New decision-tree model for defining the risk of reproductive failure

American Journal of Reproductive Immunology

Volumn 70, Issue 1, 2013, Pages 59-68

  Ramos Medina, Rocío ^a   García Segovia, Áurea ^b   León, Juan A ^a   Alonso, Bárbara ^a   Tejera Alhambra, Marta ^a   Gil, Juana ^a   Caputo, Juan D ^a   Seyfferth, Ansgar ^c   Aguarón, Ángel ^a   Vicente, Ángeles ^d   Ordoñez, Daniel ^e   Alonso, Jorge ^b   de Albornoz, Elena Carrillo ^e   Carbone, Javier ^a   Caballero, Pedro ^b   Fernandez Cruz, Eduardo ^a   Ortiz Quintana, Luis ^a   Sánchez Ramón, Silvia ^a  

^a HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^b Clinica Tambre   (Spain)

^c STAT UP Statistical Consulting and Services   (Spain)

^d UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^e HOSPITAL RUBER INTERNACIONAL   (Spain)

Author keywords

Decision tree model; NK cells; Recurrent reproductive failure

Indexed keywords

ADULT; ARTICLE; CELL EXPANSION; CONTROLLED STUDY; DECISION TREE; FEMALE; FLOW CYTOMETRY; GENITAL SYSTEM DISEASE; HUMAN; HUMAN CELL; MENSTRUAL CYCLE; NATURAL KILLER CELL; NATURAL KILLER T CELL; PREGNANCY OUTCOME; PRIORITY JOURNAL; REPRODUCTION; REPRODUCTIVE FAILURE; RISK FACTOR; SPONTANEOUS ABORTION;

ABORTION, HABITUAL; ADULT; ANTIGENS, CD56; DECISION SUPPORT TECHNIQUES; EMBRYO LOSS; FEMALE; GPI-LINKED PROTEINS; HUMANS; KILLER CELLS, NATURAL; PREGNANCY; RECEPTORS, IGG; RISK FACTORS;

EID: 84879023076     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/aji.12098     Document Type: Article

References (34)

