Characterization of ciliary targeting sequence of rat melanin-concentrating hormone receptor 1

General and Comparative Endocrinology

Volumn 188, Issue 1, 2012, Pages 159-165

  Nagata, Asami ^a   Hamamoto, Akie ^a   Horikawa, Manabu ^b   Yoshimura, Kentarou ^c   Takeda, Sen ^c   Saito, Yumiko ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b SUNTORY INSTITUTE FOR BIOORGANIC RESEARCH   (Japan)

^c UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

G protein coupled receptor; HRPE1 cells; Melanin concentrating hormone; Primary cilia; Targeting signal

Indexed keywords

ENHANCED GREEN FLUORESCENT PROTEIN; MELANIN CONCENTRATING HORMONE RECEPTOR; MELANIN CONCENTRATING HORMONE RECEPTOR 1; MELANIN CONCENTRATING HORMONE RECEPTOR 2; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DAMAGE; CELL FUNCTION; CELLULAR DISTRIBUTION; CILIARY MOTILITY; CILIATED EPITHELIUM; CONTROLLED STUDY; DNA SEQUENCE; GENE MUTATION; INTRACELLULAR SIGNALING; MOLECULAR IMAGING; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN TARGETING; RAT;

EID: 84878996565     PISSN: 00166480     EISSN: 10956840     Source Type: Journal    
DOI: 10.1016/j.ygcen.2013.02.020     Document Type: Article

References (42)

