Obesity and metallothionein

Current Pharmaceutical Biotechnology

Volumn 14, Issue 4, 2013, Pages 432-440

  Sato, Masao ^a   Kawakami, Takashige ^a   Kadota, Yoshito ^a   Mori, Maki ^a   Suzuki, Shinya ^a  

^a TOKUSHIMA BUNRI UNIVERSITY   (Japan)

Author keywords

Adipocyte; MEST Peg1; Metallothionein; Obesity

Indexed keywords

FIBROBLAST GROWTH FACTOR 10; GLYCOGEN SYNTHASE KINASE 3; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LEPTIN; METALLOTHIONEIN; METALLOTHIONEIN I; METALLOTHIONEIN II; METALLOTHIONEIN III; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLASMINOGEN ACTIVATOR INHIBITOR; REACTIVE OXYGEN METABOLITE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADIPOCYTE; ADIPOSE TISSUE; CELL DIFFERENTIATION; DIABETIC CARDIOMYOPATHY; DISEASE PREDISPOSITION; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; GENETIC POLYMORPHISM; HEART DISEASE; HUMAN; INFLAMMATION; LIPID DIET; NONHUMAN; OBESITY; OXIDATIVE STRESS; PROTEIN EXPRESSION; REVIEW;

ADIPOCYTES; ADIPOSE TISSUE; ANIMALS; HUMANS; METALLOTHIONEIN; OBESITY;

MUS;

EID: 84878777407     PISSN: 13892010     EISSN: 18734316     Source Type: Journal    
DOI: 10.2174/1389201011314040008     Document Type: Review

References (67)

