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Volumn 15, Issue 2, 2010, Pages 878-916

3-nitropropionic acid as a tool to study the mechanisms involved in huntington's disease: Past, present and future

Author keywords

3 nitropropionic acid; Huntington's disease; Quinolinic acid; Succinate dehydrogenase; Transgenic mice models

Indexed keywords

3 NITROPROPIONIC ACID; 3-NITROPROPIONIC ACID; NITRO DERIVATIVE; PROPIONIC ACID DERIVATIVE;

EID: 77649215222     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules15020878     Document Type: Article
Times cited : (168)

References (271)
  • 1
    • 33745174181 scopus 로고    scopus 로고
    • Clinical characteristics of childhood-onset (juvenile) Huntington disease: Report of 12 patients and review of the literature
    • Gonzalez-Alegre, P.; Afifi, A.K. Clinical characteristics of childhood-onset (juvenile) Huntington disease: Report of 12 patients and review of the literature. J. Child. Neurol. 2006, 21, 223-229.
    • (2006) J. Child. Neurol. , vol.21 , pp. 223-229
    • Gonzalez-Alegre, P.1    Afifi, A.K.2
  • 2
    • 0008800552 scopus 로고
    • Medical and social aspects of Huntington's chorea in the state of Zulia, Venezuela
    • Avila-Giron, R. Medical and social aspects of Huntington's chorea in the state of Zulia, Venezuela. Adv. Neurol. 1973, 1, 261-266.
    • (1973) Adv. Neurol. , vol.1 , pp. 261-266
    • Avila-Giron, R.1
  • 4
    • 3242811180 scopus 로고    scopus 로고
    • Americo Negrette (1924 to 2003): Diagnosing Huntington disease in Venezuela
    • Okun, M.S.; Thommi, N. Americo Negrette (1924 to 2003): Diagnosing Huntington disease in Venezuela. Neurology 2004, 63, 340-343.
    • (2004) Neurology , vol.63 , pp. 340-343
    • Okun, M.S.1    Thommi, N.2
  • 5
    • 38949205940 scopus 로고    scopus 로고
    • Huntington disease mutation in Venezuela: Age of onset, haplotype analyses and geographic aggregation
    • Paradisi, I.; Hernández, A.; Arias, S. Huntington disease mutation in Venezuela: Age of onset, haplotype analyses and geographic aggregation. J. Hum. Genet. 2008, 53, 127-135.
    • (2008) J. Hum. Genet. , vol.53 , pp. 127-135
    • Paradisi, I.1    Hernández, A.2    Arias, S.3
  • 7
    • 0025221228 scopus 로고
    • The large Huntington's disease family of Tasmania
    • Pridmore, S.A.The large Huntington's disease family of Tasmania. Med. J. Aust. 1990a, 153, 593-595.
    • (1990) Med. J. Aust. , vol.153 , pp. 593-595
    • Pridmore, S.A.1
  • 8
    • 0024995126 scopus 로고
    • The prevalence of Huntington's disease in Tasmania
    • Pridmore, S.A. The prevalence of Huntington's disease in Tasmania. Med. J. Aust. 1990b, 153, 133-134.
    • (1990) Med. J. Aust. , vol.153 , pp. 133-134
    • Pridmore, S.A.1
  • 9
    • 0019424470 scopus 로고
    • Huntington's disease in black kindreds in South Carolina
    • Wright, H.H.; Still, C.N.; Abramson, R.K. Huntington's disease in black kindreds in South Carolina. Arch. Neurol. 1981, 38, 412-414.
    • (1981) Arch. Neurol. , vol.38 , pp. 412-414
    • Wright, H.H.1    Still, C.N.2    Abramson, R.K.3
  • 11
    • 45149103327 scopus 로고    scopus 로고
    • Huntington's disease. Part 2: Treatment and management issues in juvenile HD
    • Aubeeluck, A.; Brewer, H. Huntington's disease. Part 2: Treatment and management issues in juvenile HD. Br. J. Nurs. 2008, 17, 260-263.
    • (2008) Br. J. Nurs. , vol.17 , pp. 260-263
    • Aubeeluck, A.1    Brewer, H.2
  • 12
    • 34250362708 scopus 로고    scopus 로고
    • Juvenile-onset Huntington disease: A matter of perspective
    • Biglan, K.; Shoulson, I. Juvenile-onset Huntington disease: A matter of perspective. Arch. Neurol. 2007, 64, 783-784.
    • (2007) Arch. Neurol. , vol.64 , pp. 783-784
    • Biglan, K.1    Shoulson, I.2
  • 14
    • 15944413899 scopus 로고    scopus 로고
    • The paradigm of Huntington's disease: Therapeutic opportunities in neurodegeneration
    • Leegwater, J.; Jang-Ho, J. The paradigm of Huntington's disease: Therapeutic opportunities in neurodegeneration. Am. Soc. Exp. Neuro.Ther. 2004, 1, 128-138.
    • (2004) Am. Soc. Exp. Neuro.Ther. , vol.1 , pp. 128-138
    • Leegwater, J.1    Jang-Ho, J.2
  • 15
    • 0034847765 scopus 로고    scopus 로고
    • Juvenile onset Huntington's disease-clinical and research perspectives
    • Nance, M.A.; Myers, R.H. Juvenile onset Huntington's disease-clinical and research perspectives. Ment. Retard Dev. Disabil. Res. Rev. 2001, 7, 153-157.
    • (2001) Ment. Retard Dev. Disabil. Res. Rev. , vol.7 , pp. 153-157
    • Nance, M.A.1    Myers, R.H.2
  • 17
    • 0027480960 scopus 로고
    • The Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
    • The Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 1993, 72, 971-983.
    • (1993) Cell , vol.72 , pp. 971-983
  • 20
    • 77649227768 scopus 로고    scopus 로고
    • A Darwinian approach to Huntington's disease: Subtle health benefits of a neurological disorder
    • Eskenazi, B.R.; Wilson-Rich, N.S.; Starks, P.T. A Darwinian approach to Huntington's disease: Subtle health benefits of a neurological disorder. Med. Hypoth.2007, 71, 151-152.
    • (2007) Med. Hypoth. , vol.71 , pp. 151-152
    • Eskenazi, B.R.1    Wilson-Rich, N.S.2    Starks, P.T.3
  • 24
    • 0022876328 scopus 로고
    • Huntington's disease. Pathogenesis and management
    • Martin, J.B.; Gusella, J.F. Huntington's disease. Pathogenesis and management. N. Engl. J. Med. 1986, 315, 1267-1276.
    • (1986) N. Engl. J. Med. , vol.315 , pp. 1267-1276
    • Martin, J.B.1    Gusella, J.F.2
  • 26
    • 53049084348 scopus 로고    scopus 로고
    • The current clinical management of Huntington's disease
    • Phillips, W.; Shannon, K.M.; Barker, R.A. The current clinical management of Huntington's disease. Mov. Disord. 2008, 23, 1491-1504.
    • (2008) Mov. Disord. , vol.23 , pp. 1491-1504
    • Phillips, W.1    Shannon, K.M.2    Barker, R.A.3
  • 28
    • 52049085768 scopus 로고    scopus 로고
    • Pathophysiology of Huntington's disease: From huntingtin functions to potential treatments
    • Roze, E.; Saudou, F.; Caboche, J. Pathophysiology of Huntington's disease: From huntingtin functions to potential treatments. Curr. Opin. Neurol. 2008, 21, 497-503.
    • (2008) Curr. Opin. Neurol. , vol.21 , pp. 497-503
    • Roze, E.1    Saudou, F.2    Caboche, J.3
  • 29
    • 0026951246 scopus 로고
    • Pineal and habenula calcification in schizophrenia
    • Sandyk, R. Pineal and habenula calcification in schizophrenia. Int. J. Neurosci. 1992, 67, 19-30.
    • (1992) Int. J. Neurosci. , vol.67 , pp. 19-30
    • Sandyk, R.1
  • 30
    • 0027934078 scopus 로고
    • A controlled psychiatric study of individuals at risk for Huntington's disease
    • Shiwach, R.S.; Norbury, C.G. A controlled psychiatric study of individuals at risk for Huntington's disease. Br. J. Psychiatry 1994, 165, 500-505.
    • (1994) Br. J. Psychiatry , vol.165 , pp. 500-505
    • Shiwach, R.S.1    Norbury, C.G.2
  • 31
    • 36348978522 scopus 로고    scopus 로고
    • Psychopathology in verified Huntington's disease gene carriers. J. Neuropsychiatry
    • Van Duijn, E.; Kingma, E.M.; van der Mast, R.C. Psychopathology in verified Huntington's disease gene carriers. J. Neuropsychiatry. Clin. Neurosci. 2007, 19, 441-448.
    • (2007) Clin. Neurosci. , vol.19 , pp. 441-448
    • Van Duijn, E.1    Kingma, E.M.2    Van Der Mast, R.C.3
  • 32
    • 33846225133 scopus 로고    scopus 로고
    • Huntington's disease
    • Walker, F. Huntington's disease. Lancet 2007, 369, 218-228.
    • (2007) Lancet , vol.369 , pp. 218-228
    • Walker, F.1
  • 33
    • 0034283877 scopus 로고    scopus 로고
    • Transcriptional dysregulation in Huntington's disease
    • Cha, J.H. Transcriptional dysregulation in Huntington's disease. Trends Neurosci. 2000, 23, 387-392.
    • (2000) Trends Neurosci. , vol.23 , pp. 387-392
    • Cha, J.H.1
  • 35
    • 0030752709 scopus 로고    scopus 로고
    • Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
    • DiFiglia, M.; Sapp, E.; Chase, K.O.; Davies, S.W.; Bates, G.P.; Vonsattel, J.P.; Aronin, N. Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science 1997, 277, 1990-1993.
    • (1997) Science , vol.277 , pp. 1990-1993
    • DiFiglia, M.1    Sapp, E.2    Chase, K.O.3    Davies, S.W.4    Bates, G.P.5    Vonsattel, J.P.6    Aronin, N.7
  • 36
    • 3142679404 scopus 로고    scopus 로고
    • Huntington's disease: How does huntingtin, an antiapoptotic protein, become toxic?
    • Rangone, H.; Humbert, S.; Saudou, F. Huntington's disease: How does huntingtin, an antiapoptotic protein, become toxic? Pathol. Biol. (Paris) 2004, 52, 338-342.
    • (2004) Pathol. Biol. (Paris) , vol.52 , pp. 338-342
    • Rangone, H.1    Humbert, S.2    Saudou, F.3
  • 37
    • 0032815680 scopus 로고    scopus 로고
    • Replicating Huntington's disease phenotype in experimental animals
    • Brouillet, E.; Condé, F.; Beal, M.F.; Hantraye, P. Replicating Huntington's disease phenotype in experimental animals. Prog. Neurobiol. 1999, 59, 427-468.
    • (1999) Prog. Neurobiol. , vol.59 , pp. 427-468
    • Brouillet, E.1    Condé, F.2    Beal, M.F.3    Hantraye, P.4
  • 38
    • 0034750095 scopus 로고    scopus 로고
    • Synthesis and release of neurotoxic kynurenine metabolites by human monocyte-derived macrophages
    • Chiarugi, A.; Calvani, M.; Meli, E.; Traggiai, E.; Moroni, F. Synthesis and release of neurotoxic kynurenine metabolites by human monocyte-derived macrophages. J. Neuroimmunol. 2001a, 120, 190-198.
    • (2001) J. Neuroimmunol. , vol.120 , pp. 190-198
    • Chiarugi, A.1    Calvani, M.2    Meli, E.3    Traggiai, E.4    Moroni, F.5
  • 39
    • 0035010218 scopus 로고    scopus 로고
    • Similarities and differences in the neural death processes activated by 3OH-Kynurenine and quinolinic acid
    • Chiarugi, A.; Meli, E.; Moroni,; F. Similarities and differences in the neural death processes activated by 3OH-Kynurenine and quinolinic acid. J. Neurochem. 2001b, 77, 1310-1318.
    • (2001) J. Neurochem. , vol.77 , pp. 1310-1318
    • Chiarugi, A.1    Meli, E.2    Moroni3    , F.4
  • 40
    • 38949103036 scopus 로고    scopus 로고
    • Excitotoxic neuronal death and the pathogenesis of Huntington's disease
    • Estrada-Sánchez, A.M.; Mejía-Toiber, J.; Massieu, L. Excitotoxic neuronal death and the pathogenesis of Huntington's disease. Arch. Med. Res. 2008, 39, 265-276.
    • (2008) Arch. Med. Res. , vol.39 , pp. 265-276
    • Estrada-Sánchez, A.M.1    Mejía-Toiber, J.2    Massieu, L.3
  • 41
    • 0029147523 scopus 로고
    • Excitotoxins aging, and environmental neurotoxins: Implications for understanding human neurodegenerative diseases
    • Dawson, R.; Beal, M.F.; Bondy, S.C.; Di Monte, D.A.; Isom, G.E. Excitotoxins, aging, and environmental neurotoxins: Implications for understanding human neurodegenerative diseases. Toxicol. Appl. Pharmacol. 1995, 134, 1-17.
    • (1995) Toxicol. Appl. Pharmacol. , vol.134 , pp. 1-17
    • Dawson, R.1    Beal, M.F.2    Bondy, S.C.3    Di Monte, D.A.4    Isom, G.E.5
  • 43
    • 36949037945 scopus 로고    scopus 로고
    • Integrative hypothesis for Huntington's disease: A brief review of experimental evidence
    • Pérez-de la Cruz, V.; Santamaría, A. Integrative hypothesis for Huntington's disease: A brief review of experimental evidence. Physiol. Res. 2007b, 56, 513-526.
