Hepatitis B virus e antigen induces activation of rat hepatic stellate cells

Biochemical and Biophysical Research Communications

Volumn 435, Issue 3, 2013, Pages 391-396

  Zan, Yanlu ^a,b   Zhang, Yuxia ^a   Tien, Po ^a  

^a INSTITUTE OF MICROBIOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

SMA; Collagen I; Hepatic stellate cells; Hepatitis B virus e antigen; TGF ; TIMP 1

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; HEPATITIS E ANTIGEN; NEUTRALIZING ANTIBODY; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA ANTIBODY;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL LINE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE RELEASE; FIBROGENESIS; GENETIC TRANSDUCTION; GENETIC TRANSFECTION; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; STELLATE CELL; UPREGULATION;

ANIMALS; CELL LINE; GENE EXPRESSION REGULATION; HEPATIC STELLATE CELLS; HEPATITIS B E ANTIGENS; HEPATITIS B VIRUS; HOST-PATHOGEN INTERACTIONS; RATS; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA;

HEPATITIS B VIRUS; RATTUS;

EID: 84878974193     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.04.098     Document Type: Article

References (30)

1. Gressner A.M. The cell biology of liver fibrogenesis - an imbalance of proliferation, growth arrest and apoptosis of myofibroblasts. Cell Tissue Res. 1998, 292:447-452.
2. Wilensky A.O. The pathogenesis and mechanism of cirrhosis of the liver. Am. J. Dig. Dis. 1946, 13:367-372.
3. Bataller R., Brenner D.A. Liver fibrosis. J. Clin. Invest. 2005, 115:209-218.
4. Desmouliere A. Hepatic stellate cells: the only cells involved in liver fibrogenesis? A dogma challenged. Gastroenterology 2007, 132:2059-2062.
5. Bissell D.M., Roulot D., George J. Transforming growth factor beta and the liver. Hepatology 2001, 34:859-867.
6. Zhu H., Zeng L., Zhu D., Yuan Y. The role of TGF-beta 1 in mice hepatic fibrosis by Schistosomiasis Japonica. J. Tongji Med. Univ. 2000, 20:320-321. (329).
7. Liu X., Zhu S.T., You H., Cong M., Liu T.H., Wang B.E., Jia J.D. Hepatitis B virus infects hepatic stellate cells and affects their proliferation and expression of collagen type I. Chin. Med. J. (Engl.) 2009, 122:1455-1461.
8. Seto W.K., Lee C.F., Lai C.L., Ip P.P., Fong D.Y., Fung J., Wong D.K., Yuen M.F. A new model using routinely available clinical parameters to predict significant liver fibrosis in chronic hepatitis B. PLoS One 2011, 6:e23077.
9. Clement S., Pascarella S., Conzelmann S., Gonelle-Gispert C., Guilloux K., Negro F. The hepatitis C virus core protein indirectly induces alpha-smooth muscle actin expression in hepatic stellate cells via interleukin-8. J. Hepatol. 2010, 52:635-643.
10. Coenen M., Nischalke H.D., Kramer B., Langhans B., Glassner A., Schulte D., Korner C., Sauerbruch T., Nattermann J., Spengler U. Hepatitis C virus core protein induces fibrogenic actions of hepatic stellate cells via toll-like receptor 2. Lab. Invest. 2011, 91:1375-1382.
11. Pace F.H., Ferreira L.E., Silva A.E., Ferraz M.L. Liver fibrosis progression in HIV/hepatitis C virus coinfected patients with normal aminotransferases levels. Rev. Soc. Bras. Med. Trop. 2012, 45:444-447.
12. Probst A., Dang T., Bochud M., Egger M., Negro F., Bochud P.Y. Role of hepatitis C virus genotype 3 in liver fibrosis progression - a systematic review and meta-analysis. J Viral Hepat. 2011, 18:745-759.
13. Martin-Vilchez S., Sanz-Cameno P., Rodriguez-Munoz Y., Majano P.L., Molina-Jimenez F., Lopez-Cabrera M., Moreno-Otero R., Lara-Pezzi E. The hepatitis B virus X protein induces paracrine activation of human hepatic stellate cells. Hepatology 2008, 47:1872-1883.
14. Liaw Y.F., Sung J.J., Chow W.C., Farrell G., Lee C.Z., Yuen H., Tanwandee T., Tao Q.M., Shue K., Keene O.N., Dixon J.S., Gray D.F., Sabbat J. Lamivudine for patients with chronic hepatitis B and advanced liver disease. N. Engl. J. Med. 2004, 351:1521-1531.
