Nitrogen dioxide is genotoxic in urban concentrations

Inhalation Toxicology

Volumn 25, Issue 6, 2013, Pages 341-347

  Koehler, Christian ^a   Thielen, Sebastian ^a   Ginzkey, Christian ^a   Hackenberg, Stephan ^a   Scherzed, Agmal ^a   Burghartz, Marc ^a   Paulus, Michael ^a   Hagen, Rudolf ^a   Kleinsasser, Norbert Helmut ^a  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

Comet assay; Cytotoxicty; Genotoxicity; Nitrogen dioxide

Indexed keywords

CASPASE 3; NITROGEN DIOXIDE;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DNA STRAND; GENOTOXICITY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LONG TERM EXPOSURE; MICRONUCLEUS; MITOSIS; NOSE MUCOSA; PRIORITY JOURNAL; URBAN AREA;

AIR POLLUTANTS; APOPTOSIS; CASPASE 3; CELLS, CULTURED; COMET ASSAY; DNA DAMAGE; HUMANS; MICRONUCLEUS TESTS; MUTAGENS; NASAL MUCOSA; NITROGEN DIOXIDE;

EID: 84878917547     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.3109/08958378.2013.788104     Document Type: Article

References (32)

1. Alberg T, Nilsen A, Hansen JS, et al. (2011). Nitrogen dioxide: no influence on allergic sensitization in an intranasal mouse model with ovalbumin and diesel exhaust particles. Inhal Toxicol 23:268-76.
2. Ayyagari VN, Januszkiewicz A, Nath J. (2007). Effects of nitrogen dioxide on the expression of intercellular adhesion molecule-1, neutrophil adhesion, and cytotoxicity: studies in human bronchial epithelial cells. Inhal Toxicol 19:181-94. (Pubitemid 46005627)
3. Azad N, Rojanasakul Y, Vallyathan V. (2008). Inflammation and lung cancer: roles of reactive oxygen/nitrogen species. J Toxicol Environ Health B Crit Rev 11:1-15.
4. Bakand S, Winder C, Khalil C, Hayes A. (2006a). An experimental in vitro model for dynamic direct exposure of human cells to airborne contaminants. Toxicol Lett 165:1-10. (Pubitemid 43867173)
5. Bakand S, Winder C, Khalil C, Hayes A. (2006b). A novel in vitro exposure technique for toxicity testing of selected volatile organic compounds. J Environ Monit 8:100-5. (Pubitemid 43362490)
6. Brandsma CA, Hylkema MN, Luinge MA, et al. (2008). Nitrogen dioxide exposure attenuates cigarette smoke-induced cytokine production in mice. Inhal Toxicol 20:183-9. (Pubitemid 351196180)
7. Fehrenbach H, Zimmermann G, Starke E, et al. (2007). Nitrogen dioxide induces apoptosis and proliferation but not emphysema in rat lungs. Thorax 62:438-46. (Pubitemid 46698395)
8. Ginzkey C, Kampfinger K, Friehs G, et al. (2009). Nicotine induces DNA damage in human salivary glands. Toxicol Lett 184:1-4.
9. Grisham MB, Jourd'Heuil D, Wink DA. (2000). Review article: chronic inflammation and reactive oxygen and nitrogen metabolism - implications in DNA damage and mutagenesis. Aliment Pharmacol Ther 14:3-9. (Pubitemid 30199099)
10. Han M, Guo Z, Li G, Sang N. (2013). Nitrogen dioxide inhalation induces genotoxicity in rats. Chemosphere 90:2737-42.
11. Hansel NN, Breysse PN, McCormack MC, et al. (2008). A longitudinal study of indoor nitrogen dioxide levels and respiratory symptoms in inner-city children with asthma. Environ Health Perspect 116: 1428-32.
12. Jerrett M, Finkelstein MM, Brook JR, et al. (2009). A cohort study of traffic-related air pollution and mortality in Toronto, Ontario, Canada. Environ Health Perspect 117:772-7.
13. Jerrett M, Shankardass K, Berhane K, et al. (2008). Traffic-related air pollution and asthma onset in children: a prospective cohort study with individual exposure measurement. Environ Health Perspect 116: 1433-8.