    • (2007) Physiol. Res. , vol.56 , pp. 513-526
    • Pérez-De La Cruz, V.1    Santamaría, A.2
  • 44
    • 29144468251 scopus 로고    scopus 로고
    • 3-Nitropropionic acid: A mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease
    • Brouillet, E.; Jacquard, C.; Bizat, N.; Blum, D. 3-Nitropropionic acid: A mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease. J. Neurochem. 2005, 95, 1521-1540.
    • (2005) J. Neurochem. , vol.95 , pp. 1521-1540
    • Brouillet, E.1    Jacquard, C.2    Bizat, N.3    Blum, D.4
  • 45
    • 0021883670 scopus 로고
    • Regional mitochondiral respieratoy activity in Huntington's disease brain
    • Brennan, W.A.Jr.; Bird, E.D.; Aprille, J.R. Regional mitochondiral respieratoy activity in Huntington's disease brain. J. Neurochem. 1985, 44, 1948-1950.
    • (1985) J. Neurochem. , vol.44 , pp. 1948-1950
    • Brennan, W.A.Jr.1    Bird, E.D.2    Aprille, J.R.3
  • 46
    • 0025087726 scopus 로고
    • Evidence for a defect in NADH: Ubiquinone oxidoreductase (complex I) in Huntington's disease
    • Parker, W.D.Jr.; Baoyson, S.J.; Luder, A.S.; Parks, J.K. Evidence for a defect in NADH: Ubiquinone oxidoreductase (complex I) in Huntington's disease. Neurology 1990, 40, 1231-1234.
    • (1990) Neurology , vol.40 , pp. 1231-1234
    • Parker Jr., W.D.1    Baoyson, S.J.2    Luder, A.S.3    Parks, J.K.4
  • 48
    • 67449155877 scopus 로고    scopus 로고
    • Protective effect of rivastigmine against 3-nitropropionic acid-induced Huntington's disease like symptoms: Possible behavioural, biochemical and cellular alterations
    • Kumar, P.; Kumar A. Protective effect of rivastigmine against 3-nitropropionic acid-induced Huntington's disease like symptoms: Possible behavioural, biochemical and cellular alterations. Eur. J. Pharmacol. 2009, 615, 91-101.
    • (2009) Eur. J. Pharmacol. , vol.615 , pp. 91-101
    • Kumar, P.1    Kumar, A.2
  • 49
    • 65449129628 scopus 로고    scopus 로고
    • Model of Huntington's disease induced with 3-nitropropionic acid
    • Túnez, I.; Santamaría, A. Model of Huntington's disease induced with 3-nitropropionic acid. Rev. Neurol. 2009, 48, 430-434.
    • (2009) Rev. Neurol. , vol.48 , pp. 430-434
    • Túnez, I.1    Santamaría, A.2
  • 50
    • 70350502590 scopus 로고    scopus 로고
    • The molecular bases of Huntington's disease: The role played by oxidative stress
    • Tasset, I.; Sánchez, F.; Túnez, I. The molecular bases of Huntington's disease: The role played by oxidative stress. Rev. Neurol. 2009, 49, 424-429.
    • (2009) Rev. Neurol. , vol.49 , pp. 424-429
    • Tasset, I.1    Sánchez, F.2    Túnez, I.3
  • 51
    • 45149107487 scopus 로고    scopus 로고
    • Mechanisms of neurodegeneration in Huntington's disease
    • Gil, J.M.; Rego, A.C. Mechanisms of neurodegeneration in Huntington's disease. Eur. J. Neurosci. 2008, 27, 2803-2820.
    • (2008) Eur. J. Neurosci. , vol.27 , pp. 2803-2820
    • Gil, J.M.1    Rego, A.C.2
  • 52
    • 0029125857 scopus 로고
    • Aging energy, and oxidative stress in neurodegenerative diseases
    • Beal, M.F. Aging, energy, and oxidative stress in neurodegenerative diseases. Ann. Neurol. 1995, 38, 357-366.
    • (1995) Ann. Neurol. , vol.38 , pp. 357-366
    • Beal, M.F.1
  • 53
    • 37549045045 scopus 로고    scopus 로고
    • Huntington's disease and mitochondrial DNA deletions: Event or regular mechanism for mutant huntingtin protein and CAG repeats expansion?!
    • Banoei, M.M.; Houshmand, M.; Panahi, M.S., Shariati, P.; Rostami, M.; Manshadi, M.D.;Majidizadeh, T. Huntington's disease and mitochondrial DNA deletions: Event or regular mechanism for mutant huntingtin protein and CAG repeats expansion?! Cell. Mol. Neurobiol. 2007, 27, 867-875.
    • (2007) Cell. Mol. Neurobiol. , vol.27 , pp. 867-875
    • Banoei, M.M.1    Houshmand, M.2    Panahi, M.S.3    Shariati, P.4    Rostami, M.5    Manshadi, M.D.6    Majidizadeh, T.7
  • 54
    • 41949126549 scopus 로고    scopus 로고
    • Calcium homeostasis and mitochondrial dysfunction in striatal neurons of Huntington disease
    • Lim, D.; Fedrizzi, L.; Tartari, M.; Zuccato, C.; Cattaneo, E.; Brini, M.; Carafoli, E. Calcium homeostasis and mitochondrial dysfunction in striatal neurons of Huntington disease. J. Biol. Chem. 2008, 283, 5780-5789.
    • (2008) J. Biol. Chem. , vol.283 , pp. 5780-5789
    • Lim, D.1    Fedrizzi, L.2    Tartari, M.3    Zuccato, C.4    Cattaneo, E.5    Brini, M.6    Carafoli, E.7
  • 55
    • 72349098221 scopus 로고    scopus 로고
    • Effects of caffeic acid, rofecoxib, and their combination against quinolinic acid-induced behavioral alterations and disruption in glutathione redox status
    • Kalonia, H.; Kumar, P.; Kumar, A.; Nehru, B. Effects of caffeic acid, rofecoxib, and their combination against quinolinic acid-induced behavioral alterations and disruption in glutathione redox status. Neurosci. Bull. 2009, 25, 343-352.
    • (2009) Neurosci. Bull. , vol.25 , pp. 343-352
    • Kalonia, H.1    Kumar, P.2    Kumar, A.3    Nehru, B.4
  • 56
    • 70350307195 scopus 로고    scopus 로고
    • Lycopene modulates nitric oxide pathways against 3-nitropropioni acid-induced neurotoxicity
    • Kumar, P.; Kalonia, H.; Kumar, A. Lycopene modulates nitric oxide pathways against 3-nitropropioni acid-induced neurotoxicity. Life Sci. 2009, 85, 711-718.
    • (2009) Life Sci. , vol.85 , pp. 711-718
    • Kumar, P.1    Kalonia, H.2    Kumar, A.3
  • 57
    • 70350196372 scopus 로고    scopus 로고
    • Protective effect of hesperidin and naringin against 3-nitropropionic acid induced Huntington's like symptoms in rats: Possible role of nitric oxide
    • Kumar, P.; Kumar, A. Protective effect of hesperidin and naringin against 3-nitropropionic acid induced Huntington's like symptoms in rats: Possible role of nitric oxide. Behav. Brain Res. 2010, 38-46.
    • Behav. Brain Res. , vol.2010 , pp. 38-46
    • Kumar, P.1    Kumar, A.2
  • 58
    • 57649187103 scopus 로고    scopus 로고
    • Mitochondrial and Huntingon's disease pathogenesis: Insight from genetic and chemical models
    • Browne, S.E. Mitochondrial and Huntingon's disease pathogenesis: Insight from genetic and chemical models. Ann. N.Y. Acad. 2008, 1147, 358-382.
    • (2008) Ann. N.Y. Acad. , vol.1147 , pp. 358-382
    • Browne, S.E.1
  • 60
    • 0035947372 scopus 로고    scopus 로고
    • Impairment of the ubiquitin-proteasome system by protein aggregation
    • Bence, N.F.; Sampat, R.M.; Kopito, R.R. Impairment of the ubiquitin-proteasome system by protein aggregation. Science 2001, 292, 1552-1555.
    • (2001) Science , vol.292 , pp. 1552-1555
    • Bence, N.F.1    Sampat, R.M.2    Kopito, R.R.3
  • 61
    • 43449129732 scopus 로고    scopus 로고
    • The ubiquitin-proteasome pathway in Huntington's disease
    • Finkbeiner, S.; Mitra, S. The ubiquitin-proteasome pathway in Huntington's disease. Sci.Word J. 2008, 8, 421-433.
    • (2008) Sci.Word J. , vol.8 , pp. 421-433
    • Finkbeiner, S.1    Mitra, S.2
  • 62
    • 2442631459 scopus 로고    scopus 로고
    • Inhibition of calpain cleavage of huntingtin reduces toxicity: Accumulation of calpain/caspase fragments in the nucleus
    • Gafni, J.; Hermel, E.; Young, J.E.; Wellington, C.L.; Hayden, M.R.; Ellerby, L.M. Inhibition of calpain cleavage of huntingtin reduces toxicity: Accumulation of calpain/caspase fragments in the nucleus J. Biol. Chem. 2004, 279, 20211-20220.
    • (2004) J. Biol. Chem. , vol.279 , pp. 20211-20220
    • Gafni, J.1    Hermel, E.2    Young, J.E.3    Wellington, C.L.4    Hayden, M.R.5    Ellerby, L.M.6
  • 63
    • 0036671821 scopus 로고    scopus 로고
    • Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions
    • Lunkes, A.; Lindenberg, K.S.; Ben-Haïem, L.; Weber, C.; Devys, D.; Landwehrmeyer, G.B.; Mandel, J.L.; Trottier, Y. Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions. Mol. Cell. 2002, 10, 259-269.
    • (2002) Mol. Cell. , vol.10 , pp. 259-269
    • Lunkes, A.1    Lindenberg, K.S.2    Ben-Haïem, L.3    Weber, C.4    Devys, D.5    Landwehrmeyer, G.B.6    Mandel, J.L.7    Trottier, Y.8
  • 64
    • 0037461730 scopus 로고    scopus 로고
    • Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders
    • Sánchez, I.; Mahlke, C.; Yuan, J. Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders. Nature 2003, 421, 373-379.
    • (2003) Nature , vol.421 , pp. 373-379
    • Sánchez, I.1    Mahlke, C.2    Yuan, J.3
  • 65
    • 0037174879 scopus 로고    scopus 로고
    • Huntingtin spheroids and protofibrils as precursors in polyglutamine fibrilization
    • Poirier, M.A.; Li, H.; Macosko, J.; Cai, S.; Amzel, M.; Ross, C.A. Huntingtin spheroids and protofibrils as precursors in polyglutamine fibrilization. J. Biol. Chem. 2002, 277, 41032-41037.
    • (2002) J. Biol. Chem. , vol.277 , pp. 41032-41037
    • Poirier, M.A.1    Li, H.2    Macosko, J.3    Cai, S.4    Amzel, M.5    Ross, C.A.6
  • 66
    • 15544372340 scopus 로고    scopus 로고
    • A structure-based analysis of huntingtin mutant polyglutamine aggregation and toxicity: Evidence for a compact beta-sheet structure
    • Poirier, M.A.; Jiang, H.; Ross, C.A. A structure-based analysis of huntingtin mutant polyglutamine aggregation and toxicity: Evidence for a compact beta-sheet structure. Hum. Mol. Genet. 2005, 14, 765-774.
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 765-774
    • Poirier, M.A.1    Jiang, H.2    Ross, C.A.3
  • 67
    • 3142604036 scopus 로고    scopus 로고
    • The ubiquitin-proteasome pathway in Parkinson's disease and other neurodegenerative diseases
    • Ross, C.A.; Pickart, C.M. The ubiquitin-proteasome pathway in Parkinson's disease and other neurodegenerative diseases. Trends Cell Biol. 2004, 14, 703-711.
    • (2004) Trends Cell Biol. , vol.14 , pp. 703-711
    • Ross, C.A.1    Pickart, C.M.2
  • 68
    • 1842766144 scopus 로고    scopus 로고
    • Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutaminecontaining proteins
    • Venkatraman, P.; Wetzel, R.; Tanaka, M.; Nukina, N.; Goldberg, A.L Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutaminecontaining proteins. Mol. Cell. 2004, 14, 95-104.
    • (2004) Mol. Cell. , vol.14 , pp. 95-104
    • Venkatraman, P.1    Wetzel, R.2    Tanaka, M.3    Nukina, N.4    Goldberg, A.L.5
  • 69
    • 4444350918 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease
    • Canals, J.M.; Pineda, J.R.; Torres-Peraza, J.F.; Bosch, M.; Martín-Ibáñez, R.; Muñoz, M.T.; Mengod, G.; Ernfors, P.; Alberch, J. Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease. J. Neurosci. 2004, 24, 7727-7739.
    • (2004) J. Neurosci. , vol.24 , pp. 7727-7739
    • Canals, J.M.1    Pineda, J.R.2    Torres-Peraza, J.F.3    Bosch, M.4    Martín- Ibáñez, R.5    Muñoz, M.T.6    Mengod, G.7    Ernfors, P.8    Alberch, J.9
  • 70
    • 0037292586 scopus 로고    scopus 로고
    • Dysfunction of wild-type huntingtin in Huntington disease
    • Cattaneo, E. Dysfunction of wild-type huntingtin in Huntington disease. News Physiol. Sci. 2003, 18, 34-37.
    • (2003) News Physiol. Sci. , vol.18 , pp. 34-37
    • Cattaneo, E.1
  • 73
    • 33646492607 scopus 로고    scopus 로고
    • Aging and neurodegeneration. Molecular mechanisms of neuronal loss in Huntington's disease
    • Lee, S.T.; Kim, M. Aging and neurodegeneration. Molecular mechanisms of neuronal loss in Huntington's disease. Mech Ageing Dev. 2006, 127, 432-435.