1. WHO. Technical report series, No. 916. Diet, nutrition and the prevention of chronic diseases. Report of a joint WHO/FAO expert consultation. 2003.
2. Halleux, C.M., Takahashi, M., Delporte, M.L., Detry, R., Funahashi, T., Matsuzawa, Y., Brichard, S.M. Secretion of adiponectin and regulation of apM1 gene expression in human visceral adipose tissue. Biochem. Biophys. Res. Commun., 2001, 288, 1102-1107.
3. Steppan, C.M., Bailey, S.T., Bhat, S., Brown, E.J., Banerjee, R.R., Wright, C.M., Patel, H.R., Ahima, R.S., Lazar, M.A. The hormone resistin links obesity to diabetes. Nature, 2001, 409, 307-312.
4. Rabe K., Lehrke, M., Parhofer, K.G., Broedl, U.C. Adipokines and insulin resistance. Mol. Med., 2008, 14, 741-751.
5. Okuno, A., Tamemoto, H., Tobe, K., Ueki, K., Mori, Y., Iwamoto, K., Umesono, K., Akanuma, Y., Fujiwara, T., Horikoshi, H., Yazaki, Y., Kadowaki, T. Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. J. Clin. Invest., 1998, 101, 1354-1361.
6. Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., Shimomura, I. Increased oxidative stress in obesity and its impact on metabolic syndrome. J. Clin. Invest., 2004, 114, 1751-1761.
7. Özcan, U., Cao, Q., Yilmaz, E., Lee, A. H., Iwakoshi, N. N., Ozdelen, E., Tuncman, G., Görgün, C., Glimcher, LH., Hotamisligil, G. S. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science, 2004, 306, 457-461.
8. Davis, S.R., Cousins, R.J. Metallothionein expression in animals: A physiological perspective on function. J. Nutr., 2000, 130, 1085-1088.
9. Sato, M., Kondoh, M. Recent studies on metallothionein: protection against toxicity of heavy metals and oxygen free radicals. Tohoku J. Exp. Med., 2002, 196, 9-22.
10. Sato, M., Bremner, I. Oxygen free radicals and metallothionein. Free Rad.Biol.Med., 1993, 14, 325-337.
11. Kondoh, M., Tsukada, M., Kuronaga, M., Higashimoto, M., Takiguchi, M., Himeno, S., Watanabe, Y., Sato, M. Induction of hepatic metallotlionein synthesis by endoplasmic reticulum stress in mice. Toxicol. Lett., 2004, 148,133-139.
12. Wallenius, V., Wallenius, K., Ahren, B., Rulding, M., Carlsten, H., Dickson, S. L., Ohlsson, C., Jansson, J-O. Interleukin-6-deficient mice develop mature-onset obesity. Nat. Med., 2002, 6, 75-79.
13. Netes, M. G., Netea, M. G., Joosten, L. A., Lewis, E., Jensen, D. R., Voshol, P. J., Kullberg, B. J., Tack, C. J., van Krieken, H., Kim, S.H., Stalenhoef, A. F., van de Loo, F. A., Verschueren, I., Pulawa, L., Akira, S., Eckel, R. H., Dinarello, C. A., van den Berg, W., van der Meer, J. W. Deficiency of interleukin-18 in mice leads to hyperpahgia, obesity and insulin resistance. Nat. Med., 2006, 12, 650-656.
14. Oike, Y., Akao, M., Yasunaga, K., Yamauchi, T., Morisada, T., Ito, Y., Urano, T., Kimura, Y., Kubota, Y., Maekawa, H., Miyamoto, T., Miyata, K., Matsumoto, S., Sakai, J., Nakagata, N., Takeya, M., Koseki, H., Ogawa, Y., Kadowaki, T., Suda, T. Angio-poietin-related growth factor antagonizes obesity and insulin resistance. Nat. Med., 2005, 11, 400-408.
15. Sato, M., Kawakami, T., Kondoh, M., Takiguchi, M., Kadota, Y., Himeno, H., Suzuki, S. Development of high-fat diet-induced obesity in female metallothionein-null mice. FASEB J., 2010, 24, 2375-2384.
16. Kuo, L. E., Kitlinska, J. B., Tilan, J. U., Li, L., Baker, S. B., Johnson, M. D., Lee, E. W., Burnett, M. S., Fricke, S. T., Kyetmasnsky, R., Herzog, H., Zukowska, Z. Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome. Nat. Med., 2007, 13, 803-811.
17. Suzuki, S., Yamamoto, M., Sato, M. Modulated responses to restraint stress and inflammation in metallothionein-null mice. J. Health Sci. 2009, 55(4) 554-559.
18. del Pozo, C.H., Calvo, R.M., Vesperinas-García, G., Gómez-Ambrosi, J., Frühbeck, G., Rubio, M.A., Obregon, M.A. Expression profile in omental and subcutaneous adipose tissue from lean and obese subjects. Repression of lipolytic and lipogenic genes. Obese Surg, 2011, 21, 633-43.
