Interaction of the melanocortin 2 receptor with nucleoporin 50: Evidence for a novel pathway between a G-protein-coupled receptor and the nucleus

FASEB Journal

Volumn 21, Issue 14, 2007, Pages 4095-4100

  Doufexis, Marina ^a,b   Storr, Helen L ^a   King, Peter J ^a   Clark, Adrian J L ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b Academy of Athens Biomedical Research Foundation   (Greece)

Author keywords

ACTH; GPCR

Indexed keywords

G PROTEIN COUPLED RECEPTOR; MELANOCORTIN 2 RECEPTOR; NUCLEOPORIN; NUCLEOPORIN 50; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CELL NUCLEUS; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN INTERACTION;

ACTIVE TRANSPORT, CELL NUCLEUS; ADRENOCORTICOTROPIC HORMONE; ANIMALS; CELL LINE, TUMOR; CELL NUCLEUS; HUMANS; MICE; NUCLEAR PORE COMPLEX PROTEINS; RECEPTOR, MELANOCORTIN, TYPE 2; SIGNAL TRANSDUCTION;

BACTERIA (MICROORGANISMS);

EID: 36849011950     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.06-7927com     Document Type: Article

References (40)

1. Halkerston, I. D. K. (1975) Cyclic AMP and adrenocortical function. Adv. Cycl. Nucleot. Res. 6, 100-136
2. Mountjoy, K. G., Robbins, L. S., Mortrud, M. T., and Cone, R. D. (1992) The cloning of a family of genes that encode melanocortin receptors. Science 257, 1248-1251
3. Cammas, F. M., Pullinger, G. D., Barker, S., and Clark, A. J. L. (1997) The mouse ACTH receptor gene: cloning and characterization of its promoter and evidence for a role for the orphan nuclear receptor SF-1. Mol. Endocrinol. 11, 867-876
4. Naville, D., Barjhoux, L., Jaillard, C., Lebrethon, M. C., Saez, J. M., and Begeot, M. (1994) Characterization of the transcription start site of the ACTH receptor gene: presence of an intronic sequence in the 5′-flanking region. Mol. Cell Endocrinol. 106, 131-135
5. Boston, B. A., and Cone, R. D. (1996) Characterization of melanocortin receptor subtype expression in murine adipose tissues and in the 3T3-L1 cell line. Endocrinology 137, 2043-2050
6. Morris, D. G., Kola, B., Borboli, N., Kaltsas, G. A., Gueorguiev, M., McNicol, A. M., Ferrier, R., Jones, T. H., Baldeweg, S., Powell, M., et al. (2003) Identification of adrenocorticotropin receptor messenger ribonucleic acid in the human pituitary and its loss of expression in pituitary adenomas. J. Clin. Endocrinol. Metab. 88, 6080-6087
7. Slominski, A., Ermak, G., and Mihm, M. (1996) ACTH receptor, CYP11A1, CYP17 and CYP21A2 genes are expressed in skin. J. Clin. Endocrinol. Metab. 81, 2746-2749
8. Nankova, B. B., Kvetnansky, R., and Sabban, E. L. (2003) Adrenocorticotropic hormone (MC-2) receptor mRNA is expressed in rat sympathetic ganglia and up-regulated by stress. Neurosci. Lett. 344, 149-152
9. Kojima, I., Kojima, K., and Rasmussen, H. (1985) Role of calcium and cAMP in the action of adrenocorticotropin on aldosterone secretion. J. Biol. Chem. 260, 4248-4256
10. Durroux, T., Gallo-Payet, N., and Payet, M. D. (1991) Effects of adrenocorticotropin on action potential and calcium currents in cultured rat and bovine glomerulosa cells. Endocrinology 129, 2139-2147
11. Enyeart, J. J. (2005) Biochemical and Ionic signaling mechanisms for ACTH-stimulated cortisol production. Vitam. Horm. 70, 265-279
