Efficacy of intradiscal hepatocyte growth factor injection for the treatment of intervertebral disc degeneration

Molecular Medicine Reports

Volumn 8, Issue 1, 2013, Pages 118-122

  Zou, Fei ^a   Jiang, Jianyuan ^a   Lu, Feizhou ^a   Ma, Xiaosheng ^a   Xia, Xinlei ^a   Wang, Lixun ^a   Wang, Hongli ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Degeneration; Hepatocyte growth factor; Intervertebral disc; Rat model

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; COLLAGEN TYPE 1; COLLAGEN TYPE 2; POLYMER; RECOMBINANT SCATTER FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DRUG EFFICACY; FLUOROSCOPY; GEL; HISTOLOGY; IMMUNOHISTOCHEMISTRY; INTERVERTEBRAL DISK DEGENERATION; INTRADISCAL DRUG ADMINISTRATION; INTRASPINAL DRUG ADMINISTRATION; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; NUCLEUS PULPOSUS; PROTEIN EXPRESSION; RAT; STAB WOUND; TREATMENT DURATION;

ANIMALS; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN TYPE I; COLLAGEN TYPE II; DISEASE MODELS, ANIMAL; HEPATOCYTE GROWTH FACTOR; INJECTIONS; INTERVERTEBRAL DISC; INTERVERTEBRAL DISC DEGENERATION; MAGNETIC RESONANCE IMAGING; MALE; RATS;

RATTUS;

EID: 84878901895     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2013.1450     Document Type: Article

References (24)

1. Andersson GB: Epidemiological features of chronic low-back pain. Lancet 354: 581-585, 1999.
2. Nerlich AG, Boos N, Wiest I and Aebi M: Immunolocalization of major interstitial collagen types in human lumbar intervertebral discs of various ages. Virchows Arch 432: 67-76, 1998. (Pubitemid 28065841)
3. Zhao CQ, Wang LM, Jiang LS and Dai LY: The cell biology of intervertebral disc aging and degeneration. Ageing Res Rev 6: 247-261, 2007.
4. Bernick S, Walker JM and Paule WJ: Age changes to the anulus fibrosus in human intervertebral discs. Spine (Phila Pa 1976) 16: 520-524, 1991.
5. Masuda K, Oegema TR Jr and An HS: Growth factors and treatment of intervertebral disc degeneration. Spine (Phila Pa 1976) 29: 2757-2769, 2004.
6. Matsumoto K and Nakamura T: Hepatocyte growth factor: molecular structure, roles in liver regeneration, and other biological functions. Crit Rev Oncog 3: 27-54, 1992.
7. Mizuno S and Nakamura T: Hepatocyte growth factor: a regenerative drug for acute hepatitis and liver cirrhosis. Regen Med 2: 161-170, 2007. (Pubitemid 46831077)
8. Mizuno S, Matsumoto K and Nakamura T: HGF as a renotrophic and anti-fibrotic regulator in chronic renal disease. Front Biosci 13: 7072-7086, 2008.
9. Shigematsu H, Yasuda K, Iwai T, et al: Randomized, double-blind, placebo-controlled clinical trial of hepatocyte growth factor plasmid for critical limb ischemia. Gene Ther 17: 1152-1161, 2010.
10. Powell RJ, Simons M, Mendelsohn FO, et al: Results of a double-blind, placebo-controlled study to assess the safety of intramuscular injection of hepatocyte growth factor plasmid to improve limb perfusion in patients with critical limb ischemia. Circulation 118: 58-65, 2008.
11. Zhang H, La Marca F, Hollister SJ, Goldstein SA and Lin CY: Developing consistently reproducible intervertebral disc degeneration at rat caudal spine by using needle puncture. J Neurosurg Spine 10: 522-530, 2009.
12. Hsieh AH, Hwang D, Ryan DA, Freeman AK and Kim H: Degenerative anular changes induced by puncture are associated with insufficiency of disc biomechanical function. Spine (Phila Pa 1976) 34: 998-1005, 2009.
13. Chen S and Singh J: Controlled release of growth hormone from thermosensitive triblock copolymer systems: In vitro and in vivo evaluation. Int J Pharm 352: 58-65, 2008. (Pubitemid 351284586)
14. Jeong JH, Lee JH, Jin ES, Min JK, Jeon SR and Choi KH: Regeneration of intervertebral discs in a rat disc degeneration model by implanted adipose-tissue-derived stromal cells. Acta Neurochir (Wien) 152: 1771-1777, 2010.
15. Mao HJ, Chen QX, Han B, et al: The effect of injection volume on disc degeneration in a rat tail model. Spine (Phila Pa 1976) 36: E1062-E1069, 2011.
16. Masuda K, Aota Y, Muehleman C, et al: A novel rabbit model of mild, reproducible disc degeneration by an anulus needle puncture: correlation between the degree of disc injury and radiological and histological appearances of disc degeneration. Spine (Phila Pa 1976) 30: 5-14, 2005.
17. Roberts N, Gratin C and Whitehouse GH: MRI analysis of lumbar intervertebral disc height in young and older populations. J Magn Reson Imaging 7: 880-886, 1997. (Pubitemid 28359537)
18. Schiebler ML, Camerino VJ, Fallon MD, Zlatkin MB, Grenier N and Kressel HY: In vivo and ex vivo magnetic resonance imaging evaluation of early disc degeneration with histopathologic correlation. Spine (Phila Pa 1976) 16: 635-640, 1991.
19. Ruan DK, Xin H, Zhang C, et al: Experimental intervertebral disc regeneration with tissue-engineered composite in a canine model. Tissue Engineering Part A 16: 2381-2389, 2010.
20. Sobajima S, Shimer AL, Chadderdon RC, et al: Quantitative analysis of gene expression in a rabbit model of intervertebral disc degeneration by real-time polymerase chain reaction. Spine J 5: 14-23, 2005. (Pubitemid 40104285)
21. Sowa G, Vadalà G, Studer R, et al: Characterization of intervertebral disc aging: longitudinal analysis of a rabbit model by magnetic resonance imaging, histology, and gene expression. Spine (Phila Pa 1976) 33: 1821-1828, 2008.
22. Guehring T, Omlor GW, Lorenz H, et al: Stimulation of gene expression and loss of anular architecture caused by experimental disc degeneration - an in vivo animal study. Spine (Phila Pa 1976) 30: 2510-2515, 2005.
23. Leckie SK, Bechara BP, Hartman RA, et al: Injection of AAV2-BMP2 and AAV2-TIMP1 into the nucleus pulposus slows the course of intervertebral disc degeneration in an in vivo rabbit model. Spine J 12: 7-20, 2012.
24. Li J, Yoon ST and Hutton WC: Effect of bone morphogenetic protein-2 (BMP-2) on matrix production, other BMPs, and BMP receptors in rat intervertebral disc cells. J Spinal Disord Tech 17: 423-428, 2004. (Pubitemid 43020807)