Formulation and in vitro evaluation of salbutamol sulphate in situ gelling nasal inserts

AAPS PharmSciTech

Volumn 14, Issue 2, 2013, Pages 712-718

  Farid, Ragwa M ^a   Etman, Mohamed A ^b   Nada, Aly H ^c   Ebian, Abd El Azeem R ^b  

^a Pharos University of Alexandria   (Egypt)

^b Alexandria University Faculty of Pharmacy   (Egypt)

^c KUWAIT UNIVERSITY   (Kuwait)

Author keywords

in situ gelling inserts; mucoadhesion; nasal delivery; salbutamol sulfate

Indexed keywords

ALGINIC ACID; CARBOXYMETHYLCELLULOSE; CHITOSAN; HYDROXYPROPYLMETHYLCELLULOSE; SALBUTAMOL SULFATE;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG SCREENING; FIRST PASS EFFECT; HUMAN; IN VITRO STUDY; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; WATER TRANSPORT;

ADHESIVENESS; ADMINISTRATION, INTRANASAL; ALBUTEROL; ALGINATES; BRONCHODILATOR AGENTS; CALORIMETRY, DIFFERENTIAL SCANNING; CARBOXYMETHYLCELLULOSE SODIUM; CHEMISTRY, PHARMACEUTICAL; CHITOSAN; DELAYED-ACTION PREPARATIONS; DIFFUSION; DRUG CARRIERS; GELS; GLUCURONIC ACID; HEXURONIC ACIDS; HYDROGEN-ION CONCENTRATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; KINETICS; METHYLCELLULOSE; MUCINS; POLYMERS; SOLUBILITY; SURFACE PROPERTIES; TECHNOLOGY, PHARMACEUTICAL;

EID: 84879114664     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-013-9956-y     Document Type: Article

References (47)

