Functional Characterization of the Cardiac Ryanodine Receptor Pore-Forming Region

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Euden, Joanne ^a   Mason, Sammy A ^a   Williams, Alan J ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOLIPID; POTASSIUM CHANNEL; RYANODINE RECEPTOR 2;

ARTICLE; CONTROLLED STUDY; HUMAN; PHOSPHOLIPID BILAYER; PORE FORMING REGION; POROSITY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN ISOLATION; PROTEIN PURIFICATION; PROTEIN STRUCTURE;

BASE SEQUENCE; BLOTTING, WESTERN; CALCIUM CHANNEL BLOCKERS; CATIONS; CHROMATOGRAPHY, GEL; CRYOELECTRON MICROSCOPY; DNA PRIMERS; ION TRANSPORT; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MYOCARDIUM; NEOMYCIN; POLYMERASE CHAIN REACTION; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SEQUENCE ANALYSIS, DNA;

PROKARYOTA;

EID: 84878918033     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0066542     Document Type: Article

References (36)

1. Bers DM, (2002) Cardiac excitation-contraction coupling. Nature 415: 198-205.
2. Welch W, Rheault S, West DJ, Williams AJ, (2004) A model of the putative pore region of the cardiac ryanodine receptor channel. Biophys J 87: 2335-2351.
3. Ramachandran S, Serohijos AW, Xu L, Meissner G, Dokholyan NV, (2009) A structural model of the pore-forming region of the skeletal muscle ryanodine receptor (RyR1). PLoS Comput Biol 5: e1000367.
4. Ramachandran S, Chakraborty A, Xu L, Mei Y, Samso M, et al. (2013) Structural Determinants of Skeletal Muscle Ryanodine Receptor Gating. J Biol Chem.
5. Samso M, Wagenknecht T, Allen PD, (2005) Internal structure and visualization of transmembrane domains of the RyR1 calcium release channel by cryo-EM. Nat Struct Mol Biol 12: 539-544.
6. Samso M, Feng W, Pessah IN, Allen PD, (2009) Coordinated movement of cytoplasmic and transmembrane domains of RyR1 upon gating. PLoS Biol 7: e85.
7. Ludtke SJ, Serysheva II, Hamilton SL, Chiu W, (2005) The pore structure of the closed RyR1 channel. Structure 13: 1203-1211.
8. Pagliuca C, Goetze TA, Wagner R, Thiel G, Moroni A, et al. (2007) Molecular properties of Kcv, a virus encoded K+ channel. Biochemistry 46: 1079-1090.
9. Butterwick JA, MacKinnon R, (2010) Solution structure and phospholipid interactions of the isolated voltage-sensor domain from KvAP. J Mol Biol 403: 591-606.
10. McCusker EC, D'Avanzo N, Nichols CG, Wallace BA, (2011) Simplified bacterial "pore" channel provides insight into the assembly, stability, and structure of sodium channels. J Biol Chem 286: 16386-16391.
11. Santos JS, Grigoriev SM, Montal M, (2008) Molecular template for a voltage sensor in a novel K+ channel. III. Functional reconstitution of a sensorless pore module from a prokaryotic Kv channel. J Gen Physiol 132: 651-666.
12. Swartz KJ, (2008) Sensing voltage across lipid membranes. Nature 456: 891-897.
13. Shaya D, Kreir M, Robbins RA, Wong S, Hammon J, et al. (2011) Voltage-gated sodium channel (NaV) protein dissection creates a set of functional pore-only proteins. Proc Natl Acad Sci U S A.
14. Gola M, Ducreux C, Chagneux H, (1990) Ca2(+)-activated K+ current involvement in neuronal function revealed by in situ single-channel analysis in Helix neurones. J Physiol 420: 73-109.
15. Hille B (2001) Ion Channels in Excitable Membranes, 3rd Edition, Chapter 12: Sunderland, MA: Sinauer Associates, Inc.
16. Boraso A, Williams AJ, (1994) Modification of the gating of the cardiac sarcoplasmic reticulum Ca(2+)-release channel by H2O2 and dithiothreitol. Am J Physiol 267: H1010-1016.
