of STAT3 and potentiates the action of epidermal growth factor in cultured cells
    • Lin HY, Shih A, Davis FB, Davis PJ,. 1999b. Thyroid hormone promotes the phosphorylation of STAT3 and potentiates the action of epidermal growth factor in cultured cells. Biochem J 338: 427-432.
    • (1999) Biochem J , vol.338 , pp. 427-432
    • Lin, H.Y.1    Shih, A.2    Davis, F.B.3    Davis, P.J.4
  • 27
    • 0036072056 scopus 로고    scopus 로고
    • Resveratrol induced serine phosphorylation of p53 causes apoptosis in a mutant p53 prostate cancer cell line
    • Lin HY, Shih A, Davis FB, Tang HY, Martino LJ, Bennett JA, Davis PJ,. 2002. Resveratrol induced serine phosphorylation of p53 causes apoptosis in a mutant p53 prostate cancer cell line. J Urol 168: 748-755.
    • (2002) J Urol , vol.168 , pp. 748-755
    • Lin, H.Y.1    Shih, A.2    Davis, F.B.3    Tang, H.Y.4    Martino, L.J.5    Bennett, J.A.6    Davis, P.J.7
  • 28
    • 18244371648 scopus 로고    scopus 로고
    • Acetylation of nuclear hormone receptor superfamily members: Thyroid hormone causes acetylation of its own receptor by a mitogen-activated protein kinase-dependent mechanism
    • Lin HY, Hopkins R, Cao HJ, Tang HY, Alexander C, Davis FB, Davis PJ,. 2005. Acetylation of nuclear hormone receptor superfamily members: Thyroid hormone causes acetylation of its own receptor by a mitogen-activated protein kinase-dependent mechanism. Steroids 70: 444-449.
    • (2005) Steroids , vol.70 , pp. 444-449
    • Lin, H.Y.1    Hopkins, R.2    Cao, H.J.3    Tang, H.Y.4    Alexander, C.5    Davis, F.B.6    Davis, P.J.7
  • 35
    • 29244467982 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibition sensitizes human colon carcinoma cells to TRAIL-induced apoptosis through clustering of DR5 and concentrating death-inducing signaling complex components into ceramide-enriched caveolae
    • Martin S, Phillips DC, Szekely-Szucs K, Elghazi L, Desmots F, Houghton JA,. 2005. Cyclooxygenase-2 inhibition sensitizes human colon carcinoma cells to TRAIL-induced apoptosis through clustering of DR5 and concentrating death-inducing signaling complex components into ceramide-enriched caveolae. Cancer Res 65: 11447-11458.
    • (2005) Cancer Res , vol.65 , pp. 11447-11458
    • Martin, S.1    Phillips, D.C.2    Szekely-Szucs, K.3    Elghazi, L.4    Desmots, F.5    Houghton, J.A.6
  • 36
    • 1942442191 scopus 로고    scopus 로고
    • Insulin-like growth factor binding protein-3 interacts with autocrine motility factor/phosphoglucoseisomerase (AMF/PGI) and inhibits the AMF/PGI function
    • Mishra S, Raz A, Murphy LJ,. 2004. Insulin-like growth factor binding protein-3 interacts with autocrine motility factor/phosphoglucoseisomerase (AMF/PGI) and inhibits the AMF/PGI function. Cancer Res 64: 2516-2522.
    • (2004) Cancer Res , vol.64 , pp. 2516-2522
    • Mishra, S.1    Raz, A.2    Murphy, L.J.3
  • 37
    • 44449167562 scopus 로고    scopus 로고
    • Chemotherapy versus surgery for initial treatment in advanced ovarian epithelial cancer
    • Morrison J, Swanton A, Collins S, Kehoe S,. 2007. Chemotherapy versus surgery for initial treatment in advanced ovarian epithelial cancer. Cochrane Database Syst Rev 17: CD005343.
    • (2007) Cochrane Database Syst Rev , vol.17
    • Morrison, J.1    Swanton, A.2    Collins, S.3    Kehoe, S.4
  • 38
    • 0029558856 scopus 로고
    • The architectural organization of nuclear metabolism
    • Nickerson JA, Blencowe BJ, Penman S,. 1995. The architectural organization of nuclear metabolism. Int Rev Cytol 162: 67-123.
