-
1
-
-
0029898731
-
Tamoxifen: Teaching an old drug new tricks?
-
Grainger DJ, Metcalfe JC. Tamoxifen: teaching an old drug new tricks? Nat. Med., 2, 381-385 (1996).
-
(1996)
Nat. Med.
, vol.2
, pp. 381-385
-
-
Grainger, D.J.1
Metcalfe, J.C.2
-
2
-
-
0027521287
-
Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain
-
Beekman JM, Allan GF, Tsai SY, Tsai MJ, O'Malley BW. Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain. Mol. Endocrinol., 7, 1266-1274 (1993).
-
(1993)
Mol. Endocrinol.
, vol.7
, pp. 1266-1274
-
-
Beekman, J.M.1
Allan, G.F.2
Tsai, S.Y.3
Tsai, M.J.4
O'Malley, B.W.5
-
3
-
-
0028021955
-
Molecular mechanisms of antiestrogen action in breast cancer
-
Jordan VC. Molecular mechanisms of antiestrogen action in breast cancer. Breast Cancer Res. Treat., 31, 41-52 (1994).
-
(1994)
Breast Cancer Res. Treat.
, vol.31
, pp. 41-52
-
-
Jordan, V.C.1
-
4
-
-
0027238781
-
A risk-benefit assessment of tamoxifen therapy
-
Catherino WH, Jordan VC. A risk-benefit assessment of tamoxifen therapy. Drug Saf., 8, 381-397 (1993).
-
(1993)
Drug Saf.
, vol.8
, pp. 381-397
-
-
Catherino, W.H.1
Jordan, V.C.2
-
5
-
-
27944492407
-
Tamoxifen for the prevention of breast cancer: Current status of the National Surgical Adjuvant Breast and Bowel Project P-1 study
-
Fisher B, Costantino JP, Wickerham DL, Cecchini RS, Cronin WM, Robidoux A, Bevers TB, Kavanah MT, Atkins JN, Margolese RG, Runowicz CD, James JM, Ford LG, Wolmark N. Tamoxifen for the prevention of breast cancer: current status of the National Surgical Adjuvant Breast and Bowel Project P-1 study. J. Natl. Cancer Inst., 97, 1652-1662 (2005).
-
(2005)
J. Natl. Cancer Inst.
, vol.97
, pp. 1652-1662
-
-
Fisher, B.1
Costantino, J.P.2
Wickerham, D.L.3
Cecchini, R.S.4
Cronin, W.M.5
Robidoux, A.6
Bevers, T.B.7
Kavanah, M.T.8
Atkins, J.N.9
Margolese, R.G.10
Runowicz, C.D.11
James, J.M.12
Ford, L.G.13
Wolmark, N.14
-
6
-
-
0000661662
-
The Molecular Pharmacology of SERMs
-
McDonnell DP. The Molecular Pharmacology of SERMs. Trends Endocrinol. Metab., 10, 301-311 (1999).
-
(1999)
Trends Endocrinol. Metab.
, vol.10
, pp. 301-311
-
-
McDonnell, D.P.1
-
7
-
-
0035181465
-
Mechanisms of tamoxifen-induced apoptosis
-
Mandlekar S, Kong AN. Mechanisms of tamoxifen-induced apoptosis. Apoptosis, 6, 469-477 (2001).
-
(2001)
Apoptosis
, vol.6
, pp. 469-477
-
-
Mandlekar, S.1
Kong, A.N.2
-
8
-
-
0037160095
-
Estrogen receptor-dependent and estrogen receptor-independent pathways for tamoxifen and 4-hydroxytamoxifen-induced programmed cell death
-
Obrero M, Yu DV, Shapiro DJ. Estrogen receptor-dependent and estrogen receptor-independent pathways for tamoxifen and 4-hydroxytamoxifen-induced programmed cell death. J. Biol. Chem., 277, 45695-45703 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 45695-45703
-
-
Obrero, M.1
Yu, D.V.2
Shapiro, D.J.3
-
9
-
-
33947733205
-
Synthesis of the new pseudo-symmetrical tamoxifen derivatives and their anti-tumor activity
-
Shiina I, Sano Y, Nakata K, Kikuchi T, Sasaki A, Ikekita M, Hasome Y. Synthesis of the new pseudo-symmetrical tamoxifen derivatives and their anti-tumor activity. Bioorg. Med. Chem. Lett., 17, 2421-2424 (2007).