1. Aizaki Y., Maruyama K., Nakano-Tetsuka M., Saito Y. Distinct roles of the DRY motif in rat melanin-concentrating hormone receptor 1 in signaling control. Peptides 2009, 30:974-981.
2. Alon T., Friedman J.M. Late-onset leanness in mice with targeted ablation of melanin concentrating hormone neurons. Neuron 2006, 26:389-397.
3. An S., Cutler G., Zhao J.J., Huang S.G., Tian H., Li W., Liang L., Rich M., Bakleh A., Du J., Chen J.L., Dai K. Identification and characterization of a melanin-concentrating hormone receptor. Proc. Natl. Acad. Sci. USA 2001, 98:7576-7581.
4. Berbari N.F., Lewis J.S., Bishop G.A., Askwith C.C., Mykytyn K. Bardet-Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia. Proc. Natl. Acad. Sci. USA 2008, 105:4242-4246.
5. Berbari N.F., Johnson A.D., Lewis J.S., Askwith C.C., Mykytyn K. Identification of ciliary localization sequences within the third intracellular loop of G protein-coupled receptors. Mol. Biol. Cell 2008, 19:1540-1547.
6. Bishop G.A., Berbari N.F., Lewis J., Mykytyn K. Type III adenylyl cyclase localizes to primary cilia throughout the adult mouse brain. J. Comp. Neurol. 2007, 505:562-571.
7. Bittencourt J.C., Presse F., Arias C., Peto C., Vaughan J., Nahon J.L., Vale W., Sawchenko P.E. The melanin-concentrating hormone system of the rat brain: an immuno- and hybridization histochemical characterization. J. Comp. Neurol. 1992, 319:218-245.
8. Borowsky B., Durkin M.M., Ogozalek K., Marzabadi M.R., DeLeon J., Lagu B., Heurich R., Lichtblau H., Shaposhnik Z., Daniewska I., Blackburn T.P., Branchek T.A., Gerald C., Vaysse P.J., Forray C. Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist. Nat. Med. 2002, 8:825-830.
9. Chambers J., Ames R.S., Bergsma D., Muir A., Fitzgerald L.R., Hervieu G., Dytko G.M., Foley J.J., Martin J., Liu W.S., Park J., Ellis J.C., Ganguly S., Konchar S., Cluderay J., Leslie R., Wilson S., Sarau H.M. Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1. Nature 1999, 400:261-265.
10. Chen Y., Hu C., Hsu C., Zhang Q., Bi C., Asnicar M., Hsiung H.M., Fox N., Slieker L.J., Yang D.D., Heiman M.L., Shi Y. Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity. Endocrinology 2002, 143:2469-2477.
11. Chung S., Parks G.S., Lee C., Civelli O. Recent updates on the melanin-concentrating hormone (MCH) and its receptor system: lessons from MCH1R antagonists. J. Mol. Neurosci. 2011, 43:115-121.
12. Corbit K.C., Aanstad P., Singla V., Norman A.R., Stainier D.Y., Reiter J.F. Vertebrate smoothened functions at the primary cilium. Nature 2005, 437:1018-10121.
13. Domire J.S., Green J.A., Lee K.G., Johnson A.D., Askwith C.C., Mykytyn K. Dopamine receptor 1 localizes to neuronal cilia in a dynamic process that requires the Bardet-Biedl syndrome proteins. Cell Mol. Life Sci. 2011, 68:2951-2960.
14. Emmer B.T., Maric D., Engman D.M. Molecular mechanism of protein and lipid targeting to ciliary membranes. J. Cell Sci. 2010, 123:529-536.
15. Geng L., Okuhara D., Yu Z., Tian X., Cai Y., Shibazaki S., Somlo S. Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif. J. Cell Sci. 2006, 119:1383-1395.
16. Gibson W.T., Pissios P., Trombly D.J., Luan J., Keogh J., Wareham N.J., Maratos-Flier E., O'Rahilly S., Farooqi I.S. Melanin-concentrating hormone receptor mutations and human obesity: functional analysis. Obes. Res. 2004, 12:743-749.
17. Guo D.F., Rahmouni K. Molecular basis of the obesity associated with Bardet-Biedl syndrome. Trends Endocrinol. Metab. 2011, 22:286-293.
18. Hamamoto A., Horikawa M., Saho T., Saito Y. Mutation of Phe318 within the NPxxY(x)5,6F motif in melanin-concentrating hormone receptor 1 results in an efficient signaling activity. Front. Endocrinol. 2012, 3:147.1-147.11.
19. Hawes B.E., Kil E., Green B., O'Neill K., Fried S., Graziano M.P. The melanin-concentrating hormone couples to multiple G proteins to activate diverse intracellular signaling pathways. Endocrinology 2000, 141:4524-4532.
20. Hildebrandt F., Benzing T., Katsanis N. Ciliopathies. New Engl. J. Med. 2011, 364:1533-1543.
21. Ito M., Gomori A., Ishihara A., Oda Z., Mashiko S., Matsushita H., Yumoto M., Ito M., Sano S., Tokita H., Moriya M., Iwaasa H., Kanatani A. Characterization of MCH-mediated obesity in mice. Am. J. Physiol. Endocrinol. Metab. 2003, 284:E940-945.
22. Jenkins P.M., Hurd T.W., Zhang L., McEwen D.P., Brown R.L., Margolis B., Verhey K.J., Martens J.R. Ciliary targeting of olfactory CNG channels requires the CNGB1b subunit and the kinesin-2 motor protein, KIF17. Curr. Biol. 2006, 16:1211-1216.
