Changes in negative charge at the luminal mouth of the pore alter ion handling and gating in the cardiac ryanodine-receptor

Biophysical Journal

Volumn 96, Issue 4, 2009, Pages 1374-1387

  Mead Savery, Fiona C ^a,d   Wang, Ruiwu ^b   Tanna Topan, Bhavna ^a   Wayne Chen, S R ^b   Welch, William ^c   Williams, Alan J ^a,e  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b UNIVERSITY OF CALGARY   (Canada)

^c UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

^d HAREFIELD HOSPITAL   (United Kingdom)

^e CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ASPARTIC ACID; GLUTAMIC ACID; POTASSIUM; RYANODINE RECEPTOR; RYANODINE RECEPTOR 2; BARIUM; CAFFEINE; CALCIUM; RYANODINE;

AMINO ACID SUBSTITUTION; ARTICLE; CALCIUM TRANSPORT; CHANNEL GATING; ELECTRIC FIELD; HUMAN; HUMAN CELL; ION CONDUCTANCE; ION TRANSPORT; MOLECULAR INTERACTION; MOUSE; NONHUMAN; POINT MUTATION; POTASSIUM CONDUCTANCE; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CELL MEMBRANE POTENTIAL; CHEMICAL MODEL; CHEMICAL STRUCTURE; COMPUTER SIMULATION; GENETICS; HEART MUSCLE; METABOLISM; MOLECULAR GENETICS; MUTATION; PHYSIOLOGY;

AMINO ACID SEQUENCE; ANIMALS; BARIUM; CAFFEINE; CALCIUM; CELL LINE; COMPUTER SIMULATION; HUMANS; ION CHANNEL GATING; MEMBRANE POTENTIALS; MICE; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; MYOCARDIUM; POTASSIUM; RYANODINE; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL;

EID: 62649166490     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2008.10.054     Document Type: Article

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