    • (2006) Mech Ageing Dev. , vol.127 , pp. 432-435
    • Lee, S.T.1    Kim, M.2
  • 74
    • 0000790724 scopus 로고    scopus 로고
    • SH3 domain-dependent association of huntingtin with epidermal growth factor receptor signalling complexes
    • Liu, Y.F.; Deth, R.C.; Devys, D. SH3 domain-dependent association of huntingtin with epidermal growth factor receptor signalling complexes. J. Biol. Chem. 1997, 272, 8121-8124.
    • (1997) J. Biol. Chem. , vol.272 , pp. 8121-8124
    • Liu, Y.F.1    Deth, R.C.2    Devys, D.3
  • 76
    • 3142514201 scopus 로고    scopus 로고
    • Protein aggregation and neurodegenerative disease
    • Ross, C.A.; Poirier, M.A. Protein aggregation and neurodegenerative disease. Nat. Med. 2004, 10, S10-S17.
    • (2004) Nat. Med. , vol.10
    • Ross, C.A.1    Poirier, M.A.2
  • 77
    • 34547843693 scopus 로고    scopus 로고
    • Intersectin enhances huntingtin aggregation and neurodegeneration through activation of c-Jun-NH2-terminal kinase
    • Scappini, E.; Koh, T.W.; Martin, N.P.; O'Bryan, J.P. Intersectin enhances huntingtin aggregation and neurodegeneration through activation of c-Jun-NH2-terminal kinase. Hum. Mol. Genet. 2007, 16, 1862-1871.
    • (2007) Hum. Mol. Genet. , vol.16 , pp. 1862-1871
    • Scappini, E.1    Koh, T.W.2    Martin, N.P.3    O'Bryan, J.P.4
  • 79
    • 0037408279 scopus 로고    scopus 로고
    • Transcriptional abnormalities in Huntington disease
    • Sugars, K.L.; Rubinsztein, D.C. Transcriptional abnormalities in Huntington disease. Trends Genet. 2003, 19, 233-238.
    • (2003) Trends Genet. , vol.19 , pp. 233-238
    • Sugars, K.L.1    Rubinsztein, D.C.2
  • 81
    • 0017167057 scopus 로고
    • Lesion of striatal neurones with kainic acid provides a model for Huntington's chorea
    • Coyle, J.T.; Schwarcz, R. Lesion of striatal neurones with kainic acid provides a model for Huntington's chorea. Nature 1976, 263, 244-246.
    • (1976) Nature , vol.263 , pp. 244-246
    • Coyle, J.T.1    Schwarcz, R.2
  • 82
    • 0028872674 scopus 로고
    • Excitotoxicity and the NMDA receptor-still lethal after eight years
    • Rothman, S.M.; Olney, J.W. Excitotoxicity and the NMDA receptor-still lethal after eight years. Trends Neurosci. 1995, 18, 57-58.
    • (1995) Trends Neurosci. , vol.18 , pp. 57-58
    • Rothman, S.M.1    Olney, J.W.2
  • 84
    • 0035818590 scopus 로고    scopus 로고
    • Expanded poluglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death
    • Parker, J.A.; Connolly, J.B.;Wellington, C.; Hayden, M.; Dausset, J.; Neri, C. Expanded poluglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death. Proc. Natl. Acad. Sci. USA 2001, 98, 13318-13323.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 13318-13323
    • Parker, J.A.1    Connolly, J.B.2    Wellington, C.3    Hayden, M.4    Dausset, J.5    Neri, C.6
  • 87
    • 0026584524 scopus 로고    scopus 로고
    • Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?
    • Beal, M.F. Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses? Ann. Neurol. 2007, 31, 119-130.
    • (2007) Ann. Neurol. , vol.31 , pp. 119-130
    • Beal, M.F.1
  • 88
    • 0023118066 scopus 로고
    • Nature and distribution of brain lesions in rats intoxicated with 3-nitropropionic acid: A type of hypoxic (energy deficient) brain damage
    • Hamilton, B.F.; Gould, D.H. Nature and distribution of brain lesions in rats intoxicated with 3-nitropropionic acid: A type of hypoxic (energy deficient) brain damage. Acta Neuropathol. 1987, 72, 286-297.
    • (1987) Acta Neuropathol. , vol.72 , pp. 286-297
    • Hamilton, B.F.1    Gould, D.H.2
  • 89
    • 0026876637 scopus 로고
    • Studies on the epidemiology and etiology of moldy sugarcane poisoning in China
    • Liu, X.; Luo, X.; Hu, W. Studies on the epidemiology and etiology of moldy sugarcane poisoning in China. Biomed. Environ. Sci. 1992, 5, 161-177.
    • (1992) Biomed. Environ. Sci. , vol.5 , pp. 161-177
    • Liu, X.1    Luo, X.2    Hu, W.3
  • 90
    • 36049044225 scopus 로고    scopus 로고
    • Animal models of Huntington's disease
    • Ramaswamy, S.; McBrid, J.L.; Kordower, J.H. Animal models of Huntington's disease. ILAR. J. 2007, 48, 356-373.
    • (2007) ILAR. J. , vol.48 , pp. 356-373
    • Ramaswamy, S.1    McBrid, J.L.2    Kordower, J.H.3
  • 92
    • 0034127284 scopus 로고    scopus 로고
    • Major strain differences in response to chronic systemic administration of the mitochondrialtoxin 3-nitropropionic acid in rats: Implications for neuroprotection studies
    • Ouary, S.; Bizat, N.; Altairac, S.; Ménétrat, H.; Mittoux,V.; Condé, F.; Hantraye, P.; Brouillet, E. Major strain differences in response to chronic systemic administration of the mitochondrialtoxin 3-nitropropionic acid in rats: Implications for neuroprotection studies. Neuroscience 2000, 97, 521-530.
    • (2000) Neuroscience , vol.97 , pp. 521-530
    • Ouary, S.1    Bizat, N.2    Altairac, S.3    Ménétrat, H.4    Mittoux, V.5    Condé, F.6    Hantraye, P.7    Brouillet, E.8
  • 93
    • 38749087581 scopus 로고    scopus 로고
    • Protective effect of minocycline, a semi-synthetic secondgeneration tetracycline against 3-nitropropionic acid (3-NP)-induced neurotoxicity
    • Ahuja, M.; Bishnoi, M.; Chopra, K. Protective effect of minocycline, a semi-synthetic secondgeneration tetracycline against 3-nitropropionic acid (3-NP)-induced neurotoxicity. Toxicology 2008, 244, 111-122.
    • (2008) Toxicology , vol.244 , pp. 111-122
    • Ahuja, M.1    Bishnoi, M.2    Chopra, K.3
  • 94
    • 33747778678 scopus 로고    scopus 로고
    • Involvement of nitric oxide in 3-nitropropionic acid-induced striatal toxicity in rats
    • Deshpande, S.B.; Hida, H.; Takei-Io, N.; Masuda ,T.; Baba, H.; Nishino, H. Involvement of nitric oxide in 3-nitropropionic acid-induced striatal toxicity in rats. Brain Res. 2006, 1108, 205-215.
    • (2006) Brain Res. , vol.1108 , pp. 205-215
    • Deshpande, S.B.1    Hida, H.2    Takei-Io, N.3    Masuda, T.4    Baba, H.5    Nishino, H.6
  • 95
    • 39749100656 scopus 로고    scopus 로고
    • GABA uptake inhibitor, attenuates 3-nitropropionic acid-induced alterations in various behavioral and biochemical parameters in rats
    • Dhir, A.; Akula, KK.; Kulkarni, S.K.; Tiagabine, A. GABA uptake inhibitor, attenuates 3-nitropropionic acid-induced alterations in various behavioral and biochemical parameters in rats. Prog. Neuropsychopharmacol. Biol. Psychiatry 2008, 32, 835-843.
    • (2008) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.32 , pp. 835-843
    • Dhir, A.1    Akula, K.K.2    Kulkarni, S.K.3    Tiagabine, A.4
  • 96
    • 33751011945 scopus 로고    scopus 로고
    • The acute effects of 3-nitropropionic acid on the behavior and spontaneous cortical electrical activity of rats
    • Lukács, A.; Szabó, A.; Vezér, T.; Papp, A. The acute effects of 3-nitropropionic acid on the behavior and spontaneous cortical electrical activity of rats. Acta Neurobiol. Exp. (Wars). 2006, 66, 227-233.
    • (2006) Acta Neurobiol. Exp. (Wars). , vol.66 , pp. 227-233
    • Lukács, A.1    Szabó, A.2    Vezér, T.3    Papp, A.4
  • 97
    • 0037762555 scopus 로고    scopus 로고
    • Structural and functional neuroprotection in a rat model of Huntington's disease by viral gene transfer of GDNF
    • McBride, J.L.; During, M.J.; Wuu .J.; Chen, E.Y.; Leurgans, S.E.; Kordower, J.H. Structural and functional neuroprotection in a rat model of Huntington's disease by viral gene transfer of GDNF. Exp. Neurol. 2003, 181, 213-223.
    • (2003) Exp. Neurol. , vol.181 , pp. 213-223
    • McBride, J.L.1    During, M.J.2    Wuu, .J.3    Chen, E.Y.4    Leurgans, S.E.5    Kordower, J.H.6
  • 98
    • 43049141550 scopus 로고    scopus 로고
    • Altered striatal vulnerability to 3-nitropropionic acid in rats due to sex hormone levels during late phase of brain development
    • Mogami, M.; Hayashi, Y.; Masuda, T.; Kohri, K.; Nishino, H.; Hida, H. Altered striatal vulnerability to 3-nitropropionic acid in rats due to sex hormone levels during late phase of brain development. Neurosci. Lett. 2008, 436, 321-325.
    • (2008) Neurosci. Lett. , vol.436 , pp. 321-325
    • Mogami, M.1    Hayashi, Y.2    Masuda, T.3    Kohri, K.4    Nishino, H.5    Hida, H.6
  • 100
  • 101
    • 33645841052 scopus 로고    scopus 로고
    • Transcranial magnetic stimulation attenuates cell loss and oxidative damage in the striatum induced in the 3-nitropropionic model of Huntington's disease
    • Túnez, I.; Drucker-Colín, R.; Jimena, I.; Medina, F.J.; Muñoz, M.C.; Peña, J.; Montilla, P. Transcranial magnetic stimulation attenuates cell loss and oxidative damage in the striatum induced in the 3-nitropropionic model of Huntington's disease. J. Neurochem. 2006b, 97, 619-630.
    • (2006) J. Neurochem. , vol.97 , pp. 619-630
    • Túnez, I.1    Drucker-Colín, R.2    Jimena, I.3    Medina, F.J.4    Muñoz, M.C.5    Peña, J.6    Montilla, P.7
  • 103
    • 7644237780 scopus 로고    scopus 로고
    • Protective effect of melatonin on 3-nitropropionic acid-induced oxidative stress in synaptosomes in an animal model of Huntington's disease
    • Túnez, I.; Montilla, P.; Muñoz, M.C.; Feijóo, M.; Salcedo, M. Protective effect of melatonin on 3-nitropropionic acid-induced oxidative stress in synaptosomes in an animal model of Huntington's disease. J. Pineal Res. 2004b, 37, 252-256.
    • (2004) J. Pineal Res. , vol.37 , pp. 252-256
    • Túnez, I.1    Montilla, P.2    Muñoz, M.C.3    Feijóo, M.4    Salcedo, M.5
  • 104
    • 8444222031 scopus 로고    scopus 로고
    • Effect of nicotine on 3-nitropropionic acid-induced oxidative stress in synaptosomes
    • Túnez, I.; Montilla, P.; Muñoz, M.C.; Drucker-Colín, R. Effect of nicotine on 3-nitropropionic acid-induced oxidative stress in synaptosomes. Eur. J. Pharmacol. 2004a, 504, 169-175.
    • (2004) Eur. J. Pharmacol. , vol.504 , pp. 169-175
    • Túnez, I.1    Montilla, P.2    Muñoz, M.C.3    Drucker-Colín, R.4
  • 105
    • 22144463233 scopus 로고    scopus 로고
    • Treatment with dehydroepiandrosterone prevents oxidative stress induced by 3-nitropropionic acid in synaptosomes
    • Túnez, I.; Muñoz, M.C.; Montilla, P. Treatment with dehydroepiandrosterone prevents oxidative stress induced by 3-nitropropionic acid in synaptosomes. Pharmacology 2005, 74, 113-118.
    • (2005) Pharmacology , vol.74 , pp. 113-118
    • Túnez, I.1    Muñoz, M.C.2    Montilla, P.3
  • 106
    • 20744440945 scopus 로고    scopus 로고
    • Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo
    • Shih, A.Y.; Imbeault, S.; Barakauskas, V.; Erb, H.; Jiang, L.; Li, P.; Murphy, T.H. Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo. J. Biol. Chem. 2005, 280, 22925-22936.
    • (2005) J. Biol. Chem. , vol.280 , pp. 22925-22936
    • Shih, A.Y.1    Imbeault, S.2    Barakauskas, V.3    Erb, H.4    Jiang, L.5    Li, P.6    Murphy, T.H.7
  • 109
    • 0030997707 scopus 로고    scopus 로고
    • Quantifiable bradykinesia, gait abnormalities and Huntington's disease-like striatal lesions in rats chronically treated with 3-nitropropionic acid
    • Guyot, M.C.; Hantraye, P., Dolan, R.; Palfi S., Maziére, M.; Brouillet, E. Quantifiable bradykinesia, gait abnormalities and Huntington's disease-like striatal lesions in rats chronically treated with 3-nitropropionic acid. Neuroscience 1997, 79, 45-56.