19. Kubota, N., Terauchi, Y., Miki, H., Tamemoto, H., Yamauchi, T., Komeda, K., Satoh, S., Nakano, R., Ishii, C, Sugiyama, T., Eto, K., Tsubamoto, Y., Okuno, A., Murakami, K., Sekihara, H., Hase-gawa, G., Naito, M., Toyoshima, Y., Tanaka, S., Shiota, K., Kita-mura, T., Fujita, T., Ezaki, O., Aizawa, S., Kadowaki, T. PPARy mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol. Cell, 1999, 4, 597-609.
20. Rozen, E. D., Walkey, C. J., Puigserver, P., Christopher, J. Transcriptional regulation of adipogenesis. Gene Dev., 2000, 14, 1293-1306.
21. Masaki, T., Arakawa, M., Seike, M., Yoshimatsu, H. Isoleucine prevents the accumulation of tissue triglycerides and upregulates the expression of PPARa and uncoupling protein in diet-induced obese mice. J. Nutr., 2010, 140, 496-500.
22. Jones, J. R., Barrick, C, Kim, K.-A., Linder, J., Blondeau, B., Fujimoto, Y., Shiota, M., Kesterson, R. A., Kahn, B. B., Magnuson, M. A. Deletion of PPARy in adipose tissues of mice protects against high-fat diet-induced obesity and insulin resistance. Proc. Natl. Acad. Sci. USA., 2005, 102, 6207-6212.
23. Tominaga, K., Kagata, T., Johmura, Y., Hishida, T., Nishizuka, M., Imagawa, M. SLC39A14, a LZT protein, is induced in adipogenesis and transports zinc. FEBS J., 2005, 272, 1590-1599.
24. Carrière, A., Carmona, M.C., Fernandez, Y., Rigoulet, M., Wenger, R.H., Pénicaud, L., Casteilla, L. Mitochondrial reactive oxygen species control the transcription factor CHOP-10/GADD153 and adipocyte differentiation: a mechanism for hy-poxia-dependent effect. J. Biol. Chem., 2004, 279, 40462-4069.
25. Lee, H., Lee, Y. J., Choi, H., Ko, E. H., Kim, J.W. Reactive oxygen species facilitate adipocyte differentiation by accelerating mitotic clonal expansion. J. Biol. Chem., 2009, 284, 10601-10609.
26. Sekiya, M., Hiraishi, A., Touyama, M., Sakamoto, K. Oxidative stress induced lipid accumulation via SREBP1c activation in GepG2 cells. Biochem. Biophys.Res. Commun., 2008, 375, 602-607.
27. Koza, R. A., Nikonova, L., Hogan J., Rim J-S., Mendoza T., Faulk C, Skaf J., Kozak L. P. Changes in gene expression foreshadow diet-induced obesity in genetically identical mice. PLoS Genet., 2006, 2, e81, 0769-0780.
28. Takahashi, M., Kamei, Y., Ezaki, O. Mest/Peg1 imprinted gene enlarges adipocytes and it is a marker of adipocyte size. Am. J. Physiol. Endocrinol. Metab., 2006, 288, E117-E124.
29. Okada, Y., Sakaue, H., Nagare, T., Kasuga, M. Diet-induced up-regulation of gene expression in adipocytes without changes in DNA methylation. Kobe J. Med. Sci., 2008, 54, E241-E249.
30. Do, M. S., Nam, S. Y., Hong, S. E., Kim, K.W., Duncan, J. S., Beattie, J. H., Trayhurn P. Metallothionein gene expression in human adipose tissue from lean and obese subjects. Horm. Metab. Res., 2002, 34, 348-351.
31. Chen, M.D., Song, Y.M. Tissue metallothionein concentrations in mice and humans with hyperglycemia. Biol. Trace Elem. Res., 2009, 127, 251-256.
32. Trayhurn, P., Duncan, J. S., Wood, A. M., Beattie, J. H. Metallothionein gene expression and secretion in white adipose tissue. Am. J. Physiol. Regul. Integr. Comp. Physiol., 2000, 279, R2329-2335.
33. Kim, J.R., Ryu, H.H., Chung, H.J., Lee, J.H., Kim, S.W., Kwun, W.H., Baek, S-H., Kim, J.H. Association of anti-obesity activity of N-acetylcysteine with metallothionein-II down-regulation. Exp. Mol. Med., 2006, 38, 162-172.
34. Beattie, J. H., Black, D. J., Duncan, J. S., Wood, A. M., Trayhurn, P. Cold-induced expression of metallothionein-I gene in brown adipose tissue of rat. Am. J. Physiol. Regul. Integr. Comp. Physiol., 1996, 270, R971-977.
