N-terminal region of the PB1-F2 protein is responsible for increased expression of influenza A viral protein PB1

Acta Virologica

Volumn 55, Issue 1, 2011, Pages 45-53

  Kosik I ^a   Krejnusova I ^a   Bystricka M ^a   Polakova K ^b   Russ, G ^a  

^a INSTITUTE OF VIROLOGY   (Slovakia)

^b CANCER RESEARCH INSTITUTE   (Slovakia)

Author keywords

Influenza virus; N terminus; PB1; PB1 F2; vRNA polymerase

Indexed keywords

UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS PROTEIN PB1 F2; VIRUS RNA; DNA DIRECTED RNA POLYMERASE; DNA VACCINE; INFLUENZA VIRUS POLYMERASE BASIC PROTEIN 1; PB1 F2 PROTEIN, INFLUENZA A VIRUS; PB1-F2 PROTEIN, INFLUENZA A VIRUS;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL STRAIN; CONTROLLED STUDY; INFLUENZA A; INFLUENZA VIRUS A H1N1; NONHUMAN; PLASMID; PROTEIN EXPRESSION; PROTEIN FUNCTION; AMINO ACID SEQUENCE; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CELL CULTURE; DOG; FEMALE; GENETICS; HUMAN; METABOLISM; MOUSE; NUCLEOTIDE SEQUENCE; PUERTO RICO;

BACTERIA (MICROORGANISMS); INFLUENZA A VIRUS; ORTHOMYXOVIRIDAE;

AMINO ACID SEQUENCE; ANIMALS; CELLS, CULTURED; DNA-DIRECTED RNA POLYMERASES; DOGS; FEMALE; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; MICE; MICE, INBRED BALB C; PUERTO RICO; READING FRAMES; RNA, VIRAL; VACCINES, DNA; VIRAL PROTEINS;

EID: 79957450448     PISSN: 0001723X     EISSN: None     Source Type: Journal    
DOI: 10.4149/av_2011_01_45     Document Type: Article

References (23)

