C2′-OH of amphotericin B plays an important role in binding the primary sterol of human cells but not yeast cells

Journal of the American Chemical Society

Volumn 135, Issue 23, 2013, Pages 8488-8491

  Wilcock, Brandon C ^a   Endo, Matthew M ^a   Uno, Brice E ^a   Burke, Martin D ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING CAPACITIES; BINDING INTERACTION; CHANNEL FORMATION; HYDROXYL GROUPS; ISOTHERMAL TITRATION CALORIMETRY; LIMITS OF DETECTION; PRIMARY MECHANISM; STRUCTURAL MODELS;

ALCOHOLS; BINDING ENERGY; CHOLESTEROL; CYTOLOGY; MODEL STRUCTURES; TOXICITY; YEAST;

CELLS;

AMPHOTERICIN B; CHOLESTEROL; ERGOSTEROL; HYDROXYL GROUP; ANTIFUNGAL AGENT; DRUG DERIVATIVE; STEROL;

ANTIFUNGAL ACTIVITY; ARTICLE; BINDING AFFINITY; CHANNEL GATING; CYTOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; ISOTHERMAL TITRATION CALORIMETRY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; YEAST CELL; BINDING SITE; CANDIDA ALBICANS; CHEMISTRY; CONFORMATION; CYTOLOGY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; EPITHELIUM CELL; KIDNEY TUBULE; SACCHAROMYCES CEREVISIAE; STRUCTURE ACTIVITY RELATION; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS;

AMPHOTERICIN B; ANTIFUNGAL AGENTS; BINDING SITES; CANDIDA ALBICANS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; HUMANS; KIDNEY TUBULES; MOLECULAR CONFORMATION; SACCHAROMYCES CEREVISIAE; STEROLS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84878899238     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja403255s     Document Type: Article

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