Robust autoactivation, chymotrypsin C independence and diminished secretion define a subset of hereditary pancreatitis-associated cationic trypsinogen mutants

FEBS Journal

Volumn 280, Issue 12, 2013, Pages 2888-2899

  Geisz, Andrea ^a,b   Hegyi, Péter ^b   Sahin Tõth, Miklõs ^a  

^a BOSTON UNIVERSITY   (United States)

^b UNIVERSITY OF SZEGED   (Hungary)

Author keywords

autoactivation; chymotrypsin C; hereditary pancreatitis; trypsin; trypsinogen

Indexed keywords

CHYMOTRYPSIN; CHYMOTRYPSIN C; TRYPSINOGEN; TRYPSINOGEN ACTIVATION PEPTIDE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CALCIUM BINDING; CELL STRAIN HEK293; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYMATIC DEGRADATION; ENZYME ACTIVATION; ENZYME AUTOACTIVATION; ENZYME RELEASE; GENETIC TRANSFECTION; HUMAN; MOLECULAR DYNAMICS; MUTANT; MUTATIONAL ANALYSIS; PANCREATITIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN MOTIF; PROTEIN PROCESSING; WILD TYPE;

CALCIUM; CHYMOTRYPSIN; ENZYME ACTIVATION; HEK293 CELLS; HUMANS; MUTATION, MISSENSE; PANCREATITIS, CHRONIC; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEOLYSIS; TRYPSIN; TRYPSINOGEN;

TETRA;

EID: 84878765205     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12292     Document Type: Article

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