Pretreatment of PC12 cells with 17β-estradiol prevents aβ-induced down-regulation of CREB phosphorylation and prolongs inhibition of GSK-3β

Journal of Molecular Neuroscience

Volumn 50, Issue 3, 2013, Pages 394-401

  Chen, Yanxing ^a   Su, Ying ^a   Run, Xiaoqin ^a   Sun, Zhou ^a   Wang, Tao ^a   Sun, Shenggang ^a   Liang, Zhihou ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

AKT; Amyloid beta; CREB; Estrogen; GSK 3

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; AMYLOID BETA PROTEIN[1-42]; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; ESTRADIOL; ESTROGEN; GLYCOGEN SYNTHASE KINASE 3BETA; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; LEARNING; MEMORY; NERVE CELL; NEUROPROTECTION; NONHUMAN; PROTEIN PHOSPHORYLATION; RAT; UPREGULATION;

AMYLOID BETA-PEPTIDES; ANIMALS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DOWN-REGULATION; ESTRADIOL; GLYCOGEN SYNTHASE KINASE 3; PC12 CELLS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; RATS;

EID: 84878909755     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-012-9938-7     Document Type: Article

References (39)

1. Balaraman Y, Limaye AR, Levey AI, Srinivasan S (2006) Glycogen synthase kinase 3beta and Alzheimer's disease: pathophysiological and therapeutic significance. Cell Mol Life Sci 63(11):1226-1235. doi: 10.1007/s00018-005-5597-y
2. Cimarosti H, Zamin LL, Frozza R, Nassif M, Horn AP, Tavares A, Netto CA, Salbego C (2005) Estradiol protects against oxygen and glucose deprivation in rat hippocampal organotypic cultures and activates Akt and inactivates GSK-3beta. Neurochem Res 30(2):191-199
3. Craig MC, Murphy DG (2010) Estrogen therapy and Alzheimer's dementia. Ann N Y Acad Sci 1205:245-253. doi: 10.1111/j.1749-6632.2010.05673.x
4. Das A, Smith JA, Gibson C, Varma AK, Ray SK, Banik NL (2011) Estrogen receptor agonists and estrogen attenuate TNF-alpha-induced apoptosis in VSC4.1 motoneurons. J Endocrinol 208(2):171-182. doi: 10.1677/joe-10-0338
5. Forde JE, Dale TC (2007) Glycogen synthase kinase 3: a key regulator of cellular fate. Cell Mol Life Sci 64(15):1930-1944. doi: 10.1007/s00018-007-7045- 7
6. Forman MS, Trojanowski JQ, Lee VM (2004) Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs. Nat Med 10(10):1055-1063. doi: 10.1038/nm1113
7. Giese KP (2009) GSK-3: a key player in neurodegeneration and memory. IUBMB Life 61(5):516-521
8. Gresack JE, Frick KM (2006) Post-training estrogen enhances spatial and object memory consolidation in female mice. Pharmacol Biochem Behav 84(1):112-119. doi: 10.1016/j.pbb.2006.04.013
9. Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297(5580):353-356
10. Henderson VW (2010) Action of estrogens in the aging brain: dementia and cognitive aging. Biochim Biophys Acta 1800(10):1077-1083. doi: 10.1016/j.bbagen.2009.11.005
11. Henderson VW, Benke KS, Green RC, Cupples LA, Farrer LA (2005) Postmenopausal hormone therapy and Alzheimer's disease risk: interaction with age. J Neurol Neurosurg Psychiatry 76(1):103-105. doi: 10.1136/jnnp.2003.024927
12. Iqbal K, Grundke-Iqbal I, Zaidi T, Merz PA, Wen GY, Shaikh SS, Wisniewski HM, Alafuzoff I, Winblad B (1986) Defective brain microtubule assembly in Alzheimer's disease. Lancet 2(8504):421-426
13. Ivanova T, Mendez P, Garcia-Segura LM, Beyer C (2002) Rapid stimulation of the PI3-kinase/Akt signalling pathway in developing midbrain neurones by oestrogen. J Neuroendocrinol 14(1):73-79
14. Kelly A, Lynch MA (2000) Long-term potentiation in dentate gyrus of the rat is inhibited by the phosphoinositide 3-kinase inhibitor, wortmannin. Neuropharmacology 39(4):643-651
15. Lamprecht R (1999) CREB: a message to remember. Cell Mol Life Sci 55(4):554-563
16. LeBlanc ES, Janowsky J, Chan BK, Nelson HD (2001) Hormone replacement therapy and cognition: systematic review and meta-analysis. JAMA 285(11):1489-1499
17. Lee SJ, Campomanes CR, Sikat PT, Greenfield AT, Allen PB, McEwen BS (2004) Estrogen induces phosphorylation of cyclic AMP response element binding (pCREB) in primary hippocampal cells in a time-dependent manner. Neuroscience 124(3):549-560. doi: 10.1016/j.neuroscience.2003.11.035
18. Liang Z, Liu F, Grundke-Iqbal I, Iqbal K, Gong CX (2007) Down-regulation of cAMP-dependent protein kinase by over-activated calpain in Alzheimer disease brain. J Neurochem 103(6):2462-2470
19. Manning BD, Cantley LC (2007) AKT/PKB signaling: navigating downstream. Cell 129(7):1261-1274. doi: 10.1016/j.cell.2007.06.009