    • (1997) Neuroscience , vol.79 , pp. 45-56
    • Guyot, M.C.1    Hantraye, P.2    Dolan, R.3    Palfi, S.4    Maziére, M.5    Brouillet, E.6
  • 110
    • 0023118066 scopus 로고
    • Nature and distribution of brain lesions in rats intoxicated with 3-nitropropionic acid: A type of hypoxic (energy deficient) brain damage
    • Hamilton, B.F.; Gould, D.H. Nature and distribution of brain lesions in rats intoxicated with 3-nitropropionic acid: A type of hypoxic (energy deficient) brain damage. Acta Neuropathol. 1987, 72, 286-297.
    • (1987) Acta Neuropathol. , vol.72 , pp. 286-297
    • Hamilton, B.F.1    Gould, D.H.2
  • 111
    • 0028077894 scopus 로고
    • Neurochemistry and toxin models in Huntington's disease
    • Beal, M.F. Neurochemistry and toxin models in Huntington's disease. Curr. Opin. Neurol. 1994, 7, 542-547.
    • (1994) Curr. Opin. Neurol. , vol.7 , pp. 542-547
    • Beal, M.F.1
  • 112
    • 0031914584 scopus 로고    scopus 로고
    • Partial inhibition of brain succinate dehydrogenase by 3-nitropropionic acid is sufficient to initiate striatal degeneration in rat
    • Brouillet, E.; Guyot, M.C.; Mittoux, V.; Altairac, S.; Conde, F.; Palfi, S.; Hantraye, P. Partial inhibition of brain succinate dehydrogenase by 3-nitropropionic acid is sufficient to initiate striatal degeneration in rat. J. Neurochem. 1998, 70, 794-805.
    • (1998) J. Neurochem. , vol.70 , pp. 794-805
    • Brouillet, E.1    Guyot, M.C.2    Mittoux, V.3    Altairac, S.4    Conde, F.5    Palfi, S.6    Hantraye, P.7
  • 113
    • 0028862452 scopus 로고
    • Behavioral pathology induced by repeated systemic injections of 3-nitropropionic acid mimics the motoric symptoms of Huntington's disease
    • Borlongan, C.V.; Koutouzis, T.K.; Freeman, T.B.; Cahill, D.W.; Sanberg, P.R. Behavioral pathology induced by repeated systemic injections of 3-nitropropionic acid mimics the motoric symptoms of Huntington's disease. Brain Res. 1995a, 697, 254-257.
    • (1995) Brain Res. , vol.697 , pp. 254-257
    • Borlongan, C.V.1    Koutouzis, T.K.2    Freeman, T.B.3    Cahill, D.W.4    Sanberg, P.R.5
  • 115
    • 0029118136 scopus 로고
    • Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates
    • Brouillet, E.; Hantraye, P.; Ferrante, R.J.; Dolan R.; Leroy-Willig, A.; Kowall, N.W.; Beal, M.F. Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates. Proc. Natl. Acad. Sci. USA 1995, 92, 7105-7109.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 7105-7109
    • Brouillet, E.1    Hantraye, P.2    Ferrante, R.J.3    Dolan, R.4    Leroy-Willig, A.5    Kowall, N.W.6    Beal, M.F.7
  • 116
    • 0015294581 scopus 로고
    • Choreoathetosis and striopallidonigral necrosis due to sodium azide
    • Mettler, F.A. Choreoathetosis and striopallidonigral necrosis due to sodium azide. Exp. Neurol. 1972, 34, 291-308.
    • (1972) Exp. Neurol. , vol.34 , pp. 291-308
    • Mettler, F.A.1
  • 117
    • 0030001887 scopus 로고    scopus 로고
    • Chronic 3-nitropropionic acid treatment in baboons replicates the cognitive and motor deficits of Huntington's disease
    • Palfi, S.; Ferrante, R.J.; Brouillet, E.; Beal M.F.; Dolan, R.; Guyot, M.C.; Peschanski, M.; Hantraye, P. Chronic 3-nitropropionic acid treatment in baboons replicates the cognitive and motor deficits of Huntington's disease. J. Neurosci. 1996, 16, 3019-3025.
    • (1996) J. Neurosci. , vol.16 , pp. 3019-3025
    • Palfi, S.1    Ferrante, R.J.2    Brouillet, E.3    Beal, M.F.4    Dolan, R.5    Guyot, M.C.6    Peschanski, M.7    Hantraye, P.8
  • 118
    • 0021325983 scopus 로고
    • Bicaudate diameter the most specific and simple CT parameter in the diagnosis of Huntington's disease
    • Stober, T., Wussow, W.; Schimrigk, K. Bicaudate diameter the most specific and simple CT parameter in the diagnosis of Huntington's disease. Neuroradiology 1984, 26, 25-28.
    • (1984) Neuroradiology , vol.26 , pp. 25-28
    • Stober, T.1    Wussow, W.2    Schimrigk, K.3
  • 119
    • 0029098675 scopus 로고
    • Moldy sugarcane poisoning-a case report with a brief review
    • Ming, L. Moldy sugarcane poisoning-a case report with a brief review. J. Toxicol. Clin. Toxicol. 1995, 33, 363-367.
    • (1995) J. Toxicol. Clin. Toxicol. , vol.33 , pp. 363-367
    • Ming, L.1
  • 120
    • 0026357457 scopus 로고
    • 3-Nitropropinic acid-exogenous animal neurotoxin and possible human striatal toxin
    • Ludolph, A.C.; He, F.; Spencer, P.S.; Hammerstad, J.; Sabri, M. 3-Nitropropinic acid-exogenous animal neurotoxin and possible human striatal toxin. Can. J. Neurol. Sci. 1991, 18, 492-498.
    • (1991) Can. J. Neurol. Sci. , vol.18 , pp. 492-498
    • Ludolph, A.C.1    He, F.2    Spencer, P.S.3    Hammerstad, J.4    Sabri, M.5
  • 121
    • 0343983913 scopus 로고
    • Nitropropionate the toxic substance of Indigofera, is a suicide inactivator of succinate dehydrogenase
    • Alston, T.A.; Mela, L.; Bright, H.J. Nitropropionate, the toxic substance of Indigofera, is a suicide inactivator of succinate dehydrogenase. Proc. Natl. Acad. Sci. USA 1977, 74, 3767-3771.
    • (1977) Proc. Natl. Acad. Sci. USA , vol.74 , pp. 3767-3771
    • Alston, T.A.1    Mela, L.2    Bright, H.J.3
  • 122
    • 0030919567 scopus 로고    scopus 로고
    • Oxidative damage and metabolic dysfunction in Huntington's disease: Selective vulnerability of the basal ganglia
    • Browne, S.E.; Bowling, A.C.; MacGarvey, U.; Baik, M.J.; Berger, S.C.; Muqit, M.M.; Bird, E.D.; Beal. M. Oxidative damage and metabolic dysfunction in Huntington's disease: Selective vulnerability of the basal ganglia. Ann. Neurol. 1997, 41, 646-653.
    • (1997) Ann. Neurol. , vol.41 , pp. 646-653
    • Browne, S.E.1    Bowling, A.C.2    MacGarvey, U.3    Baik, M.J.4    Berger, S.C.5    Muqit, M.M.6    Bird, E.D.7    Beal., M.8
  • 125
    • 0141621061 scopus 로고    scopus 로고
    • NF-E2-related factor-2 mediates neuroprotection against mitochondrial complex I inhibitors and increased concentrations of intracellular calcium in primary cortical neurons
    • Lee, J.M.; Shih, A.Y.; Murphy, T.H.; Johnson, J.A. NF-E2-related factor-2 mediates neuroprotection against mitochondrial complex I inhibitors and increased concentrations of intracellular calcium in primary cortical neurons. J. Biol. Chem. 2003, 278, 37948-37956.
    • (2003) J. Biol. Chem. , vol.278 , pp. 37948-37956
    • Lee, J.M.1    Shih, A.Y.2    Murphy, T.H.3    Johnson, J.A.4
  • 128
    • 1642497588 scopus 로고    scopus 로고
    • Death of cortical and striatal neurons induced by mitochondrial defect involves differential molecular mechanisms
    • Galas, M.C.; Bizat, N.; Cuvelier, L.; Bantubungi, K.; Brouillet E.; Schiffmann, S.N.; Blum, D. Death of cortical and striatal neurons induced by mitochondrial defect involves differential molecular mechanisms. Neurol. Dis. 2004, 15, 152-159.
    • (2004) Neurol. Dis. , vol.15 , pp. 152-159
    • Galas, M.C.1    Bizat, N.2    Cuvelier, L.3    Bantubungi, K.4    Brouillet, E.5    Schiffmann, S.N.6    Blum, D.7
  • 129
    • 0032479940 scopus 로고    scopus 로고
    • 3-Nitropropionic acid's lethal triplet: Cooperative pathways of neurodegeneration
    • Alexi, T.; Hughes, P.E.; Faull, R.L.; Williams, C.E. 3-Nitropropionic acid's lethal triplet: Cooperative pathways of neurodegeneration. NeuroReport 1998, 9, R57-R64.
    • (1998) Neuro Report , vol.9
    • Alexi, T.1    Hughes, P.E.2    Faull, R.L.3    Williams, C.E.4
  • 133
    • 0027221998 scopus 로고
    • NMDA-dependent superoxide production and neurotoxicity
    • Lafon-Cazal, M.; Pietri, S.; Culcasi, M.; Bockaert, J. NMDA-dependent superoxide production and neurotoxicity. Nature 1993, 364, 535-537.
    • (1993) Nature , vol.364 , pp. 535-537
    • Lafon-Cazal, M.1    Pietri, S.2    Culcasi, M.3    Bockaert, J.4
  • 134
    • 0034628981 scopus 로고    scopus 로고
    • 3-Nitropropionic acid induced in vivo protein oxidation in striatal and cortical synaptosomes: Insights into Huntington's disease
    • La Fontaine, M.A.; Geddes, J.W.; Banks, A.; Butterfield D.A. 3-Nitropropionic acid induced in vivo protein oxidation in striatal and cortical synaptosomes: Insights into Huntington's disease. Brain Res. 2000, 858, 356-362.
    • (2000) Brain Res. , vol.858 , pp. 356-362
    • La Fontaine, M.A.1    Geddes, J.W.2    Banks, A.3    Butterfield, D.A.4
  • 135
    • 0041914628 scopus 로고    scopus 로고
    • Differential responsiveness of rat striatal nerve endings to the mitochondrial toxin 3-nitropropionic acid: Implications for Huntington's disease
    • Marti, M.; Mela, F.; Ulazzi, L.; Hanau, S.; Stocchi, S.; Paganini, F.; Beani, L.; Bianchi, C.; Morari, M. Differential responsiveness of rat striatal nerve endings to the mitochondrial toxin 3-nitropropionic acid: Implications for Huntington's disease. Eur. J. Neurosci. 2003, 18, 759-767.
    • (2003) Eur. J. Neurosci. , vol.18 , pp. 759-767
    • Marti, M.1    Mela, F.2    Ulazzi, L.3    Hanau, S.4    Stocchi, S.5    Paganini, F.6    Beani, L.7    Bianchi, C.8    Morari, M.9
  • 136
    • 0033930553 scopus 로고    scopus 로고
    • 3-Nitropropionic acid neurotoxicity in organotypic striatal and corticostriatal slice cultures is dependent on glucose and glutamate
    • Storgaard, J.; Kornblit, BT.; Zimmer, J; Gramsbergen, J.B. 3-Nitropropionic acid neurotoxicity in organotypic striatal and corticostriatal slice cultures is dependent on glucose and glutamate. Exp. Neurol. 2000, 164, 227-235.
    • (2000) Exp. Neurol. , vol.164 , pp. 227-235
    • Storgaard, J.1    Kornblit, B.T.2    Zimmer J3    Gramsbergen, J.B.4
  • 137
    • 0023895734 scopus 로고
    • Glutamate becomes neurotoxic via the Nmethyl-D-aspartate receptor when intracellular energy levels are reduced
    • Novelli, A.; Reilly, A.; Lysk, P.G.; Henneberry, R.C. Glutamate becomes neurotoxic via the Nmethyl-D-aspartate receptor when intracellular energy levels are reduced. Brain Res. 1988, 451, 205-212.
    • (1988) Brain Res. , vol.451 , pp. 205-212
    • Novelli, A.1    Reilly, A.2    Lysk, P.G.3    Henneberry, R.C.4
  • 138
    • 0022446150 scopus 로고
    • Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid
    • Beal, M.F.; Kowall, N.W.; Ellison, D.W.; Mazurek, M.F.; Swartz, K.J.; Martin, J.B. Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid. Nature 1986, 321, 168-171.
    • (1986) Nature , vol.321 , pp. 168-171
    • Beal, M.F.1    Kowall, N.W.2    Ellison, D.W.3    Mazurek, M.F.4    Swartz, K.J.5    Martin, J.B.6
  • 139
    • 59849105972 scopus 로고    scopus 로고
    • N-methyl-D-aspartate receptor antagonists have variable affect in 3-nitropropionic acid toxicity
    • Nasr, P.; Carbery, T.; Geddes, J.W. N-methyl-D-aspartate receptor antagonists have variable affect in 3-nitropropionic acid toxicity. Neurochem. Res. 2009, 34, 490-498.
    • (2009) Neurochem. Res. , vol.34 , pp. 490-498
    • Nasr, P.1    Carbery, T.2    Geddes, J.W.3
  • 141
    • 0344837396 scopus 로고    scopus 로고
    • Microglial activation and cell death induced by the mitochondial toxin 3-nitropropionic acid: In vitro and in vivo studies
    • Ryu, J.K.; Nagai, A.; Kim, J.; Lee, M.C.; McLarnon, J.G.; Kim, S.U. Microglial activation and cell death induced by the mitochondial toxin 3-nitropropionic acid: In vitro and in vivo studies. Neurobiol. Dis. 2003, 12, 121-132.