35. Wang, B., Wood, I.S., Trayhurn, P. PCR arrays identify metal-lothionein-3 as a highly hypoxia inducible gene in human adipocytes. Biochem. Biophys. Res. Commun., 2008, 368, 88-93.
36. O'Hara, A., Lim, F-L, Mazzatti, D.J., Trayhurn, P. Microarray analysis identifies matrix metalloproteinases (MMPs) as key genes whose expression is up-regulated in human adipocytes by macrophage-conditioned medium. Eur. J. Physiol, 2009, 458, 1103-1114.
37. Kawakami, T., Sugimoto, H., Furuichi, R., Kadota, K., Inoue, M., Setsu, K., Suzuki, S., Sato, M. Cadmium reduces adipocyte size and expression levels of adiponectin and Peg1/Mest in adipose tissue. Toxicology, 2004, 267, 20-26
38. Marselli, L., Thorne, J., Dahiya S., Sgroi, D.C, Sharma, A., Bonner-Weir, S., Marchetti, P., Weir, G.C. Gene expression profiles of p-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes. PLoS One., 2010, 5(7), e11499.
39. Beattie, J. H., Wood, A. M., Newman, A. M., Bremner, I., Choo, K. H., Michalska, A. E., Duncan, J. S., Trayhurn, P. Obesity and hyperleptinemia in metallothionein (-I and -II) null mice. Proc. Natl. Acad. Sci. USA., 1998, 95, 358-363.
40. Palmiter, R. D. The elusive function of metallothioneins. Proc. Natl. Acad. Sci. USA., 1998, 95, 8428-8430.
41. Dong, F., Li Q., Sreejayan, N., Nunn, J.M., Ren, J. Metallothionein prevents high-fat diet-induced cardiac contractile dysfunction: Role of peroxisome proliferator-activated receptor coactivator 1 and mitochondrial biogenesis. Diabetes, 2007, 56, 2201-2212.
42. Spalding, K.L., Arner, E., Westermark, P.O., Bernard, S., Buchholz, B.A., Bergmann, O., Blomqvist, L., Hoffstedt, J., Nä slund, E., Britton, T., Concha, H., Hassan, M. Dynamics of fat cell turnover in humans. Nature, 2008, 453, 783-787.
43. Ellis, CD., Wang, F., MacDiarmid, C.W., Clark, S., Lyons, T., Eide, D.J. Zinc and the Msc2 zinc transporter protein are required for endoplasmic reticulum function. J. Cell Biol., 2004, 166, 325-335.
44. Hosoi, T., Sasaki, M., Miyahara, T., Hashimoto, C, Matsuo, S., Yoshii, M., Ozawa, K. Endoplasmic reticulum stress induces leptin resistance. Mol. Pharmacol., 2008, 74, 1610-1619.
45. Futakawa, N., Kondoh, M., Ueda, S., Higashimoto, M., Takiguchi, M., Suzuki, S., Sato, M. Involvement of oxidative stress in the synthesis of metallothionein induced by mitochondrial inhibitors. Biol. Pharm. Bull., 2006, 29, 2016-2020.
46. Zimny, S., Gogolin, F., Abel, J., Gleichmann, H. Metallothionein in isolated pancreatic islets of mice: induction by zinc and strepto-zotocin, a naturally occurring diabetogen. Arch. Toxicol., 1993, 67, 61-65.
47. Yang, J., Cherian, M.G. Protective effects of metallothionein on streptozotocin-induced diabetes in rats. Life Sci., 1994, 55, 43-51.
48. Apostolova, M.D., Choo, K.H., Michalska, A.E., Tohyama, C. Analysis of the possible protective role of metallothionein in streptozotocin-induced diabetes using metallothionein-null mice. J. Trace Elem. Med. Biol, 1997, 11, 1-7.
49. Xu, J., Wang, G., Wang, Y., Liu Q., Xu, W., Tan Y., Cai, L. Diabetes- and angiotensin II-induced cardiac endoplasmic reticulum stress and cell death: metallothionein protection. J. Cell. Mol. Med., 2009, 13(8A), 1499-1512.
50. Guo, R., Ma, H., Gao, F., Zhong, L, Ren, J. Metallothionein alleviates oxidative stress-induced endoplasmic reticulum stress and myocardial dysfunction. J. Mol. Cell Cardiol, 2009, 47, 228-237.
51. Cai, L., Wang, J., Li, Y., Sun, X., Wang, L., Zhou, Z., Kang, Y.J. Inhibition of superoxide generation and associated nitrosative damage is involved in metallothionein prevention of diabetic cardiomyopathy. Diabetes, 2005, 54, 1829-1837.
52. Dong, F., Li, Q., Sreejayan, N., Nunn, J.M., Ren, J. Metallothionein prevents high-fat diet-induced cardiac contractile dysfunction role of peroxisome proliferator-activated receptor coactivator 1 and mitochondrial biogenesis. Diabetes, 2007, 56, 2201-2212.
