Comprehensive global amino acid sequence analysis of PB1F2 protein of influenza A H5N1 viruses and the influenza A virus subtypes responsible for the 20th-century pandemics

Influenza and other Respiratory Viruses

Volumn 7, Issue 4, 2013, Pages 497-505

  Pasricha, Gunisha ^a   Mishra, Akhilesh C ^a   Chakrabarti, Alok K ^a  

^a NATIONAL INSTITUTE OF VIROLOGY   (India)

Author keywords

Influenza A viruses; Mutation; Pandemics; PB1F2 protein; Truncation

Indexed keywords

PROTEIN PB1F2; UNCLASSIFIED DRUG; VIRUS PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; GENETIC VARIABILITY; HUMAN; INFLUENZA VIRUS A H1N1; INFLUENZA VIRUS A H2N2; INFLUENZA VIRUS A H3N2; INFLUENZA VIRUS A H5N1; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PANDEMIC; PANDEMIC INFLUENZA; PHYLOGENY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; UNINDEXED SEQUENCE;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIGENIC VARIATION; CLUSTER ANALYSIS; COMPUTATIONAL BIOLOGY; GENETIC VARIATION; HUMANS; INFLUENZA A VIRUS; INFLUENZA, HUMAN; MUTANT PROTEINS; ORTHOMYXOVIRIDAE INFECTIONS; PANDEMICS; PHYLOGENY; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, PROTEIN; VIRAL PROTEINS;

EID: 84879111712     PISSN: 17502640     EISSN: 17502659     Source Type: Journal    
DOI: 10.1111/j.1750-2659.2012.00400.x     Document Type: Article

References (23)

1. Taubenberger JK, Reid AH, Lourens RM et al. Characterization of the 1918 influenza virus polymerase genes. Nature 2005; 437:889-893.
2. Palese P, Shaw ML. Orthomyxoviridae: the viruses and their replication; in Knipe DM, Howley PM (eds): Fields Virology. Philadelphia, PA: Lippincott Williams & Wilkins, 2007; 1647-1689.
3. Kawaoka Y, Krauss S, Webster RG. Avian-to-human transmission of the PB1 gene of influenza A viruses in the 1957 and 1968 pandemics. J Virol 1989; 63:4603-4608.
4. Karasin AI, Schutten MM, Cooper LA et al. Genetic characterization of H3N2 influenza viruses isolated from pigs in North America, 1977-1999: evidence for wholly human and reassortant virus genotypes. Virus Res 2000; 68:71-85.
5. Tumpey TM, Basler CF, Aguilar PV et al. Characterization of the reconstructed 1918 Spanish influenza pandemic virus. Science 2005; 310:77-80.
6. Zamarin D, Ortigoza MB, Palese P. Influenza A virus PB1-F2 protein contributes to viral pathogenesis in mice. J Virol 2006; 80:7976-7983.
7. Chen W, Calvo PA, Malide D et al. A novel influenza A virus mitochondrial protein that induces cell death. Nat Med 2001; 7:1306-1312.
8. Košík I, Krejnusová I, Bystrická M et al. N-terminal region of the PB1-F2 protein is responsible for increased expression of influenza A viral protein PB1. Acta Virol 2011; 55:45-53.
9. Conenello GM, Tisoncik JR, Rosenzweig E et al. A single N66S mutation in the PB1-F2 protein of influenza A virus increases virulence by inhibiting the early interferon response in vivo. J Virol 2011; 85:652-662.
10. McAuley JL, Hornung F, Boyd KL et al. Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia. Cell Host Microbe 2007; 2:240-249.
11. Mazur I, Anhlan D, Mitzner D, Wixler L, Schuber U, Ludwig S. The proapoptotic influenza A virus protein PB1-F2 regulates viral polymerase activity by interaction with the PB1 protein. Cell Microbiol. 2008; 10:1140-1152.
12. Le Goffic R, Leymarie O, Chevalier C et al. Transcriptomic analysis of host immune and cell death responses associated with the influenza A virus PB1-F2 protein. PLoS Pathog 2011; 7:e1002202.
13. Krumbholz A, Philipps A, Oehring H. Current knowledge on PB1-F2 of infuenza A viruses. Med Microbiol Immunol 2011; 200:69-75.
14. Zell R, Krumbholz A, Eitner A et al. Prevalence of PB1-F2 of influenza A viruses. J Gen Virol 2007; 88:536-546.
15. Wang TT, Palese P. Unraveling the mystery of swine influenza virus. Cell 2009; 137:983-985.
16. Squires B, Macken C, Garcia-Sastre A et al. BioHealthBase: informatics support in the elucidation of influenza virus host pathogen interactions and virulence. Nucleic Acids Res 2008;36:D497.
17. Conenello GM, Zamarin D, Perrone LA et al. A single mutation in the PB1-F2 of H5N1 (HK/97) and 1918 influenza A viruses contributes to increased virulence. PLoS Pathog 2007; 3:1414-1421.
18. Mishra AC, Cherian SS, Chakrabarti AK et al. A unique influenza A (H5N1) virus causing a focal poultry outbreak in 2007 in Manipur, India. Virol J 2009; 6:26.
19. Heiny AT, Miotto O, Srinivasan KN et al. Evolutionarily conserved protein sequences of influenza A viruses, avian and human, as vaccine targets. PLoS ONE 2007; 2:e1190.
20. Gibbs JS, Malide D, Hornung F, Bennink JR, Yewdell JW. The influenza A virus PB1-F2 protein targets the inner mitochondrial membrane via a predicted basic amphipathic helix that disrupts mitochondrial function. J Virol 2003; 77:7214-7224.
21. Yamada H, Chouna R, Higashi Y, Kurihara N, Kido H. Mitochondrial targeting sequence of the influenza A virus PB1-F2 protein and its function in mitochondria. FEBS Lett 2004; 578:331-336.
22. Danishuddin M, Khan SN, Khan AU. Molecular interactions between mitochondrial membrane proteins and the C-terminal domain of PB1-F2: an in silico approach. J Mol Model 2010; 16:535-541.
23. Nabel GJ, Wei C-J, Ledgerwood JE. Vaccinate for the next H2N2 pandemic now. Nature 2011; 471:157-158.