Extracellular ATP formation on vascular endothelial cells is mediated by ecto-nucleotide kinase activities via phosphotransfer reactions

FASEB Journal

Volumn 15, Issue 1, 2001, Pages 251-260

  Yegutkin, G G ^a   Henttinen, T ^a   Jalkanen, S ^a  

^a UNIVERSITY OF TURKU   (Finland)

Author keywords

Adenine nucleotides; Ecto enzymes; Hydrolysis; Interconversion; Vasculature

Indexed keywords

ADENOSINE TRIPHOSPHATE; LUCIFERASE; LUCIFERIN;

ARTICLE; CELL MEDIATED CYTOTOXICITY; CELL TYPE; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME SPECIFICITY; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; PHOSPHATE TRANSPORT; PRIORITY JOURNAL; PROTEIN FAMILY; REACTION ANALYSIS; THIN LAYER CHROMATOGRAPHY; VASCULAR ENDOTHELIUM;

5'-NUCLEOTIDASE; ADENINE; ADENOSINE; ADENOSINE DIPHOSPHATE; ADENOSINE MONOPHOSPHATE; ADENOSINE TRIPHOSPHATE; ADENYLATE KINASE; APYRASE; CELLS, CULTURED; CHROMATOGRAPHY, THIN LAYER; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; HUMANS; KINETICS; LUMINESCENT MEASUREMENTS; MEMBRANE PROTEINS; NUCLEOSIDE-DIPHOSPHATE KINASE; PHOSPHATES; PHOSPHORYLATION; PHOSPHOTRANSFERASES (PHOSPHATE GROUP ACCEPTOR); SUBSTRATE SPECIFICITY;

EID: 0035148585     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.00-0268com     Document Type: Article

References (39)

1. Biochemistry, localization and functional roles of ecto-nucleotidases in the nervous system
2. 2-purinergic receptors for extracellular ATP and other nucleotides
3. The past, present and future of purine nucleotides as signalling molecules
4. Release of ATP and UTP from astrocytoma cells
5. P2-purinergic receptors: Subtype-associated signaling responses and structure
6. Receptors for purines and pyrimidines
7. Ecto-ATPases: Identities and functions
8. Two novel families of ectonucleotidases: Molecular structures, catalytic properties and a search for function
9. Ecto-phosphodiesterase/pyrophosphatase of lymphocytes and non-lymphoid cells: Structure and function of the PC-1 family
10. An ecto-nucleotide pyrophosphatase is one of the main enzymes involved in the extracellular metabolism of ATP in rat C6 glioma
11. 5′-Nucleotidase: Molecular structure and functional aspects
12. Ectoenzyme and signaling functions of lymphocyte CD73
13. NM23-NDP kinase
14. The ATP synthase - A splendid molecular machine
15. Formation of extracellular adenosine triphosphate by human erythrocytes
16. Nucleoside diphosphate kinase at the cell surface of neoplastic human cells in culture
17. Identification of an ecto-nucleoside diphosphokinase and its contribution to interconversion of P2 receptor agonists
18. Metabolism of adenine nucleotides by ectoenzymes of vascular endothelial and smooth-muscle cells in culture
19. Angiostatin binds ATP synthase on the surface of human endothelial cells
20. + transporting ATP synthase on the surface of tumor cell lines
21. Thromboregulatory potential of endothelial CD39/ nucleoside triphosphate diphosphohydrolase: Modulation of purinergic signalling in platelets
22. Stage-specific expression of P2Y receptors, ectoapyrase, and ecto-5′-nucleotidase in myeloid leukocytes
23. Kinetics of extracellular ATP hydrolysis by microvascular endothelial cells from rat heart
24. Analysis of CD39/ATP diphosphohydrolase (ATPDase) expression in endothelial cells, platelets and leukocytes
25. Identification and characterization of CD39/vascular ATP diphosphohydrolase
26. The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39
27. Differential regulation and function of CD73, a glycosyl-phosphatidylinositol-linked 70-kD adhesion molecule, on lymphocytes and endothelial cells
28. Microdomains in lymphocyte signalling: Beyond GPI-anchored proteins
29. Quantitative thin-layer chromatography of ATP and the products of its degradation in meat tissue
30. 3H]ATP tor at liver plasma membranes and competition by various purinergic agonists and antagonists
31. Effect of shear stress on the release of soluble ecto-enzymes ATPase and 5′-nucleotide along with endogenous ATP from vascular endothelial cells
32. Nucleoside monophosphate kinases: Structure, mechanism, and substrate specificity
33. The hydrolysis of extracellular adenine nucleotides by arterial smooth muscle cells. Regulation of adenosine production at the cell surface
34. 2+)-apyrase
35. Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation
36. Failing energetics in failing hearts
37. + channels
38. Phosphotransfer reactions as a means of G-protein activation