1. Werner U. In situ gelling nasal inserts for prolonged drug delivery. Berlin: Fachbereich Biologie, Chemie, Pharmazie der Freien Universität Berlin; 2003.
2. Thapa P, Baillie AJ, Stevens HN. Lyophilization of unit dose pharmaceutical dosage forms. Drug Dev Ind Pharm. 2003;29:595-602.
3. Bertram U, Bernard MC, Haensler J, Maincent P, Bodmeier R. In situ gelling nasal inserts for influenza vaccine delivery. Drug Dev Ind Pharm. 2010;36:581-93.
4. McInnes FJ, Thapa P, Baillie AJ, Welling PG, Watson DG, Gibson I, et al. In vivo evaluation of nicotine lyophilised nasal insert in sheep. Int J Pharm. 2005;304:72-82.
5. Garmise RJ, Mar K, Crowder TM, Hwang CR, Ferriter M, Huang J, et al. Formulation of a dry powder influenza vaccine for nasal delivery. AAPS PharmSciTech. 2006;7:E19.
6. Garmise RJ, Staats HF, Hickey AJ. Novel dry powder preparations of whole inactivated influenza virus for nasal vaccination. AAPS PharmSciTech. 2007;8:E81.
7. D'Souza R, Mutalik S, Venkatesh M, Vidyasagar S, Udupa N. Insulin gel as an alternate to parenteral insulin: formulation, preclinical, and clinical studies. AAPS PharmSciTech. 2005;6:E184-9.
8. Pardeshi CV, Rajput PV, Belgamwar VS, Tekade AR. Formulation, optimization and evaluation of spray-dried mucoadhesive microspheres as intranasal carriers for Valsartan. J Microencapsul. 2012;29:103-14.
9. Bertram U, Bodmeier R. In situ gelling, bioadhesive nasal inserts for extended drug delivery: in vitro characterization of a new nasal dosage form. Eur J Pharm Sci. 2006;27:62-71.
10. McInnes FJ, O'Mahony B, Lindsay B, Band J, Wilson CG, Hodges LA, et al. Nasal residence of insulin containing lyophilised nasal insert formulations, using gamma scintigraphy. Eur J Pharm Sci. 2007;31:25-31.
11. Cho HJ, Balakrishnan P, Shim WS, Chung SJ, Shim CK, Kim DD. Characterization and in vitro evaluation of freeze-dried microparticles composed of granisetron-cyclodextrin complex and carboxymethylcellulose for intranasal delivery. Int J Pharm. 2010;400:59-65.
12. Lee JW, Park JH, Robinson JR. Bioadhesive-based dosage forms: the next generation. J Pharm Sci. 2000;89:850-66.
13. Tafaghodi M, Rastegar S. Preparation and in vivo study of dry powder microspheres for nasal immunization. J Drug Target. 2010;18:235-42.
14. Patil SB, Sawant KK. Chitosan microspheres as a delivery system for nasal insufflation. Colloids Surf B: Biointerfaces. 2011;84:384-9.
15. Singla AK, Chawla M. Chitosan: some pharmaceutical and biological aspects - an update. J Pharm Pharmacol. 2001;53:1047-67.
16. Cerchiara T, Luppi B, Bigucci F, Zecchi V. Chitosan salts as nasal sustained delivery systems for peptidic drugs. J Pharm Pharmacol. 2003;55:1623-7.
17. Nand KG, Priti T, Vikas S, Vinod KD. Development and characterization of chitosan coated poly-(ε-caprolactone) nanoparticulate system for effective immunization against influenza. Vaccine. 2011;29:9026-37.
18. Patil S, Babbar A, Mathur R, Mishra A, Sawant K. Mucoadhesive chitosan microspheres of carvedilol for nasal administration. J Drug Target. 2010;8:321-31.
19. Dyer AM, Hinchcliffe M, Watts P, Castile J, Jabbal-Gill I, Nankervis R, et al. Nasal delivery of insulin using novel chitosan based formulations: a comparative study in two animal models between simple chitosan formulations and chitosan nanoparticles. Pharm Res. 2002;19:998-1008.
20. Morgan DJ, Paull JD, Richmond BH, Wilson-Evered E, Ziccone SP. Pharmacokinetics of intravenous and oral salbutamol and its sulphate conjugate. Br J Clin Pharmacol. 1986;22:587-93.
21. Martinac A, Filipovic-Grcic J, Voinovich D, Perissutti B, Franceschinis E. Development and bioadhesive properties of chitosan-ethylcellulose microspheres for nasal delivery. Int J Pharm. 2005;291:69-77.
22. Nafee NA, Ismail FA, Boraie NA, Mortada LM. Mucoadhesive buccal patches of miconazole nitrate: in vitro/in vivo performance and effect of ageing. Int J Pharm. 2003;264:1-14.
23. Varshosaz J, Sadrai H, Heidari A. Nasal delivery of insulin using bioadhesive chitosan gels. Drug Deliv. 2006;13:31-8.
24. Khan KA. The concept of dissolution efficiency. J Pharm Pharmacol. 1975;27:48-9.
25. Korsmeyer RW, Gurny R, Doelker E, Buri P, Peppas NA. Mechanisms of solute release from porous hydrophilic polymers. Int J Pharm. 1983;15:25-35.
26. Etman MA, Nada AH. Evaluation of simple and ball mill ground mixtures of two NSAIDs with different hydrophilc carriers. Alex J Pharm Sci. 1999;13:135-40.
27. Kim KH, Frank MJ, Henderson NL. Application of differential scanning calorimetry to the study of solid drug dispersions. J Pharm Sci. 1985;74:283-9.
28. Doijad RC, Manvi FV, Malleswara Rao VSN, Patel PS. Buccoadhesive drug delivery system of isosorbide dinitrate: formulation and evaluation. Indian J Pharm Sci. 2006;68:744-8.
29. Washington N, Steele RJ, Jackson SJ, Bush D, Mason J, Gill DA, et al. Determination of baseline human nasal pH and the effect of intranasally administered buffers. Int J Pharm. 2000;198:139-46.
30. Nappinnai M, Chandanbala R, Balaijirajan R. Formulation and evaluation of nitrendipine buccal films. Indian J Pharm Sci. 2008;70:631-5.
31. Peppas NA, Khare AR. Preparation, structure and diffusional behavior of hydrogels in controlled release. Adv Drug Deliv Rev. 1993;11:1-35.
32. Perioli L, Ambrogi V, Angelici F, Ricci M, Giovagnoli S, Capuccella M, et al. Development of mucoadhesive patches for buccal administration of ibuprofen. J Control Release. 2004;99:73-82.
33. Lehr C-M, Bouwstra JA, Schacht EH, Junginger HE. In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers. Int J Pharm. 1992;78:43-8.
34. Aksungur P, Sungur A, Unal S, Iskit AB, Squier CA, Senel S. Chitosan delivery systems for the treatment of oral mucositis: in vitro and in vivo studies. J Control Release. 2004;98:269-79.
35. Nafee NA, Boraie MA, Ismail FA, Mortada LM. Design and characterization of mucoadhesive buccal patches containing cetylpyridinium chloride. Acta Pharm. 2003;53:199-212.
36. Gu JM, Robinson JR, Leung SH. Binding of acrylic polymers to mucin/epithelial surfaces: structure-property relationships. Crit Rev Ther Drug Carrier Syst. 1988;5:21-67.
37. Madsen F, Eberth K, Smart JD. A rheological examination of the mucoadhesive/mucus interaction: the effect of mucoadhesive type and concentration. J Control Release. 1998;50:167-78.
38. Bertram U, Bodmeier R. Parameters affecting the drug release from in situ gelling nasal inserts. Eur J Pharm Biopharm. 2006;63:310-9.
39. Rodriguez CF, Bruneau N, Barra J, Alfonso D, Doelker E. Hydrophilic cellulose derivatives as drug delivery carriers: influence of the substitution type on the properties of compressed matrix tablets. In: Wise DL, editor. Handbook of pharmaceutical controlled release technology. New York: Marcell Dekker; 2000. p. 1-30.
40. Moffat AC (2004) Salbutamol sulfate,Clarke's analysis of drug and poisons. In: Galichet LY, editor. London: Pharmaceutical Press.
41. Vigoreaux V, Ghaly ES. Fickian and relaxational contribution quantification of drug release in a swellable hydrophillic polymer matrix. Drug Dev Ind Pharm. 1994;20:2519-26.
42. Mishra DN, Gilhotra RM. Design and characterization of bioadhesive in-situ gelling ocular inserts of gatifloxacin sesquihydrate. DARU. 2008;16:1-8.
43. Peppas NA, Buri PA. Surface, interfacial and molecular aspects of polymer bioadhesion on soft tissues. J Control Release. 1985;2:257-75.
44. Ritger PL, Peppas NA. A simple equation for description of solute release II Fickian and anomalous from swellable devices. J Control Release. 1987;5:37-42.
45. Rao V, Shyale S. Preparation and evaluation of ocular inserts containing norfloxacin. Turk J Med Sci. 2004;34:239-46.
46. Peppas NA, Sahlin JJ. A simple equation for the description of sustained release. III Coupling of diffusion and relaxation. Int J Pharm. 1989;57:169-72.
47. Lindner WD, Lippold BC. Drug release from hydrocolloid embeddings with high or low susceptibility to hydrodynamic stress. Pharm Res. 1995;12:1781-5.