Improving oral bioavailability and pharmacokinetics of liposomal metformin by glycerolphosphate-chitosan microcomplexation

AAPS PharmSciTech

Volumn 14, Issue 2, 2013, Pages 485-496

  Manconi, Maria ^a   Nácher, Amparo ^b   Merino, Virginia ^b   Merino Sanjuan, Matilde ^b   Manca, Maria Letizia ^a   Mura, Carla ^a   Mura, Simona ^c   Fadda, Anna Maria ^a   Diez Sales, Octavio ^b  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b UNIVERSITAT POLITÈCNICA DE VALÈNCIA   (Spain)

^c UNIV PARIS SUD   (France)

Author keywords

chitosan; controlled release; in vivo bioavailability; liposomes; oral delivery

Indexed keywords

CHITOSAN; GLYCEROL 2 PHOSPHATE; LIPOSOME; METFORMIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG BIOAVAILABILITY; DRUG RELEASE; ENCAPSULATION; IN VITRO STUDY; IN VIVO STUDY; INTESTINE ABSORPTION; LIPOSOMAL DELIVERY; MALE; MORPHOLOGY; MUCOADHESION; NONHUMAN; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; SWELLING; TRANSMISSION ELECTRON MICROSCOPY; X RAY DIFFRACTION; ZETA POTENTIAL;

ADHESIVENESS; ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CHITOSAN; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; GLYCEROPHOSPHATES; HYPOGLYCEMIC AGENTS; INTESTINAL ABSORPTION; INTESTINES; LIPOSOMES; MALE; METFORMIN; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, ELECTRON, TRANSMISSION; RATS; RATS, WISTAR; RHEOLOGY; SOLUBILITY; STOMACH; TECHNOLOGY, PHARMACEUTICAL; X-RAY DIFFRACTION;

EID: 84879104409     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-013-9926-4     Document Type: Article

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