    • (1995) Int Rev Cytol , vol.162 , pp. 67-123
    • Nickerson, J.A.1    Blencowe, B.J.2    Penman, S.3
  • 39
    • 78049510823 scopus 로고    scopus 로고
    • Cancer treatment strategies targeting sphingolipid metabolism
    • Oskouian B, Saba JD,. 2010. Cancer treatment strategies targeting sphingolipid metabolism. Adv Exp Med Biol 688: 185-205.
    • (2010) Adv Exp Med Biol , vol.688 , pp. 185-205
    • Oskouian, B.1    Saba, J.D.2
  • 40
    • 0030759849 scopus 로고    scopus 로고
    • Upregulation of COX-2 in cerebral microvascular endothelial cells by smooth muscle cell signals
    • Parfenova H, Eidson TH, Leffler CW,. 1997. Upregulation of COX-2 in cerebral microvascular endothelial cells by smooth muscle cell signals. Am J Physiol 273: C277-C288.
    • (1997) Am J Physiol , vol.273
    • Parfenova, H.1    Eidson, T.H.2    Leffler, C.W.3
  • 42
    • 0033120588 scopus 로고    scopus 로고
    • Regulation of cytosolic COX-2 and prostaglandin E2 production by nitric oxide in activated murine macrophages
    • Patel R, Attur MG, Dave M, Abramson SB, Amin AR,. 1999. Regulation of cytosolic COX-2 and prostaglandin E2 production by nitric oxide in activated murine macrophages. J Immunol 162: 4191-4197.
    • (1999) J Immunol , vol.162 , pp. 4191-4197
    • Patel, R.1    Attur, M.G.2    Dave, M.3    Abramson, S.B.4    Amin, A.R.5
  • 43
    • 0032571368 scopus 로고    scopus 로고
    • Thinking about a nuclear matrix
    • Pederson T,. 1998. Thinking about a nuclear matrix. J Mol Biol 277: 147-159.
    • (1998) J Mol Biol , vol.277 , pp. 147-159
    • Pederson, T.1
  • 44
    • 0037659648 scopus 로고    scopus 로고
    • Ceramide and sphingosine 1-phosphate in anti-cancer therapies
    • Perry DK, Kolesnick RN,. 2003. Ceramide and sphingosine 1-phosphate in anti-cancer therapies. Cancer Treat Res 115: 345-354.
    • (2003) Cancer Treat Res , vol.115 , pp. 345-354
    • Perry, D.K.1    Kolesnick, R.N.2
  • 45
    • 0142179099 scopus 로고    scopus 로고
    • Ceramide is involved in R(+)-methanandamide-induced cyclooxygenase-2 expression in human neuroglioma cells
    • Ramer R, Weinzierl U, Schwind B, Brune K, Hinz B,. 2003. Ceramide is involved in R(+)-methanandamide-induced cyclooxygenase-2 expression in human neuroglioma cells. Mol Pharmacol 64: 1189-1198.
    • (2003) Mol Pharmacol , vol.64 , pp. 1189-1198
    • Ramer, R.1    Weinzierl, U.2    Schwind, B.3    Brune, K.4    Hinz, B.5
  • 46
    • 0034676089 scopus 로고    scopus 로고
    • Cross-talk in cell death signaling
    • Roy S, Nicholson DW,. 2000. Cross-talk in cell death signaling. J Exp Med 192: F21-F25.
    • (2000) J Exp Med , vol.192
    • Roy, S.1    Nicholson, D.W.2
  • 47
    • 0242576329 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs and COX-2 inhibitors as anti-cancer therapeutics: Hypes, hopes and reality
    • Rüegg C, Zaric J, Stupp R,. 2003. Non-steroidal anti-inflammatory drugs and COX-2 inhibitors as anti-cancer therapeutics: Hypes, hopes and reality. Ann Med 35: 476-487.
    • (2003) Ann Med , vol.35 , pp. 476-487
    • Rüegg, C.1    Zaric, J.2    Stupp, R.3
  • 48
    • 0642364447 scopus 로고    scopus 로고
    • Resveratrol induces growth inhibition and apoptosis in metastatic breast cancer cells via de novo ceramide signaling
    • Scarlatti F, Sala G, Somenzi G, Signorelli P, Sacchi N, Ghidoni R,. 2003. Resveratrol induces growth inhibition and apoptosis in metastatic breast cancer cells via de novo ceramide signaling. FASEB J 17: 2339-2341.
