CD73 Is a Major Regulator of Adenosinergic Signalling in Mouse Brain

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Kulesskaya, Natalia ^a   Võikar, Vootele ^a   Peltola, Marjaana ^a   Yegutkin, Gennady G ^b   Salmi, Marko ^b   Jalkanen, Sirpa ^b   Rauvala, Heikki ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

5' NUCLEOTIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; BASAL GANGLION; BRAIN FUNCTION; CAUDATE NUCLEUS; CONTROLLED STUDY; CORPUS STRIATUM; ENZYME ACTIVITY; ENZYME DEFICIENCY; FEMALE; GLOBUS PALLIDUS; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOGENESIS; LOCOMOTION; MALE; MENINX; MOUSE; NONHUMAN; OLFACTORY BULB; PHENOTYPE; PUTAMEN; SIGNAL TRANSDUCTION; SOCIAL BEHAVIOR; SOCIAL INTERACTION;

MUS;

EID: 84878898774     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0066896     Document Type: Article

References (54)

1. Hasko G, Linden J, Cronstein B, Pacher P, (2008) Adenosine receptor: therapeutic aspects for inflammatory and immune diseases. Nat Rev Drug Discov 7: 759-770.
2. Boison D, Chen JF, Fredholm BB, (2010) Adenosine signaling and function in glial cells. Cell Death Differ 17: 1071-1082.
3. Jones BE, (2009) Glia, adenosine, and sleep. Neuron 61: 156-157.
4. Sebastião AM, Ribeiro JA, (2009) Tuning and fine-tuning of synapses with adenosine. Curr Neuropharmacol 7: 180-194.
5. Ribeiro JA, Sebastião AM, de Mendonça A, (2003) Adenosine receptors in the nervous system: pathophysiological implications. Prog Neurobiol 68: 377-392.
6. Dunwiddie TV, Masino SA, (2001) The role and regulation of adenosine in the central nervous system. Annu Rev Neurosci 24: 31-55.
7. Eltzschig HK, Sitkovsky MV, Robson SC, (2012) Purinergic signaling during inflammation. N Engl J Med 367: 2322-2333.
8. Yegutkin GG, (2008) Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade. Biochim Biophys Acta 1783: 673-694.
9. Niemelä J, Ifergan I, Yegutkin G, Jalkanen S, Prat A, et al. (2008) Interferon-B regulates CD73 and adenosine expression at the blood-brain-barrier. Eur J Immunol 38: 2718-2726.
10. Kiss J, Jalkanen S, Fulop F, Savunen T, Salmi M, (2008) Ischemia-reperfusion injury is attenuated in VAP-1-deficient mice and by VAP-1 inhibitors. Eur J Immunol 38: 3041-3049.
11. Koszalka P, Ozuyaman B, Huo YQ, Zernecke A, Flogel U, et al. (2004) Targeted disruption of cd73/ecto-5 '-nucleotidase alters thromboregulation and augments vascular inflammatory response. Circ Res 95: 814-821.
12. Thompson LF, Eltzschig HK, Ibla JC, Van De Wiele CJ, Resta R, et al. (2004) Crucial role for ecto-5'-nucleotidase (CD73) in vascular leakage during hypoxia. J Exp Med 200: 1395-1405.
13. Võikar V, Polus A, Vasar E, Rauvala H, (2005) Long-term individual housing in C57BL/6J and DBA/2 mice: assessment of behavioral consequences. Genes Brain Behav 4: 240-252.
14. Võikar V, Vasar E, Rauvala H, (2004) Behavioral alterations induced by repeated testing in C57BL/6J and 129S2/Sv mice: implications for phenotyping screens. Genes Brain Behav 3: 27-38.
15. Yegutkin GG, Henttinen T, Jalkanen S, (2001) Extracellular ATP formation on vascular endothelial cells is mediated by ecto-nucleotide kinase activities via phosphotransfer reactions. FASEB J 15: 251-260.
16. Wrenn C, Harris A, Saavedra M, Crawley J, (2003) Social transmission of food preference in mice: methodology and application to galanin-overexpressing transgenic mice. Behav Neurosci 117: 21-31.
