An in vitro repositioning study reveals antifungal potential of chloroquine to inhibit growth and morphogenesis in Candida albicans

Journal of General and Applied Microbiology

Volumn 59, Issue 2, 2013, Pages 167-170

  Shinde, Ravikumar B ^a   Rajput, Sandeep B ^a   Raut, Jayant S ^a   Mohan Karuppayil, S ^a  

^a SWAMI RAMANAND TEERTH MARATHWADA UNIVERSITY   (India)

Author keywords

Antifungal; Candida albicans; Chloroquine; Drug repositioning; Morphogenesis

Indexed keywords

CHLOROQUINE;

ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CONCENTRATION RESPONSE; DRUG MECHANISM; DRUG TARGETING; FUNGAL STRAIN; FUNGAL VIRULENCE; FUNGUS GROWTH; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MORPHOGENESIS; NONHUMAN;

ANTIFUNGAL AGENTS; CANDIDA ALBICANS; CHLOROQUINE; ERGOSTEROL;

CANDIDA ALBICANS;

EID: 84878837712     PISSN: 00221260     EISSN: 13498037     Source Type: Journal    
DOI: 10.2323/jgam.59.167     Document Type: Article

References (17)

1. Achudume, A. C. (2009) The influence of chloroquine administration on antioxidant levels, oxidant marker and total cholesterol in Wistar rats. Biol. Med., 1, 39-43.
2. Arthington-Skaggs, B. A., Jradi, H., Desai, T., and Morrison, C. J. (1999) Quantitation of ergosterol content: Novel method for determination of fluconazole susceptibility of Candida albicans. J. Clin. Microbiol., 37, 3332-3337.
3. Ashburn, T. T. and Thor, A. B. (2004) Drug repositioning: Identifying and developing new uses for existing drugs. Nat. Rev. Drug Disc., 3, 673-683.
4. Chauhan, N. M., Raut, J. S., and Karuppayil, S. M. (2011) A morphogenetic regulatory role for ethyl alcohol in Candida albicans. Mycose., 54, e697-e703.
5. Chen, H. W. and Leonard, D. A. (1984) Chloroquine inhibits cyclization of squalene oxide to lanosterol in mammalian cells. J. Biol. Chem., 259, 8156-8162.
6. Clatworthy, A. E., Pierson, E., and Hung, D. T. (2007) Targeting virulence: A new paradigm for antimicrobial therapy. Nat. Chem. Biol., 3, 541-548.
7. Khan, M. A., Jabeen, R., Nasti, T. H., and Mohammad, O. (2005) Enhanced anticryptococcal activity of chloroquine in phosphatidylserine-containing liposomes in a murine model. J. Antimicrobiol. Chemother., 55, 223-228.
8. Mishra, N. N., Prasad, T., Sharma, N., Payasi, A., Prasad, R., Gupta, D. K., and Singh, R. (2007) Pathogenicity and drug resistance in Candida albicans and other yeast species. Acta Microbiol. Immunol. Hung., 54, 201-235.
9. Newman, S. L., Gootee, L., Brunner, G., and Deepe, G. S., Jr. (1993) Chloroquine induces human macrophage killing of Histoplasma capsulatum by limiting the availability of intracellular iron and is therapeutic in a murine model of histoplasmosis. J. Clin. Invest., 93, 1422-1429.
10. Öncü, S. (2011) In vitro effectiveness of antifungal lock solutions on catheters infected with Candida species. J. Infect. Chemother., 17, 634-639.
11. Park, Y., Chang, K., Choi, J., Park, Y., Cho, J., Han, S., Chin, B., Choi, S., Song, Y., and Kim, J. (2003) Chloroquine (CQ) potentiates antifungal agents against Candida spp. 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, USA, 2003 Sep 14-17; abstract no. M-1246.
12. Pasrija, R., Krishnamurthy, S., Prasad, T., Ernst, JF., and Prasad, R. (2005) Squalene epoxidase encoded by ERG1 affects morphogenesis and drug susceptibilities of Candida albicans. J. Antimicrob. Chemother., 55, 905-913.
13. Routh, M. M., Raut, J. S., and Karuppayil, S. M. (2011) Dual properties of anticancer agents: An exploratory study on the in vitro anti-Candida properties of thirty drugs. Chemotherapy, 57, 372-380.
14. Savarino, A., Boelaert, J. R., Cassone, A., Majori, G., and Cauda, R. (2003) Effects of chloroquine on viral infections: An old drug against today's diseases? Lancet Infect. Dis., 3, 722-727.
15. Shakoury-Elizeh, M., Protchenko, O., Berger, A., Cox, J., Gable, K., Dunn, T. M., Prinz, W. A., Bard, M., and Philpott, C. C. (2010) Metabolic response to iron deficiency in Saccharomyces cerevisiae. J. Biol. Chem., 285, 14823-14833.
16. Sotelo, J., Briceno, E., and Lopez-Gonzalez, M. A. (2006) Adding chloroquine to conventional treatment for glioblastoma multiforme: A randomized, double-blind, placebo-controlled trial. Ann. Intern. Med., 144, 337-343.
17. Wellems, T. E., Walker-Jonah, A. S., and Panton, L. S. (1991) Understanding the biochemical properties and functional role of CQ. Proc. Natl. Acad. Sci. USA, 88, 3382-3386.