Adenosine 2A receptor modulates inflammation and phenotype in experimental abdominal aortic aneurysms

FASEB Journal

Volumn 27, Issue 6, 2013, Pages 2122-2131

  Bhamidipati, Castigliano M ^a   Mehta, Gaurav S ^a   Moehle, Christopher W ^a   Meher, Akshaya K ^a   Su, Gang ^a   Vigneshwar, Navin G ^a   Barbery, Carlos ^a   Sharma, Ashish K ^a   Kron, Irving L ^a   Laubach, Victor E ^a   Owens, Gary K ^a   Upchurch, Gilbert R ^a   Ailawadi, Gorav ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Gpcr signaling; Immune modulation; Inflammation; Physiological regulation

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A2 RECEPTOR; ELASTIN; GELATINASE B;

ABDOMINAL ABSCESS; ABDOMINAL AORTA ANEURYSM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CELL INFILTRATION; CHEMOTAXIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE INACTIVATION; HUMAN; HUMAN TISSUE; IMMUNOCOMPETENT CELL; IN VITRO STUDY; INFLAMMATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

MUS;

EID: 84878755808     PISSN: None     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.12-214197     Document Type: Article

References (45)

1. Heron, M. P., Hoyert, D. L., Murphy, S. L., Xu, J. Q., Kochanek, K. D., and Tejada-Vera, B. (2009) Deaths: final data for 2006. Natl. Vital Stat. Rep. 57, 14 http://www.cdc.gov/nchs/data/nvsr/nvsr57/nvsr57-14.pdff
2. Guo, D. C., Papke, C. L., He, R., and Milewicz, D. M. (2006) Pathogenesis of thoracic and abdominal aortic aneurysms. Ann. N. Y. Acad. Sci. 1085, 339-3522
3. Thompson, R. W., Curci, J. A., Ennis, T. L., Mao, D., Pagano, M. B., and Pham, C. T. (2006) Pathophysiology of abdominal aortic aneurysms: insights from the elastase-induced model in mice with different genetic backgrounds. Ann. N. Y. Acad. Sci. 1085, 59-733
4. Curci, J. A., and Thompson, R. W. (2004) Adaptive cellular immunity in aortic aneurysms: cause, consequence, or context? J. Clin. Invest. 114, 168-1711
5. Ailawadi, G., Moehle, C. W., Pei, H., Walton, S. P., Yang, Z., Kron, I. L., Lau, C. L., and Owens, G. K. (2009) Smooth muscle phenotypic modulation is an early event in aortic aneurysms. J. Thorac. Cardiovasc. Surg. 138, 1392-13999
6. Ailawadi, G., Eliason, J. L., and Upchurch, G. R., Jr. (2003) Current concepts in the pathogenesis of abdominal aortic aneurysm. J. Vasc. Surg. 38, 584-5888
7. Rizas, K. D., Ippagunta, N., and Tilson, M. D., 3rd (2009) Immune cells and molecular mediators in the pathogenesis of the abdominal aortic aneurysm. Cardiol. Rev. 17, 201-2100
8. +CD28- T-cells in patients with small abdominal aortic aneurysms. Arterioscler. Thromb. Vasc. Biol. 25, 1347-13522
9. Valente, A. J., Rozek, M. M., Sprague, E. A., and Schwartz, C. J. (1992) Mechanisms in intimal monocyte-macrophage recruitment. A special role for monocyte chemotactic protein-1. Circulation 86, III20-255
10. Taub, D. D., Proost, P., Murphy, W. J., Anver, M., Longo, D. L., van Damme, J., and Oppenheim, J. J. (1995) Monocyte chemotactic protein-1 (MCP-1), -2, and -3 are chemotactic for human T lymphocytes. J. Clin. Invest. 95, 1370-13766
11. + T cells and IFN-γ in the development of abdominal aortic aneurysms in a murine model. J. Immunol. 172, 2607-26122
12. Haskó, G., Linden, J., Cronstein, B., and Pacher, P. (2008) Adenosine receptors: therapeutic aspects for inflammatory and immune diseases. Nat. Rev. Drug. Discov. 7, 759-7700
13. Lappas, C. M., Sullivan, G. W., and Linden, J. (2005) Adenosine A2A agonists in development for the treatment of inflammation. Expert Opin. Investig. Drugs 14, 797-8066