    • (2003) Neurobiol. Dis. , vol.12 , pp. 121-132
    • Ryu, J.K.1    Nagai, A.2    Kim, J.3    Lee, M.C.4    McLarnon, J.G.5    Kim, S.U.6
  • 142
    • 0033844723 scopus 로고    scopus 로고
    • Astroglial trophic support and neuronal cell death: influence of cellular energy level on type of cell death induced by mitochondrial toxin in cultured rat cortical neurons
    • Ohgoh, M.; Shimizu, H.; Ogura, H.; Nishizawa, Y. Astroglial trophic support and neuronal cell death: influence of cellular energy level on type of cell death induced by mitochondrial toxin in cultured rat cortical neurons. J. Neurochem. 2000, 75, 925-933.
    • (2000) J. Neurochem. , vol.75 , pp. 925-933
    • Ohgoh, M.1    Shimizu, H.2    Ogura, H.3    Nishizawa, Y.4
  • 144
    • 39749150607 scopus 로고    scopus 로고
    • Endogenous dopamine enhances the neurotoxicity of 3-nitropropionic acid in the striatum through the increase of mitochondrial respiratory inhibition and free radicals production
    • Villarán, R.F.; Tomás-Camardiel, M.; de Pablos, R.M.; Santiago, M.; Herrera, A.J.; Navarro, A.; Machado, A.; Cano, J. Endogenous dopamine enhances the neurotoxicity of 3-nitropropionic acid in the striatum through the increase of mitochondrial respiratory inhibition and free radicals production. Neurotoxicology 2008, 29, 244-258.
    • (2008) Neurotoxicology , vol.29 , pp. 244-258
    • Villarán, R.F.1    Tomás-Camardiel, M.2    De Pablos, R.M.3    Santiago, M.4    Herrera, A.J.5    Navarro, A.6    Machado, A.7    Cano, J.8
  • 146
    • 0035936965 scopus 로고    scopus 로고
    • White matter damage following systemic injection of the mitochondrial inhibitor 3-nitropropionic acid in rat
    • McCracken, E.; Dewar, D.; Hunter, A.J. White matter damage following systemic injection of the mitochondrial inhibitor 3-nitropropionic acid in rat. Brain Res. 2001, 892, 329-335.
    • (2001) Brain Res. , vol.892 , pp. 329-335
    • McCracken, E.1    Dewar, D.2    Hunter, A.J.3
  • 150
    • 0034022333 scopus 로고    scopus 로고
    • The striatum is the most vulnerable region in the brain to mitochondrial energy compromise: A hypothesis to explain its specific vulnerability
    • Nishino, H.; Hida, H.; Kumazaki, M.; Shimano, Y.; Nakajima, K.; Shimizu, H.; Ooiwa, T.; Baba, H. The striatum is the most vulnerable region in the brain to mitochondrial energy compromise: A hypothesis to explain its specific vulnerability. J. Neurotrauma 2000, 17, 251-260.
    • (2000) J. Neurotrauma , vol.17 , pp. 251-260
    • Nishino, H.1    Hida, H.2    Kumazaki, M.3    Shimano, Y.4    Nakajima, K.5    Shimizu, H.6    Ooiwa, T.7    Baba, H.8
  • 151
    • 33745013111 scopus 로고    scopus 로고
    • Oxidative stress and neurodegeneration: Where are we now?
    • Halliwell, B. Oxidative stress and neurodegeneration: Where are we now? J. Neurochem. 2006, 97, 1634-1658.
    • (2006) J. Neurochem. , vol.97 , pp. 1634-1658
    • Halliwell, B.1
  • 152
    • 33745039466 scopus 로고    scopus 로고
    • Nitric oxide, cell bioenergetics and neurodegeneration
    • Moncada, S.; Bolaños, J.P. Nitric oxide, cell bioenergetics and neurodegeneration. J. Neurochem. 2006, 97, 1676-1689.
    • (2006) J. Neurochem. , vol.97 , pp. 1676-1689
    • Moncada, S.1    Bolanos, J.P.2
  • 153
    • 0018801043 scopus 로고
    • Inactivation of succinate dehydrogenase by 3-nitropropionate
    • Coles, C.J.; Edmondson, D.E.; Singer, T.P. Inactivation of succinate dehydrogenase by 3-nitropropionate. J. Biol. Chem. 1979, 254, 5161-5167.
    • (1979) J. Biol. Chem. , vol.254 , pp. 5161-5167
    • Coles, C.J.1    Edmondson, D.E.2    Singer, T.P.3
  • 154
    • 0027477946 scopus 로고
    • Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?
    • Beal, M.F.; Hyman, B.T.; Koroshetz, W. Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases? Trends Neurosci. 1993, 16, 125-131.
    • (1993) Trends Neurosci. , vol.16 , pp. 125-131
    • Beal, M.F.1    Hyman, B.T.2    Koroshetz, W.3
  • 155
  • 156
    • 10144229354 scopus 로고    scopus 로고
    • A novel azulenyl nitrone antioxidant protects against MPTP and 3-nitropropionic acid neurotoxicities
    • Yang, L.; Calingasan, N.Y.; Chen, J.; Ley, J.J.; Becker, D.A.; Beal, M.F. A novel azulenyl nitrone antioxidant protects against MPTP and 3-nitropropionic acid neurotoxicities. Exp. Neurol. 2005, 191, 86-93.
    • (2005) Exp. Neurol. , vol.191 , pp. 86-93
    • Yang, L.1    Calingasan, N.Y.2    Chen, J.3    Ley, J.J.4    Becker, D.A.5    Beal, M.F.6
  • 157
    • 0032584691 scopus 로고    scopus 로고
    • Effect of acute exposure to 3-nitropropionic acid on activities of endogenous antioxidants in the rat brain
    • Binienda, Z.; Simmons, C.; Hussain, S.; Slikker, W. Jr.; Ali, S.F. Effect of acute exposure to 3-nitropropionic acid on activities of endogenous antioxidants in the rat brain. Neurosci. Lett. 1998, 251, 173-176.
    • (1998) Neurosci. Lett. , vol.251 , pp. 173-176
    • Binienda, Z.1    Simmons, C.2    Hussain, S.3    Slikker Jr., W.4    Ali, S.F.5
  • 159
    • 20144376099 scopus 로고    scopus 로고
    • Melatonin protects against neuronal damage induced by 3-nitropropionic acid in rat striatum
    • Nam, E.; Lee, S.M.; Koh, S.E.; Joo, W.S.; Maeng, S.; Im, H.I.; Kim, Y.S. Melatonin protects against neuronal damage induced by 3-nitropropionic acid in rat striatum. Brain Res. 2005, 1046, 90-96.
    • (2005) Brain Res. , vol.1046 , pp. 90-96
    • Nam, E.1    Lee, S.M.2    Koh, S.E.3    Joo, W.S.4    Maeng, S.5    Im, H.I.6    Kim, Y.S.7
  • 161
    • 0030222107 scopus 로고    scopus 로고
    • Involvement of oxidative stress in 3- nitropropionic acid neurotoxicity
    • Schulz, J.B.; Henshaw, D.R.; MacGarvey, U.; Beal, M.F. Involvement of oxidative stress in 3- nitropropionic acid neurotoxicity. Neurochem. Int. 1996, 29, 167-171.
    • (1996) Neurochem. Int. , vol.29 , pp. 167-171
    • Schulz, J.B.1    Henshaw, D.R.2    MacGarvey, U.3    Beal, M.F.4
  • 163
    • 0037293568 scopus 로고    scopus 로고
    • Nitric oxide, superoxide, and peroxynitrite in myocardial ischaemiareperfusion injury and preconditioning
    • Ferdinandy, P.; Schulz, R. Nitric oxide, superoxide, and peroxynitrite in myocardial ischaemiareperfusion injury and preconditioning. Br. J. Pharmacol. 2003, 138, 532-543.
    • (2003) Br. J. Pharmacol. , vol.138 , pp. 532-543
    • Ferdinandy, P.1    Schulz, R.2
  • 164
    • 0035854087 scopus 로고    scopus 로고
    • Topological analysis of striatal lesions induced by 3-nitropropionic acid in the Lewis rat
    • Blum, D.; Gall, D.; Cuvelier, L.; Schiffmann, S.N. Topological analysis of striatal lesions induced by 3-nitropropionic acid in the Lewis rat. Neuroreport 2001, 12, 1769-1772.
    • (2001) Neuroreport , vol.12 , pp. 1769-1772
    • Blum, D.1    Gall, D.2    Cuvelier, L.3    Schiffmann, S.N.4
  • 165
    • 0030946503 scopus 로고    scopus 로고
    • Mechanisms of cell death induced by the mitochondrial toxin 3- nitropropionic acid: Acute excitotoxic necrosis and delayed apoptosis
    • Pang, Z.; Geddes, J.W. Mechanisms of cell death induced by the mitochondrial toxin 3- nitropropionic acid: Acute excitotoxic necrosis and delayed apoptosis. J. Neurosci. 1997, 17, 3064-3073.
    • (1997) J. Neurosci. , vol.17 , pp. 3064-3073
    • Pang, Z.1    Geddes, J.W.2
  • 166
    • 0027406823 scopus 로고
    • Age dependence of striatal neuronal death caused by mitochondrial dysfunction
    • Bossi, S.R.; Simpson, J.R.; Isacson, O. Age dependence of striatal neuronal death caused by mitochondrial dysfunction. Neuroreport 1993, 4, 73-76.
    • (1993) Neuroreport , vol.4 , pp. 73-76
    • Bossi, S.R.1    Simpson, J.R.2    Isacson, O.3
  • 168
    • 0027510177 scopus 로고
    • Pre- and postsynaptic neurotoxic effects of dopamine demostrated by intrastriatal injection
    • Filloux, F.; Townsend, J.J. Pre- and postsynaptic neurotoxic effects of dopamine demostrated by intrastriatal injection. Exp. Neuro. 1993, 119, 79-88.
    • (1993) Exp. Neuro. , vol.119 , pp. 79-88
    • Filloux, F.1    Townsend, J.J.2
  • 169
    • 0032402138 scopus 로고    scopus 로고
    • Dopamine modulates the susceptibility of striatal neurons to 3-nitropropionic acid in the rat model of Huntington's disease
    • Reynolds, D.S.; Carter, R.J.; Morton, A.J. Dopamine modulates the susceptibility of striatal neurons to 3-nitropropionic acid in the rat model of Huntington's disease. J. Neurosci. 1998, 18, 10116-10127.
    • (1998) J. Neurosci. , vol.18 , pp. 10116-10127
    • Reynolds, D.S.1    Carter, R.J.2    Morton, A.J.3
  • 171
    • 0038231381 scopus 로고    scopus 로고
    • Adenosine receptors and Huntington's disease: Implications for pathogenesis and therapeutics
    • Blum, D.; Hourez, R.; Galas, M.C.; Popoli, P.; Schiffmann, S.N. Adenosine receptors and Huntington's disease: Implications for pathogenesis and therapeutics. Lancet Neurol. 2003, 2, 366-374.
    • (2003) Lancet Neurol. , vol.2 , pp. 366-374
    • Blum, D.1    Hourez, R.2    Galas, M.C.3    Popoli, P.4    Schiffmann, S.N.5
  • 173
    • 0036856107 scopus 로고    scopus 로고
    • Loss of Cannabinoid CB(1) receptors in the basal ganglia in the late akinetic phase of rats with experimental Huntington's disease
    • Lastres-Becker, I.; Gómez, M.; De Miguel, R.; Ramos, J.A.; Fernández-Ruiz, J. Loss of Cannabinoid CB(1) receptors in the basal ganglia in the late akinetic phase of rats with experimental Huntington's disease. Neurotox Res. 2002, 4, 601-608.
    • (2002) Neurotox Res. , vol.4 , pp. 601-608
    • Lastres-Becker, I.1    Gómez, M.2    De Miguel, R.3    Ramos, J.A.4    Fernández-Ruiz, J.5
  • 178
    • 34047130812 scopus 로고    scopus 로고
    • Role of brain-derived neurotrophic factor in Huntington's disease
    • Zuccato, C.; Cattaneo, E. Role of brain-derived neurotrophic factor in Huntington's disease. Prog. Neurobiol. 2007, 81, 294-330.
    • (2007) Prog. Neurobiol. , vol.81 , pp. 294-330
    • Zuccato, C.1    Cattaneo, E.2
  • 180
    • 0036500605 scopus 로고    scopus 로고
    • Postsynaptic induction of BDNF-mediated long-term potentiation
    • Kovalchuk, Y.; Hanse, E.; Kafitz , KW.; Konnerth, A. Postsynaptic induction of BDNF-mediated long-term potentiation. Science 2002, 295, 1729-1734.
    • (2002) Science , vol.295 , pp. 1729-1734
    • Kovalchuk, Y.1    Hanse, E.2    Kafitz, K.W.3    Konnerth, A.4
  • 181
    • 0034595722 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor in Huntington disease
    • Ferrer, I.; Goutan, E.; Marín, C.; Rey, M.J.; Ribalta, T. Brain-derived neurotrophic factor in Huntington disease. Brain Res. 2000, 866, 257-261.
    • (2000) Brain Res. , vol.866 , pp. 257-261
    • Ferrer, I.1    Goutan, E.2    Marín, C.3    Rey, M.J.4    Ribalta, T.5
  • 182
    • 0037383626 scopus 로고    scopus 로고
    • The coupling of a trkB tyrosine residue to LTP
    • Ernfors, P.; Bramham, C.R. The coupling of a trkB tyrosine residue to LTP. Trends Neurosci. 2003, 26, 171-173.
