Immune Etiology of Recurrent Pregnancy Loss and Its Diagnosis

American Journal of Reproductive Immunology

Volumn 67, Issue 4, 2012, Pages 319-325

  Beaman, Kenneth D ^a   Ntrivalas, Evangelos ^a   Mallers, Timothy M ^a   Jaiswal, Mukesh K ^a   Kwak Kim, Joanne ^a   Gilman Sachs, Alice ^a  

^a ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

Author keywords

Pregnancy loss; recurrent spontaneous abortion; Recurrent spontaneous abortion of immunological origin

Indexed keywords

ALLOANTIBODY; AUTOANTIBODY; HLA A ANTIGEN; HLA ANTIGEN; HLA B ANTIGEN; HLA C ANTIGEN; HLA D ANTIGEN; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

AUTOIMMUNE DISEASE; CELLULAR IMMUNITY; CYTOTOXICITY; FETUS WASTAGE; HUMAN; IMMUNE RESPONSE; IMMUNOPATHOLOGY; LABORATORY DIAGNOSIS; MULTIPLE PREGNANCY; NATURAL KILLER CELL; PATHOGENESIS; PRIORITY JOURNAL; RECURRENT ABORTION; RECURRENT SPONTANEOUS ABORTION OF IMMUNOLOGICAL ORIGIN; REVIEW; SERODIAGNOSIS; SPONTANEOUS ABORTION; TH1 TH2 BALANCE; THROMBOPHILIA;

ABORTION, HABITUAL; AUTOANTIBODIES; FEMALE; HUMANS; INFANT, NEWBORN; KILLER CELLS, NATURAL; PREGNANCY; RECEPTORS, KIR;

EID: 84858698460     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/j.1600-0897.2012.01118.x     Document Type: Review

References (29)