17. Messeri P, Eleftheriou B, Oliverio A, (1975) Dominance behavior: a phylogenetic analysis in the mouse. Physiol Behav 14: 53-58.
18. Nadler J, Moy S, Dold G, Trang D, Simmons N, et al. (2004) Automated apparatus for quantitation of social approach behaviors in mice. Genes Brain Behav 3: 303-314.
19. Krackow S, Vannoni E, Codita A, Mohammed AH, Cirulli F, et al. (2010) Consistent behavioral phenotype differences between inbred mouse strains in the IntelliCage. Genes Brain Behav 9: 722-731.
20. Zimmermann H, (1996) Biochemistry, localization and functional roles of ecto-nucleotidases in the nervous system. Prog Neurobiol 49: 589-618.
21. Langer D, Hammer K, Koszalka P, Schrader J, Robson S, et al. (2008) Distribution of ectonucleotidases in the rodent brain revisited. Cell Tissue Res 334: 199-217.
22. Schoen S, Kreutzberg G, (1995) Evidence that 5'-nucleotidase is associated with malleable synapses- an enzyme cytochemical investigation of the olfactory bulb of adult rats. Neuroscience 65: 37-50.
23. Mills J, Thompson L, Mueller C, Waickman A, Jalkanen S, et al. (2008) CD73 is required for efficient entry of lymphocytes into the central nervous system during experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A 105: 9325-9330.
24. Burnstock G, Krugel U, Abbracchio MP, Illes P, (2011) Purinergic signalling: from normal behaviour to pathological brain function. Prog Neurobiol 95: 229-274.
25. Shen HY, Chen JF, (2009) Adenosine A(2A) receptors in psychopharmacology: modulators of behavior, mood and cognition. Curr Neuropharmacol 7: 195-206.
26. Yaar R, Jones MR, Chen JF, Ravid K, (2005) Animal models for the study of adenosine receptor function. J Cell Physiol 202: 9-20.
27. Zlomuzica A, Burghoff S, Schrader J, Dere E (2012) Superior working memory and behavioural habituation but diminished psychomotor coordination in mice lacking the ecto-5'-nucleotidase (CD73) gene. Purinergic Signal in press.
28. Salamone JD, Ishiwari K, Betz AJ, Farrar AM, Mingote SM, et al. (2008) Dopamine/adenosine interactions related to locomotion and tremor in animal models: possible relevance to parkinsonism. Parkinsonism Relat Disord 14Suppl 2: S130-134.
29. Florio C, Rosati AM, Traversa U, Vertua R, (1997) Inhibitory and excitatory effects of adenosine antagonists on spontaneous locomotor activity in mice. Life Sci 60: 1477-1486.
30. Xie X, Ramkumar V, Toth LA, (2007) Adenosine and dopamine receptor interactions in striatum and caffeine-induced behavioral activation. Comp Med 57: 538-545.
31. Ferre S, Fredholm BB, Morelli M, Popoli P, Fuxe K, (1997) Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal ganglia. Trends Neurosci 20: 482-487.
32. Salmi P, Chergui K, Fredholm BB, (2005) Adenosine-dopamine interactions revealed in knockout mice. J Mol Neurosci 26: 239-244.
33. Kalueff A, Minasyan A, Keisala T, Shah Z, P T, (2006) Hair barbering in mice: implications for neurobehavioural research. Behav Processes 71: 8-15.
34. Moy S, Nadle rJ, Young N, Nonneman R, Grossman A, et al. (2009) Social approach in genetically engineered mouse lines relevant to autism. Genes Brain Behav 8: 129-142.
35. Ledent C, Vaugeois JM, Schiffmann SN, Pedrazzini T, El Yacoubi M, et al. (1997) Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor. Nature 388: 674-678.
36. Gimenez-Llort L, Fernandez-Teruel A, Escorihuela RM, Fredholm BB, Tobena A, et al. (2002) Mice lacking the adenosine A1 receptor are anxious and aggressive, but are normal learners with reduced muscle strength and survival rate. Eur J Neurosci 16: 547-550.
