Functional expression of Squalus acanthias melanocortin-5 receptor in CHO cells: Ligand selectivity and interaction with MRAP

European Journal of Pharmacology

Volumn 680, Issue 1-3, 2012, Pages 1-7

  Reinick, Christina L ^a   Liang, Liang ^a   Angleson, Josepha K ^a   Dores, Robert M ^a  

^a UNIVERSITY OF DENVER   (United States)

Author keywords

MSH; ACTH; CHO cells; Melanocortin MC5 receptor; MRAP; Squalus acanthias

Indexed keywords

ALPHA INTERMEDIN; BETA INTERMEDIN; COMPLEMENTARY DNA; CORTICOTROPIN; CORTICOTROPIN[1-24]; CORTICOTROPIN[1-25]; DELTA INTERMEDIN; GAMMA INTERMEDIN; INTERMEDIN; MELANOCORTIN 5 RECEPTOR; MELANOCORTIN RECEPTOR; MELANOCORTIN RECEPTOR ACCESSORY PROTEIN; MELANOCORTIN RECEPTOR ACCESSORY PROTEIN 1; MELANOCORTIN RECEPTOR ACCESSORY PROTEIN 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALLORHINCHUS MILII; CHO CELL; CONTROLLED STUDY; FISH; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR SENSITIVITY; SQUALUS; ZEBRA FISH;

AMINO ACID SEQUENCE; ANIMALS; CHO CELLS; CRICETINAE; HUMANS; LIGANDS; MELANOCORTINS; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; RECEPTORS, MELANOCORTIN; SQUALUS ACANTHIAS; ZEBRAFISH;

EID: 84857914788     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.01.021     Document Type: Article

References (33)

