Mitochondrial impairment induced by 3-nitropropionic acid is enhanced by endogenous metalloprotease activity inhibition in cultured rat striatal neurons

Neuroscience Letters

Volumn 546, Issue , 2013, Pages 16-20

  De Oca Balderas, Pavel Montes ^a   Ospina, Gabriel Gutiérrez ^b,c   del Ángel, Abel Santamaría ^a  

^a NATIONAL INSTITUTE OF NEUROLOGY AND NEUROSURGERY   (Mexico)

^b INSTITUTO DE INVESTIGACIONES BIOMÉDICAS   (Mexico)

^c UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

Ectodomain shedding; GM6001; Metalloproteases; NMDAR; NR1; Striatal neurons

Indexed keywords

3 NITROPROPIONIC ACID; ILOMASTAT; METALLOPROTEINASE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; UBIQUINOL CYTOCHROME C REDUCTASE;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ARTICLE; BRAIN NERVE CELL; CORPUS STRIATUM; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME INHIBITION; IN VITRO STUDY; IN VIVO STUDY; NERVE CELL DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY SEQUENCE;

ANIMALS; APOPTOSIS; CELL SURVIVAL; CELLS, CULTURED; CORPUS STRIATUM; ENZYME ACTIVATION; METALLOPROTEASES; MITOCHONDRIA; NEURONS; NITRO COMPOUNDS; PROPIONATES; RATS; RATS, WISTAR;

EID: 84878902497     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2013.04.041     Document Type: Article

References (35)

