The 1976C>T polymorphism in the adenosine A2A receptor gene does not affect the vasodilator response to adenosine in humans in vivo

Pharmacogenetics and Genomics

Volumn 17, Issue 7, 2007, Pages 551-554

  Riksen, Niels P ^a   Franke, Barbara ^a   Van Den Broek, Petra ^a   Smits, Paul ^a   Rongen, Gerard A ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Adenosine A2A receptor; Caffeine; Polymorphism; Vasodilation

Indexed keywords

ADENOSINE; ADENOSINE A2A RECEPTOR; CAFFEINE;

ADULT; ARTICLE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; FEMALE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN EXPERIMENT; IN VIVO STUDY; MALE; NORMAL HUMAN; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; VASODILATATION; VEIN OCCLUSION PLETHYSMOGRAPHY;

ADENOSINE; ADULT; ALLELES; AMP DEAMINASE; BASE SEQUENCE; CAFFEINE; DNA PRIMERS; FEMALE; GENOTYPE; HUMANS; MALE; PHARMACOGENETICS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, ADENOSINE A2A; VASODILATION;

EID: 34250165762     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e32803fb78f     Document Type: Article

References (14)

1. 2A-adenosine receptor activation is due primarily to its action on lymphocytes. Circulation 2005; 111:2190-2197.
2. Zernecke A, Bidzhekov K, Ozuyaman B, Fraemohs L, Liehn EA, Luscher-Firzlaff JM, et al. CD73/ecto-5′-nucleotidase protects against vascular inflammation and neointima formation. Circulation 2006; 113:2120-2127.
3. Fredholm BB, Chen JF, Masino SA, Vaugeois JM. Actions of adenosine at its receptors in the CNS: insights from knockouts and drugs. Annu Rev Pharmacol Toxicol 2005; 45:385-412.
4. 2A receptor gene polymorphisms and caffeine-induced anxiety. Neuropsychopharmacol 2003; 28:1694-1702.
5. 2A gene to the development of disease. Mol Psychiatry 1998; 3:81-85.
6. 2A adenosine receptor mediates coronary vasodilation. J Pharmacol Exp Ther 1998; 284:1066-1073.
7. Riksen NP, Rongen GA, Boers GHJ, Blom HJ, van den Broek PHH, Smits P. Enhanced cellular adenosine uptake limits adenosine receptor stimulation in patients with hyperhomocysteinemia. Arterioscler Thromb Vasc Biol 2005; 25:109-114.
8. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988; 16:1215.
9. Ronaghi M. Pyrosequencing for SNP genotyping. Methods Mol Biol 2003; 212:189-195.
10. Riksen NP, Oyen WJ, Ramakers BP, Van den Broek PH, Engbersen R, Boerman OC, et al. Oral therapy with dipyridamole limits ischemia-reperfusion injury in humans. Clin Pharmacol Ther 2005; 78:52-59.
11. Smits P, Lenders JW, Thien T. Caffeine and theophylline attenuate adenosine-induced vasodilation in humans. Clin Pharmacol Ther 1990; 48:410-418.
12. Pedrinelli R, Spessot M, Salvetti A. Reactive hyperemia during short-term blood flow and pressure changes in the hypertensive forearm. J Hypertens 1990; 8:467-471.
13. Ohta A, Sitkovsky M. Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage. Nature 2001; 414:916-920.
14. Anderson JL, Habashi J, Carlquist JF, Muhlestein JB, Horne BD, Bair TL, et al. A common variant of the AMPD1 gene predicts improved cardiovascular survival in patients with coronary artery disease. J Am Coll Cardiol 2000; 36:1248-1252.