1. Rai R, Regan L: Recurrent miscarriage. Lancet 2006; 368:601-611.
2. Wilcox AJ, Weinberg CR, O'Connor JF, Baird DD, Schlatterer JP, Canfield RE, Armstrong EG, Nisula BC: Incidence of early loss of pregnancy. N Engl J Med 1988; 319:189-194.
3. Stephenson MD: Frequency of factors associated with habitual abortion in 197 couples. Fertil Steril 1996; 66:24-29.
4. Stephenson MD, Kutteh WH, Purkiss S, Librach C, Schultz P, Houlihan E, Liao C: Intravenous immunoglobulin and idiopathic secondary recurrent miscarriage: a multicentered randomized placebo-controlled trial. Hum Reprod 2010; 25:2203-2209.
5. Porter T, LaCoursiere Y, Scott J: Immunotherapy for recurrent miscarriage. Cochrane Database Syst Rev 2006; CD000112.
6. Fukui A, Ntrivalas E, Fukuhara R, Fujii S, Mizunuma H, Gilman-Sachs A, Beaman K, Kwak-Kim J: Correlation between natural cytotoxicity receptors and intracellular cytokine expression of peripheral blood NK cells in women with recurrent pregnancy losses and implantation failures. Am J Reprod Immunol 2009; 62:371-380.
7. Fukui A, Kwak-Kim J, Ntrivalas E, Gilman-Sachs A, Lee SK, Beaman K: Intracellular cytokine expression of peripheral blood natural killer cell subsets in women with recurrent spontaneous abortions and implantation failures. Fertil Steril 2008; 89:157-165.
8. Fukui A, Ntrivalas E, Gilman-Sachs A, Kwak-Kim J, Lee SK, Levine R, Beaman K: Expression of natural cytotoxicity receptors and a2V-ATPase on peripheral blood NK cell subsets in women with recurrent spontaneous abortions and implantation failures. Am J Reprod Immunol 2006; 56:312-320.
9. Winger EE, Reed JL, Ashoush S, El-Toukhy T, Ahuja S, Taranissi M: Elevated preconception CD56+16+ and/or Th1:Th2 levels predict benefit from IVIG therapy in subfertile women undergoing IVF. Am J Reprod Immunol 2011; 66:394-403.
10. Winger EE, Reed JL, Ashoush S, El-Toukhy T, Ahuja S, Taranissi M: Degree of TNF-α/IL-10 cytokine elevation correlates with IVF success rates in women undergoing treatment with Adalimumab (Humira) and IVIG. Am J Reprod Immunol 2011; 65:610-618.
11. Gleicher N, Weghofer A, Barad DH: Cutting edge assessment of the impact of autoimmunity on female reproductive success. J Autoimmun 2011.
12. Winger EE, Reed JL, Ashoush S, Ahuja S, El-Toukhy T, Taranissi M: Treatment with adalimumab (Humira) and intravenous immunoglobulin improves pregnancy rates in women undergoing IVF. Am J Reprod Immunol 2009; 61:113.
13. Winger EE, Reed JL: A retrospective analysis of fondaparinux versus enoxaparin treatment in women with infertility or pregnancy loss. Am J Reprod Immunol 2009; 62:253-260.
14. Hutton B, Sharma R, Fergusson D, Tinmouth A, Hebert P, Jamieson J, Walker M: Use of intravenous immunoglobulin for treatment of recurrent miscarriage: a systematic review. BJOG 2007; 114:134-142.
15. Detrick B: Manual of Molecular and Clinical Immunology. Washington, DC, ASM Press, 2006, 1037.
16. Hiby SE, Walker JJ, O'Shaughnessy KM, Redman CW, Carrington M, Trowsdale J, Moffett A: Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success. J Exp Med 2004; 200:957-965.
17. Parham P: NK cells and trophoblasts: partners in pregnancy. J Exp Med 2004; 200:951-955.
18. Jaiswal MK, Mallers T, Kwong C, Chaouat G, Gilman-Sachs A, Beaman KD: Abortion-prone mating influences alteration of systemic a2 vacuolar ATPase expression in spleen and blood immune cells. Am J Reprod Immunol 2012.
19. Jaiswal MK, Gilman-Sachs A, Chaouat G, Beaman KD: Placental ATPase expression is a link between multiple causes of spontaneous abortion in mice. Biol Reprod 2011; 85:1285.
20. Gammill HS, Nelson JL: Naturally acquired microchimerism. Int J Dev Biol 2010; 54:531-543.
21. Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham III CO, Birnbaum NS, Burmester GR, Bykerk VP, Cohen MD, Combe B, Costenbader KH, Dougados M, Emery P, Ferraccioli G, Hazes JM, Hobbs K, Huizinga TW, Kavanaugh A, Kay J, Kvien TK, Laing T, Mease P, Ménard HA, Moreland LW, Naden RL, Pincus T, Smolen JS, Stanislawska-Biernat E, Symmons D, Tak PP, Upchurch KS, Vencovský J, Wolfe F, Hawker G: 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum 2010; 62:2569-2581.
22. Poole BD, Schneider RI, Guthridge JM, Velte CA, Reichlin M, Harley JB, James JA: Early targets of nuclear RNP humoral autoimmunity in human systemic lupus erythematosus. Arthritis Rheum 2009; 60:848-859.
23. Marlin R, Duriez M, Berkane N, de Truchis C, Madec Y, Rey-Cuille MA, Cummings JS, Cannou C, Quillay H, Barré-Sinoussi F, Nugeyre MT, Menu E: Dynamic shift from CD85j/ILT-2 to NKG2D NK receptor expression pattern on human decidual NK during the first trimester of pregnancy. PLoS ONE 2012; 7:e30017.
24. Ntrivalas EI, Bowser C, Kwak-Kim JY, Beaman KD, Gilman-Sachs A: Expression of Killer Immunoglobulin-like Receptors (KIRs) on peripheral blood NK cell subsets of women with recurrent spontaneous abortions or implantation failures. Am J Reprod Immunol 2005; 53:1-7.
25. Varla-Leftherioti M: Role of a KIR/HLA-C allorecognition system in pregnancy. J Reprod Immunol 2004; 62:19-27.
26. Varla-Leftherioti M, Spyropoulou-Vlachou M, Niokou D, Keramitsoglou T, Darlamitsou A, Tsekoura C, Papadimitropoulos M, Lepage V, Balafoutas C, Stavropoulos-Giokas C: Natural killer (NK) cell receptors' repertoire in couples with recurrent spontaneous abortions. Am J Reprod Immunol 2003; 49:183-191.
27. Khakoo SI, Thio CL, Martin MP, Brooks CR, Gao X, Astemborski J, Cheng J, Goedert JJ, Vlahov D, Hilgartner M, Cox S, Little AM, Alexander GJ, Cramp ME, O'Brien SJ, Rosenberg WM, Thomas DL, Carrington M: HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection. Science 2004; 305:786-787.
28. Hong Y, Wang X, Lu P, Song Y, Lin Q: Killer immunoglobulin-like receptor repertoire on uterine natural killer cell subsets in women with recurrent spontaneous abortions. Eur J Obstet Gynecol Reprod Biol 2008; 140:218-223.
29. Hiby SE, Regan L, Lo W, Farrell L, Carrington M, Moffett A: Association of maternal killer-cell immunoglobulin-like receptors and parental HLA-C genotypes with recurrent miscarriage. Eur J Obstet Gynecol Reprod Biol 2008; 23:972-976.