How do sterols determine the antifungal activity of amphotericin B? Free energy of binding between the drug and its membrane targets

Journal of the American Chemical Society

Volumn 132, Issue 51, 2010, Pages 18266-18272

  Neumann, Anna ^a   Baginski, MacIej ^a   Czub, Jacek ^a,b  

^a GDANSK UNIVERSITY OF TECHNOLOGY   (Poland)

^b MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; ANTI-FUNGAL ACTIVITY; BINARY COMPLEXES; BIOLOGICAL ACTIVITIES; ENERGY PROFILE; FREE ENERGY OF BINDING; FUNGAL CELLS; FUNGAL INFECTION; ION CHANNEL; MAMMALIAN MEMBRANES; MECHANISM OF ACTION; PHOSPHOLIPID BILAYER; STRUCTURAL ORIGIN; TRANSMEMBRANES;

CELL MEMBRANES; CHOLESTEROL; CYTOLOGY; FREE ENERGY; FUNGI; LIPID BILAYERS; MAMMALS; MEMBRANES; PHOSPHOLIPIDS; TOXICITY;

ALCOHOLS;

AMPHOTERICIN B; CHOLESTEROL; ERGOSTEROL; PHOSPHOLIPID;

ANTIFUNGAL ACTIVITY; ARTICLE; BILAYER MEMBRANE; BIOLOGICAL ACTIVITY; COMPLEX FORMATION; DRUG BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; FUNGAL CELL; NONHUMAN; SYSTEMIC MYCOSIS;

AMPHOTERICIN B; ANTIFUNGAL AGENTS; CELL MEMBRANE; CHOLESTEROL; ENTROPY; ERGOSTEROL; FUNGI; STEROLS;

EID: 78650608765     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja1074344     Document Type: Article

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