1. Almeida S., Domingues A., Rodrigues L., Oliveira C.R., Rego A.C. FK506 prevents mitochondrial-dependent apoptotic cell death induced by 3-nitropropionic acid in rat primary cortical cultures. Neurobiol. Dis. 2004, 17:435-444.
2. Arribas J., Borroto A. Protein ectodomain shedding. Chem. Rev. 2002, 102:4627-4638.
3. Bartsch J.W., Wildeboer D., Koller G., Naus S., Rittger A., Moss M.L., Minai Y., Jockusch H. Tumor necrosis factor-alpha (TNF-alpha) regulates shedding of TNF-alpha receptor 1 by the metalloprotease-disintegrin ADAM8: evidence for a protease-regulated feedback loop in neuroprotection. J. Neurosci. 2010, 30:12210-12218.
4. Brewer G.J., Torricelli J.R. Isolation and culture of adult neurons and neurospheres. Nat. Protoc. 2007, 2:1490-1498.
5. Brouillet E., Jacquard C., Bizat N., Blum D. 3-Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease. J. Neurochem. 2005, 95:1521-1540.
6. Butler G.S., Overall C.M. Updated biological roles for matrix metalloproteinases and new intracellular substrates revealed by degradomics. Biochemistry 2009, 48:10830-10845.
7. Choi D.H., Kim E.M., Son H.J., Joh T.H., Kim Y.S., Kim D., Flint Beal M., Hwang O. A novel intracellular role of matrix metalloproteinase-3 during apoptosis of dopaminergic cells. J. Neurochem. 2008, 106:405-415.
8. De Strooper B., Vassar R., Golde T. The secretases: enzymes with therapeutic potential in Alzheimer disease. Nat. Rev. Neurol. 2010, 6:99-107.
9. Diaz-Rodriguez E., Cabrera N., Esparis-Ogando A., Montero J.C., Pandiella A. Cleavage of the TrkA neurotrophin receptor by multiple metalloproteases generates signalling-competent truncated forms. Eur. J. Neurosci. 1999, 11:1421-1430.
10. Dries D.R., Yu G. Rip exposed: how ectodomain shedding regulates the proteolytic processing of transmembrane substrates. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:14737-14738.
11. Eguchi T., Kubota S., Kawata K., Mukudai Y., Uehara J., Ohgawara T., Ibaragi S., Sasaki A., Kuboki T., Takigawa M. Novel transcription-factor-like function of human matrix metalloproteinase 3 regulating the CTGF/CCN2 gene. Mol. Cell. Biol. 2008, 28:2391-2413.
12. Fath T., Ke Y.D., Gunning P., Gotz J., Ittner L.M. Primary support cultures of hippocampal and substantia nigra neurons. Nat. Protoc. 2009, 4:78-85.
13. Galas M.C., Bizat N., Cuvelier L., Bantubungi K., Brouillet E., Schiffmann S.N., Blum D. Death of cortical and striatal neurons induced by mitochondrial defect involves differential molecular mechanisms. Neurobiol. Dis. 2004, 15:152-159.
14. Gu Z., Cui J., Brown S., Fridman R., Mobashery S., Strongin A.Y., Lipton S.A. A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia. J. Neurosci. 2005, 25:6401-6408.
15. Kaminsky Y.G., Marlatt M.W., Smith M.A., Kosenko E.A. Subcellular and metabolic examination of amyloid-beta peptides in Alzheimer disease pathogenesis: evidence for Abeta(25-35). Exp. Neurol. 2010, 221:26-37.
16. Kim S.T., Kim E.M., Choi J.H., Son H.J., Ji I.J., Joh T.H., Chung S.J., Hwang O. Matrix metalloproteinase-3 contributes to vulnerability of the nigral dopaminergic neurons. Neurochem. Int. 2009, 56:161-167.
17. Lee H., Park J.W., Kim S.P., Lo E.H., Lee S.R. Doxycycline inhibits matrix metalloproteinase-9 and laminin degradation after transient global cerebral ischemia. Neurobiol. Dis. 2009, 34:189-198.
18. Liu P.C., Liu X., Li Y., Covington M., Wynn R., Huber R., Hillman M., Yang G., Ellis D., Marando C., Katiyar K., Bradley J., Abremski K., Stow M., Rupar M., Zhuo J., Li Y.L., Lin Q., Burns D., Xu M., Zhang C., Qian D.Q., He C., Sharief V., Weng L., Agrios C., Shi E., Metcalf B., Newton R., Friedman S., Yao W., Scherle P., Hollis G., Burn T.C. Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells. Cancer Biol. Ther. 2006, 5:657-664.
19. Lynch D.R., Guttmann R.P. Excitotoxicity: perspectives based on N-methyl-d-aspartate receptor subtypes. J. Pharmacol. Exp. Ther. 2002, 300:717-723.
20. Maatta J.A., Sundvall M., Junttila T.T., Peri L., Laine V.J., Isola J., Egeblad M., Elenius K. Proteolytic cleavage and phosphorylation of a tumor-associated ErbB4 isoform promote ligand-independent survival and cancer cell growth. Mol. Biol. Cell 2006, 17:67-79.
21. Miller J.P., Holcomb J., Al-Ramahi I., de Haro M., Gafni J., Zhang N., Kim E., Sanhueza M., Torcassi C., Kwak S., Botas J., Hughes R.E., Ellerby L.M. Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease. Neuron 2010, 67:199-212.
22. Mizoguchi H., Takuma K., Fukuzaki E., Ibi D., Someya E., Akazawa K.H., Alkam T., Tsunekawa H., Mouri A., Noda Y., Nabeshima T., Yamada K. Matrix metalloprotease-9 inhibition improves amyloid beta-mediated cognitive impairment and neurotoxicity in mice. J. Pharmacol. Exp. Ther. 2009, 331:14-22.
23. Montes de Oca B.P. Ectodomain shedding and regulated intracellular proteolysis in the central nervous system. Cent. Nerv. Syst. Agents Med. Chem. 2010, 10:337-359.
24. Naus S., Richter M., Wildeboer D., Moss M., Schachner M., Bartsch J.W. Ectodomain shedding of the neural recognition molecule CHL1 by the metalloprotease-disintegrin ADAM8 promotes neurite outgrowth and suppresses neuronal cell death. J. Biol. Chem. 2004, 279:16083-16090.
25. Panov A.V., Gutekunst C.A., Leavitt B.R., Hayden M.R., Burke J.R., Strittmatter W.J., Greenamyre J.T. Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines. Nat. Neurosci. 2002, 5:731-736.
26. Pauly T., Ratliff M., Pietrowski E., Neugebauer R., Schlicksupp A., Kirsch J., Kuhse J. Activity-dependent shedding of the NMDA receptor glycine binding site by matrix metalloproteinase 3: a putative mechanism of postsynaptic plasticity. PLoS ONE 2008, 3:e2681.
27. Rosenberg G.A. Matrix metalloproteinases and their multiple roles in neurodegenerative diseases. Lancet Neurol. 2009, 8:205-216.
28. Scott A.J., O'Dea K.P., O'Callaghan D., Williams L., Dokpesi J.O., Tatton L., Handy J.M., Hogg P.J., Takata M. Reactive oxygen species and p38 mitogen-activated protein kinase mediate tumor necrosis factor alpha-converting enzyme (TACE/ADAM-17) activation in primary human monocytes. J. Biol. Chem. 2011, 286:35466-35476.
29. Szklarczyk A., Ewaleifoh O., Beique J.C., Wang Y., Knorr D., Haughey N., Malpica T., Mattson M.P., Huganir R., Conant K. MMP-7 cleaves the NR1 NMDA receptor subunit and modifies NMDA receptor function. FASEB J. 2008, 22:3757-3767.
30. Tunez I., Tasset I., Perez-De La Cruz V., Santamaria A. 3-Nitropropionic acid as a tool to study the mechanisms involved in Huntington's disease: past, present and future. Molecules 2010, 15:878-916.
31. Unal-Cevik I., Kilinc M., Gursoy-Ozdemir Y., Gurer G., Dalkara T. Loss of NeuN immunoreactivity after cerebral ischemia does not indicate neuronal cell loss: a cautionary note. Brain Res. 2004, 1015:169-174.
32. Vega, Montes de Oca L., Saavedra P., Ostrosky-Wegman R., Helper P. T cell subpopulations from women are more susceptible to the toxic effect of sodium arsenite in vitro. Toxicology 2004, 199:121-128.
33. Vos C.M., Sjulson L., Nath A., McArthur J.C., Pardo C.A., Rothstein J., Conant K. Cytotoxicity by matrix metalloprotease-1 in organotypic spinal cord and dissociated neuronal cultures. Exp. Neurol. 2000, 163:324-330.
34. Wetzel M., Li L., Harms K.M., Roitbak T., Ventura P.B., Rosenberg G.A., Khokha R., Cunningham L.A. Tissue inhibitor of metalloproteinases-3 facilitates Fas-mediated neuronal cell death following mild ischemia. Cell Death Differ. 2008, 15:143-151.
35. Xue M., Fan Y., Liu S., Zygun D.A., Demchuk A., Yong V.W. Contributions of multiple proteases to neurotoxicity in a mouse model of intracerebral haemorrhage. Brain 2009, 132:26-36.