Heterocyclic modification of a novel bicyclo[3.1.0]hexane NPY1 receptor antagonist

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 13, 2013, Pages 3814-3817

  Luo, Guanglin ^a   Chen, Ling ^a   Hu, Shuanghua ^a   Huang, Yazhong ^a   Mattson, Gail ^a   Iben, Lawrence G ^a   Russell, John W ^a   Clarke, Wendy J ^a   Hogan, John B ^a   Antal Zimanyi, Ildiko ^a   Poindexter, Graham S ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Bicyclo 3.1.0 hexanes; NPY1 receptor antagonist; Obesity

Indexed keywords

1 (4,4 DIPHENYL 3 BUTENYL)GUVACINE; 2 (1,3,5 TRIAZINE); 2 ANILINE; 2 PYRAZINE; 2 PYRIDINE; 2 PYRIDINEMETHANOL; 2 PYRIMIDINE; 3 PYRAZINE; 3 PYRIMIDINE; 4 PYRIDINE; 6 (2 METHYLOXIDE PYRIDINE); 6 (3 CHLOROPYRADAZINE); BICYCLO[3.1.0]HEXANE; NEUROPEPTIDE Y RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; ARTICLE; BINDING AFFINITY; CHEMICAL MODIFICATION; CONTROLLED STUDY; CONVERGENT SYNTHESIS; DRUG BIOAVAILABILITY; DRUG SOLUBILITY; FOOD INTAKE; HETEROCYCLIC MODIFICATION; MALE; NONHUMAN; PROTEIN BINDING; RAT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; BICYCLO COMPOUNDS; DOSE-RESPONSE RELATIONSHIP, DRUG; HETEROCYCLIC COMPOUNDS; MALE; MOLECULAR STRUCTURE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NEUROPEPTIDE Y; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 84878885866     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.04.095     Document Type: Article

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