14. Kalpaklioglu AF, Kalkan IK. (2012). Comparison of orally exhaled nitric oxide in allergic versus nonallergic rhinitis. Am J Rhinol Allergy 26: e50-4.
15. Kienast K, Knorst M, Riechelmann H, et al. (1993). In vitro studies of the beat frequency of ciliary cell cultures after short-term exposure to SO2 and NO2. Med Klin 88:520-4.
16. Kleinsasser NH, Harreus UA, Gamarra F, et al. (2009). Cytochrome P4502A6 stability in a mini organ culture model of human nasal mucosa for genotoxicology studies as detected by flow cytometry. Eur Archiv Otorhinolaryngol 266:385-9.
17. Kleinsasser NH, Juchhoff J, Wallner BC, et al. (2004). The use of miniorgan cultures of human upper aerodigestive tract epithelia in ecogenotoxicology. Mutat Res 561:63-73. (Pubitemid 38845054)
18. Kleinsasser NH, Schmid K, Sassen AW, et al. (2006). Cytotoxic and genotoxic effects of resin monomers in human salivary gland tissue and lymphocytes as assessed by the single cell microgel electrophoresis (Comet) assay. Biomaterials 27:1762-70. (Pubitemid 41759470)
19. Koehler C, Ginzkey C, Friehs G, et al. (2010). Aspects of nitrogen dioxide toxicity in environmental urban concentrations in human nasal epithelium. Toxicol Appl Pharmacol 245:219-25.
20. Koehler C, Ginzkey C, Friehs G, et al. (2011). Ex vivo toxicity of nitrogen dioxide in human nasal epithelium at the WHO defined 1-h limit value. Toxicol Lett 207:89-95.
21. Newland N, Baxter A, Hewitt K, Minet E. (2011). CYP1A1/1B1 and CYP2A6/2A13 activity is conserved in cultures of differentiated primary human tracheobronchial epithelial cells. Toxicol In Vitro 25: 922-9.
22. Olive PL, Durand RE, Le Riche J, et al. (1993). Gel electrophoresis of individual cells to quantify hypoxic fraction in human breast cancers. Cancer Res 53:733-6. (Pubitemid 23077852)
23. Pedersen M, Wichmann J, Autrup H, et al. (2009). Increased micronuclei and bulky DNA adducts in cord blood after maternal exposures to traffic-related air pollution. Environ Res 109:1012-20.
24. Singh NP, McCoy MT, Tice RR, Schneider EL. (1988). A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res, 175:184-91.
25. Spitale N, Popat N, McIvor A. (2012). Update on exhaled nitric oxide in pulmonary disease. Expert Rev Respir Med 6:105-15.
26. Szabo C, Ohshima H. (1997). DNA damage induced by peroxynitrite: subsequent biological effects. Nitric Oxide 1:373-85. (Pubitemid 28076545)
27. Tice RR, Agurell E, Anderson D, et al. (2000). Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen 35:206-21. (Pubitemid 30196665)
28. Villarini M, Moretti M, Fatigoni C, et al. (2008). Evaluation of primary DNA damage, cytogenetic biomarkers and genetic polymorphisms for CYP1A1 and GSTM1 in road tunnel construction workers. J Toxicol Environ Health A 71:1430-9.
29. WHO. (2000). Air quality guidelines, 2nd edon. WHO Regional Publications, European Series, No. 91.
30. WHO. (2005). Air quality guidelines global update 2005. WHO Regional Publications, European Series.
31. Wiseman H, Halliwell B. (1996). Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer. Biochem J 313:17-29. (Pubitemid 26013419)
32. Wolz L, Krause G, Scherer G, et al. (2002). In vitro genotoxicity assay of sidestream smoke using a human bronchial epithelial cell line. Food Chem Toxicol 40:845-50. (Pubitemid 34450780)