N-Succinyl-chitosan systems for 5-aminosalicylic acid colon delivery: In vivo study with TNBS-induced colitis model in rats

International Journal of Pharmaceutics

Volumn 416, Issue 1, 2011, Pages 145-154

  Mura, C ^a,b   Nacher A ^b,c   Merino, V ^b,c   Merino Sanjuan, M ^b,c   Carda, C ^d   Ruiz, A ^d   Manconi, M ^a   Loy, G ^a   Fadda, A M ^a   Diez Sales, O ^b,c  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b UNIVERSITY OF VALENCIA   (Spain)

^c UNIVERSITAT POLITÈCNICA DE VALÈNCIA   (Spain)

^d UNIVERSITY OF VALENCIA   (Spain)

Author keywords

5 Aminosalicylic acid; Colon delivery, TNBS induced colitis; N Succinyl chitosan systems

Indexed keywords

5 ACETAMIDOSALICYLIC ACID; ADHESIVE AGENT; DRUG CARRIER; MUCOADHESIVE AGENT; MYELOPEROXIDASE; N SUCCINYL CHITOSAN; POLYMER; TRINITROBENZENESULFONIC ACID; UNCLASSIFIED DRUG;

ARTICLE; BODY WEIGHT; COLITIS; COLON; COMPARATIVE STUDY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; ENZYME ACTIVITY; HEALING; HISTOLOGY; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; SCORING SYSTEM; SUSPENSION; WISTAR RAT;

ABSORPTION; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHITOSAN; COLITIS; COLON; DISEASE MODELS, ANIMAL; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; FREEZE DRYING; INTESTINAL MUCOSA; LYMPHOCYTE ACTIVATION; MALE; MESALAMINE; ORGAN SIZE; PEROXIDASE; POLYMERS; RATS; RATS, WISTAR; TRINITROBENZENESULFONIC ACID;

EID: 80051799777     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.06.025     Document Type: Article

References (39)