12. Yamazaki, T., Kimoto, T., Higuchi, K., Ohta, Y., Kawato, S., and Kominami, S. (1998) Calcium ion as a second messenger for o-nitrophenylsulfenyl- adrenocorticotropin (NPS-ACTH) and ACTH in bovine adrenal steroidogenesis. Endocrinology 139, 4765-4771
13. Chorvatova, A., Gendron, L., Bilodeau, L., Gallo-Payet, N., and Payet, M. D. (2000) A Ras-dependent chloride current activated by adrenocorticotropin in rat adrenal zona glomerulosa cells. Endocrinology 141, 684-692
14. Wang, X., Walsh, L. P., Reinhart, A. J., and Stocco, D. M. (2000) The role of arachidonic acid in steroidogenesis and steroidogenic acute regulatory (StAR) gene and protein expression. J. Biol. Chem. 275, 20204-20209
15. Watanabe, G., Pena, P., Albanese, C., Wilsbacher, L. D., Young, J. B., and Pestell, R. G. (1997) Adrenocorticotropin induction of stress-activated protein kinase in the adrenal cortex in vivo. J. Biol. Chem. 272, 20063-20069
16. Le, T., and Schimmer, B. P. (2001) The regulation of MAPKs in Y1 mouse adrenocortical tumor cells. Endocrinology 142, 4282-4287
17. Forti, F. L., Schwindt, T. T., Moraes, M. S., Eichler, C. B., and Armelin, H. A. (2002) ACTH promotion of p27(Kip1) induction in mouse Y1 adrenocortical tumor cells is dependent on both PKA activation and Akt/PKB inactivation. Biochemistry 41, 10133-10140
18. Noon, L. A., Franklin, J. M., King, P. J., Goulding, N. J., Hunyady, L., and Clark, A. J. L. (2002) Failed export of the adrenocorticotropin receptor from the endoplasmic reticulum in non-adrenal cells: evidence in support of a requirement for a specific adrenal accessory factor. J. Endocrinol. 174, 17-25
19. Metherell, L. A., Chapple, J. P., Cooray, S., David, A., Becker, C., Rüschendorf, F., Naville, D., Begeot, M., Khoo, B., Nürnberg, P., et al. (2005) Mutations in MRAP, encoding a novel interacting partner of the ACTH receptor, cause Familial Glucocorticoid Deficiency Type 2. Nat. Genet. 37, 166-170
20. Dove, S. L., and Hochschild, A. (2004) A bacterial two-hybrid system based on transcription activation. Methods Mol. Biol. 261, 231-246
21. Guan, T., Kehlenbach, R. H., Schirmer, E. C., Kehlenbach, A., Fan, F., Clurman, B. E., Arnheim, N., and Gerace, L. (2000) Nup50, a nucleoplasmically oriented nucleoporin with a role in nuclear protein export. Mol. Cell Biol. 20, 5619-5630
22. Fan, F., Liu, C. P., Korobova, O., Heyting, C., Offenberg, H. H., Trump, G., and Arnheim, N. (1997) cDNA cloning and characterization of Npap60: a novel rat nuclear pore-associated protein with an unusual subcellular localization during male germ cell differentiation. Genomics 40, 444-453
23. Smitherman, M., Lee, K., Swanger, J., Kapur, R., and Clurman, B. E. (2000) Characterization and targeted disruption of murine Nup50, a p27(Kip1)-interacting component of the nuclear pore complex. Mol. Cell Biol. 20, 5631-5642
24. Lindsay, M. E., Plafker, K., Smith, A. E., Clurman, B. E., and Macara, I. G. (2002) Npap60/Nup50 is a tri-stable switch that stimulates importin-alpha:beta-mediated nuclear protein import. Cell 110, 349-360
25. Matsuura, Y., and Stewart, M. (2005) Nup50/Npap60 function in nuclear protein import complex disassembly and importin recycling. EMBO J. 24, 3681-3689