1. Macklon NS, Geraedts JP, Fauser BC: Conception to ongoing pregnancy: the 'black box' of early pregnancy loss. Hum Reprod Update 2002; 8:333-343.
2. Roberts CJ, Lowe CR: Where have all the conceptions gone? Lancet 1975; 1:636-637.
3. Ford HB, Schust DJ: Recurrent pregnancy loss: etiology, diagnosis, and therapy. Rev Obstet Gynecol 2009; 2:76-83.
4. Makrigiannakis A, Petsas G, Toth B, Relakis K, Jeschke U: Recent advances in understanding immunology of reproductive failure. J Reprod Immunol 2011; 90:96-104.
5. Patel RN, Quack KC, Hill JA, Schust DJ: Expression of membrane-bound HLA-G at the maternal-fetal interface is not associated with pregnancy maintenance among patients with idiopathic recurrent pregnancy loss. Mol Hum Reprod 2003; 9:551-557.
6. Regan MMB, Rai R: The Investigation and Treatment of Couples with Recurrent First-trimester and Second-trimester Miscarriage. London, Royal College of Obstetricians and Gynaecologists, 2011.
7. Rai R, Regan L: Recurrent miscarriage. Lancet 2006; 368:601-611.
8. Margalioth EJ, Ben-Chetrit A, Gal M, Eldar-Geva T: Investigation and treatment of repeated implantation failure following IVF-ET. Hum Reprod 2006; 21:3036-3043.
9. De Carolis C, Perricone C, Perricone R: NK cells, autoantibodies, and immunologic infertility: a complex interplay. Clin Rev Allergy Immunol 2010; 39:166-175.
10. Kwak-Kim J, Park JC, Ahn HK, Kim JW, Gilman-Sachs A: Immunological modes of pregnancy loss. Am J Reprod Immunol 2010; 63:611-623.
11. Ntrivalas EI, Kwak-Kim JY, Gilman-Sachs A, et al.: Status of peripheral blood natural killer cells in women with recurrent spontaneous abortions and infertility of unknown aetiology. Hum Reprod 2001; 16:855-861.
12. Fukui A, Funamizu A, Yokota M, Yamada K, Nakamua R, Fukuhara R, Kimura H and Mizunuma H: Uterine and circulating natural killer cells and their roles in women with recurrent pregnancy loss, implantation failure and preeclampsia. J Reprod Immunol 2011; 90:105-110.
13. Yamamoto T, Takahashi Y, Kase N, Mori H: Decidual natural killer cells in recurrent spontaneous abortion with normal chromosomal content. Am J Reprod Immunol 1999; 41:337-342.
14. Zweig MH, Campbell G: Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. Clin Chem 1993; 39:561-577.
15. Branch DW, Gibson M, Silver RM: Clinical practice. Recurrent miscarriage. N Engl J Med 2010; 363:1740-1747.
16. Pantazi A, Tzonis P, Perros G, et al.: Comparative analysis of peripheral natural killer cells in the two phases of the ovarian cycle. Am J Reprod Immunol 2010; 63:46-53.
17. van den Heuvel MJ, Peralta CG, Hatta K, Han VK, Clark DA: Decline in number of elevated blood CD3(+) CD56(+) NKT cells in response to intravenous immunoglobulin treatment correlates with successful pregnancy. Am J Reprod Immunol 2007; 58:447-459.
18. Lu Y, Zeng B, Zhang Y, Xiang W, Hu L, Liao A: Quantitative and functional changes in peripheral natural killer cells in women with reproductive failure after artificial insemination with donor sperm. J Reprod Immunol 2011; 91:83-89.
19. Kwak-Kim J, Gilman-Sachs A: Clinical implication of natural killer cells and reproduction. Am J Reprod Immunol 2008; 59:388-400.
20. Park DW, Lee HJ, Park CW, Hong SR, Kwak-Kim J, Yang KM: Peripheral blood NK cells reflect changes in decidual NK cells in women with recurrent miscarriages. Am J Reprod Immunol 2010; 63:173-180.
21. Coulam CB, Krysa L, Stern JJ, Bustillo M: Intravenous immunoglobulin for treatment of recurrent pregnancy loss. Am J Reprod Immunol 1995; 34:333-337.
22. Beer AE, Kwak JY, Ruiz JE: Immunophenotypic profiles of peripheral blood lymphocytes in women with recurrent pregnancy losses and in infertile women with multiple failed in vitro fertilization cycles. Am J Reprod Immunol 1996; 35:376-382.
23. Emmer PM, Nelen WL, Steegers EA, Hendriks JC, Veerhoek M, Joosten I: Peripheral natural killer cytotoxicity and CD56(pos)CD16(pos) cells increase during early pregnancy in women with a history of recurrent spontaneous abortion. Hum Reprod 2000; 15:1163-1169.
24. Yamada H, Morikawa M, Kato EH, Shimada S, Kobashi G, Minakami H: Pre-conceptional natural killer cell activity and percentage as predictors of biochemical pregnancy and spontaneous abortion with normal chromosome karyotype. Am J Reprod Immunol 2003; 50:351-354.
25. Tang AW, Alfirevic Z, Quenby S: Natural killer cells and pregnancy outcomes in women with recurrent miscarriage and infertility: a systematic review. Hum Reprod 2011; 26:1971-1980.
26. Perricone C, De Carolis C, Giacomelli R, Zaccari G, Cipriani P, Bizzi E and Perricone R: High levels of NK cells in the peripheral blood of patients affected with anti-phospholipid syndrome and recurrent spontaneous abortion: a potential new hypothesis. Rheumatology (Oxford) 2007; 46:1574-1578.
27. Perricone R, Di Muzio G, Perricone C, Giacomelli R, De Nardo D, Fontana L and De Carolis C: High levels of peripheral blood NK cells in women suffering from recurrent spontaneous abortion are reverted from high-dose intravenous immunoglobulins. Am J Reprod Immunol 2006; 55:232-239.
28. Beaman KD, Ntrivalas E, Mallers TM, Jaiswal MK, Kwak-Kim J, Gilman-Sachs A: Immune etiology of recurrent pregnancy loss and its diagnosis. Am J Reprod Immunol 2012; 67:319-325.
29. Coulam CB and Hemenway NP: Immunology May Be Key to Pregnancy Loss. Part III. Test Available to Diagnose Immunologic Causes of Pregnancy Loss. ART Resource Directory, Chicago, 2006.
30. Perricone R, Perricone C, De Carolis C, Shoenfeld Y: NK cells in autoimmunity: a two-edg'd weapon of the immune system. Autoimmun Rev 2008; 7:384-390.
31. Kopcow HD, Eriksson M, Mselle TF, Damrauer SM, Wira CR, Sentman CL and Strominger JL: Human decidual NK cells from gravid uteri and NK cells from cycling endometrium are distinct NK cell subsets. Placenta 2010; 31:334-338.
32. Lachapelle MH, Miron P, Hemmings R, Roy DC: Endometrial T, B, and NK cells in patients with recurrent spontaneous abortion. Altered profile and pregnancy outcome. J Immunol 1996; 156:4027-4034.
33. Yagel S: The developmental role of natural killer cells at the fetal-maternal interface. Am J Obstet Gynecol 2009; 201:344-350.
34. Huppertz B, Berghold VM, Kawaguchi R, Gauster M: A variety of opportunities for immune interactions during trophoblast development and invasion. Am J Reprod Immunol 2012; 67:349-357.