17. Kang GB, Song HE, Song DW, Kim MK, Rho SH, et al. (2007) Overexpression and purification of the RyR1 pore-forming region. Protein Pept Lett 14: 742-746.
18. Tinker A, Lindsay AR, Williams AJ, (1992) A model for ionic conduction in the ryanodine receptor channel of sheep cardiac muscle sarcoplasmic reticulum. J Gen Physiol 100: 495-517.
19. Lindsay AR, Manning SD, Williams AJ, (1991) Monovalent cation conductance in the ryanodine receptor-channel of sheep cardiac muscle sarcoplasmic reticulum. J Physiol 439: 463-480.
20. Williams AJ, West DJ, Sitsapesan R, (2001) Light at the end of the Ca(2+)-release channel tunnel: structures and mechanisms involved in ion translocation in ryanodine receptor channels. Q Rev Biophys 34: 61-104.
21. West DJ, Williams AJ, (2007) Pharmacological regulators of intracellular calcium release channels. Curr Pharm Des 13: 2428-2442.
22. Mason SA, Viero C, Euden J, Bannister M, West D, et al. (2012) The contribution of hydrophobic residues in the pore-forming region of the ryanodine receptor channel to block by large tetraalkylammonium cations and Shaker B inactivation peptides. J Gen Physiol 140: 325-339.
23. Mead F, Williams AJ, (2002) Block of the ryanodine receptor channel by neomycin is relieved at high holding potentials. Biophys J 82: 1953-1963.
24. Balshaw D, Gao L, Meissner G, (1999) Luminal loop of the ryanodine receptor: a pore-forming segment? Proc Natl Acad Sci U S A 96: 3345-3347.
25. Ranatunga KM, Moreno-King TM, Tanna B, Wang R, Chen SR, et al. (2005) The Gln4863Ala mutation within a putative, pore-lining trans-membrane helix of the cardiac ryanodine receptor channel alters both the kinetics of ryanoid interaction and the subsequent fractional conductance. Mol Pharmacol 68: 840-846.
26. Williams AJ, (1992) Ion conduction and discrimination in the sarcoplasmic reticulum ryanodine receptor/calcium-release channel. J Muscle Res Cell Motil 13: 7-26.
27. Williams AJ, (2002) Ion conduction and selectivity in the ryanodine receptor channel. Front Biosci 7: d1223-1230.
28. Williams AJ, Tanna B, (2004) The interaction of ryanoids with individual ryanodine receptor channels. Biol Res 37: 527-538.
29. Meissner G, (2004) Molecular regulation of cardiac ryanodine receptor ion channel. Cell Calcium 35: 621-628.
30. Bers DM, (2004) Macromolecular complexes regulating cardiac ryanodine receptor function. J Mol Cell Cardiol 37: 417-429.
31. Lindsay AR, Williams AJ, (1991) Functional characterisation of the ryanodine receptor purified from sheep cardiac muscle sarcoplasmic reticulum. Biochim Biophys Acta 1064: 89-102.
32. Mead-Savery FC, Wang R, Tanna-Topan B, Chen SR, Welch W, et al. (2009) Changes in negative charge at the luminal mouth of the pore alter ion handling and gating in the cardiac ryanodine-receptor. Biophys J 96: 1374-1387.
33. Thompson AJ, Lummis SC, (2003) A single ring of charged amino acids at one end of the pore can control ion selectivity in the 5-HT3 receptor. Br J Pharmacol 140: 359-365.
34. Sugiharto S, Lewis TM, Moorhouse AJ, Schofield PR, Barry PH, (2008) Anion-cation permeability correlates with hydrated counterion size in glycine receptor channels. Biophys J 95: 4698-4715.
35. Tinker A, Williams AJ, (1993) Probing the structure of the conduction pathway of the sheep cardiac sarcoplasmic reticulum calcium-release channel with permeant and impermeant organic cations. J Gen Physiol 102: 1107-1129.
36. Tinker A, Williams AJ, (1995) Measuring the length of the pore of the sheep cardiac sarcoplasmic reticulum calcium-release channel using related trimethylammonium ions as molecular calipers. Biophys J 68: 111-120.