High levels of peripheral blood NK cells in women suffering from recurrent spontaneous abortion are reverted from high-dose intravenous immunoglobulins

American Journal of Reproductive Immunology

Volumn 55, Issue 3, 2006, Pages 232-239

  Perricone, Roberto ^a   Di Muzio, Gioia ^a   Perricone, Carlo ^a   Giacomelli, Roberto ^b   De Nardo, Domenico ^a   Fontana, Luigi ^a   De Carolis, Caterina ^c  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b UNIVERSITY OF L'AQUILA   (Italy)

^c ASL Roma B   (Italy)

Author keywords

Cytokine balance; IVIG therapy; Spontaneous abortion

Indexed keywords

IMMUNOGLOBULIN;

ARTICLE; BIRTH RATE; CLINICAL PROTOCOL; CYTOFLUOROMETRY; DRUG INFUSION; FEMALE; HUMAN; HUMAN CELL; IN VIVO STUDY; MAJOR CLINICAL STUDY; NATURAL KILLER CELL; PERIPHERAL LYMPHOCYTE; PREGNANCY; PRIORITY JOURNAL; RECURRENT ABORTION; STATISTICAL ANALYSIS; TREATMENT OUTCOME;

ABORTION, HABITUAL; BIRTH RATE; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; FEMALE; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS; KILLER CELLS, NATURAL; PREGNANCY;

EID: 33644682374     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/j.1600-0897.2005.00356.x     Document Type: Article

References (36)

