Synthesis of the new pseudo-symmetrical tamoxifen derivatives and their anti-tumor activity

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 9, 2007, Pages 2421-2424

  Shiina, Isamu ^a   Sano, Yoshiyuki ^a   Nakata, Kenya ^a   Kikuchi, Takaaki ^a   Sasaki, Akane ^a   Ikekita, Masahiko ^a   Hasome, Yoshimune ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Anti tumor activity; Apoptosis; pseudo Symmetrical structure; Selective estrogen receptor modulators; SERMs; Synthesis; Tamoxifen

Indexed keywords

RID B; RID C; RID D; TAMOXIFEN DERIVATIVE; UNCLASSIFIED DRUG;

AGAR GEL ELECTROPHORESIS; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER; CANCER CELL CULTURE; CELL DEATH; CELL STRAIN HL 60; CELL VIABILITY; CHEMICAL REACTION; CULTURE MEDIUM; DNA CLEAVAGE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; THREE COMPONENT COUPLING REACTION;

ANTINEOPLASTIC AGENTS; CELL DEATH; CELL SURVIVAL; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HL-60 CELLS; HUMANS; MODELS, CHEMICAL; MOLECULAR CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; TAMOXIFEN; TIME FACTORS;

EID: 33947733205     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.02.037     Document Type: Article

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