15. Sanai F.M., Helmy A., Bzeizi K.I., Babatin M.A., Al-Qahtani A., Al-Ashgar H.A., Al-Mdani A.S., Al-Akwaa A., Almutharea S., Khan M.Q., Alghamdi A.S., Farah T., Al-Hamoudi W., Saadeh M., Abdo A.A. Discriminant value of serum HBV DNA levels as predictors of liver fibrosis in chronic hepatitis B. J Viral Hepat. 2011, 18:217-225.
16. Li M.S., Lau T.C., Chan S.K., Wong C.H., Ng P.K., Sung J.J., Chan H.L., Tsui S.K. The G1613A mutation in the HBV genome affects HBeAg expression and viral replication through altered core promoter activity. PLoS One 2011, 6:e21856.
17. Yang H.I., Hung H.L., Lee M.H., Liu J., Jen C.L., Su J., Wang L.Y., Lu S.N., You S.L., Iloeje U.H., Chen C.J. Incidence and determinants of spontaneous seroclearance of hepatitis B e antigen and DNA in patients with chronic hepatitis B. Clin. Gastroenterol. Hepatol. 2011, 10:527-534.
18. Milich D., Liang T.J. Exploring the biological basis of hepatitis B e antigen in hepatitis B virus infection. Hepatology 2003, 38:1075-1086.
19. Ma H., Wei L., Guo F., Zhu S., Sun Y., Wang H. Clinical features and survival in Chinese patients with hepatitis B e antigen-negative hepatitis B virus-related cirrhosis. J. Gastroenterol. Hepatol. 2008, 23:1250-1258.
20. Vogel S., Piantedosi R., Frank J., Lalazar A., Rockey D.C., Friedman S.L., Blaner W.S. An immortalized rat liver stellate cell line (HSC-T6): a new cell model for the study of retinoid metabolism in vitro. J. Lipid Res. 2000, 41:882-893.
21. Riccalton-Banks L., Bhandari R., Fry J., Shakesheff K.M. A simple method for the simultaneous isolation of stellate cells and hepatocytes from rat liver tissue. Mol. Cell. Biochem. 2003, 248:97-102.
22. Dull T., Zufferey R., Kelly M., Mandel R.J., Nguyen M., Trono D., Naldini L. A third-generation lentivirus vector with a conditional packaging system. J. Virol. 1998, 72:8463-8471.
23. Dooley S., Hamzavi J., Ciuclan L., Godoy P., Ilkavets I., Ehnert S., Ueberham E., Gebhardt R., Kanzler S., Geier A., Breitkopf K., Weng H., Mertens P.R. Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage. Gastroenterology 2008, 135:642-659.
24. Eurich D., Bahra M., Boas-Knoop S., Lock J.F., Golembus J., Neuhaus R., Neuhaus P., Neumann U.P. Transforming growth factor beta1 polymorphisms and progression of graft fibrosis after liver transplantation for hepatitis C virus-induced liver disease. Liver Transplant 2011, 17:279-288.
25. Hong S.W., Jung K.H., Lee H.S., Zheng H.M., Choi M.J., Lee C., Hong S.S. Suppression by fucoidan of liver fibrogenesis via the TGF-beta/Smad pathway in protecting against oxidative stress. Biosci. Biotechnol. Biochem. 2011, 75:833-840.
26. Seyhan H., Hamzavi J., Wiercinska E., Gressner A.M., Mertens P.R., Kopp J., Horch R.E., Breitkopf K., Dooley S. Liver fibrogenesis due to cholestasis is associated with increased Smad7 expression and Smad3 signaling. J. Cell. Mol. Med. 2006, 10:922-932.
27. Kwon H., Lok A.S. Hepatitis B therapy. Nat. Rev. Gastroenterol. Hepatol. 2011, 8:275-284.
28. Yang C.Y., Kuo T.H., Ting L.P. Human hepatitis B viral e antigen interacts with cellular interleukin-1 receptor accessory protein and triggers interleukin-1 response. J. Biol. Chem. 2006, 281:34525-34536.
29. Meindl-Beinker N.M., Dooley S. Transforming growth factor-beta and hepatocyte transdifferentiation in liver fibrogenesis. J. Gastroenterol. Hepatol. 2008, 23(Suppl. 1):122-127.
30. Kanzler S., Lohse A.W., Keil A., Henninger J., Dienes H.P., Schirmacher P., Rose-John S., zum Buschenfelde K.H., Blessing M. TGF-beta1 in liver fibrosis: an inducible transgenic mouse model to study liver fibrogenesis. Am. J. Physiol. 1999, 276:1059-1068.