Pharmacokinetic properties of isorhamnetin, kaempferol and quercetin after oral gavage of total flavones of Hippophae rhamnoides L. in rats using a UPLC-MS method

Fitoterapia

Volumn 83, Issue 1, 2012, Pages 182-191

  Li, Guowen ^a   Zeng, Xiaoli ^a   Xie, Yan ^a,b   Cai, Zhenzhen ^a   Moore, Jeffrey C ^c   Yuan, Xiurong ^a,b   Cheng, Zhihong ^d   Ji, Guang ^a  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b Shanghai Zhongyida Yuanchuang Technology Co Ltd   (China)

^c Fudan University ^*

^d FUDAN UNIVERSITY   (China)

Author keywords

Isorhamnetin; Kaempferol; Pharmacokinetics; Quercetin; Total flavones of Hippophae rhamnoides L.; UPLC MS

Indexed keywords

ANION; FLAVONE DERIVATIVE; HIPPOPHAE RHAMNOIDES EXTRACT; ISORHAMNETIN; KAEMPFEROL; QUERCETIN;

ANIMAL EXPERIMENT; ARTICLE; BIOTRANSFORMATION; CHEMICAL STRUCTURE; CHROMATOGRAPHY; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DETERMINATION; FEEDING; HIPPOPHAE RHAMNOIDES; HYDROLYSIS; ION MONITORING; LIQUID LIQUID EXTRACTION; MALE; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ADMINISTRATION, ORAL; ANIMALS; CHROMATOGRAPHY, LIQUID; DRUG INTERACTIONS; FLAVONES; HIPPOPHAE; KAEMPFEROLS; MALE; MASS SPECTROMETRY; QUERCETIN; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM;

HIPPOPHAE RHAMNOIDES; RATTUS;

EID: 83055186458     PISSN: 0367326X     EISSN: 18736971     Source Type: Journal    
DOI: 10.1016/j.fitote.2011.10.012     Document Type: Article

References (31)