    • (2003) Trends Neurosci. , vol.26 , pp. 171-173
    • Ernfors, P.1    Bramham, C.R.2
  • 183
    • 0033762841 scopus 로고    scopus 로고
    • BDNF protects against spatial memory deficits following neonatal hypoxia-ischemia
    • Almli, C.R.; Levy, T.J.; Han, B.H.; Shah, A.R.; Gidday, J.M.; Holtzman, D.M. BDNF protects against spatial memory deficits following neonatal hypoxia-ischemia. Exp. Neurol. 2000, 166, 99-114.
    • (2000) Exp. Neurol. , vol.166 , pp. 99-114
    • Almli, C.R.1    Levy, T.J.2    Han, B.H.3    Shah, A.R.4    Gidday, J.M.5    Holtzman, D.M.6
  • 184
    • 0034087784 scopus 로고    scopus 로고
    • Region-specific neurotrophin imbalances in Alzheimer disease: Decreased levels of brain-derived neurotrophic factor and increased levels of nerve growth factor in hippocampus and cortical areas
    • Hock, C.; Heese, K.; Hulette, C.; Rosenberg, C.; Otten, U. Region-specific neurotrophin imbalances in Alzheimer disease: Decreased levels of brain-derived neurotrophic factor and increased levels of nerve growth factor in hippocampus and cortical areas. Arch. Neurol. 2000, 57, 846-851.
    • (2000) Arch. Neurol. , vol.57 , pp. 846-851
    • Hock, C.1    Heese, K.2    Hulette, C.3    Rosenberg, C.4    Otten, U.5
  • 185
    • 0141449073 scopus 로고    scopus 로고
    • Neuroprotection and neuronal dysfunction upon repetitive inhibition of oxidative phosphorylation
    • Hellweg, R.; von Arnim, C.A.; Büchner, M.; Huber, R.; Riepe, M.W. Neuroprotection and neuronal dysfunction upon repetitive inhibition of oxidative phosphorylation. Exp. Neurol. 2003, 183, 346-354.
    • (2003) Exp. Neurol. , vol.183 , pp. 346-354
    • Hellweg, R.1    Von Arnim, C.A.2    Büchner, M.3    Huber, R.4    Riepe, M.W.5
  • 187
    • 3142721782 scopus 로고    scopus 로고
    • Induction of phase 2 genes by sulforaphane protects retinal pigment epithelial cells against photooxidative damage
    • Gao, X.; Talalay, P. Induction of phase 2 genes by sulforaphane protects retinal pigment epithelial cells against photooxidative damage. Proc. Natl. Acad. Sci. USA 2004, 101, 10446-10451.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 10446-10451
    • Gao, X.1    Talalay, P.2
  • 188
    • 11844253848 scopus 로고    scopus 로고
    • Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription
    • Calkins, M.J.; Jakel, R.J.; Johnson, D.A.; Chan, K.; Kan, Y.W.; Johnson, J.A. Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription. Proc. Natl. Acad. Sci. USA 2005, 102, 244-249.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 244-249
    • Calkins, M.J.1    Jakel, R.J.2    Johnson, D.A.3    Chan, K.4    Kan, Y.W.5    Johnson, J.A.6
  • 189
    • 2442542312 scopus 로고    scopus 로고
    • PERK-dependent activation of Nrf2 contributes to redox homeostasisnd cell survival following endoplasmic reticulum stress
    • Cullinan, S.B.; Diehl, J.A. PERK-dependent activation of Nrf2 contributes to redox homeostasisnd cell survival following endoplasmic reticulum stress. J. Biol. Chem. 2004, 279, 20108-20117.
    • (2004) J. Biol. Chem. , vol.279 , pp. 20108-20117
    • Cullinan, S.B.1    Diehl, J.A.2
  • 191
    • 0037434737 scopus 로고    scopus 로고
    • Nrf2 is an inhibitor of the Fas pathway as identified by Achilles'Hell Method, a new function-based approach to gene identification in human cells
    • Kotlo, K.U.; Yehiely, F.; Harasty, H.; Hesabi, B.; Shchors, K.; Einat, P.; Rozen, A.; Berent, E.; Deiss, L.P. Nrf2 is an inhibitor of the Fas pathway as identified by Achilles'Hell Method, a new function-based approach to gene identification in human cells. Oncogene 2003, 22, 797-806.
    • (2003) Oncogene , vol.22 , pp. 797-806
    • Kotlo, K.U.1    Yehiely, F.2    Harasty, H.3    Hesabi, B.4    Shchors, K.5    Einat, P.6    Rozen, A.7    Berent, E.8    Deiss, L.P.9
  • 192
    • 33645957926 scopus 로고    scopus 로고
    • Caspase-dependent and - independent cell death induced by 3-nitropropionic acid in rat cortical neurons
    • Almeida, S.; Brett, A.C., Góis, I.N.; Oliveira, C.R.; Rego, A.C. Caspase-dependent and - independent cell death induced by 3-nitropropionic acid in rat cortical neurons. J. Cell Biochem. 2006, 98, 93-101.
    • (2006) J. Cell Biochem. , vol.98 , pp. 93-101
    • Almeida, S.1    Brett, A.C.2    Góis, I.N.3    Oliveira, C.R.4    Rego, A.C.5
  • 193
    • 9644265271 scopus 로고    scopus 로고
    • FK506 prevents mitochondrial-dependent apoptotic cell death induced by 3-nitropropionic acid in rat primary cortical cultures
    • Almeida, S.; Domingues, A.; Rodrigues, L.; Oliveira, C.R.; Rego, A.C. FK506 prevents mitochondrial-dependent apoptotic cell death induced by 3-nitropropionic acid in rat primary cortical cultures. Neurobiol. Dis. 2004, 17, 435-444.
    • (2004) Neurobiol. Dis. , vol.17 , pp. 435-444
    • Almeida, S.1    Domingues, A.2    Rodrigues, L.3    Oliveira, C.R.4    Rego, A.C.5
  • 194
    • 9644307904 scopus 로고    scopus 로고
    • Caspase-2 permeabilizes the outer mitochondrial membrane and disrupts the binding of cytochrome c to anionic phospholipids
    • Enoksson, M.; Robertson, J.D.; Gogvadze, V.; Bu, P.; Kropotov, A.; Zhivotovsky, B.; Orrenius, S. Caspase-2 permeabilizes the outer mitochondrial membrane and disrupts the binding of cytochrome c to anionic phospholipids. J. Biol. Chem. 2004, 279, 49575-49578.
    • (2004) J. Biol. Chem. , vol.279 , pp. 49575-49578
    • Enoksson, M.1    Robertson, J.D.2    Gogvadze, V.3    Bu, P.4    Kropotov, A.5    Zhivotovsky, B.6    Orrenius, S.7
  • 195
    • 0037088935 scopus 로고    scopus 로고
    • The mitochondrial toxin 3-nitropropionic acid induces striatal neurodegeneration via a c-jun N-terminal kinase/c- Jun module
    • Garcia, M.; Vanhoutte, P.; Pages, C.; Besson, M.J.; Brouillet. E.; Caboche, J. The mitochondrial toxin 3-nitropropionic acid induces striatal neurodegeneration via a c-jun N-terminal kinase/c- Jun module. J. Neurosci. 2002, 22, 2174-2184.
    • (2002) J. Neurosci. , vol.22 , pp. 2174-2184
    • Garcia, M.1    Vanhoutte, P.2    Pages, C.3    Besson, M.J.4    Brouillet., E.5    Caboche, J.6
  • 197
    • 37549034249 scopus 로고    scopus 로고
    • Induction of apoptosis signal-regulating kinase 1 and oxidative stress mediate age dependent vulnerability to 3-nitropropionic acid in the mouse striatum
    • Minn, Y.; Cho, K.J.; Kim, H.W.; Kim, H.J.; Suk, S.H., Lee, B.I.; Kim, G.W. Induction of apoptosis signal-regulating kinase 1 and oxidative stress mediate age dependent vulnerability to 3-nitropropionic acid in the mouse striatum. Neurosci. Lett. 2008, 430, 142-146.
    • (2008) Neurosci. Lett. , vol.430 , pp. 142-146
    • Minn, Y.1    Cho, K.J.2    Kim, H.W.3    Kim, H.J.4    Suk, S.H.5    Lee, B.I.6    Kim, G.W.7
  • 201
    • 0033636761 scopus 로고    scopus 로고
    • Cell cycle regulators in neuronal death evoked by excitotoxic stress: Implications for neurodegeneration and its treatment
    • Park, D.S.; Obeidat, A.; Giovanni, A.; Greene, L.A. Cell cycle regulators in neuronal death evoked by excitotoxic stress: Implications for neurodegeneration and its treatment. Neurobiol. Aging 2000, 21, 771-781.
    • (2000) Neurobiol. Aging , vol.21 , pp. 771-781
    • Park, D.S.1    Obeidat, A.2    Giovanni, A.3    Greene, L.A.4
  • 202
    • 0034608578 scopus 로고    scopus 로고
    • Differentially displayed genes in neuroblastoma cells treated with a mitochondrial toxin: Evidence for possible involvement of ICAM-1 in 3-nitropropionic acidmediated neurodegeneration
    • Seidel, B.; Jiang, L.; Wolf, G. Differentially displayed genes in neuroblastoma cells treated with a mitochondrial toxin: Evidence for possible involvement of ICAM-1 in 3-nitropropionic acidmediated neurodegeneration. Toxicol. Lett. 2000, 115, 213-222.
    • (2000) Toxicol. Lett. , vol.115 , pp. 213-222
    • Seidel, B.1    Jiang, L.2    Wolf, G.3
  • 205
    • 13444273499 scopus 로고    scopus 로고
    • Development of novel therapies for Huntington's disease: Hope and challenge
    • Qin, Z.H.; Wang, J.; Gu, Z.L. Development of novel therapies for Huntington's disease: Hope and challenge. Acta Pharmacol. Sin. 2005, 26, 129-142.
    • (2005) Acta Pharmacol. Sin. , vol.26 , pp. 129-142
    • Qin, Z.H.1    Wang, J.2    Gu, Z.L.3
  • 206
    • 33748975934 scopus 로고    scopus 로고
    • Animal models of Huntington's disease: Implications in uncovering pathogenic mechanisms and developing therapies
    • Wang, L.H.; Qin, Z.H. Animal models of Huntington's disease: Implications in uncovering pathogenic mechanisms and developing therapies. Acta Pharmacol. Sin. 2006, 27, 1287-1302.
    • (2006) Acta Pharmacol. Sin. , vol.27 , pp. 1287-1302
    • Wang, L.H.1    Qin, Z.H.2
  • 209
    • 42449088459 scopus 로고    scopus 로고
    • Oxidative/nitrative stress, a common factor in different neurotoxic paradigms: An overview
    • Santamaría, A.; Jiménez, M.E. Oxidative/nitrative stress, a common factor in different neurotoxic paradigms: An overview. Curr. Topics Neurochem. 2006, 1-20.
    • (2006) Curr. Topics Neurochem. , pp. 1-20
    • Santamaría, A.1    Jiménez, M.E.2
  • 211
    • 0022323862 scopus 로고
    • Neural grafting in a rat model of Huntington's disease: Progressive neurochemical changes after neostriatal ibotenate lesions and striatal tissue grafting
    • Isacson, O.; Brundin, P.; Gage, F.H.; Björklund, A. Neural grafting in a rat model of Huntington's disease: Progressive neurochemical changes after neostriatal ibotenate lesions and striatal tissue grafting. Neuroscience 1985, 16, 799-817
    • (1985) Neuroscience , vol.16 , pp. 799-817
    • Isacson, O.1    Brundin, P.2    Gage, F.H.3    Björklund, A.4
  • 212
    • 0025279038 scopus 로고
    • A primate model of Huntington's disease: Behavioral and anatomical studies of unilateral excitotoxic lesions of the caudate-putamen in the baboon
    • Hantraye, P.; Riche, D.; Maziere, M.; Isacson, O. A primate model of Huntington's disease: Behavioral and anatomical studies of unilateral excitotoxic lesions of the caudate-putamen in the baboon. Exp. Neurol. 1990, 108, 91-104.
    • (1990) Exp. Neurol. , vol.108 , pp. 91-104
    • Hantraye, P.1    Riche, D.2    Maziere, M.3    Isacson, O.4
  • 214
    • 0034652442 scopus 로고    scopus 로고
    • Comparative effects of oxygen on indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase of the kynurenine pathway
    • Dang, Y.; Dale, W.E.; Brown, O.R. Comparative effects of oxygen on indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase of the kynurenine pathway. Free Radic. Biol. Med. 2000, 15, 615-624.
    • (2000) Free Radic. Biol. Med. , vol.15 , pp. 615-624
    • Dang, Y.1    Dale, W.E.2    Brown, O.R.3
  • 215
    • 9644270316 scopus 로고    scopus 로고
    • Neostriatal and cortical quinolinate levels are increased in early grade Huntington's disease
    • Guidetti, P.; Luthi-Carter, R.E.; Augood, S.J.; Schwarcz, R. Neostriatal and cortical quinolinate levels are increased in early grade Huntington's disease. Neurobiol. Dis. 2004, 17, 455-461.
    • (2004) Neurobiol. Dis. , vol.17 , pp. 455-461
    • Guidetti, P.1    Luthi-Carter, R.E.2    Augood, S.J.3    Schwarcz, R.4
  • 216
    • 77649199751 scopus 로고    scopus 로고
    • New perspectives on brain cell damage, neurodegeneration and neuroprotective strategies
    • Santamaría, A., Jiménez-Capdeville, M.E., Eds.
