The Gln4863Ala mutation within a putative, pore-lining trans-membrane helix of the cardiac ryanodine receptor channel alters both the kinetics of ryanoid interaction and the subsequent fractional conductance

Molecular Pharmacology

Volumn 68, Issue 3, 2005, Pages 840-846

  Ranatunga, Kishani M ^a   Moreno King, Tracy M ^a   Tanna, Bhavna ^a   Wang, Ruiwu ^b   Chen, S R Wayne ^b   Ruest, Luc ^c   Welch, William ^d   Williams, Alan J ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b UNIVERSITY OF CALGARY   (Canada)

^c UNIVERSITÉ DE SHERBROOKE   (Canada)

^d UNIVERSITY OF NEVADA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

21 AMINO 9ALPHA HYDROXYRYANODINE; 21,4 NITROBENZOYLAMINO 9ALPHA HYDROXYRYANODINE; 8BETA AMINO 9ALPHA HYDROXYRYANODINE; ALANINE; ALKALOID DERIVATIVE; GLUTAMINE; GUANIDINOPROPIONYLRYANODINE; RYANODINE; RYANODINE RECEPTOR; UNCLASSIFIED DRUG; DRUG DERIVATIVE; GLYCINE;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; DISSOCIATION; DRUG PROTEIN BINDING; ION CONDUCTANCE; MEMBRANE POTENTIAL; MUTATION; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN MODIFICATION; ANIMAL; CELL MEMBRANE POTENTIAL; GENETICS; HEART MUSCLE; KINETICS; METABOLISM; MOUSE; POINT MUTATION; SITE DIRECTED MUTAGENESIS;

ALANINE; ANIMALS; GLYCINE; KINETICS; MEMBRANE POTENTIALS; MICE; MUTAGENESIS, SITE-DIRECTED; MYOCARDIUM; POINT MUTATION; RYANODINE; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL;

EID: 23944436197     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.105.012807     Document Type: Article

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