1. E.U. Graefe, J. Wittig, S. Mueller, A.K. Riethling, B. Uehleke, B. Drewelow, H. Pforte, G. Jacobasch, H. Derendorf, and M. Veit Pharmacokinetics and bioavailability of quercetin glycosides in humans J Clin Pharmacol 41 2001 492 499 (Pubitemid 32381866)
2. V. Crespy, C. Morand, C. Manach, C. Besson, C. Demigne, and C. Remesy Part of quercetin absorbed in the small intestine is conjugated and further secreted in the intestinal lumen Am J Physiol 277 1999 G120 G126 (Pubitemid 29352652)
3. G.W. Plumb, R. McLauchlan, P.A. Kroon, A. Day, C.B. Faulds, J.M. Gee, S. Dupont, and G. Williamson Uptake and metabolism of quercetin glycosides in Caco-2 cell cultures and everted rat gut sacs Polyphen Commun 2 2000 401 402
4. K. Lan, J.L. He, Y. Tian, F. Tan, X.H. Jiang, L. Wang, and L.M. Ye Intra-herb pharmacokinetics interaction between quercetin and isorhamnetin Acta Pharmacol Sin 29 2008 1376 1382
5. M.S. Dupont, A.J. Day, R.N. Bennett, F.A. Mellon, and P.A. Kroon Absorption of kaempferol from endive, a source of kaempferol-3-glucuronide, in humans Eur J Clin Nutr 58 2004 947 954 (Pubitemid 38923194)
6. Q. Chang, Z. Zuo, W.K.K. Ho, and M.S.S. Chow Comparison of the pharmacokinetics of hawthorn phenolics in extract versus individual pure compound J Clin Pharmacol 45 2005 106 112
7. K.M. Joo, J.H. Lee, H.Y. Jeon, C.W. Park, D.K. Hong, H.J. Jeong, S.J. Lee, S.Y. Lee, and K.M. Lim Pharmacokinetic study of ginsenoside Re with pure ginsenoside Re and ginseng berry extracts in mouse using ultra performance liquid chromatography/mass spectrometric method J Pharm Biomed Anal 51 2010 278 283
8. V.B. Guliyev, M. Gul, and A. Yildirim Hippophae rhamnoides L.: chromatographic methods to determine chemical composition, use in traditional medicine and pharmacological effects J Chromatogr B 812 2004 291 307 (Pubitemid 39535418)
9. J.P. Suomela, M. Ahotupa, B. Yang, T. Vasankari, and H. Kallio Absorption of flavonols derived from sea buckthorn (Hippophaë rhamnoides L.) and their effect on emerging risk factors for cardiovascular disease in humans J Agric Food Chem 54 2006 7364 7369 (Pubitemid 44554964)
10. X. Pang, J. Zhao, W. Zhang, X. Zhuang, J. Wang, R. Xu, Z. Xu, and W. Qu Antihypertensive effect of total flavones extracted from seed residues of Hippophae rhamnoides L. in sucrose-fed rats J Ethnopharmacol 117 2008 325 331
11. L.G. Apollonio, D.J. Pianca, I.R. Whittall, W.A. Maher, and J.M. Kyd A demonstration of the use of ultra-performance liquid chromatography-mass spectrometry [UPLC/MS] in the determination of amphetamine-type substances and ketamine for forensic and toxicological analysis J Chromatogr B 836 2006 111 115
12. Y. Wang, Y. Yao, R. An, L. You, and X. Wang Simultaneous determination of puerarin, daidzein, baicalin, wogonoside and liquiritin of Gegen Qinlian decoction in rat plasma by ultra-performance liquid chromatography-mass spectrometry J Chromatogr B 877 2009 1820 1826
13. W. Zhang, M. Xu, C. Yu, G. Zhang, and X. Tang Simultaneous determination of vitexin-4″-O-glucoside, vitexin-2″-O-rhamnoside, rutin and vitexin from hawthorn leaves flavonoids in rat plasma by UPLC-ESI-MS/MS J Chromatogr B 878 2010 1837 1844
14. Y. Gu, D. Si, J. Gao, Y. Zeng, and C. Liu Simultaneous quantification of psoralen and isopsoralen in rat plasma by ultra-performance liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study after oral administration of Haigou Pill J Chromatogr B 877 2009 3137 3143
15. Y. Wang, J. Cao, J.H. Weng, and S. Zeng Simultaneous determination of quercetin, kaempferol and isorhamnetin accumulated human breast cancer cells, by high-performance liquid chromatography J Pharm Biomed Anal 39 2005 328 333 (Pubitemid 41112156)
16. T. Walle, Y. Otake, U.K. Walle, and F.A. Wilson Quercetin glucosides are completely hydrolyzed in ileostomy patients before absorption J Nutr 130 2000 2658 2661
17. Z. Zuo, L. Zhang, L. Zhou, Q. Chang, and M. Chow Intestinal absorption of hawthorn flavonoids-in vitro, in situ and in vivo correlations Life Sci 79 2006 2455 2462 (Pubitemid 44755430)
18. Y. Zhao, L. Wang, Y. Bao, and C. Li A sensitive method for the detection and quantification of ginkgo flavonols from plasma Rapid Commun Mass Spectrom 21 2007 971 981 (Pubitemid 46426817)
19. L. Gu, M. Laly, H.V. Chang, R.L. Prior, N. Fang, M.J.J. Ronis, and T.M. Badger Isoflavone conjugates are underestimated in tissues using enzymatic hydrolysis J Agric Food Chem 53 2005 6858 6863 (Pubitemid 41260735)
20. K. Lan, X. Jiang, and J. He Quantitative determination of isorhamnetin, quercetin and kaempferol in rat plasma by liquid chromatography with electrospray ionization tandem mass spectrometry and its application to the pharmacokinetic study of isorhamnetin Rapid Commun Mass Spectrom 21 2007 112 120 (Pubitemid 46095469)
21. H.U. Schulz, M. Schurer, D. Bassler, and D. Weiser Investigation of the bioavailability of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin following single and multiple oral dosing of a hypericum extract containing tablet Arzneimittelforschung 55 2005 15 22 (Pubitemid 40175249)
22. R.A. Walgren, K.J. Karnaky Jr. , G.E. Lindenmayer, and T. Walle Efflux of dietary flavonoid quercetin 4′-beta-glucoside across human intestinal Caco-2 cell monolayers by apical multidrug resistance-associated protein-2 J Pharmacol Exp Ther 294 2000 830 836 (Pubitemid 30666830)
23. H.C. Cooray, T. Janvilisri, H.W. Van Veen, S.B. Hladky, and M.A. Barrand Interaction of the breast cancer resistance protein with plant polyphenols Biochem Biophys Res Commun 317 2004 269 275 (Pubitemid 38401995)
24. D. Pal, and A.K. Mitra MDR- and CYP 3A4-mediated drug-herbal interactions Life Sci 78 2006 2131 2145
25. Y. Wang, J. Cao, and S. Zeng Involvement of P-glycoprotein in regulating cellular levels of Ginkgo flavonols: quercetin, kaempferol, and isorhamnetin J Pharm Pharmacol 57 2005 751 758 (Pubitemid 40694883)
26. N. Romiti, G. Tramonti, A. Donati, and E. Chieli Effects of grapefruit juice on the multidrug transporter P-glycoprotein in the human proximal tubular cell line HK-2 Life Sci 76 2004 293 302 (Pubitemid 39452911)
27. K. Murota, S. Shimizu, H. Chujo, J.H. Moon, and J. Terao Efficiency of absorption and metabolic conversion of quercetin and its glucosides in human intestinal cell line Caco-2 Arch Biochem Biophys 384 2000 391 397 (Pubitemid 32012816)
28. X. Chen, L. Cui, X. Duan, B. Ma, and D. Zhong Pharmacokinetics and metabolism of the flavonoid scutellarin in humans after a single oral administration Drug Metab Dispos 34 2006 1345 1352 (Pubitemid 44079875)
29. H. Hibasami, A. Mitani, H. Katsuzaki, K. Imai, K. Yoshioka, and T. Komiya Isolation of five types of flavonol from seabuckthorn (Hippophae rhamnoides) and induction of apoptosis by some of the flavonols in human promyelotic leukemia HL-60 cells Int J Mol Med 15 2005 805 809
30. Y. Zu, C. Li, Y. Fu, and C. Zhao Simultaneous determination of catechin, rutin, quercetin, kaempferol and isorhamnetin in the extract of sea buckthorn (Hippophae rhamnoides L.) leaves by RP-HPLC with DAD J Pharm Biomed Anal 41 2006 714 719
31. Y. Xie, X. Zeng, G. Li, Z. Cai, N. Ding, and G. Ji Assessment of intestinal absorption of total flavones of Hippophae rhamnoides L. in rat using in situ absorption models Drug Dev Ind Pharm 36 2010 787 794