1. Bruns K, Studtrucker N, Sharma A, Fossen T, Mitzner D, Eissmann A, Tessmer U, Röder R, Henklein P, Wray V, Schubert U (2007): Structural characterization and oligomerization of PB1-F2, a proapoptotic influenza A virus protein. J. Biol. Chem. 282, 353-363.
2. Chen GW, Yang CC, Tsao KC, Huang CG, Lee LA, Yang WZ, Huang YL, Lin TY, Shih SR (2004): Influenza A virus PB1-F2 gene in recent Taiwanese isolates. Emerg. Infect. Dis. 10, 630-636.
3. Chen W, Calvo PA, Malide D, Gibbs J, Schubert U, Bacik I, Basta S, O'Neill R, Schickli J, Palese P, Henklein P, Bennink JR, Yewdell JW (2001): A novel influenza A virus mitochondrial protein that induces cell death. Nat. Med. 7, 1306-1312.
4. Coleman JR (2007): The PB1-F2 protein of Influenza A virus: increasing pathogenicity by disrupting alveolar macrophages. Virol. J. 4, 9.
5. Dalton RM, Mullin AE, Amorim MJ, Medcalf E, Tiley LS, Digard P (2006): Temperature sensitive influenza A virus genome replication results from low thermal stability of polymerase-cRNA complexes. Virol. J. 3, 58.
6. de Wit E, Kawaoka Y, de Jong MD, Fouchier RA (2008): Pathogenicity of highly pathogenic avian influenza virus in mammals. Vaccine 26, D54-58.
7. Gibbs JS, Malide D, Hornung F, Bennink JR, Yewdell JW (2003): The influenza A virus PB1-F2 protein targets the inner mitochondrial membrane via a predicted basic amphipathic helix that disrupts mitochondrial function. J. Virol. 77, 7214-7224.
8. Henkel M, Mitzner D, Henklein P, Meyer-Almes FJ, Moroni A, Difrancesco ML, Henkes LM, Kreim M, Kast SM, Schubert U, Thiel G (2010): The proapoptotic influenza A virus protein PB1-F2 forms a nonselective ion channel. PLoS One 5, e11112.
9. Kobayashi M, Toyoda T, Ishihama A (1996): Influenza virus PB1 protein is the minimal and essential subunit of RNA polymerase. Arch. Virol. 141, 525-539.
10. Krejnusová I, Gocníková H, Bystrická M, Blaskovicová H, Poláková K, Yewdell J, Bennink J, Russ G (2009): Antibodies to PB1-F2 protein are induced in response to influenza A virus infection. Arch. Virol. 154, 1599-1604.
11. Mazur I, Anhlan D, Mitzner D, Wixler L, Schubert U, Ludwig S (2008): The proapoptotic influenza A virus protein PB1-F2 regulates viral polymerase activity by interaction with the PB1 protein. Cell. Microbiol. 10, 1140-1152.
12. McAuley JL, Hornung F, Boyd KL, Smith AM, McKeon R, Bennink J, Yewdell JW, McCullers JA (2007): Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia. Cell Host Microbe 2, 240-249.
13. McAuley JL, Chipuk JE, Boyd KL, Van De Velde N, Green DR, McCullers JA (2010a): PB1-F2 proteins from H5N1 and 20 century pandemic influenza viruses cause immunopathology. PLoS Pathog. 6, e1001014.
14. McAuley JL, Zhang K, McCullers JA (2010b): The effects of influenza A virus PB1-F2 protein on polymerase activity are strain specific and do not impact pathogenesis. J. Virol. 84, 558-564.
15. Pančuchárová H, Russ G (2006): PB1-F2 gene in influenza a viruses of different hemagglutinin subtype. Acta Virol. 50, 269-272.
16. Perez-Padilla R, de la Rosa-Zamboni D, Ponce de Leon S, Hernandez M, Quiñones-Falconi F, Bautista E, Ramirez-Venegas A, Rojas-Serrano J, Ormsby CE, Corrales A, Higuera A, Mondragon E, Cordova-Villalobos JA, INER Working Group on Influenza (2009): Pneumonia and respiratory failure from swine-origin influenza A (H1N1) in Mexico. N. Engl. J. Med. 361, 680-689.
17. Varečková E, Betáková T, Mucha V, Soláriková L, Kostolanský F, Waris M, Russ G (1995): Preparation of monoclonal antibodies for the diagnosis of influenza A infection using different immunization protocols. J. Immunol. Methods 180, 107-116.
18. Vreede FT, Jung TE, Brownlee GG (2004): Model suggesting that replication of influenza virus is regulated by stabilization of replicative intermediates. J. Virol. 78, 9568-9572.
19. Wise HM, Foeglein A, Sun J, Dalton RM, Patel S, Howard W, Anderson EC, Barclay WS, Digard P (2009): A complicated message: Identification of a novel PB1-related protein translated from influenza A virus segment 2 mRNA. Virology 83, 8021-8031.
20. Yamada H, Chounan R, Higashi Y, Kurihara N, Kido H (2004): Mitochondrial targeting sequence of the influenza A virus PB1-F2 protein and its function in mitochondria. FEBS Lett. 578, 331-336.
21. Zamarin D, García-Sastre A, Xiao X, Wang R, Palese P (2005): Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1. PLoS Pathog. 1, e4.
22. Zamarin D, Ortigoza MB, Palese P (2006): Influenza A virus PB1-F2 protein contributes to viral pathogenesis in mice. J. Virol. 80, 7976-7983.
23. Zell R, Krumbholz A, Eitner A, Krieg R, Halbhuber KJ, Wutzler P (2007): Prevalence of PB1-F2 of influenza A viruses. J. Gen. Virol. 88, 536-546.