14. Gazoni, L. M., Walters, D. M., Unger, E. B., Linden, J., Kron, I. L., and Laubach, V. E. (2010) Activation of A1, A2A, or A3 adenosine receptors attenuates lung ischemia-reperfusion injury. J. Thorac. Cardiovasc. Surg. 140, 440-4466
15. Haskó, G., Pacher, P., Deitch, E. A., and Vizi, E. S. (2007) Shaping of monocyte and macrophage function by adenosine receptors. Pharmacol. Ther. 113, 264-2755
16. + T lymphocytes and neutrophils attenuates lung ischemia-reperfusion injury. J. Thorac. Cardiovasc. Surg. 139, 474-4822
17. Laubach, V. E., French, B. A., and Okusa, M. D. (2011) Targeting of adenosine receptors in ischemia-reperfusion injury. Expert Opin. Ther. Targets 15, 103-1188
18. Anvari, F., Sharma, A. K., Fernandez, L. G., Hranjec, T., Ravid, K., Kron, I. L., and Laubach, V. E. (2010) Tissue-derived proinflammatory effect of adenosine A2B receptor in lung ischemia-reperfusion injury. J. Thorac. Cardiovasc. Surg. 140, 871-8777
19. Pyo, R., Lee, J. K., Shipley, J. M., Curci, J. A., Mao, D., Ziporin, S. J., Ennis, T. L., Shapiro, S. D., Senior, R. M., and Thompson, R. W. (2000) Targeted gene disruption of matrix metalloproteinase- 9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms. J. Clin. Invest. 105, 1641-16499
20. Ledent, C., Vaugeois, J. M., Schiffmann, S. N., Pedrazzini, T., El Yacoubi, M., Vanderhaeghen, J. J., Costentin, J., Heath, J. K., Vassart, G., and Parmentier, M. (1997) Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor. Nature 388, 674-6788
21. Institute for Laboratory Animal Research (2011) Guide for the Care and Use of Laboratory Animals, National Academies Press, Washington, DCC
22. Applied Research Ethics National Organization/Office of Laboratory Animal Welfare (2002) Institutional Animal Care and Use Committee Guidebook, National Institutes of Health, Bethesda, MD, USA
23. Cassada, D. C., Tribble, C. G., Long, S. M., Kaza, A. K., Linden, J., Rieger, J. M., Rosin, D., Kron, I. L., and Kern, J. A. (2002) Adenosine A2A agonist reduces paralysis after spinal cord ischemia: correlation with A2A receptor expression on motor neurons. Ann. Thorac. Surg. 74, 846-849; discussion 849-8500
24. Chehata, V. J., Domeier, P. P., Weilnau, J. N., and Lappas, C. M. (2011) Adenosine A(2A) receptor activation limits chronic granulomatous disease-induced hyperinflammation. Cell. Immunol. 267, 39-499
25. Feoktistov, I., and Biaggioni, I. (1997) Adenosine A2B receptors. Pharmacol. Rev. 49, 381-4022
26. Alexander, M. R., Moehle, C. W., Johnson, J. L., Yang, Z., Lee, J. K., Jackson, C. L., and Owens, G. K. (2012) Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice. J. Clin. Invest. 122, 70-799
27. Linden, J. (2011) Regulation of leukocyte function by adenosine receptors. Advances Pharmacol. 61, 95-1144
28. Moehle, C. W., Bhamidipati, C. M., Alexander, M. R., Mehta, G. S., Irvine, J. N., Salmon, M., Upchurch, G. R., Jr., Kron, I. L., Owens, G. K., and Ailawadi, G. (2011) Bone marrow-derived MCP1 required for experimental aortic aneurysm formation and smooth muscle phenotypic modulation. J. Thorac. Cardiovasc. Surg. 142, 1567-15744
29. Olah, M. E., and Stiles, G. L. (1995) Adenosine receptor subtypes: characterization and therapeutic regulation. Annu. Rev. Pharmacol. Toxicol. 35, 581-6066
30. Bruns, R. F. (1990) Adenosine receptors. Roles and pharmacology. Ann. N. Y. Acad. Sci. 603, 211-225; discussion 225-2166