1. K. Aiedeh, and M.O. Taha Synthesis of chitosan succinate and chitosan phthalate and their evaluation as suggested matrices in orally administered, colon-specific drug delivery systems Arch. Pharm. (Weinheim) 332 1999 103 107 (Pubitemid 29162586)
2. D.C. Baumgart, and S.R. Carding Inflammatory bowel disease: cause and immunobiology Lancet 369 2007 1627 1640 (Pubitemid 46722636)
3. F. Bigucci, B. Luppi, T. Cerchiara, M. Sorrenti, G. Bettinetti, L. Rodriguez, and V. Zecchi Chitosan/pectin polyelectrolyte complexes: selection of suitable preparative conditions for colon-specific delivery of vancomycin Eur. J. Pharm. Sci. 35 2008 435 441
4. M.E.A. Borm, and G. Bouma Animal models of inflammatory bowel disease Drug. Discov. Today 4 2004 437 443 (Pubitemid 41123754)
5. M.K. Chourasia, and S.K. Jain Pharmaceutical approaches to colon targeted drug delivery systems J. Pharm. Pharm. Sci. 6 2003 33 66 (Pubitemid 37207241)
6. M.S. Crcarevska, M.G. Dodov, G. Petrusevska, I. Gjorgoski, and K. Goracinova Bioefficacy of budesonide loaded crosslinked polyeletrolyte microparticles in rat model of induced colitis J. Drug Target 2009
7. L.M. De Young, J.B. Kheifets, S.J. Ballaron, and J.M. Young Edema and cell infiltration in the phorbol ester-treated mouse ear are temporally separate and can be differentially modulated by pharmacologic agents Agents Actions 26 1989 335 341 (Pubitemid 19078128)
8. J.J. Escobar-Chavez, V. Merino, O. Diez-Sales, A. Nacher-Alonso, A. Ganem-Quintanar, M. Herraez, and M. Merino-Sanjuan Transdermal nortriptyline hydrocloride patch formulated within a chitosan matrix intended to be used for smoking cessation Pharm. Dev. Technol. 16 2011 162 169
9. G. Hartmann, C. Bidlingmaier, B. Siegmund, S. Albrich, J. Schulze, K. Tschoep, A. Eigler, H.A. Lehr, and S. Endres Specific type IV phosphodiesterase inhibitor rolipram mitigates experimental colitis in mice J. Pharmacol. Exp. Ther. 292 2000 22 30 (Pubitemid 30026352)
10. T. Hibi, H. Ogata, and A. Sakuraba Animal models of inflammatory bowel disease J. Gastroenterol. 37 2002 409 417 (Pubitemid 34846282)
11. S. Hirano, and T. Moriyasu N-(carboxyacyl)chitosans Carbohydr. Res. 92 1981 323 327
12. F.N. Hussain, R.A. Ajjan, M. Moustafa, J.C. Anderson, and S.A. Riley Simple method for the determination of 5-aminosalicylic and N-acetyl-5- aminosalicylic acid in rectal tissue biopsies J. Chromatogr. B: Biomed. Sci. Appl. 716 1998 257 266 (Pubitemid 28464570)
13. K. Ishiguro, T. Ando, O. Maeda, O. Watanabe, and H. Goto Novel mouse model of colitis characterized by hapten-protein visualization Biotechniques 49 2010 641 648
14. S.K. Jain, A. Jain, Y. Gupta, and M. Ahirwar Design and development of hydrogel beads for targeted drug delivery to the colon AAPS PharmSciTech 8 2007 E56
15. T.T. Jubeh, Y. Barenholz, and A. Rubinstein Differential adhesion of normal and inflamed rat colonic mucosa by charged liposomes Pharm. Res. 21 2004 447 453 (Pubitemid 38338980)
16. Y. Jung, H.H. Kim, H. Kim, H. Kong, B. Choi, Y. Yang, and Y. Kim Evaluation of 5-aminosalicyltaurine as a colon-specific prodrug of 5-aminosalicylic acid for treatment of experimental colitis Eur. J. Pharm. Sci. 28 2006 26 33
17. M.N.V.R. Kumar A review of chitin and chitosan applications React. Funct. Polym. 46 2000 1 27
18. P. Kumar, and B. Mishra Colon targeted drug delivery systems - an overview Curr. Drug Deliv. 5 2008 186 198 (Pubitemid 351977882)
19. A. Lamprecht, N. Ubrich, H. Yamamoto, U. Schafer, H. Takeuchi, P. Maincent, Y. Kawashima, and C.M. Lehr Biodegradable nanoparticles for targeted drug delivery in treatment of inflammatory bowel disease J. Pharmacol. Exp. Ther. 299 2001 775 781
20. M.L. Lorenzo-Lamosa, C. Remunan-Lopez, J.L. Vila-Jato, and M.J. Alonso Design of microencapsulated chitosan microspheres for colonic drug delivery J. Control. Release 52 1998 109 118 (Pubitemid 28123178)