37. Gammie SC, Auger AP, Jessen HM, Vanzo RJ, Awad TA, et al. (2007) Altered gene expression in mice selected for high maternal aggression. Genes Brain Behav 6: 432-443.
38. Schoen S, Kreutzberg G, (1997) 5'-nucleotidase enzyme cytochemistry as a tool for revealing activated glial cells and malleable synapses in CNS development and regeneration. Brain Res Brain Res Protoc 1: 33-43.
39. Sanchez-Andrade G, Kendrick K, (2009) The main olfactory system and social learning in mammals. Behav Brain Res 200: 323-335.
40. Stork O, Welzl H, Cremer H, Schachner M, (1997) Increased intermale aggression and neuroendocrine response in mice deficient for the neural cell adhesion molecule (NCAM). Eur J Neurosci 9: 1117-1125.
41. Vinkers CH, Breuer ME, Westphal KG, Korte SM, Oosting RS, et al. (2009) Olfactory bulbectomy induces rapid and stable changes in basal and stress-induced locomotor activity, heart rate and body temperature responses in the home cage. Neuroscience 159: 39-46.
42. Murphy C, Solomon E, Haase L, Wang M, Morgan C, (2009) Olfaction in aging and Alzheimer's disease: event-related potentials to a cross-modal odor-recognition memory task discriminate ApoE epsilon4+ and ApoE epsilon 4- individuals. Ann N Y Acad Sci 1170: 647-657.
43. Wesson D, Levy E, Nixon R, Wilson D, (2010) Olfactory dysfunction correlates with amyloid-beta burden in an Alzheimer's disease mouse model. J Neurosci 30: 505-514.
44. Karpa M, Gopinath B, Rochtchina E, Wang JJ, Cumming R, et al. (2010) Prevalence and neurodegenerative or other associations with olfactory impairment in an older community. J Aging Health 22: 154-168.
45. Oka H, Toyoda C, Yogo M, Mochio S, (2010) Olfactory dysfunction and cardiovascular dysautonomia in Parkinson's disease. J Neurol 257: 969-976.
46. Lazic S, Goodman A, Grote H, Blakemore C, Morton A, et al. (2007) Olfactory abnormalities in Huntington's disease: decreased plasticity in the primary olfactory cortex of R6/1 transgenic mice and reduced olfactory discrimination in patients. Brain Res 1151: 219-226.
47. Sowa N, Taylor-Blake B, Zylka M, (2010) Ecto-5′-Nucleotidase (CD73) inhibits nociception by hydrolyzing AMP to adenosine in nociceptive circuits. J Neurosci 30: 2235-2244.
48. Bonan CD, Roesler R, Pereira GS, Battastini AM, Izquierdo I, et al. (2000) Learning-specific decrease in synaptosomal ATP diphosphohydrolase activity from hippocampus and entorhinal cortex of adult rats. Brain Res 854: 253-256.
49. Bonan CD, Dias MM, Battastini AM, Dias RD, Sarkis JJ, (1998) Inhibitory avoidance learning inhibits ectonucleotidases activities in hippocampal synaptosomes of adult rats. Neurochem Res 23: 977-982.
50. Gould TD, Gottesman II, (2006) Psychiatric endophenotypes and the development of valid animal models. Genes Brain Behav 5: 113-119.
51. Powell CM, Miyakawa T, (2006) Schizophrenia-relevant behavioral testing in rodent models: a uniquely human disorder? Biol Psychiatry 59: 1198-1207.
52. Crawley JN, (2007) Mouse behavioral assays relevant to the symptoms of autism. Brain Pathol 17: 448-459.
53. Gotoh L, Mitsuyasu H, Kobayashi Y, Oribe N, Takata A, et al. (2009) Association analysis of adenosine A1 receptor gene (ADORA1) polymorphisms with schizophrenia in a Japanese population. Psychiatr Genet 19: 328-335.
54. Ikemoto S, (2007) Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex. Brain Res Rev 56: 27-78.