    • González-Cortés, C.; Santamaría, A. New Perspectives on Brain Cell Damage, Neurodegeneration and Neuroprotective Strategies; Santamaría, A., Jiménez-Capdeville, M.E., Eds. Research Signpost 2007, 37-60.
    • (2007) Research Signpost , pp. 37-60
    • González-Cortés, C.1    Santamaría, A.2
  • 218
    • 0027486072 scopus 로고
    • Neuropharmacology of quinolinic and kynurenic acids
    • Stone, T.W. Neuropharmacology of quinolinic and kynurenic acids. Pharmacol. Rev. 1993, 45, 309-379.
    • (1993) Pharmacol. Rev. , vol.45 , pp. 309-379
    • Stone, T.W.1
  • 219
    • 0025330797 scopus 로고
    • Increased cerebrospinal fluid quinolinic acid, kynurenic acid, and Lkynurenine in acute septicemia
    • Heyes, M.P.; Lackner, A.; Increased cerebrospinal fluid quinolinic acid, kynurenic acid, and Lkynurenine in acute septicemia. J. Neurochem. 1990, 55, 338-341.
    • (1990) J. Neurochem. , vol.55 , pp. 338-341
    • Heyes, M.P.1    Lackner, A.2
  • 220
    • 0025358692 scopus 로고
    • Increased ratio of quinolinic acid to kynurenic acid in cerebrospinal fluid of D retrovirus-infected rhesus macaques: Relationship to clinical and viral status
    • Heyes ,M.P.; Mefford, I.N.; Quearry, B.J.; Dedhia, M.; Lackner, A. Increased ratio of quinolinic acid to kynurenic acid in cerebrospinal fluid of D retrovirus-infected rhesus macaques: Relationship to clinical and viral status. Ann. Neurol. 1990, 27, 666-675.
    • (1990) Ann. Neurol. , vol.27 , pp. 666-675
    • Heyes, M.P.1    Mefford, I.N.2    Quearry, B.J.3    Dedhia, M.4    Lackner, A.5
  • 222
    • 0022622323 scopus 로고
    • Content of quinolinic acid and of other tryptophan metabolites increases in brain regions of rats used as experimental models of hepatic encephalopathy
    • Moroni, F.; Lombardi, G.; Carlà, V.; Pellegrini, D.; Carassale, G.L.; Cortesini, C. Content of quinolinic acid and of other tryptophan metabolites increases in brain regions of rats used as experimental models of hepatic encephalopathy. J. Neurochem. 1986, 46, 869-874.
    • (1986) J. Neurochem. , vol.46 , pp. 869-874
    • Moroni, F.1    Lombardi, G.2    Carlà, V.3    Pellegrini, D.4    Carassale, G.L.5    Cortesini, C.6
  • 224
    • 0024024251 scopus 로고
    • Jr. 3-Hydroxyanthranilate oxygenase activity is increased in the brains of Huntington disease victims
    • Schwarcz, R.; Okuno, E.; White, R.J.; Bird, E.D.; Whetsell, W.O., Jr. 3-Hydroxyanthranilate oxygenase activity is increased in the brains of Huntington disease victims. Proc. Natl. Acad. Sci. USA 1988, 85, 4079-4081.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 4079-4081
    • Schwarcz, R.1    Okuno, E.2    White, R.J.3    Bird, E.D.4    Whetsell, W.O.5
  • 225
    • 0035239223 scopus 로고    scopus 로고
    • Endogenous neurotoxins from tryptophan
    • Stone, T.W. Endogenous neurotoxins from tryptophan. Toxicology 2001, 39, 61-73.
    • (2001) Toxicology , vol.39 , pp. 61-73
    • Stone, T.W.1
  • 226
    • 0022416845 scopus 로고
    • Quinolinic acid and other kynurenines in the central nervous system.
    • Stone, T.W.; Connick, J.H. Quinolinic acid and other kynurenines in the central nervous system. Neuroscience 1985, 15, 597-617.
    • (1985) Neuroscience , vol.15 , pp. 597-617
    • Stone, T.W.1    Connick, J.H.2
  • 227
    • 0024498260 scopus 로고
    • Quinolinic acid concentrations in striatal extracellular fluid reach potentially neurotoxic levels following systemic L-tryptophan loading
    • During, M.J., Heyes, M.P.; Freese, A.; Markey, S.P.; Martin, J.B.; Roth, R.H. Quinolinic acid concentrations in striatal extracellular fluid reach potentially neurotoxic levels following systemic L-tryptophan loading. Brain Res. 1989, 476, 384-387.
    • (1989) Brain Res. , vol.476 , pp. 384-387
    • During, M.J.1    Heyes, M.P.2    Freese, A.3    Markey, S.P.4    Martin, J.B.5    Roth, R.H.6
  • 228
    • 0021042967 scopus 로고
    • On the excitotoxic properties of quinolinic acid, 2,3-piperidine dicarboxylic acids and structurally related compounds
    • Foster, A.C.; Collins, J.F.; Schwarcz, R. On the excitotoxic properties of quinolinic acid, 2,3-piperidine dicarboxylic acids and structurally related compounds. Neuropharmacology 1983, 22, 1331-1342.
    • (1983) Neuropharmacology , vol.22 , pp. 1331-1342
    • Foster, A.C.1    Collins, J.F.2    Schwarcz, R.3
  • 229
    • 0027180115 scopus 로고
    • MK-801, an N-methyl-D-aspartate receptor antagonist, blocks quinolinic acid-induced lipid peroxidation in rat corpus striatum
    • Santamaría, A.; Ríos, C. MK-801, an N-methyl-D-aspartate receptor antagonist, blocks quinolinic acid-induced lipid peroxidation in rat corpus striatum. Neurosci. Lett. 1993, 159, 51-54.
    • (1993) Neurosci. Lett. , vol.159 , pp. 51-54
    • Santamaría, A.1    Ríos, C.2
  • 230
    • 0032191581 scopus 로고    scopus 로고
    • Comparison of intrastriatal injections of quinolinic acid and 3-nitropropionic acid for use in animal models of Huntington's disease
    • Shear, D.A.; Dong, J.; Gundy, C.D.; Haik-Creguer, K.L.; Dunbar, G.L. Comparison of intrastriatal injections of quinolinic acid and 3-nitropropionic acid for use in animal models of Huntington's disease. Prog. Neuropsychopharmacol. Biol. Psychiatry 1998, 22, 1217-1240.
    • (1998) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.22 , pp. 1217-1240
    • Shear, D.A.1    Dong, J.2    Gundy, C.D.3    Haik-Creguer, K.L.4    Dunbar, G.L.5
  • 231
    • 0033406026 scopus 로고    scopus 로고
    • Oxidative stress as a mechanism for quinolinic acid-induced hippocampal damage: Protection by melatonin and deprenyl
    • Behan, W.M.; McDonald, M.; Darlington, L.G.; Stone ,T.W. Oxidative stress as a mechanism for quinolinic acid-induced hippocampal damage: Protection by melatonin and deprenyl. Br. J. Pharmacol. 1999, 128, 1754-1760.
    • (1999) Br. J. Pharmacol. , vol.128 , pp. 1754-1760
    • Behan, W.M.1    McDonald, M.2    Darlington, L.G.3    Stone, T.W.4
  • 232
    • 24944529983 scopus 로고    scopus 로고
    • Excitotoxic brain damage involves early peroxynitrite formation in a model of Huntington's disease in rats: Protective role of iron porphyrinate 5,10,15,20-tetrakis (4-sulfonatophenyl)porphyrinate iron (III)
    • Pérez-De La Cruz, V.; González-Cortés, C.; Galván-Arzate, S.; Medina-Campos, O.N.; Pérez- Severiano, F.; Ali, S.F.; Pedraza-Chaverrí, J.; Santamaría, A. Excitotoxic brain damage involves early peroxynitrite formation in a model of Huntington's disease in rats: Protective role of iron porphyrinate 5,10,15,20-tetrakis (4-sulfonatophenyl)porphyrinate iron (III). Neuroscience 2005, 135, 463-474.
    • (2005) Neuroscience , vol.135 , pp. 463-474
    • Pérez-De La Cruz, V.1    González-Cortés, C.2    Galván-Arzate, S.3    Medina-Campos, O.N.4    Pérez- Severiano, F.5    Ali, S.F.6    Pedraza-Chaverrí, J.7    Santamaría, A.8
  • 234
    • 0033795889 scopus 로고    scopus 로고
    • Possible mediation of quinolinic acid-induced hippocampal damage by reactive oxygen species
    • Stone, T.W.; Behan, W.M.; MacDonald, M.; Darlington, L.G. Possible mediation of quinolinic acid-induced hippocampal damage by reactive oxygen species. Amino Acids. 2000, 19, 275-281.
    • (2000) Amino Acids , vol.19 , pp. 275-281
    • Stone, T.W.1    Behan, W.M.2    MacDonald, M.3    Darlington, L.G.4
  • 235
    • 34249098111 scopus 로고    scopus 로고
    • Exacerbation of excitotoxic neuronal death induced during mitochondrial inhibition in vivo: Relation to energy imbalance or ATP depletion?
    • del Río, P.; Montiel, T.; Chagoya, V.; Massieu, L. Exacerbation of excitotoxic neuronal death induced during mitochondrial inhibition in vivo: Relation to energy imbalance or ATP depletion? Neuroscience 2007, 146, 1561-1570.
    • (2007) Neuroscience , vol.146 , pp. 1561-1570
    • Del Río, P.1    Montiel, T.2    Chagoya, V.3    Massieu, L.4
  • 236
    • 44649183938 scopus 로고    scopus 로고
    • Mild mitochondrial inhibition in vivo enhances glutamate-induced neuronal damage through calpain but not caspase activation: Role of ionotropic glutamate receptors
    • del Río, P.; Massieu, L. Mild mitochondrial inhibition in vivo enhances glutamate-induced neuronal damage through calpain but not caspase activation: Role of ionotropic glutamate receptors. Exp. Neurol. 2008, 212, 179-188.
    • (2008) Exp. Neurol. , vol.212 , pp. 179-188
    • Del Río, P.1    Massieu, L.2
  • 237
    • 0024953850 scopus 로고
    • Neurotoxicity at the N-methyl-Daspartate receptor in energy-compromised neurons. An hypothesis for cell death in aging and disease
    • Henneberry, R.C.; Novelli, A.; Cox, J.A.; Lysko, P.G. Neurotoxicity at the N-methyl-Daspartate receptor in energy-compromised neurons. An hypothesis for cell death in aging and disease. Ann. N.Y. Acad. Sci. 1989a, 568, 225-233.
    • (1989) Ann. N.Y. Acad. Sci. , vol.568 , pp. 225-233
    • Henneberry, R.C.1    Novelli, A.2    Cox, J.A.3    Lysko, P.G.4
  • 238
    • 0024820427 scopus 로고
    • Energy-related neurotoxicity at the NMDA receptor: A possible role in Alzheimer's disease and related disorders
    • Henneberry, R.C.; Novelli, A.; Vigano, M.A.; Reilly, J.A.; Cox, J.A.; Lysko, P.G. Energy-related neurotoxicity at the NMDA receptor: A possible role in Alzheimer's disease and related disorders. Prog. Clin. Biol. Res. 1989b, 317, 143-156.
    • (1989) Prog. Clin. Biol. Res. , vol.317 , pp. 143-156
    • Henneberry, R.C.1    Novelli, A.2    Vigano, M.A.3    Reilly, J.A.4    Cox, J.A.5    Lysko, P.G.6
  • 239
    • 0030047159 scopus 로고    scopus 로고
    • Manipulation of membrane potential modulates malonate-induced striatal excitotoxicity in vivo
    • Greene, J.G.; Greenamyre, J.T.; Manipulation of membrane potential modulates malonate-induced striatal excitotoxicity in vivo. J. Neurochem. 1996, 66, 637-643.
    • (1996) J. Neurochem. , vol.66 , pp. 637-643
    • Greene, J.G.1    Greenamyre, J.T.2
  • 240
    • 0030478699 scopus 로고    scopus 로고
    • Neurodegenerative disorders: Clues from glutamate and energy metabolism
    • Ikonomidou, C.; Turski, L. Neurodegenerative disorders: Clues from glutamate and energy metabolism. Crit. Rev. Neurobiol. 1996, 10, 239-263.
    • (1996) Crit. Rev. Neurobiol. , vol.10 , pp. 239-263
    • Ikonomidou, C.1    Turski, L.2
  • 241
    • 0032454849 scopus 로고    scopus 로고
    • The role of excitotoxicity and metabolic failure in the pathogenesis of neurological disorders
    • Massieu, L.; García, O. The role of excitotoxicity and metabolic failure in the pathogenesis of neurological disorders. Neurobiology (Bp). 1998, 6, 99-108.
    • (1998) Neurobiology (Bp). , vol.6 , pp. 99-108
    • Massieu, L.1    García, O.2
  • 243
    • 0030005568 scopus 로고    scopus 로고
    • Synergistic effects of chronic exposure to subthreshold concentrations of quinolinic acid and malonate in the rat striatum
    • Bazzett, T.J.; Falik, R.C.; Becker, J.B.; Albin, R.L. Synergistic effects of chronic exposure to subthreshold concentrations of quinolinic acid and malonate in the rat striatum. Brain Res. 1996, 718, 228-232.
    • (1996) Brain Res. , vol.718 , pp. 228-232
    • Bazzett, T.J.1    Falik, R.C.2    Becker, J.B.3    Albin, R.L.4
  • 244
    • 1842814974 scopus 로고    scopus 로고
    • Blockade of quinolinic acid-induced neurotoxicity by pyruvate is associated with inhibition of glial activation in a model of Huntington's disease
    • Ryu, J.K.; Kim, S.U.; McLarnon, J.G. Blockade of quinolinic acid-induced neurotoxicity by pyruvate is associated with inhibition of glial activation in a model of Huntington's disease. Exp. Neurol. 2004, 187, 150-159.