26. Schimmer, B. P., Kwan, W. K., Tsao, J., and Qiu, R. (1995) Adrenocorticotropin-resistant mutants of the Y1 adrenal cell line fail to express the adrenocorticotropin receptor. J. Cell Physiol. 163, 164-171
27. Jo, Y., and Stocco, D. M. (2004) Regulation of steroidogenesis and steroidogenic acute regulatory protein in R2C cells by DAX-1 (dosage-sensitive sex reversal, adrenal hypoplasia congenita, critical region on the X chromosome, gene-1). Endocrinology 145, 5629-5637
28. Baig, A. H., Szaszák, M., King, P. J., Hunyady, L., and Clark, A. J. L. (2002) Agonist activated adrenocorticotropin receptor internalizes via a clathrin-mediated G protein receptor kinase dependent mechanism. Endocr. Res. 28, 281-289
29. Kobayashi, H., Kambe, F., Imai, T., Hibi, Y., Kikumori, T., Ohmori, S., Nakao, A., and Seo, H. (2006) Differential expression of cyclin-dependent kinase inhibitors, p27Kip1 and p57Kip2, by corticotropin in rat adrenal cortex. J. Endocrinol. 189, 671-679
30. Nakayama, K., Ishida, N., Shirane, M., Inomata, A., Inoue, T., Shishido, N., Horii, I., Loh, D. Y., and Nakayama, K. (1996) Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 85, 707-720
31. Bhattacharya, M., Peri, K. G., Almazan, G., Ribeiro-da-Silva, A., Shichi, H., Durocher, Y., Abramovitz, M., Hou, X., Varma, D. R., and Chemtob, S. (1998) Nuclear localization of prostaglandin E2 receptors. Proc. Natl. Acad. Sci. U. S. A. 95, 15792-15797
32. Gobeil, F. Jr., Dumont, I., Marrache, A. M., Vazquez-Tello, A., Bernier, S. G., Abran, D., Hou, X., Beauchamp, M. H., Quiniou, C., Bouayad, A., et al. (2002) Regulation of eNOS expression in brain endothelial cells by perinuclear EP(3) receptors. Circ. Res. 90, 682-689
33. Cieslik, K., Abrams, C. S., and Wu, K. K. (2001) Up-regulation of endothelial nitric-oxide synthase promoter by the phosphatidyl-inositol 3-kinase gamma/Janus kinase 2/MEK-1-dependent pathway. J. Biol. Chem. 276, 1211-1219
34. 2+ changes in heterologous cell types and neurons. J. Biol. Chem. 278, 28210-28219
35. Lee, H. J., Chun, M., and Kandror, K. V. (2001) Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling. J. Biol. Chem. 276, 16597-16600
36. Boivin, B., Chevalier, D., Villeneuve, L. R., Rousseau, E., and Allen, B. G. (2003) Functional endothelin receptors are present on nuclei in cardiac ventricular myocytes. J. Biol. Chem. 278, 29153-29163
37. Willard, F. S., and Crouch, M. F. (2000) Nuclear and cytoskeletal translocation and localization of heterotrimeric G-proteins. Immunol. Cell Biol. 78, 387-394
38. Yamamoto, S., Kawamura, K., and James, T. N. (1998) Intracellular distribution of adenylate cyclase in human cardiocytes determined by electron microscopic cytochemistry. Microsc. Res. Tech. 40, 479-487
39. Faenza, I., Matteucci, A., Manzoli, L., Billi, A. M., Aluigi, M., Peruzzi, D., Vitale, M., Castorina, S., Suh, P. G., and Cocco, L. (2000) A role for nuclear phospholipase Cbeta 1 in cell cycle control. J. Biol. Chem. 275, 30520-30524
40. Kang, J., Shi, Y., Xiang, B., Qu, B., Su, W., Zhu, M., Zhang, M., Bao, G., Wang, F., Zhang, X., et al. (2005) A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription. Cell 123, 833-847