1. Stirrat GM: Recurrent miscarriage. Lancet 1990; 336: 673-675.
2. Hatasaka HH: REcurrent miscarriage: epidemiologic factors, definitions and incidence. Clin Obstet Gynecol 1994; 37: 625-634.
3. Daya S: Immunotherapy for unexplained recurrent spontaneous abortion. Infertil Reprod Med Clinics N Am 1996; 8: 65-77.
4. Chaouat G, Ledee-Bataille N, Zourbas S, Ostojic S, Dubanchet S, Martal J, Frydman R: Cytokines, implantation Rnd early abortion: re-examining the Th1/Th2 paradigm leads to question the single pathway, single therapy concept. Am J Reprod Immunol 2003; 50: 177-186.
5. Chaouat G, Ledee-Bataille N, Dubanchet S, Zourbas S, Sandra O, Martal J: Reproductive immunoloRy 2003: reassessing the Th1/Th2 paradigm? Immunol Lett 2004; 92: 207-214.
6. Wegman TG, Lin H, Guilbert L, Mosmann TR: Bidirectional cytokine interactions in the maternal-fetal relationship: Is successful pregnancy a Th2 phenomenon? Immunol Today 1993; 14: 353-356.
7. Coulam CB, Krysa L, Stern JJ, Bustillo M: Intravenous immunoglobulin for treatment of recurrent pregnancy loss. Am J Reprod Immunol 1995; 34: 333-337.
8. Polgar K, Hill JA: Identification of the white blood cell populations responsible for Th1 immunity to trophoblast and the timing of the response in women with recurrent pregnancy loss. Gynecol Obstet Invest 2002; 53: 59-64.
9. Desiou C, Giudice LC: Natural killer cells in pregnancy and recurrent pregnancy loss: Endocrine and immunologic perspectives. End Rev 2005; 26: 44-62.
10. Lachapelle MH, Miron P, Hennings R: Endometrial T and NK cells in patients with recurrent spontaneous abortion. Altered profile and pregnancy outcome. J Immunol 1995; 156: 4027-4034.
11. Robertson MJ, Ritz J: Biology and clinical relevance of human natural killer cells. Blood 1990; 76: 2421-2438.
12. Lee RM, Silver RMS Recurrent pregnancy loss: summary and clinical recommendations. Semin Reprod Med 2000; 18: 433-440.
13. Hill JA: Recurrent pregnancy loss. In Maternal-Fetal Medicine. 4th edn. Creasy RK, Resnik R, (eds). Philadelphia, PA, W.B. Saunders Company, 1999, pp. 423-443.
14. Rai R, Regan L: The endometrium in recurrent miscarriage. In The Endometrium. Glasser SR, Aplin DJ, Giudice LC, Tabibzadeh S (eds). New York, Taylor Francis, 2002, pp. 546-555.
15. Carp HJA, Asherson RA, Shoenfeld Y: Intravenous immunoglobulin in pregnancies complicated by the antiphospholipid syndrome: What is its role? J Clin Rheumatol 2001; 7: 291-294.
16. Christiansen OB: Intravenous immunoglobulin in the prevention of recurrent spontaneous abortion the European experience. Am J Reprod Immunol 1998; 39: 77-81.
17. Hill JA, Polgar K, Anderson DJ: T-helper type-1 immunity to trophoblast in women with recurrent spontaneous abortion. J Am Med Assoc 1995; 273: 1933-1936.
18. Mollnes TE, Hogasen K, De Carolis C, Vaquero E, Nielsen EW, Fontana L, Perricone R: High-dose intravenous immunoglobulin treatment activates complement in vivo. Scand J Immunol 1998; 48: 312-317.
19. King A, Loke YW: On the nature and function of human uterine granular lymphocytes. Immunol Today 1991; 12: 432-435.
20. Carp HJ, Toder V, Gazit E, Ahiron R, Torchinski A, Mashiach S, Shoenfeld Y: Further experience with intravenous immunoglobulin in women with recurrent miscarriage and a poor prognosis. Am J Reprod Immunol 2001; 46: 268-273.
21. Perricone R, De Carolis C, Giacomelli R, Guarino MD, De Sanctis G, Fontana L: GM-CSE and pregnancy: evidence of significantly reduced blood concentrations in unexplained recurrent abortion efficiently reverted by intravenous immunoglobulin treatment. Am J Reprod Immunol 2003; 50: 232-237.
22. Zaidan R, Al Moallem M, Wani BA, Shameena AR, Al Tahan AR, Daif AK, Al Rajeh S. Thrombosis complicating high dose intravenous immunoglobulin: Report of three cases and review of the literature. Eur J Neurol 2003; 10: 367- 372.
23. Brown HC, Ballas ZK. Acute thromboembolic events associated with intravenous immunoglobulin infusion in antibody-deficient patients. J Allergy Clin Immunol 2003; 112: 797-799.
24. Shoenfeld Y, Katz U. IVIg therapy in autoimmunity and related disorders: Our experience with a large cohort of patients. Autoimmunity. 2005; 38: 123-137.
25. Carp H, Toder V, Aviram A, Daniely M, Mashiach S, Barkai G: Karyotype of the abortus in recurrent miscarriage. Fertil Steril 2001; 75: 678-682.
26. Aoki K, Kayiura S, Matsumoto Y, Ogasawara M, Okada S, Yagami Y, Gleicher N: Preconceptional natural-killer-cell activity as a predictor of miscarriage. Lancet 1995; 345: 1340-1342.
27. + natural killer cells in women with recurrent miscarriage: A histomorphometry study. Hum Reprod 1999; 14: 2727-2730.
28. Koopman LA, Kopcow HD, Rybalov B, Boison JE, Orange JS, Schatz F, Mash R, Lockwood CJ, Scachter AD, Park PJ, Strominger JL: Human decidual natural killer cells are a unique subset with immunomodulatory potential. J Exp Med 2003; 198: 1201-1212.
29. Bussel JB, Pham LC, Aledort L, Nachman R: Maintenance treatment of adults with refractory immune thrombocytopenic purpura using repeated intravenous infusions of gamma globulin. Blood 1988; 72: 121-127.
30. Kimberly RP, Salomon JR, Bussel JB: Modulation of mononuclear phagocyte function by intravenous gammaglobulin. J Immunol 1987; 132: 745-750.
31. Mannhalter JW, Ahmad R, Wolf HM, Eibl MM: Effect of polymeric IgG on human monocyte functions. Int Arch Allergy Appl Immunol 1987; 82: 159-167.
32. Sultan Y, Kazatchine MD, Maisonneuve P, Nydegger UE: Antiidiotypic suppression of autoantibodies to Factor VIII (antihemophilic factor) by high-dose intravenous gammaglobulin. Lancet 1984; 2: 765-768.
33. Dietrich G, Kaveri SV, Kazatchine MD: Modulation of autoimmunity by intravenous immuneglobulina through interaction with the function of the immune/idiotypic network. Clin Immunol 1992; 62: S73-S81.
34. Dweyer JM: Manipulating the immune system with immune globuline. N Engl J Med 1992; 326: 107-116.
35. Ruiz JE, Kwak JYH, Baum L, Gilman-Sachs A, Beaman KD, Kim YB, Beer AE: Intravenous immunoglobulin inhibits natural killer cell activity in vivo in women with recurrent spontaneous abortion. Am J Reprod Immunol 1996; 35: 370-375.
36. Ruitz JE: Effect of intravenous immunoglobulin on natural killer cell activity in women with recurrent spontaneous abortion. Master Degree Thesis, Finch University of Health Science, The Chicago Medical School, USA, 1995.