Parameters affecting the drug release from in situ gelling nasal inserts

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 63, Issue 3, 2006, Pages 310-319

  Bertram, Ulrike ^a   Bodmeier, Roland ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Carrageenan; Drug polymer interaction; Extended drug release; HPMC; Inserts; Nasal drug delivery; Release medium

Indexed keywords

CARRAGEENAN; DIPROPHYLLINE; HYDROXYPROPYLMETHYLCELLULOSE; METHYLCELLULOSE; OXYMETAZOLINE; PARACETAMOL; POLYMER; SODIUM ION;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DISSOLUTION; DRUG RELEASE; ELECTRICITY; FREEZE DRYING; GEL; PHYSICAL CHEMISTRY; RAMAN SPECTROMETRY; SCANNING ELECTROCHEMICAL MICROSCOPY; WATER TRANSPORT;

ADMINISTRATION, INTRANASAL; CARRAGEENAN; DELAYED-ACTION PREPARATIONS; ELECTROSTATICS; GELS; HYDROGEN-ION CONCENTRATION; METHYLCELLULOSE; NASAL MUCOSA; OSMOLAR CONCENTRATION; SOLUBILITY;

EID: 33646840846     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2005.11.008     Document Type: Article

References (21)

1. R. Bodmeier, P. Maincent, Zubereitungen mit verlängerter Verweildauer am Applikationsort, German Patent DE 197 56 314 A 1, 1999.
2. Werner U., Damgé C., Maincent P., and Bodmeier R. Properties of in situ gelling nasal insert containing estradiol/methyl β-cyclodextrin. J. Drug Del. Sci. Technol. 14 4 (2004) 275-284
3. McInnes F., Thapa P., Stevens H., Baillie A., Watson D., Nolan A., and Gibson I. Nasal absorption of nicotine in sheep from a lyophilised insert formulation. AAPS Ann. Meeting Suppl. 2 (2000) 2121
4. Merkus F.W.H.M., and Verhoef J.C. Nasal drug delivery: trends and perspectives. In: Swarbrick J., and Boyian J.C. (Eds). Encyclopedia of Pharmaceutical Technology vol. 10 (1994), Marcel Dekker, New York 191-220
5. Ahsan F., Arnold J., Meezan E., and Pillion D.J. Enhanced bioavailability of calcitonin formulated with alkylglycosides following nasal and ocular administration in rats. Pharm. Res. 18 12 (2001) 1742-1746
6. Oh Y.-K., Kim J.-P., Hwang T.S., Ko J.J., Kim J.M., Yang J.-S., and Kim C.-K. Nasal absorption and biodistribution of plasmid DNA: an alternative route of DNA vaccine delivery. Vaccine 19 (2001) 4519-4525
7. Pereswetoff-Morath L., and Edman P. Dextran microspheres as a potential nasal drug delivery system for insulin - in vitro and in vivo properties. Int. J. Pharm. 124 (1995) 37-44
8. Teshima D., Yamauchi A., Makino K., Kataoka Y., Arita Y., Nawata H., and Oishi R. Nasal glucagon delivery using microcrystalline cellulose in healthy volunteers. Int. J. Pharm. 233 (2002) 61-66
9. Junginger H.E., Verhoef J.C., and Merkus F.W.H.M. Nasal Arzneiformen für die systemische Wirkstoffabsorption. Dtsch. Apoth. Ztg. 131 8 (1991) 295-303
10. Washington N., Steele R.J.C., Jackson S.J., Bush D., Mason J., Gill D.A., Pitt K., and Rawlins D.A. Determination of baseline human nasal pH and the effect of intranasally administered buffers. Int. J. Pharm. 198 (2000) 139-146
11. J. Berendes, R. Link, F. Zöllner, Hals-Nasen-Ohren-Heilkunde in Praxis und Klinik: Obere und untere Luftwege, I. Thieme-Verlag, Stuttgart, Chapters 2, 10, 11, 16 (1977).
12. Sachdeva A., Sachdeva O.P., Gulati S.P., and Kakkar V. Nasal mucociliary clearance and mucus pH in patients with diabetes mellitus. Indian J. Med. Res. 98 3 (1993) 265-268
13. Togias A.G., Proud D., Lichtenstein L.M., Adams G.K., Norman P.S., Kagey-Sobotka A., and Naclerio R.M. The osmolality of nasal secretions increases when inflammatory mediators are released in response to inhalation of cold, dry air. Am. Rev. Respir. Dis. 137 3 (1988) 625-629
14. Knowles M.R., Robinson J.M., Wood R.E., Pue C.A., Mentz W.M., Wager G.C., Gatzy J.T., and Boucher R.C. Ion composition of airway surface liquid of patients with cystic fibrosis as compared with normal and disease-control subjects. J. Clin. Invest. 100 10 (1997) 2588-2596
15. Atsuta S., and Majima Y. Nasal mucociliary clearance of chronic sinusitis in relation to rheological properties of nasal mucus. Ann. Otol. Rhinol. Laryngol. 107 1 (1998) 47-51
16. Majima Y., Harada T., Shimizu T., Takeuchi K., Sakakura Y., and Yoshinaga S. Effect of biochemical components on rheologic properties of nasal mucus in chronic sinusitis. Am. J. Respir. Crit. Care Med. 160 (1999) 421-426
17. Behl C.R., Pimplaskar H.K., Sileno A.P., deMeireles J., and Romeo V.D. Effects of physicochemical properties and other factors on systemic nasal drug delivery. Adv. Drug Deliv. Rev. 29 (1998) 89-116
18. Puttipipatkhachorn S., Nunthanid J., Ymamoto K., and Peck G.E. Drug physical state and drug-polymer interaction on drug release from chitosan matrix films. J. Contr. Rel. 75 (2001) 143-153
19. Akahane T., Kawashima S., Hirao I., Shimizu T., and Minakata A. Ion selectivities of some extracellular viscous polysaccharides from red algae. Polymer J. (Tokyo, Japan) 14 3 (1982) 181-188
20. Gupta V.K., Hariharan M., Wheatley T.A., and Price J.C. Controlled-release tablets from carrageenans: effect of formulation, storage and dissolution factors. Eur. J. Pharm. Biopharm. 51 3 (2001) 241-248
21. ® carrageenan - general description. Product information, 1997.