31. Genovese, T., Melani, A., Esposito, E., Mazzon, E., Di Paola, R., Bramanti, P., Pedata, F., and Cuzzocrea, S. (2009) The selective adenosine A2A receptor agonist CGS 21680 reduces JNK MAPK activation in oligodendrocytes in injured spinal cord. Shock 32, 578-5855
32. Mazzon, E., Esposito, E., Impellizzeri, D., Di Paola, R., Melani, A., Bramanti, P., Pedata, F., and Cuzzocrea, S. (2011) CGS 21680, an agonist of the adenosine (A2A) receptor, reduces progression of murine type II collagen-induced arthritis. J. Rheumatol. 38, 2119-21299
33. Wang, S., Zhang, C., Zhang, M., Liang, B., Zhu, H., Lee, J., Viollet, B., Xia, L., Zhang, Y., and Zou, M. H. (2012) Activation of AMP-activated protein kinase alpha2 by nicotine instigates formation of abdominal aortic aneurysms in mice in vivo. Nat. Med. 18, 902-9100
34. Eliason, J. L., Hannawa, K. K., Ailawadi, G., Sinha, I., Ford, J. W., Deogracias, M. P., Roelofs, K. J., Woodrum, D. T., Ennis, T. L., Henke, P. K., Stanley, J. C., Thompson, R. W., and Upchurch, G. R., Jr. (2005) Neutrophil depletion inhibits experimental abdominal aortic aneurysm formation. Circulation 112, 232-2400
35. Hannawa, K. K., Eliason, J. L., Woodrum, D. T., Pearce, C. G., Roelofs, K. J., Grigoryants, V., Eagleton, M. J., Henke, P. K., Wakefield, T. W., Myers, D. D., Stanley, J. C., and Upchurch, G. R., Jr. (2005) L-selectin-mediated neutrophil recruitment in experimental rodent aneurysm formation. Circulation 112, 241-2477
36. Xiong, W., MacTaggart, J., Knispel, R., Worth, J., Persidsky, Y., and Baxter, B. T. (2009) Blocking TNF-α attenuates aneurysm formation in a murine model. J. Immunol. 183, 2741-27466
37. Zarek, P. E., Huang, C. T., Lutz, E. R., Kowalski, J., Horton, M. R., Linden, J., Drake, C. G., and Powell, J. D. (2008) A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells. Blood 111, 251-2599
38. + T regulatory cell function in patients with abdominal aortic aneurysms. Arterioscler. Thromb. Vasc. Biol. 30, 1825-18311
39. Shryock, J. C., and Belardinelli, L. (1997) Adenosine and adenosine receptors in the cardiovascular system: biochemistry, physiology, and pharmacology. Am. J. Cardiol. 79, 2-100
40. Wagner, D. R., Kubota, T., Sanders, V. J., McTiernan, C. F., and Feldman, A. M. (1999) Differential regulation of cardiac expression of IL-6 and TNF-α by A2- and A3-adenosine receptors. Am. J. Physiol. Heart Circ. Physiol. 276, H2141-H21477
41. 2+ pathway. Circ. Res. 99, 590-5977
42. Emaminia, A., Lapar, D. J., Zhao, Y., Steidle, J. F., Harris, D. A., Laubach, V. E., Linden, J., Kron, I. L., and Lau, C. L. (2011) Adenosine AA agonist improves lung function during ex vivo lung perfusion. Ann. Thorac. Surg. 92, 1840-18466
43. LaPar, D. J., Laubach, V. E., Emaminia, A., Crosby, I. K., Hajzus, V. A., Sharma, A. K., Sumner, H. M., Webb, D. V., Lau, C. L., and Kron, I. L. (2011) Pretreatment strategy with adenosine A2A receptor agonist attenuates reperfusion injury in a preclinical porcine lung transplantation model. J. Thorac. Cardiovasc. Surg. 142, 887-8944
44. Riksen, N. P., Franke, B., van den Broek, P., Smits, P., and Rongen, G. A. (2007) The 1976C>T polymorphism in the adenosine A2A receptor gene does not affect the vasodilator response to adenosine in humans in vivo. Pharmacogenet. Genom. 17, 551-5544
45. Riksen, N. P., Franke, B., Oyen, W. J., Borm, G. F., van den Broek, P., Boerman, O. C., Smits, P., and Rongen, G. A. (2007) Augmented hyperaemia and reduced tissue injury in response to ischaemia in subjects with the 34C>T variant of the AMPD1 gene. Eur. Heart. J. 28, 1085-10911