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, pp. 2421-2424
-
-
Shiina, I.1
Sano, Y.2
Nakata, K.3
Kikuchi, T.4
Sasaki, A.5
Ikekita, M.6
Hasome, Y.7
-
10
-
-
38949143301
-
Synthesis and pharmacological evaluation of the novel pseudo-symmetrical tamoxifen derivatives as anti-tumor agents
-
Shiina I, Sano Y, Nakata K, Kikuchi T, Sasaki A, Ikekita M, Nagahara Y, Hasome Y, Yamori T, Yamazaki K. Synthesis and pharmacological evaluation of the novel pseudo-symmetrical tamoxifen derivatives as anti-tumor agents. Biochem. Pharmacol., 75, 1014-1026 (2008).
-
(2008)
Biochem. Pharmacol.
, vol.75
, pp. 1014-1026
-
-
Shiina, I.1
Sano, Y.2
Nakata, K.3
Kikuchi, T.4
Sasaki, A.5
Ikekita, M.6
Nagahara, Y.7
Hasome, Y.8
Yamori, T.9
Yamazaki, K.10
-
11
-
-
0042827269
-
Panel of human cancer cell lines provides valuable data-base for drug discovery and bioinformatics
-
Yamori T. Panel of human cancer cell lines provides valuable data-base for drug discovery and bioinformatics. Cancer Chemother. Pharmacol., 52 (Suppl. 1), S74-S79 (2003).
-
(2003)
Cancer Chemother. Pharmacol.
, vol.52
, Issue.SUPPL. 1
-
-
Yamori, T.1
-
12
-
-
35548960145
-
Evaluation of action mechanisms of toxic chemicals using JFCR39, a panel of human cancer cell lines
-
Nakatsu N, Nakamura T, Yamazaki K, Sadahiro S, Makuuchi H, Kanno J, Yamori T. Evaluation of action mechanisms of toxic chemicals using JFCR39, a panel of human cancer cell lines. Mol. Pharmacol., 72, 1171-1180 (2007).
-
(2007)
Mol. Pharmacol.
, vol.72
, pp. 1171-1180
-
-
Nakatsu, N.1
Nakamura, T.2
Yamazaki, K.3
Sadahiro, S.4
Makuuchi, H.5
Kanno, J.6
Yamori, T.7
-
13
-
-
0036168343
-
An integrated database of chemosensitivity to 55 anticancer drugs and gene expression profiles of 39 human cancer cell lines
-
Dan S, Tsunoda T, Kitahara O, Yanagawa R, Zembutsu H, Katagiri T, Yamazaki K, Nakamura Y, Yamori T. An integrated database of chemosensitivity to 55 anticancer drugs and gene expression profiles of 39 human cancer cell lines. Cancer Res., 62, 1139-1147 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 1139-1147
-
-
Dan, S.1
Tsunoda, T.2
Kitahara, O.3
Yanagawa, R.4
Zembutsu, H.5
Katagiri, T.6
Yamazaki, K.7
Nakamura, Y.8
Yamori, T.9
-
14
-
-
0033566694
-
FJ5002: A potent telomerase inhibitor identified by exploiting the disease-oriented screening program with COMPARE analysis
-
Naasani I, Seimiya H, Yamori T, Tsuruo T. FJ5002: a potent telomerase inhibitor identified by exploiting the disease-oriented screening program with COMPARE analysis. Cancer Res., 59, 4004-4011 (1999).