    • (2003) FASEB J , vol.17 , pp. 2339-2341
    • Scarlatti, F.1    Sala, G.2    Somenzi, G.3    Signorelli, P.4    Sacchi, N.5    Ghidoni, R.6
  • 49
    • 6344258651 scopus 로고    scopus 로고
    • Phagocytosis of apoptotic eosinophils but not neutrophils by bronchial epithelial cells
    • Sexton DW, Al-Rabia M, Blaylock MG, Walsh GM,. 2004. Phagocytosis of apoptotic eosinophils but not neutrophils by bronchial epithelial cells. Clin Exp Allergy 34: 1514-1524.
    • (2004) Clin Exp Allergy , vol.34 , pp. 1514-1524
    • Sexton, D.W.1    Al-Rabia, M.2    Blaylock, M.G.3    Walsh, G.M.4
  • 50
    • 0036962164 scopus 로고    scopus 로고
    • Resveratrol induces apoptosis in thyroid cancer cell lines via a MAPK- and p53-dependent mechanism
    • Shih A, Davis FB, Lin HY, Davis PJ,. 2002. Resveratrol induces apoptosis in thyroid cancer cell lines via a MAPK- and p53-dependent mechanism. J Clin Endocrinol Metab 87: 1223-1232.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1223-1232
    • Shih, A.1    Davis, F.B.2    Lin, H.Y.3    Davis, P.J.4
  • 51
    • 15444339428 scopus 로고    scopus 로고
    • Ceramide regulates the transcription of cyclooxygenase-2. Evidence for involvement of extracellular signal-regulated kinase/c-Jun N-terminal kinase and p38 mitogen-activated protein kinase pathways
    • Subbaramaiah K, Chung WJ, Dannenberg AJ,. 1998. Ceramide regulates the transcription of cyclooxygenase-2. Evidence for involvement of extracellular signal-regulated kinase/c-Jun N-terminal kinase and p38 mitogen-activated protein kinase pathways. J Biol Chem 273: 32943-32949.
    • (1998) J Biol Chem , vol.273 , pp. 32943-32949
    • Subbaramaiah, K.1    Chung, W.J.2    Dannenberg, A.J.3
  • 52
    • 0034685876 scopus 로고    scopus 로고
    • Microtubule-interfering agents stimulate the transcription of cyclooxygenase-2. Evidence for involvement of ERK1/2 and p38 mitogen-activated protein kinase pathways
    • Subbaramaiah K, Hart JC, Norton L, Dannenberg AJ,. 2000. Microtubule-interfering agents stimulate the transcription of cyclooxygenase-2. Evidence for involvement of ERK1/2 and p38 mitogen-activated protein kinase pathways. J Biol Chem 275: 14838-14845.
    • (2000) J Biol Chem , vol.275 , pp. 14838-14845
    • Subbaramaiah, K.1    Hart, J.C.2    Norton, L.3    Dannenberg, A.J.4
  • 53
    • 0141816863 scopus 로고    scopus 로고
    • Inhibition of COX-2 in colon cancer cell lines by celecoxib increases the nuclear localization of active p53
    • Swamy MV, Herzog CR, Rao CV,. 2003. Inhibition of COX-2 in colon cancer cell lines by celecoxib increases the nuclear localization of active p53. Cancer Res 63: 5239-5242.
    • (2003) Cancer Res , vol.63 , pp. 5239-5242
    • Swamy, M.V.1    Herzog, C.R.2    Rao, C.V.3
  • 54
    • 3042693890 scopus 로고    scopus 로고
    • Thyroid hormone causes mitogen-activated protein kinase-dependent phosphorylation of the nuclear estrogen receptor
    • Tang HY, Lin HY, Zhang S, Davis FB, Davis PJ,. 2004. Thyroid hormone causes mitogen-activated protein kinase-dependent phosphorylation of the nuclear estrogen receptor. Endocrinology 145: 3265-3272.
    • (2004) Endocrinology , vol.145 , pp. 3265-3272
    • Tang, H.Y.1    Lin, H.Y.2    Zhang, S.3    Davis, F.B.4    Davis, P.J.5
  • 55
    • 33748357134 scopus 로고    scopus 로고
    • Resveratrol-induced cyclooxygenase-2 facilitates p53-dependent apoptosis in human breast cancer cells
    • Tang HY, Shih A, Cao HJ, Davis FB, Davis PJ, Lin HY,. 2006. Resveratrol-induced cyclooxygenase-2 facilitates p53-dependent apoptosis in human breast cancer cells. Mol Cancer Ther 5: 2034-2042.