1. M.J. Agulleiro, S. Roy, E. Sanchez, P. Puchol, N. Gallo-Payet, and J.M. Cerda-Reverter Role of melanocortin receptor accessory proteins in the function of zebrafish melanocortin receptor type 2 Mol. Cell. Endocrinol. 320 2010 145 152
2. Y. Amemiya, A. Takahashi, H. Meguro, and H. Kawauchi A newly characterized melanotropin in proopiomelanocortin in pituitaries of an elasmobranch, Squalus acanthias Gen. Comp. Endocrinol. 114 1999 387 395 (Pubitemid 29256976)
3. A. Baron, K. Veo, J. Angleson, and R.M. Dores Modeling the evolution of the MC2R and MC5R genes: studies on the cartilaginous fish Heterodontus francisci Gen. Comp. Endocrinol. 161 2009 13 19
4. L.F. Chan, T.R. Webb, T. Chung, E. Meimaridou, S. Cooray, L. Guasti, J.P. Chapple, M. Egertova, M.R. Elphick, M.E. Cheetham, L.A. Metherell, and A.J. Clark MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family Proc. Natl. Acad. Sci. U. S. A. 106 2009 6146 6151
5. O.G. Chepurny, and G.G. Holz A novel cyclic adenosine monophosphate responsive luciferase reporter incorporating a nonpalindromic cyclic adenosine monophosphate response element provides optimal performance for use in G protein coupled receptor drug discovery efforts J. Biomol. Screen. 12 2007 740 746 (Pubitemid 47231236)
6. R.D. Cone Studies on the physiological functions of the melanocortin system Endocr. Rev. 27 2006 736 749 (Pubitemid 44936057)
7. R. deRoos, and C.C. deRoos Effects of mammalian ACTH on potential fuels and gluconeogenic substrates in the plasma of the spiny dogfish shark (Squalus acanthias) Gen. Comp. Endocrinol. 87 1992 149 158
8. R.M. Dores, D.A. Rubin, and T.W. Quinn Mini-review: is it possible to construct phylogenetic trees using polypeptide hormone sequences Gen. Comp. Endocrinol. 103 1996 1 12 (Pubitemid 26240641)
9. T. Haitina, A. Takahashi, L. Holmen, J. Enberg, and H.B. Schiöth Further evidence for ancient role of ACTH peptides at melanocortin (MC) receptors; pharmacology of dogfish and lamprey peptides at dogfish MC receptors Peptides 28 2007 798 805 (Pubitemid 46349338)
10. T. Haitina, J. Klovins, A. Takahashi, M. Löwgren, A. Ringholm, J. Enberg, H. Kawauchi, E.T. Larson, R. Fredriksson, and H.B. Schiöth Functional characterization of two melanocortin (MC) receptors in lamprey showing orthology to the MC1 and MC4 receptor subtypes BMC Evol. Biol. 7 2007 101 115
11. P.M. Hinkle, and J.A. Sebag Structure and function of the melanocortin 2 receptor accessory protein Mol. Cell. Endocrinol. 300 2009 25 31
12. P.W. Holland, J. Garcia-Fernandez, N.A. Williams, and A. Sidow Gene duplications and the origins of vertebrate development Development 1994 125 133 (Supplement)
13. J. Klovins, T. Haitina, A. Ringholm, M. Lowgren, D. Fridmanis, M. Slaidina, S. Stier, and H.B. Schiöth Cloning of two melanocortin (MC) receptors in spiny dogfish Eur. J. Biochem. 271 2004 4320 4331
14. J. Klovins, T. Haitina, D. Fridmanis, Z. Kilianova, I. Kapa, R. Fredriksson, N. Gallo Payet, and H.B. Schiöth The melanocortin system in Fugu: determination of POMC/AGRP/MCR gene repertoire and synteny, as well as pharmacology and anatomical distribution of the MCRs Mol. Biol. Evol. 21 2004 563 579 (Pubitemid 38339672)
15. M.K. Ling, E. Hotta, Z. Kilianova, T. Haitina, A. Ringholm, L. Johansson, N. Gallo-Payet, S. Takeuchi, and H.B. Schioth The melanocortin receptor subtypes in chicken have high preference to ACTH-derived peptides British J. Pharmacology 143 2004 626 637 (Pubitemid 39524281)
16. L.G. Lundin Evolution of the vertebrate genome as reflected in paralogous chromosomal regions in man and the house mouse Genomics 16 1993 1 19 (Pubitemid 23123784)
17. L.A. Metherell, J.P. Chapple, S. Cooray, A. David, C. Becker, F. Ruschendorf, D. Naville, M. Begeot, B. Khoo, P. Nurnberg, A. Huebner, M.E. Cheetham, and A.J. Clark Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2 Nat. Genet. 37 2005 166 170
18. K.G. Mountjoy, L.S. Robbins, M.T. Mortrud, and R.D. Cone The cloning of a family of genes that encode the melanocortin receptors Science 257 1992 543 546
19. S. Ohno, U. Wolf, and N.B. Atkins Evolution from fish to mammals by gene duplication Hereditas 59 1968 169 187
20. I.D. Pogozheva, B.-X. Chai, A.L. Lomize, T.M. Fong, D.H. Weinberg, R.P. Nargund, M.W. Mulholland, I. Grantz, and H.I. Mosberg Interactions of human melanocortin 4 receptors with nonpeptide and peptide agonists Biochemistry 44 2005 11329 11341 (Pubitemid 41209069)
21. A. Ringholm, R. Fredriksson, N. Poliakova, Y. Yan, J.H. Postlethwait, D. Larhammar, and H.B. Schiöth One melanocortin 4 and two melanocortin 5 receptors from zebrafish show remarkable conservation in structure and pharmacology J. Neurochem. 82 2002 6 18 (Pubitemid 34755244)
22. A. Ringholm, J. Klovins, R. Fredriksson, N. Poliakova, E.T. Larson, J.P. Kukkonen, D. Larhammar, and H.B. Schiöth Presence of melanocortin (MC4) receptor in spiny dogfish suggests an ancient vertebrate origin of central melanocortin system Eur. J. Biochem. 270 2003 213 221 (Pubitemid 36123965)
23. S. Roy, M. Rachel, and N. Gallo-Payet Differential regulation of the human adrenocorticotropin receptor [melanocortin-2 receptor (MC2R)] by human MC2R accessory protein isoforms α and β in isogenic human embryonic kidney 293 cells Mol. Endocrinol. 21 2007 1656 1669 (Pubitemid 47001089)
24. H.B. Schiöth, T. Haitina, M.K. Ling, A. Ringholm, R. Fredriksson, J.M. Cerda-Reverter, and J. Klovins Evolutionary conservation of the structural pharmacological and genomic characteristics of the melanocortin receptor subtypes Peptides 26 2005 1886 1900 (Pubitemid 41354547)
25. J.A. Sebag, and P.M. Hinkle Melanocortin-2 receptor accessory protein MRAP forms antiparallel homodimers Proc. Natl. Acad. Sci. U. S. A. 104 2007 20244 20249
26. J.A. Sebag, and P.M. Hinkle Regions of melanocortin 2 (MC2) receptor accessory protein necessary for duel topology and MC2 receptor trafficking and signaling J. Biol. Chem. 284 2009 2009 610 618
27. J.A. Sebag, and P.M. Hinkle Opposite effects of the melanocortin 2 (MC2) receptor accessory protein MRAP on MC2 and MC5 receptor dimerization and trafficking J. Biol. Chem. 284 2009 22641 22648
28. C.M. Tan, A.E. Brady, H.H. Nickols, Q. Wang, and L.E. Limbird Membrane trafficking of G-protein-coupled receptors Ann. Rev. Pharmacol. Toxicol. 44 2003 559 609
29. M. van der Kraan, R.A.H. Adan, M.L. Entwistle, W.H. Gispen, J.P.H. Burbach, and J.B. Tatro Expression of melanocortin-5-receptor in secretory epithelia supports a functional role in exocrine and endocrine glands Endocrinology 139 1998 2348 2355 (Pubitemid 28513758)
30. A. Vastermark, and H. Schiöth The early origin of melanocortin receptors, agouti-related peptide, agouti signaling peptide, and melanocortin receptor-accessory proteins, with emphasis on pufferfishes, elephant shark, lampreys, and amphioxus Eur. J. Pharmacol. 2011 10.1016/j.ejphar.2010.10.106
31. K. Veo, C. Reinick, L. Liang, E. Moser, J. Angleson, and R.M. Dores Mini review: observations on the ligand selectivity of the melanocortin 2 receptor Gen. Comp. Endocrinol. 172 2011 96 106
32. T.R. Webb, and A.J. Clark Minireview: the melanocortin 2 receptor accessory proteins Mol. Endocrinol. 24 2010 1 10
33. T.R. Webb, T.R. Chan, S.N. Cooray, M.E. Cheetham, J.P. Chapple, and A.J. Clark Distinct melanocortin 2 receptor accessory protein domains are required for melanocortin 2 receptor interaction and promotion of receptor trafficking Endocrinology 150 2009 720 726