-
(1999)
Cancer Res.
, vol.59
, pp. 4004-4011
-
-
Naasani, I.1
Seimiya, H.2
Yamori, T.3
Tsuruo, T.4
-
15
-
-
0033566690
-
Potent antitumor activity of MS-247, a novel DNA minor groove binder, evaluated by an in vitro and in vivo human cancer cell line panel
-
Yamori T, Matsunaga A, Sato S, Yamazaki K, Komi A, Ishizu K, Mita I, Edatsugi H, Matsuba Y, Takezawa K, Nakanishi O, Kohno H, Nakajima Y, Komatsu H, Andoh T, Tsuruo T. Potent antitumor activity of MS-247, a novel DNA minor groove binder, evaluated by an in vitro and in vivo human cancer cell line panel. Cancer Res., 59, 4042-4049 (1999).
-
(1999)
Cancer Res.
, vol.59
, pp. 4042-4049
-
-
Yamori, T.1
Matsunaga, A.2
Sato, S.3
Yamazaki, K.4
Komi, A.5
Ishizu, K.6
Mita, I.7
Edatsugi, H.8
Matsuba, Y.9
Takezawa, K.10
Nakanishi, O.11
Kohno, H.12
Nakajima, Y.13
Komatsu, H.14
Andoh, T.15
Tsuruo, T.16
-
16
-
-
77953761653
-
Correlating phosphatidylinositol 3-kinase inhibitor efficacy with signaling pathway status: In silico and biological evaluations
-
Dan S, Okamura M, Seki M, Yamazaki K, Sugita H, Okui M, Mukai Y, Nishimura H, Asaka R, Nomura K, Ishikawa Y, Yamori T. Correlating phosphatidylinositol 3-kinase inhibitor efficacy with signaling pathway status: in silico and biological evaluations. Cancer Res., 70, 4982-4994 (2010).
-
(2010)
Cancer Res.
, vol.70
, pp. 4982-4994
-
-
Dan, S.1
Okamura, M.2
Seki, M.3
Yamazaki, K.4
Sugita, H.5
Okui, M.6
Mukai, Y.7
Nishimura, H.8
Asaka, R.9
Nomura, K.10
Ishikawa, Y.11
Yamori, T.12
-
17
-
-
77949484879
-
Inhibition profiles of phosphatidylinositol 3-kinase inhibitors against PI3K superfamily and human cancer cell line panel JFCR39
-
Kong D, Dan S, Yamazaki K, Yamori T. Inhibition profiles of phosphatidylinositol 3-kinase inhibitors against PI3K superfamily and human cancer cell line panel JFCR39. Eur. J. Cancer, 46, 1111-1121 (2010).
-
(2010)
Eur. J. Cancer
, vol.46
, pp. 1111-1121
-
-
Kong, D.1
Dan, S.2
Yamazaki, K.3
Yamori, T.4
-
18
-
-
33646447708
-
Antitumor activity of ZSTK474, a new phosphatidylinositol 3-kinase inhibitor
-
Yaguchi S, Fukui Y, Koshimizu I, Yoshimi H, Matsuno T, Gouda H, Hirono S, Yamazaki K, Yamori T. Antitumor activity of ZSTK474, a new phosphatidylinositol 3-kinase inhibitor. J. Natl. Cancer Inst., 98, 545-556 (2006).
-
(2006)
J. Natl. Cancer Inst.
, vol.98
, pp. 545-556
-
-
Yaguchi, S.1
Fukui, Y.2
Koshimizu, I.3
Yoshimi, H.4
Matsuno, T.5
Gouda, H.6
Hirono, S.7
Yamazaki, K.8
Yamori, T.9
-
19
-
-
84856746384
-
AMF-26, a novel inhibitor of the Golgi system, targeting ADP-ribosylation factor 1 (Arf1) with potential for cancer therapy
-
Ohashi Y, Iijima H, Yamaotsu N, Yamazaki K, Sato S, Okamura M, Sugimoto K, Dan S, Hirono S, Yamori T. AMF-26, a novel inhibitor of the Golgi system, targeting ADP-ribosylation factor 1 (Arf1) with potential for cancer therapy. J. Biol. Chem., 287, 3885-3897 (2012).
