Correlating phosphatidylinositol 3-kinase inhibitor efficacy with signaling pathway status: In silico and biological evaluations

Cancer Research

Volumn 70, Issue 12, 2010, Pages 4982-4994

  Dan, Shingo ^a   Okamura, Mutsumi ^a   Seki, Mariko ^a   Yamazaki, Kanami ^a   Sugita, Hironobu ^a   Okui, Michiyo ^b,c   Mukai, Yumiko ^a   Nishimura, Hiroyuki ^c   Asaka, Reimi ^b   Nomura, Kimie ^b   Ishikawa, Yuichi ^b   Yamori, Takao ^a  

^a CANCER CHEMOTHERAPY CENTER   (Japan)

^b CANCER INSTITUTE   (Japan)

^c TOIN UNIVERSITY OF YOKOHAMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL)IMIDAZO[4,5 C]QUINOLIN 2(1H,3H) ONE; 2 (1H INDAZOL 4 YL) 6 (4 METHANESULFONYL 1 PIPERAZINYLMETHYL) 4 MORPHOLINOTHIENO[3,2 D]PYRIMIDINE; 2 (2 DIFLUOROMETHYLBENZIMIDAZOL 1 YL) 4,6 DIMORPHOLINO 1,3,5 TRIAZINE; 2 (4 HYDROXYPHENYL) 4 MORPHOLINOPYRIDO[3',2':4,5]FURO[3,2 D]PYRIMIDINE; 2 (6 AMINO 9 PURINYLMETHYL) 5 METHYL 3 (2 METHYLPHENYL) 3H QUINAZOLIN 4 ONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 DIALLYLAMINOMETHYLENE 1,3,4,7,10,11,12,13,14,15,16,17 DODECAHYDRO 6 HYDROXY 1 METHOXYMETHYL 10,13 DIMETHYL 3,7,17 TRIOXO 2 OXACYCLOPENTA[A]PHENANTHREN 11 YL ACETATE; 5 (6 QUINOXALINYLMETHYLENE) 2,4 THIAZOLIDINEDIONE; 9 (1 ANILINOETHYL) 7 METHYL 2 MORPHOLINOPYRIDO[1,2 A]PYRIMIDIN 4 ONE; B RAF KINASE; BIOLOGICAL MARKER; EPIDERMAL GROWTH FACTOR RECEPTOR; EVEROLIMUS; GLYCOGEN SYNTHASE KINASE 3BETA; K RAS PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; PERIFOSINE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; RAS PROTEIN; TEMSIROLIMUS; TRICIRIBINE; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL EXPERIMENT; ARTICLE; BRAIN CANCER; BREAST CANCER; CANCER CELL CULTURE; CELL STRAIN HEK293; COLORECTAL CANCER; COMPUTER MODEL; DRUG EFFICACY; ENZYME PHOSPHORYLATION; FEMALE; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VIVO STUDY; KIDNEY CANCER; LUNG CANCER; MALE; MELANOMA; MISSENSE MUTATION; MOUSE; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; PROSTATE CANCER; SIGNAL TRANSDUCTION; STOMACH CANCER; XENOGRAFT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; COMPUTATIONAL BIOLOGY; ENZYME INHIBITORS; FEMALE; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; MUTATION; NEOPLASMS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS B-RAF; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RAS PROTEINS; SIGNAL TRANSDUCTION; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 77953761653     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-4172     Document Type: Article

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