    • (2006) Mol Cancer Ther , vol.5 , pp. 2034-2042
    • Tang, H.Y.1    Shih, A.2    Cao, H.J.3    Davis, F.B.4    Davis, P.J.5    Lin, H.Y.6
  • 56
    • 0033607519 scopus 로고    scopus 로고
    • Overexpression of cyclooxygenase-2 induces cell cycle arrest. Evidence for a prostaglandin-independent mechanism
    • Trifan OC, Smith RM, Thompson BD, Hla T,. 1999. Overexpression of cyclooxygenase-2 induces cell cycle arrest. Evidence for a prostaglandin- independent mechanism. J Biol Chem 274: 34141-34147.
    • (1999) J Biol Chem , vol.274 , pp. 34141-34147
    • Trifan, O.C.1    Smith, R.M.2    Thompson, B.D.3    Hla, T.4
  • 58
    • 0345275877 scopus 로고    scopus 로고
    • Growth inhibition of human colon cancer cells by nitric oxide (NO)-donating aspirin is associated with cyclooxygenase-2 induction and beta-catenin/T-cell factor signaling, nuclear factor-kappaB, and NO synthase 2 inhibition: Implications for chemoprevention
    • Williams JL, Nath N, Chen J, Hundley TR, Gao J, Kopelovich L, Kashfi K, Rigas B,. 2003. Growth inhibition of human colon cancer cells by nitric oxide (NO)-donating aspirin is associated with cyclooxygenase-2 induction and beta-catenin/T-cell factor signaling, nuclear factor-kappaB, and NO synthase 2 inhibition: Implications for chemoprevention. Cancer Res 63: 7613-7618.
    • (2003) Cancer Res , vol.63 , pp. 7613-7618
    • Williams, J.L.1    Nath, N.2    Chen, J.3    Hundley, T.R.4    Gao, J.5    Kopelovich, L.6    Kashfi, K.7    Rigas, B.8
  • 60
    • 1542359063 scopus 로고    scopus 로고
    • Cyclooxygenase-2 selective inhibition with NS-398 suppresses proliferation and invasiveness and delays liver metastasis in colorectal cancer
    • Yao M, Lam EC, Kelly CR, Zhou W, Wolfe MM,. 2004. Cyclooxygenase-2 selective inhibition with NS-398 suppresses proliferation and invasiveness and delays liver metastasis in colorectal cancer. Br J Cancer 90: 712-719.
    • (2004) Br J Cancer , vol.90 , pp. 712-719
    • Yao, M.1    Lam, E.C.2    Kelly, C.R.3    Zhou, W.4    Wolfe, M.M.5
  • 61
    • 0037155787 scopus 로고    scopus 로고
    • Cyclooxygenase-2 overexpression inhibits platelet-derived growth factor-induced mesangial cell proliferation through induction of the tumor suppressor gene p53 and the cyclin-dependent kinase inhibitors p21waf-1/cip-1 and p27kip-1
    • Zahner G, Wolf G, Ayoub M, Reinking R, Panzer U, Shankland SJ, Stahl RA,. 2002. Cyclooxygenase-2 overexpression inhibits platelet-derived growth factor-induced mesangial cell proliferation through induction of the tumor suppressor gene p53 and the cyclin-dependent kinase inhibitors p21waf-1/cip-1 and p27kip-1. J Biol Chem 277: 9763-9771.
    • (2002) J Biol Chem , vol.277 , pp. 9763-9771
    • Zahner, G.1    Wolf, G.2    Ayoub, M.3    Reinking, R.4    Panzer, U.5    Shankland, S.J.6    Stahl, R.A.7
  • 62
    • 1042291173 scopus 로고    scopus 로고
    • Ceramide induces caspase-dependent and -independent apoptosis in A-431 cells
    • Zhao S, Yang YN, Song JG,. 2004. Ceramide induces caspase-dependent and -independent apoptosis in A-431 cells. J Cell Physiol 199: 47-56.
    • (2004) J Cell Physiol , vol.199 , pp. 47-56
    • Zhao, S.1    Yang, Y.N.2    Song, J.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.