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 3885-3897
-
-
Ohashi, Y.1
Iijima, H.2
Yamaotsu, N.3
Yamazaki, K.4
Sato, S.5
Okamura, M.6
Sugimoto, K.7
Dan, S.8
Hirono, S.9
Yamori, T.10
-
20
-
-
0025341331
-
New colorimetric cytotoxicity assay for anticancer-drug screening
-
Skehan P, Storeng R, Scudiero D, Monks A, McMahon J, Vistica D, Warren JT, Bokesch H, Kenney S, Boyd MR. New colorimetric cytotoxicity assay for anticancer-drug screening. J. Natl. Cancer Inst., 82, 1107-1112 (1990).
-
(1990)
J. Natl. Cancer Inst.
, vol.82
, pp. 1107-1112
-
-
Skehan, P.1
Storeng, R.2
Scudiero, D.3
Monks, A.4
McMahon, J.5
Vistica, D.6
Warren, J.T.7
Bokesch, H.8
Kenney, S.9
Boyd, M.R.10
-
21
-
-
0025775062
-
Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines
-
Monks A, Scudiero D, Skehan P, Shoemaker R, Paull K, Vistica D, Hose C, Langley J, Cronise P, Vaigro-Wolff A, Gray-Goodrich M, Campbell H, Mayo J, Boyd M. Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. J. Natl. Cancer Inst., 83, 757-766 (1991).
-
(1991)
J. Natl. Cancer Inst.
, vol.83
, pp. 757-766
-
-
Monks, A.1
Scudiero, D.2
Skehan, P.3
Shoemaker, R.4
Paull, K.5
Vistica, D.6
Hose, C.7
Langley, J.8
Cronise, P.9
Vaigro-Wolff, A.10
Gray-Goodrich, M.11
Campbell, H.12
Mayo, J.13
Boyd, M.14
-
22
-
-
0024312538
-
Display and analysis of patterns of differential activity of drugs against human tumor cell lines: Development of mean graph and COMPARE algorithm
-
Paull KD, Shoemaker RH, Hodes L, Monks A, Scudiero DA, Rubinstein L, Plowman J, Boyd MR. Display and analysis of patterns of differential activity of drugs against human tumor cell lines: development of mean graph and COMPARE algorithm. J. Natl. Cancer Inst., 81, 1088-1092 (1989).
-
(1989)
J. Natl. Cancer Inst.
, vol.81
, pp. 1088-1092
-
-
Paull, K.D.1
Shoemaker, R.H.2
Hodes, L.3
Monks, A.4
Scudiero, D.A.5
Rubinstein, L.6
Plowman, J.7
Boyd, M.R.8
-
23
-
-
0141985986
-
Enzyme fragment complementation: A flexible high throughput screening assay technology
-
Eglen RM. Enzyme fragment complementation: a flexible high throughput screening assay technology. Assay Drug Dev. Technol., 1, 97-104 (2002).
-
(2002)
Assay Drug Dev. Technol.
, vol.1
, pp. 97-104
-
-
Eglen, R.M.1
-
25
-
-
0035023196
-
Differential SERM activation of the estrogen receptors (ERalpha and ERbeta) at AP-1 sites
-
Weatherman RV, Clegg NJ, Scanlan TS. Differential SERM activation of the estrogen receptors (ERalpha and ERbeta) at AP-1 sites. Chem. Biol., 8, 427-436 (2001).
-
(2001)
Chem. Biol.
