Persistence of psychosine in brain lipid rafts is a limiting factor in the therapeutic recovery of a mouse model for Krabbe disease

Journal of Neuroscience Research

Volumn 89, Issue 3, 2011, Pages 352-364

  White, A B ^a   Galbiati, F ^a   Givogri, M I ^a   Lopez Rosas, A ^a   Qiu, X ^a   Van Breemen, R ^a   Bongarzone, E R ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Bone marrow transplants; Dying back pathology; Endosomes; Krabbe disease; Lentiviral gene transfer; Leukodystrophies; Lipid raft; Myelin; Psychosine; Twitcher

Indexed keywords

GALACTOSYLCERAMIDASE; PSYCHOSINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW TRANSPLANTATION; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; ENDOCYTOSIS; ENZYME RECONSTITUTION; ENZYME REPLACEMENT; ENZYME THERAPY; GLOBOID CELL LEUKODYSTROPHY; IN VIVO STUDY; LIPID BRAIN LEVEL; LIPID RAFT; MASS SPECTROMETRY; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; WESTERN BLOTTING;

ANIMALS; ANIMALS, NEWBORN; BONE MARROW TRANSPLANTATION; BRAIN; CELLS, CULTURED; CHOLERA TOXIN; CLATHRIN; DISEASE MODELS, ANIMAL; ENDOCYTOSIS; ENZYME REPLACEMENT THERAPY; GALACTOSYLCERAMIDASE; HUMANS; LEUKODYSTROPHY, GLOBOID CELL; MASS SPECTROMETRY; MEMBRANE MICRODOMAINS; MICE; NEURONS; PROTEIN KINASE C; PSYCHOSINE; TIME FACTORS;

EID: 78751681843     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22564     Document Type: Article

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