23. Jin H., White S.R., Shida T., Schulz S., Aguiar M., Gygi S.P., Bazan J.F., Nachury M.V. The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia. Cell 2010, 141:1208-1219.
24. Kawauchi H., Kawazoe I., Tsubokawa M., Kishida M., Baker B.L. Characterization of melanin-concentrating hormone in chum salmon pituitaries. Nature 1983, 305:321-323.
25. Louvi A., Grove E.A. Cilia in the CNS: the quiet organelle claims center stage. Neuron 2011, 69:1046-1060.
26. Ludwig D.S., Tritos N.A., Mastaitis J.W., Kulkarni R., Kokkotou E., Elmquist J., Lowell B., Flier J.S., Maratos-Flier E. Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance. J. Clin. Invest. 2001, 107:379-386.
27. Luthin D.R. Anti-obesity effects of small molecule melanin-concentrating hormone receptor 1 (MCHR1) antagonists. Life Sci. 2007, 81:423-440.
28. Macdonald D., Murgolo N., Zhang R., Durkin J.P., Yao J., Strader C.D., Graziano M.P. Molecular characterization of the melanin-concentrating hormone/receptor complex: identification of critical residues involved in binding and activation. Mol. Pharmacol. 2000, 58:217-225.
29. Marsh D.J., Weingarth D.T., Novi D.E., Chen H.Y., Trumbauer M.E., Chen A.S., Guan X.M., Jiang M.M., Feng Y., Camacho R.E., Shen Z., Frazier E.Z., Yu H., Metzger J.M., Kuca S.J., Shearman L.P., Gopal-Truter S., MacNeil D.J., Strack A.M., MacIntyre D.E., van der Ploeg L.H., Qian S. Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism. Proc. Natl. Acad. Sci. USA 2002, 99:3240-3245.
30. Mashiko S., Ishihara A., Gomori A., Moriya R., Ito M., Iwaasa H., Matsuda M., Feng Y., Shen Z., Marsh D.J., Bednarek M.A., MacNeil D.J., Kanatani A. Antiobesity effect of a melanin-concentrating hormone 1 receptor antagonist in diet-induced obese mice. Endocrinology 2005, 146:3080-3086.
31. Miyoshi K., Kasahara K., Miyazaki I., Asanuma M. Lithium treatment elongates primary cilia in the mouse brain and in cultured cells. Biochem. Biophys. Res. Commun. 2009, 388:757-762.
32. Mizusawa K., Saito Y., Wang Z., Kobayashi Y., Matsuda K., Takahashi A. Molecular cloning and expression of two melanin-concentrating hormone receptors in goldfish. Peptides 2009, 30:1990-1996.
33. Rossi M., Choi S.J., O'Shea D., Miyoshi T., Ghatei M.A., Bloom S.R. Melanin-concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight. Endocrinology 1997, 138:351-355.
34. Saito Y., Nothacker H.P., Wang Z., Lin S., Leslie F.M., Civelli O. Molecular characterization of the melanin-concentrating-hormone receptor. Nature 1999, 400:265-269.
35. Saito Y., Cheng M., Leslie F.M., Civelli O. Expression of the melanin-concentrating hormone (MCH) receptor mRNA in the rat brain. J. Comp. Neurol. 2001, 435:26-40.
36. Saito Y., Tetsuka M., Li Y., Kawamura Y., Maruyama K. Functional role of N-linked glycosylation on the rat melanin-concentrating hormone receptor 1. FEBS Lett. 2003, 533:29-34.
37. Saito Y., Tetsuka M., Li Y., Kurose H., Maruyama K. Properties of rat melanin-concentrating hormone receptor 1 internalization. Peptides 2004, 25:1597-1604.
38. Saito Y., Tetsuka M., Saito S., Imai K., Yoshikawa A., Doi H., Maruyama K. Arginine residue 155 in the second intracellular loop plays a critical role in rat melanin-concentrating hormone receptor 1. Endocrinology 2005, 146:3452-3462.
39. Shimada M., Tritos N.A., Lowell B.B., Flier J.S., Maratos-Flier E. Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature 1998, 396:670-674.
40. Takekawa S., Asami A., Ishihara Y., Terauchi J., Kato K., Shimomura Y., Mori M., Murakoshi H., Kato K., Suzuki N., Nishimura O., Fujino M. T-226296: a novel, orally active and selective melanin-concentrating hormone receptor antagonist. Eur. J. Pharmacol. 2002, 438:129-135.
41. Tan C.P., Sano H., Iwaasa H., Pan J., Sailer A.W., Hreniuk D.L., Feighner S.D., Palyha O.C., Pong S.S., Figueroa D.J., Austin C.P., Jiang M.M., Yu H., Ito J., Ito M., Guan X.M., MacNeil D.J., Kanatani A., van der Ploeg L.H., Howard A.D. Melanin-concentrating hormone receptor subtypes 1 and 2: species-specific gene expression. Genomics 2002, 79:785-792.
42. Tetsuka M., Saito Y., Imai K., Doi H., Maruyama K. The basic residues in the membrane-proximal C-terminal tail of the rat melanin-concentrating hormone receptor 1 are required for receptor function. Endocrinology 2004, 145:3712-3723.