, vol.8
, pp. 427-436
-
-
Weatherman, R.V.1
Clegg, N.J.2
Scanlan, T.S.3
-
26
-
-
0642367765
-
Effects of ospemifene, a novel SERM, on hormones, genital tract, climacteric symptoms, and quality of life in postmenopausal women: A double-blind, randomized trial
-
Rutanen EM, Heikkinen J, Halonen K, Komi J, Lammintausta R, Ylikorkala O. Effects of ospemifene, a novel SERM, on hormones, genital tract, climacteric symptoms, and quality of life in postmenopausal women: a double-blind, randomized trial. Menopause, 10, 433-439 (2003).
-
(2003)
Menopause
, vol.10
, pp. 433-439
-
-
Rutanen, E.M.1
Heikkinen, J.2
Halonen, K.3
Komi, J.4
Lammintausta, R.5
Ylikorkala, O.6
-
27
-
-
1542468777
-
Estrogen receptor modulators: Relationships of ligand structure, receptor affinity and functional activity
-
Wallace OB, Richardson TI, Dodge JA. Estrogen receptor modulators: relationships of ligand structure, receptor affinity and functional activity. Curr. Top. Med. Chem., 3, 1663-1682 (2003).
-
(2003)
Curr. Top. Med. Chem.
, vol.3
, pp. 1663-1682
-
-
Wallace, O.B.1
Richardson, T.I.2
Dodge, J.A.3
-
28
-
-
0035577693
-
Arzoxifene, a new selective estrogen receptor modulator for chemoprevention of experimental breast cancer
-
Suh N, Glasebrook AL, Palkowitz AD, Bryant HU, Burris LL, Starling JJ, Pearce HL, Williams C, Peer C, Wang Y, Sporn MB. Arzoxifene, a new selective estrogen receptor modulator for chemoprevention of experimental breast cancer. Cancer Res., 61, 8412-8415 (2001).
-
(2001)
Cancer Res.
, vol.61
, pp. 8412-8415
-
-
Suh, N.1
Glasebrook, A.L.2
Palkowitz, A.D.3
Bryant, H.U.4
Burris, L.L.5
Starling, J.J.6
Pearce, H.L.7
Williams, C.8
Peer, C.9
Wang, Y.10
Sporn, M.B.11
-
29
-
-
77949360378
-
Lasofoxifene for the prevention and treatment of postmenopausal osteoporosis
-
Lewiecki EM. Lasofoxifene for the prevention and treatment of postmenopausal osteoporosis. Ther. Clin. Risk Manag., 5, 817-827 (2009).
-
(2009)
Ther. Clin. Risk Manag.
, vol.5
, pp. 817-827
-
-
Lewiecki, E.M.1
-
30
-
-
0034095017
-
Metabolism, disposition, excretion, and pharmacokinetics of levormeloxifene, a selective estrogen receptor modulator, in the rat
-
Mountfield RJ, Kiehr B, John BA. Metabolism, disposition, excretion, and pharmacokinetics of levormeloxifene, a selective estrogen receptor modulator, in the rat. Drug Metab. Dispos., 28, 503-513 (2000).
-
(2000)
Drug Metab. Dispos.
, vol.28
, pp. 503-513
-
-
Mountfield, R.J.1
Kiehr, B.2
John, B.A.3
-
31
-
-
0035098323
-
Efficacy of levormeloxifene in the prevention of postmenopausal bone loss and on the lipid profile compared to low dose hormone replacement therapy
-
Alexandersen P, Riis BJ, Stakkestad JA, Delmas PD, Christiansen C. Efficacy of levormeloxifene in the prevention of postmenopausal bone loss and on the lipid profile compared to low dose hormone replacement therapy. J. Clin. Endocrinol. Metab., 86, 755-760 (2001).
-
(2001)
J. Clin. Endocrinol. Metab.
, vol.86
, pp. 755-760
-
-
Alexandersen, P.1
Riis, B.J.2
Stakkestad, J.A.3
Delmas, P.D.4
Christiansen, C.5
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