    • (2004) Exp. Neurol. , vol.187 , pp. 150-159
    • Ryu, J.K.1    Kim, S.U.2    McLarnon, J.G.3
  • 245
    • 0032698232 scopus 로고    scopus 로고
    • 3-Hydroxykynurenine potentiates quinolinate but not NMDA toxicity in the rat striatum
    • Guidetti, P.; Schwarcz, R. 3-Hydroxykynurenine potentiates quinolinate but not NMDA toxicity in the rat striatum. Eur. J. Neurosci. 1999, 11, 3857-3863.
    • (1999) Eur. J. Neurosci. , vol.11 , pp. 3857-3863
    • Guidetti, P.1    Schwarcz, R.2
  • 246
    • 54049100710 scopus 로고    scopus 로고
    • Prolonged exposures of cerebellar granule neurons to Snitroso- N-acetylpenicillamine (SNAP) induce neuronal damage independently of peroxynitrite
    • Fatokun, A.A.; Stone, T.W.; Smith, R.A. Prolonged exposures of cerebellar granule neurons to Snitroso- N-acetylpenicillamine (SNAP) induce neuronal damage independently of peroxynitrite. Brain Res. 2008, 1230, 265-272.
    • (2008) Brain Res. , vol.1230 , pp. 265-272
    • Fatokun, A.A.1    Stone, T.W.2    Smith, R.A.3
  • 249
    • 61649127498 scopus 로고    scopus 로고
    • Neuroprotective effect of cyclosporine and FK506 against 3-nitropropionic acid induced cognitive dysfunction and glutathione redox in rat: Possible role of nitric oxide
    • Kumar, P.; Kumar, A. Neuroprotective effect of cyclosporine and FK506 against 3- nitropropionic acid induced cognitive dysfunction and glutathione redox in rat: Possible role of nitric oxide. Neurosci. Res. 2009, 63, 302-314.
    • (2009) Neurosci. Res. , vol.63 , pp. 302-314
    • Kumar, P.1    Kumar, A.2
  • 250
    • 70449478417 scopus 로고    scopus 로고
    • Mitochondrial inhibitor 3-nitropropionic acid enhances oxidative modifications of alpha-synuclein in a transgenic mouse model of multiple system atrophy
    • Ubhi, K.; Lee, P.H.; Adame, A.; Inglis, C.; Mante, M.; Rockeinstein, E.; Stefanova, N.; Wenning, G.K.; Masliah, E. Mitochondrial inhibitor 3-nitropropionic acid enhances oxidative modifications of alpha-synuclein in a transgenic mouse model of multiple system atrophy. J. Neurosci. Res. 2009, 87, 2728-2739.
    • (2009) J. Neurosci. Res. , vol.87 , pp. 2728-2739
    • Ubhi, K.1    Lee, P.H.2    Adame, A.3    Inglis, C.4    Mante, M.5    Rockeinstein, E.6    Stefanova, N.7    Wenning, G.K.8    Masliah, E.9
  • 251
    • 67650248280 scopus 로고    scopus 로고
    • Strital dopamine level contributes vto hydroxyl radical generation and subsequent neurodegeneration in the striatum in 3-nitropropionic acid-induced Huntington's disease in rats
    • Pandey, M.; Borah, A.; Varghese, M.; Barman, P.K.; Mohanakumar K.P.; Usha, R. Strital dopamine level contributes vto hydroxyl radical generation and subsequent neurodegeneration in the striatum in 3-nitropropionic acid-induced Huntington's disease in rats. Neurochem. Int. 2009, 55, 431-437.
    • (2009) Neurochem. Int. , vol.55 , pp. 431-437
    • Pandey, M.1    Borah, A.2    Varghese, M.3    Barman, P.K.4    Mohanakumar, K.P.5    Usha, R.6
  • 252
    • 70349896185 scopus 로고    scopus 로고
    • Whole body hyperthermia reduced oxidative stress in the striatum of rats in an animal model of mitochondrial toxicity with 3-nitropropionic acid
    • Medina-Navarro, R.; Guerrero-Linares, I. Whole body hyperthermia reduced oxidative stress in the striatum of rats in an animal model of mitochondrial toxicity with 3-nitropropionic acid. Int. J. Hyperthermia 2009, 25, 280-288.
    • (2009) Int. J. Hyperthermia , vol.25 , pp. 280-288
    • Medina-Navarro, R.1    Guerrero-Linares, I.2
  • 253
    • 65549091910 scopus 로고    scopus 로고
    • Combination therapy with coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's diseases
    • Yang, L.; Calingasan, N.Y.; Wille, E.J.; Cormier, K.; Smith, K.; Ferrante, R.J.; Beal, M.F. Combination therapy with coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's diseases. J. Neurochem. 2009, 109, 1427-1439.
    • (2009) J. Neurochem. , vol.109 , pp. 1427-1439
    • Yang, L.1    Calingasan, N.Y.2    Wille, E.J.3    Cormier, K.4    Smith, K.5    Ferrante, R.J.6    Beal, M.F.7
  • 254
    • 67149091104 scopus 로고    scopus 로고
    • Sesamol attenuate 3-nitropropionic acid-induced Huntingtonlike behavioral, biochemical, and cellular atlerations in rats
    • Kumar, P.; Kalonia, H.; Kumar, A. Sesamol attenuate 3-nitropropionic acid-induced Huntingtonlike behavioral, biochemical, and cellular atlerations in rats. J. Asian Nat. Prod. Res. 2009, 11, 439-450.
    • (2009) J. Asian Nat. Prod. Res. , vol.11 , pp. 439-450
    • Kumar, P.1    Kalonia, H.2    Kumar, A.3
  • 255
    • 69549129286 scopus 로고    scopus 로고
    • Effect of lycopene and epigallocatechin-3-gallate against 3-nitropropionic acid induced cognitive dysfunction and glutathione depletion in rat: A novel nitric oxide mechanism
    • Kumar, P.; Kumar, A. Effect of lycopene and epigallocatechin-3-gallate against 3-nitropropionic acid induced cognitive dysfunction and glutathione depletion in rat: A novel nitric oxide mechanism. Food Chem. Toxicol. 2009, 47, 2522-2530.
    • (2009) Food Chem. Toxicol. , vol.47 , pp. 2522-2530
    • Kumar, P.1    Kumar, A.2
  • 256
    • 68149136975 scopus 로고    scopus 로고
    • Possible neuroprotective effect of Withania somnifera root extract against 3-nitropropionic acid-induced behavioral, biochemical, and mitochondrial dysfunction in an animal model of Huntington's disease
    • Kumar, P.; Kumar, A. Possible neuroprotective effect of Withania somnifera root extract against 3-nitropropionic acid-induced behavioral, biochemical, and mitochondrial dysfunction in an animal model of Huntington's disease. J. Med. Food 2009, 12, 591-600.
    • (2009) J. Med. Food , vol.12 , pp. 591-600
    • Kumar, P.1    Kumar, A.2
  • 260
    • 70349587923 scopus 로고    scopus 로고
    • Early nerve ending rescue from oxidative damage and energy failure by L-carnitine as post-treatment in two neurotoxic models in rat: Recovery of antioxidant and reductive capacities
    • Elinos-Calderón, D.; Robledo-Arratia, Y.; Pérez-De La Cruz, V.; Padraza-Chaverrí, J.; Ali, S.F.; Santamaría, A. Early nerve ending rescue from oxidative damage and energy failure by L-carnitine as post-treatment in two neurotoxic models in rat: Recovery of antioxidant and reductive capacities. Exp. Brain Res. 2009, 197, 287-296.
    • (2009) Exp. Brain Res. , vol.197 , pp. 287-296
    • Elinos-Calderón, D.1    Robledo-Arratia, Y.2    Pérez-De La Cruz, V.3    Padraza-Chaverrí, J.4    Ali, S.F.5    Santamaría, A.6
  • 261
    • 67349117053 scopus 로고    scopus 로고
    • A mouse model for degeneration of the spiral ligament
    • Kada, S.; Nakagawa, T.; Ito, J. A mouse model for degeneration of the spiral ligament. J. Assoc. Res. Otolaryngol. 2009, 10, 161-172.
    • (2009) J. Assoc. Res. Otolaryngol. , vol.10 , pp. 161-172
    • Kada, S.1    Nakagawa, T.2    Ito, J.3
  • 262
    • 63849206749 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors prevent p53-dependent and p53-independent Bax-mediated neuronal apoptosis through two disctinct mechanisms
    • Uo, T.; Veenstra, T.D.; Morrison, R.S. Histone deacetylase inhibitors prevent p53-dependent and p53-independent Bax-mediated neuronal apoptosis through two disctinct mechanisms. J. Neurosci. 2009, 29, 2824-2832.
    • (2009) J. Neurosci. , vol.29 , pp. 2824-2832
    • Uo, T.1    Veenstra, T.D.2    Morrison, R.S.3
  • 263
    • 67349120572 scopus 로고    scopus 로고
    • Complex II inhibition by 3-NP causes mitochondrial fragmentation and neuronal cell death via an NMDA and ROS-dependent pathway
    • Liot, G.; Bossy, B.; Lubitz, S.; Kushnareva, Y.; Sejbuk, N.; Bossy-Wetzel, E. Complex II inhibition by 3-NP causes mitochondrial fragmentation and neuronal cell death via an NMDAand ROS-dependent pathway. Cell Death Differ. 2009, 16, 899-909.
    • (2009) Cell Death Differ. , vol.16 , pp. 899-909
    • Liot, G.1    Bossy, B.2    Lubitz, S.3    Kushnareva, Y.4    Sejbuk, N.5    Bossy-Wetzel, E.6
  • 265
    • 70450220248 scopus 로고    scopus 로고
    • Cytochrome c oxidase isoform IV-2 is involved in 3-nitropropionic acid-induced toxicity in striatal astrocytes
    • Singh, S.; Misiak, M.; Beyer, C.; Arnold, S. Cytochrome c oxidase isoform IV-2 is involved in 3-nitropropionic acid-induced toxicity in striatal astrocytes. Glia 2009, 57, 1480-1491.
    • (2009) Glia , vol.57 , pp. 1480-1491
    • Singh, S.1    Misiak, M.2    Beyer, C.3    Arnold, S.4
  • 266
    • 67349240384 scopus 로고    scopus 로고
    • In vivo dopamine release and uptake impairments in rats treated with 3-nitropropionic acid
    • Kraft, J.C.; Osterhaus, G.L.; Ortiz, A.N.; Garriz, P.A.; Johnson, M.A. In vivo dopamine release and uptake impairments in rats treated with 3-nitropropionic acid. Neuroscience 2009, 161, 940-949.
    • (2009) Neuroscience , vol.161 , pp. 940-949
    • Kraft, J.C.1    Osterhaus, G.L.2    Ortiz, A.N.3    Garriz, P.A.4    Johnson, M.A.5
  • 268
    • 67651005144 scopus 로고    scopus 로고
    • Protective effects of brain-derived neurotrophic factor against neurotoxicity of 3-nitropropionic acid in rat cortical neurons
    • Wu, C.L.; Hwang, C.S.; Yang, D.I. Protective effects of brain-derived neurotrophic factor against neurotoxicity of 3-nitropropionic acid in rat cortical neurons. Neurotoxicology 2009, 30, 718-726.
    • (2009) Neurotoxicology , vol.30 , pp. 718-726
    • Wu, C.L.1    Hwang, C.S.2    Yang, D.I.3
  • 269
    • 67349156695 scopus 로고    scopus 로고
    • Sonic hedgehog mediates BDNF-induced neuroprotection against mitochondrial inhibitor 3-nitropropionic acid
    • Wu, C.L.; Chen, S.D.; Hwang, C.S.; Yang, D.I. Sonic hedgehog mediates BDNF-induced neuroprotection against mitochondrial inhibitor 3-nitropropionic acid. Biochim. Biophys. Res. Commun. 2009, 385, 112-117.
    • (2009) Biochim. Biophys. Res. Commun. , vol.385 , pp. 112-117
    • Wu, C.L.1    Chen, S.D.2    Hwang, C.S.3    Yang, D.I.4
  • 270
    • 68149169019 scopus 로고    scopus 로고
    • BDNF regulates BIM expression levels in 3-nitropropionic acid-treated cortical neurons
    • Almeida, S.; Laço, M.; Cunha-Oliveira, T.; Oliveira, C.R.; Rego, A.C. BDNF regulates BIM expression levels in 3-nitropropionic acid-treated cortical neurons. Nuerobiol. Dis. 2009, 35, 448-456.
    • (2009) Nuerobiol. Dis. , vol.35 , pp. 448-456
    • Almeida, S.1    Laço, M.2    Cunha-Oliveira, T.3    Oliveira, C.R.4    Rego, A.C.5
  • 271
    • 70349744001 scopus 로고    scopus 로고
    • The brain uncoupling protein UCP4 attenuates mitochondrial toxin-induced cell death: Role of extracellular signal-regulated kinases in bioenergetics adaptation and cell survival
    • Wei, Z.; Chigurupati, S.; Bagsiyao, P.; Henriquez, A.; Chan, S.L. The brain uncoupling protein UCP4 attenuates mitochondrial toxin-induced cell death: Role of extracellular signal-regulated kinases in bioenergetics adaptation and cell survival. Neurotox. Res. 2009, 16, 14-29.
    • (2009) Neurotox. Res. , vol.16 , pp. 14-29
    • Wei, Z.1    Chigurupati, S.2    Bagsiyao, P.3    Henriquez, A.4    Chan, S.L.5


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