21. K. Mladenovska, R.S. Raicki, E.I. Janevik, T. Ristoski, M.J. Pavlova, Z. Kavrakovski, M.G. Dodov, and K. Goracinova Colon-specific delivery of 5-aminosalicylic acid from chitosan-Ca-alginate microparticles Int. J. Pharm. 342 2007 124 136 (Pubitemid 47259341)
22. G.P. Morris, P.L. Beck, M.S. Herridge, W.T. Depew, M.R. Szewczuk, and J.L. Wallace Hapten-induced model of chronic inflammation and ulceration in the rat colon Gastroenterology 96 1989 795 803 (Pubitemid 19057602)
23. C. Mura, M. Manconi, D. Valenti, M.L. Manca, O. Diez-Sales, G. Loy, and A.M. Fadda In vitro study of N-succinyl chitosan for targeted delivery of 5-aminosalicyic acid to colon Carbohydr. Polym. 85 2011 578 583
24. I. Orienti, T. Cerchiara, B. Luppi, F. Bigucci, G. Zuccari, and V. Zecchi Influence of different chitosan salts on the release of sodium diclofenac in colon-specific delivery Int. J. Pharm. 238 2002 51 59 (Pubitemid 34457875)
25. A.I. Qureshi, and R.D. Cohen Mesalamine delivery systems: do they really make much difference? Adv. Drug Deliv. Rev. 57 2005 281 302 (Pubitemid 39536103)
26. M.R. Rekha, and C.P. Sharma pH sensitive succinyl chitosan microparticles: a preliminary investigation towards oral insulin delivery Trends Biomater. Artif. Organs 21 2008 107 115
27. W.J. Sandborn, and S.B. Hanauer Systematic review: the pharmacokinetic profiles of oral mesalazine formulations and mesalazine pro-drugs used in the management of ulcerative colitis Aliment. Pharmacol. Ther. 17 2003 29 42 (Pubitemid 36140432)
28. B.E. Sands Therapy of inflammatory bowel disease Gastroenterology 118 2000 S68 S82
29. R.B. Sartor Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis Nat. Clin. Pract. Gastroenterol. Hepatol. 3 2006 390 407 (Pubitemid 44018812)
30. H. Sato, Y. Nakayama, C. Yamashita, and H. Uno Anti-inflammatory effects of tacalcitol (1,24(R)(OH)2D3, TV-02) in the skin of TPA-treated hairless mice J. Dermatol. 31 2004 200 217 (Pubitemid 38478349)
31. V.R. Sinha, and R. Kumria Polysaccharides in colon-specific drug delivery Int. J. Pharm. 224 2001 19 38 (Pubitemid 32706482)
32. N. Thirawong, J. Nunthanid, S. Puttipipatkhachorn, and P. Sriamornsak Mucoadhesive properties of various pectins on gastrointestinal mucosa: an in vitro evaluation using texture analyzer Eur. J. Pharm. Biopharm. 67 2007 132 140 (Pubitemid 46991332)
33. H. Tozaki, T. Fujita, J. Komoike, S.I. Kim, H. Terashima, S. Muranishi, S. Okabe, and A. Yamamoto Colon-specific delivery of budesonide with azopolymer-coated pellets: therapeutic effects of budesonide with a novel dosage form against 2,4,6-trinitrobenzenesulphonic acid-induced colitis in rats J. Pharm. Pharmacol. 51 1999 257 261 (Pubitemid 29192778)
34. H. Tozaki, J. Komoike, C. Tada, T. Maruyama, A. Terabe, T. Suzuki, A. Yamamoto, and S. Muranishi Chitosan capsules for colon-specific drug delivery: improvement of insulin absorption from the rat colon J. Pharm. Sci. 86 1997 1016 1021 (Pubitemid 27382903)
35. H. Tozaki, T. Odoriba, N. Okada, T. Fujita, A. Terabe, T. Suzuki, S. Okabe, S. Muranishi, and A. Yamamoto Chitosan capsules for colon-specific drug delivery: enhanced localization of 5-aminosalicylic acid in the large intestine accelerates healing of TNBS-induced colitis in rats J. Control. Release 82 2002 51 61 (Pubitemid 34775047)
36. R. Yamaguchi, Y. Araj, T. Itoh, and S. Hirano Preparation of partially N-succinylated chitosan and their cross-linked gels Carbohydr. Res. 88 1981 172 175
37. C. Yan, D. Chen, J. Gu, H. Hu, X. Zhao, and M. Qiao Preparation of N-succinyl-chitosan and its physical-chemical properties as a novel excipient Yakugaku Zasshi 126 2006 789 793 (Pubitemid 44358777)
38. L. Yang, J.S. Chu, and J.A. Fix Colon-specific drug delivery: new approaches and in vitro/in vivo evaluation Int. J. Pharm. 235 2002 1 15 (Pubitemid 34185432)
39. S.Y. Zhou, D. Fleisher, L.H. Pao, C. Li, B. Winward, and E.M. Zimmermann Intestinal metabolism and transport of 5-aminosalicylate Drug Metab. Dispos. 27 1999 479 485 (Pubitemid 29177641)