53. Wang, Y., Feng, W., Xue, W., Tan, Y., Hein, D.W., Li, X-K., Cai, L. Inactivation of GSK-3 by metallothionein prevents diabetes-related changes in cardiac energy metabolism, inflammation, nitrosative damage, and remodeling. Diabetes, 2009, 58, 1391-1402.
54. Scheede-Bergdahl, C, Penkowa, M., Hidalgo, J., Olsen D.B., Schjerling P., Prats C, Boushel R., Dela F. Metallothionein-mediated antioxidant defense system and its response to exercise training are impaired in human type 2 diabetes. Diabetes, 2005, 54, 3089-3094.
55. Kita, K., Miura, N., Yoshida, M., Yamazaki, K., Ohkubo, T., Imai, Y., Naganuma, A. Potential effect on cellular response to cadmium of a single-nucleotide A --> G polymorphism in the promoter of the human gene for metallothionein IIA. Human Genet, 2006, 120, 553-560.
56. Yang, L., Li, H., Yu, T., Zhao, H., Cherian, M.G., Cai, L., Liu, Y. Polymorphisms in metallothionein-1 and -2 genes associated with the risk of type 2 diabetes mellitus and its complications. Am. J. Physiol. Endocrinol. Metab., 2008, 294, E987-E992.
57. Higashimoto, M., Isoyama, N., Ishibashi, I., Inoue, M., Takiguchi, M., Suzuki, S., Ohnishi, Y., Sato, M. Tissue-dependent preventive effect of metallothionein against DNA damage in dyslipidemic mice under repeated stresses of fasting or restraint. Life Sci., 2009, 84, 569-575.
58. Tanaka, T., Masuzaki, H., Yasue, S., Ebihara, K., Shiuchi, T., Ishii, T., Arai, N., Hirata, M., Yamamoto, H., Hayashi, T., Hosoda, K., Minokoshi, Y., Nakao, K. Central melanocortin signaling restores skeletal muscle AMP-activated protein kinase phosphorylation in mice fed a high-fat diet. Cell Metab., 2007, 5, 395-402.
59. Moraes, R. C, Blomdet, A., Birkenkamp, K., Tirard, A-D. J., Orn-toft, T. F., Geritler, A., Durand, P., Naville, D., Geot, M. B. Study of the alteration of gene expression in adipose tissue of diet-induced obese mice by microarray and reverse transcription-polymerase chain reaction analyses. Endocrinology, 2003, 144, 4773-4782.
60. DeFuria, J., Bennett, G., Strissel, K.J., Perfield, II J.W., Milbury, P.E., Greenberg, A.S., Obin, M.S. Dietary blueberry attenuates whole-body insulin resistance in high fat-fed mice by reducing adipocyte death and its inflammatory sequelae. J. Nutr., 2009, 139, 1510-1516.
61. Dubois, S.G., Tchoukalova, Y.D., Heilbronn, L.K., Albu, J.B., Kelley D.E., Smith, S.R., Fang, X., Ravussin, E. Potential role of increased matrix metalloproteinase-2 (MMP2) transcription in impaired adipogenesis in type 2 diabetes mellitus. Biochem. Biophys. Res. Commun., 2008, 367 725-728.
62. Vucetic, Z., Kimmel, J., Totoki, K., Hollenbeck, E., Reyes, T.M. Maternal high-fat diet alters methylation and gene expression of dopamine and opioid-related genes. Endocrinology, 2010, 151, 4756-4764.
63. Nishimura, J., Masaki, T., Arakawa, M., Seike, M., Yoshimatsu, H. Isoleucine prevents the accumulation of tissue triglycerides and upregulates the expression of PPARa and uncoupling protein in diet-induced obese mice. J. Nutr., 2010, 140, 496-500.
64. Beattie, J. H., Black, D. J., Duncan, J. S., Wood, A. M., Trayhurn, P. Cold-induced expression of metallothionein-I gene in brown adipose tissue of rat. Am. J. Physiol. Regul. Integr. Comp. Physiol, 1996, 270, R971-977.
65. Trayhurn, P. Endocrine and signalling role of adipose tissue: new perspectives on fat. Acta Physiol. Scand., 2005, 184, 285-293.
66. Miura, N., Koizumi, S. Gene expression profiles in the liver and kidney of metallothionein-null mice. Biochem. Biophys. Res. Commun., 2005, 332, 949-955.
67. Asaki, T., Konishi, M., Miyake, A., Kato, S., Tomizawa, M., Itoh, N. Roles of fibroblast growth factor 10 (Fgf10) in adipogenesis in vivo. Mol. Cell Endocrinol, 2004, 218, 119-28.