20. Morinaga A, Hirohata M, Ono K, Yamada M (2007) Estrogen has anti-amyloidogenic effects on Alzheimer's beta-amyloid fibrils in vitro. Biochem Biophys Res Commun 359(3):697-702. doi: 10.1016/j.bbrc.2007.05.158
21. Noh MY, Koh SH, Kim Y, Kim HY, Cho GW, Kim SH (2009) Neuroprotective effects of donepezil through inhibition of GSK-3 activity in amyloid-beta-induced neuronal cell death. J Neurochem 108(5):1116-1125. doi: 10.1111/j.1471-4159.2008.05837.x
22. Pike CJ, Carroll JC, Rosario ER, Barron AM (2009) Protective actions of sex steroid hormones in Alzheimer's disease. Front Neuroendocrinol 30(2):239-258. doi: 10.1016/j.yfrne.2009.04.015
23. Pugazhenthi S, Miller E, Sable C, Young P, Heidenreich KA, Boxer LM, Reusch JE (1999) Insulin-like growth factor-I induces bcl-2 promoter through the transcription factor cAMP-response element-binding protein. J Biol Chem 274(39):27529-27535
24. Pugazhenthi S, Nesterova A, Sable C, Heidenreich KA, Boxer LM, Heasley LE, Reusch JE (2000) Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein. J Biol Chem 275(15):10761-10766
25. Pugazhenthi S, Wang M, Pham S, Sze CI, Eckman CB (2011) Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons. Mol Neurodegener 6:60. doi: 10.1186/1750-1326-6-60
26. Raval AP, Saul I, Dave KR, DeFazio RA, Perez-Pinzon MA, Bramlett H (2009) Pretreatment with a single estradiol-17beta bolus activates cyclic-AMP response element binding protein and protects CA1 neurons against global cerebral ischemia. Neuroscience 160(2):307-318. doi: 10.1016/j.neuroscience.2009.02.065
27. Sakamoto K, Karelina K, Obrietan K (2011) CREB: a multifaceted regulator of neuronal plasticity and protection. J Neurochem 116(1):1-9. doi: 10.1111/j.1471-4159.2010.07080.x
28. Selkoe DJ (2002) Alzheimer's disease is a synaptic failure. Science 298(5594):789-791
29. Shao H, Breitner JC, Whitmer RA, Wang J, Hayden K, Wengreen H, Corcoran C, Tschanz J, Norton M, Munger R, Welsh-Bohmer K, Zandi PP (2012) Hormone therapy and Alzheimer disease dementia: new findings from the Cache County Study. Neurology 79(18):1846-1852. doi: 10.1212/WNL.0b013e318271f823
30. Smith CC, McMahon LL (2006) Estradiol-induced increase in the magnitude of long-term potentiation is prevented by blocking NR2B-containing receptors. J Neurosci 26(33):8517-8522. doi: 10.1523/jneurosci.5279-05.2006
31. Stine WB Jr, Dahlgren KN, Krafft GA, LaDu MJ (2003) In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis. J Biol Chem 278(13):11612-11622. doi: 10.1074/jbc.M210207200
32. Tang MX, Jacobs D, Stern Y, Marder K, Schofield P, Gurland B, Andrews H, Mayeux R (1996) Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease. Lancet 348(9025):429-432. doi: 10.1016/s0140-6736(96) 03356-9
33. 2 toxicity in human neuroblastoma SK-N-SH cells. Mol Pharmacol 70(1):395-404. doi: 10.1124/mol.106.022384
34. 2+ influx via L-type calcium channels activates the Src/ERK/cyclic-AMP response element binding protein signal pathway and BCL-2 expression in rat hippocampal neurons: a potential initiation mechanism for estrogen-induced neuroprotection. Neuroscience 135(1):59-72. doi: 10.1016/j.neuroscience.2004.12.027
35. Yamamoto-Sasaki M, Ozawa H, Saito T, Rosler M, Riederer P (1999) Impaired phosphorylation of cyclic AMP response element binding protein in the hippocampus of dementia of the Alzheimer type. Brain Res 824(2):300-303. doi: S0006899399012202
36. Yang T, Knowles JK, Lu Q, Zhang H, Arancio O, Moore LA, Chang T, Wang Q, Andreasson K, Rajadas J, Fuller GG, Xie Y, Massa SM, Longo FM (2008) Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment. PLoS One 3(11):e3604. doi: 10.1371/journal.pone.0003604
37. Yano S, Morioka M, Fukunaga K, Kawano T, Hara T, Kai Y, Hamada J, Miyamoto E, Ushio Y (2001) Activation of Akt/protein kinase B contributes to induction of ischemic tolerance in the CA1 subfield of gerbil hippocampus. J Cereb Blood Flow Metab 21(4):351-360. doi: 10.1097/00004647-200104000-00004
38. Yune TY, Park HG, Lee JY, Oh TH (2008) Estrogen-induced Bcl-2 expression after spinal cord injury is mediated through phosphoinositide-3-kinase/Akt- dependent CREB activation. J Neurotrauma 25(9):1121-1131. doi: 10.1089/neu.2008.0544
39. 2+ rise and subsequent cyclic AMP response element-binding protein activation in hippocampal neurons: a potential initiation mechanism for estrogen neurotrophism. Neuroscience 132(2):299-311. doi: 10.1016/j.neuroscience.2004.11.054