A new variant in the human Kv1.3 gene is associated with low insulin sensitivity and impaired glucose tolerance

Journal of Clinical Endocrinology and Metabolism

Volumn 91, Issue 2, 2006, Pages 654-658

  Tschritter, Otto ^a   Machicao, Fausto ^a   Stefan, Norbert ^a   Schäfer, Silke ^a   Weigert, Cora ^a   Staiger, Harald ^a   Spieth, Christian ^b   Häring, Hans Ulrich ^a   Fritsche, Andreas ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; POTASSIUM CHANNEL KV1.3; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ADULT; ARTICLE; BODY MASS; CHROMOSOME 1; CHROMOSOME ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; EXON; FEMALE; GEL MOBILITY SHIFT ASSAY; GENE; GENE EXPRESSION; GENE FREQUENCY; GENE MUTATION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE PHENOTYPE CORRELATION; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; GLUCOSE HOMEOSTASIS; HAPLOTYPE; HUMAN; HYPERINSULINEMIA; IMPAIRED GLUCOSE TOLERANCE; IN VITRO STUDY; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; ORAL GLUCOSE TOLERANCE TEST; POSTPRANDIAL STATE; PRIORITY JOURNAL; PROMOTER REGION; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; UNIVERSITY HOSPITAL;

3' UNTRANSLATED REGIONS; 5' UNTRANSLATED REGIONS; ADULT; BLOOD GLUCOSE; DNA; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FEMALE; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN RESISTANCE; KV1.3 POTASSIUM CHANNEL; MALE; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS); SEQUENCE ANALYSIS, DNA;

ANIMALIA;

EID: 32544449155     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2005-0725     Document Type: Article

References (20)

1. Jacob A, Hurley IR, Goodwin LO, Cooper GW, Benoff S 2000 Molecular characterization of a voltage-gated potassium channel expressed in rat testis. Mol Hum Reprod 6:303-313
2. Chandy KG, Williams CB, Spencer RH, Aguilar BA, Ghanshani S, Tempel BL, Gutman GA 1990 A family of three mouse potassium channel genes with intronless coding regions. Science 247:973-975
3. Mourre C, Chernova MN, Martin-Eauclaire MF, Bessone R, Jacquet G, Gola M, Alper SL, Crest M 1999 Distribution in rat brain of binding sites of kaliotoxin, a blocker of Kv1.1 and Kv1.3 α-subunits. J Pharmacol Exp Ther 291:943-952
4. Stuhmer W, Ruppersberg JP, Schroter KH, Sakmann B, Stocker M, Giese KP, Perschke A, Baumann A, Pongs O 1989 Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. EMBO J 8:3235-3244
5. + channel β-subunits in muscle: differential regulation during postnatal development and myogenesis. J Cell Physiol 195:187-193
6. Yao X, Chang AY, Boulpaep EL, Segal AS, Desir GV 1996 Molecular cloning of a glibenclamide-sensitive, voltage-gated potassium channel expressed in rabbit kidney. J Clin Invest 97:2525-2533
7. Fadool DA, Tucker K, Phillips JJ, Simmen JA 2000 Brain insulin receptor causes activity-dependent current suppression in the olfactory bulb through multiple phosphorylation of Kv1.3. J Neurophysiol 83:2332-2348
8. Fadool DA, Levitan IB 1998 Modulation of olfactory bulb neuron potassium current by tyrosine phosphorylation. J Neurosci 18:6126-6137
9. Fadool DA, Holmes TC, Berman K, Dagan D, Levitan IB 1997 Tyrosine phosphorylation modulates current amplitude and kinetics of a neuronal voltage-gated potassium channel. J Neurophysiol 78:1563-1573
10. Xu J, Koni PA, Wang P, Li G, Kaczmarek L, Wu Y, Li Y, Flavell RA, Desir GV 2003 The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight. Hum Mol Genet 12:551-559
11. Xu J, Wang P, Li Y, Li G, Kaczmarek LK, Wu Y, Koni PA, Flavell RA, Desir GV 2004 The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity. Proc Natl Acad Sci USA 101:3112-3117
12. World Health Organization Expert Committee 1980 Second report on diabetes mellitus. Geneva: World Health Organization; Tech Rep Ser 646:A-80
13. Koch M, Rett K, Volk A, Maerker E, Haist K, Deninger M, Renn W, Haring HU 1999 Amino acid polymorphism Gly 972 Arg in IRS-1 is not associated to lower clamp-derived insulin sensitivity in young healthy first degree relatives of patients with type 2 diabetes. Exp Clin Endocrinol Diabetes 107:318-322
14. Krutzfeldt J, Kausch C, Volk A, Klein HH, Rett K, Haring HU, Stumvoll M 2000 Insulin signaling and action in cultured skeletal muscle cells from lean healthy humans with high and low insulin sensitivity. Diabetes 49:992-998
15. Weigert C, Brodbeck K, Sawadogo M, Haring HU, Schleicher ED 2004 Upstream stimulatory factor (USF) proteins induce human TGF-β1 gene activation via the glucose-response element-1013/-1002 in mesangial cells: upregulation of USF activity by the hexosamine biosynthetic pathway. J Biol Chem 279:15908-15915
16. Stumvoll M, Mitrakou A, Pimenta W, Jenssen T, Yki-Jarvinen H, Van Haeften T, Renn W, Gerich J 2000 Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity. Diabetes Care 23:295-301
17. Tregouet DA, Escolano S, Tiret L, Mallet A, Golmard JL 2004 A new algorithm for haplotype-based association analysis: the Stochastic-EM algorithm. Ann Hum Genet 68:165-177
18. Yan L, Figueroa DJ, Austin CP, Liu Y, Bugianesi RM, Slaughter RS, Kaczorowski GJ, Kohler MG 2004 Expression of voltage-gated potassium channels in human and rhesus pancreatic islets. Diabetes 53:597-607
19. Bowlby MR, Fadool DA, Holmes TC, Levitan IB 1997 Modulation of the Kv1.3 potassium channel by receptor tyrosine kinases. J Gen Physiol 110:601-610
20. Fadool DA, Tucker K, Perkins R, Fasciani G, Thompson RN, Parsons AD, Overton JM, Koni PA, Flavell RA, Kaczmarek LK 2004 Kv1.3 channel gene-targeted deletion produces "Super-Smeller Mice" with altered glomeruli, interacting scaffolding proteins, and biophysics. Neuron 41:389-404