Neurotrophins and Neurotrophin Receptors in Proliferative Diabetic Retinopathy

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Abu El Asrar, Ahmed M ^a   Mohammad, Ghulam ^a   de Hertogh, Gert ^b   Nawaz, Mohd Imtiaz ^a   van den Eynde, Kathleen ^b   Siddiquei, Mohammad Mairaj ^a   Struyf, Sofie ^c   Opdenakker, Ghislain ^c   Geboes, Karel ^b  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; NERVE GROWTH FACTOR; NEUROTROPHIN; NEUROTROPHIN 3; NEUROTROPHIN 3 RECEPTOR; NEUROTROPHIN 4; NEUROTROPHIN RECEPTOR; PROTEIN TYROSINE KINASE A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DIABETIC RETINOPATHY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN VITRO STUDY; MALE; NONHUMAN; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RAT; UPREGULATION; WESTERN BLOTTING;

ANGIOGENESIS INDUCING AGENTS; ANIMALS; BLOTTING, WESTERN; DIABETIC RETINOPATHY; ENDOTHELIAL CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MALE; NERVE GROWTH FACTORS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NERVE GROWTH FACTOR; RETINAL VESSELS; VITREOUS BODY;

RATTUS;

EID: 84878748302     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0065472     Document Type: Article

References (34)

1. Spranger J, Pfeiffer AP, (2001) New concepts in pathogenesis and treatment of diabetic retinopathy. Exp Clin Endocrinol Diabetes 109: S438-S450.
2. Wynn TA, (2008) Cellular and molecular mechanisms of fibrosis. J Pathol 214: 199-210.
3. Abu El-Asrar AM, Struyf S, Kangave D, Geboes K, Van Damme J, (2006) Chemokines in proliferative diabetic retinopathy and proliferative vitreoretinopathy. Eur Cytokine Netw 17: 155-165.
4. Bothwell M, (1995) Functional interactions of neurotrophins and neurotrophin receptors. Annu Rev Neurosci 18: 223-253.
5. Cristofaro B, Stone OA, Caporali A, Dawbarn D, Leronimakis N, et al. (2010) Neurotrophin-3 is a novel angiogenic factor capable of therapeutic neovascularization in a mouse model of limb ischemia. Arterioscler Thromb Vasc Biol 30: 1143-1150.
6. Palazzo E, Marconi A, Truzzi F, Dallaglio K, Petrachi J, et al. (2012) Role of neurotrophins on dermal fibroblast survival and differentiation. J Cell Physiol 227: 1017-1025.
7. Dagnell C, Kemi C, Klominek J, Eriksson P, Sköld CM, et al. (2007) Effects of neurotrophins on human bronchial smooth muscle cell migration and matrix metalloproteinase-9 secretion. Transl Res 150: 303-310.
8. Micera A, Vigneti E, Pickholtz D, Reich R, Pappo O, et al. (2001) Nerve growth factor displays stimulatory effects on human skin and lung fibroblasts, demonstrating a direct role for this factor in tissue repair. Proc Natl Acad Sci USA 98: 6162-6167.
9. Dagnell C, Grunewald J, Kramar M, Haugom-Olsen H, Elmberger G, et al. (2010) Neurotrophins and neurotrophin receptors in pulmonary sarcoidosis-granulomas as a source of expression. Respir Res 11: 156.
10. Avcuoglu S, Wygrecka M, Marsh LM, Günther A, Seeger W, et al. (2011) Neurotrophic tyrosine kinase receptor B/neurotrophin 4 signaling axis is perturbed in clinical and experimental pulmonary fibrosis. Am J Respir Cell Mol Biol 45: 768-780.
11. Ricci A, Greco S, Mariotta S, Felici L, Bronzetti E, et al. (2001) Neurotrophins and neurotrophin receptors in human lung cancer. Am J Respir Cell Mol Biol 25: 439-446.
12. Kermani P, Rafii D, Jin DK, Whitlock P, Schaffer W, et al. (2005) Neurotrophins promote revascularization by local recruitment of TrkB+ endothelial cells and systemic mobilization of hematopoietic progenitors. J Clin Invest 115: 653-663.
13. Nakamura K, Tan F, Thiele CJ, (2011) NGF activation of TrkA induces vascular endothelial growth factor expression via induction of hypoxia-inducible factor-1α. Mol Cell Neurosci 46: 498-506.
14. Nakamura K, Martin KC, Jackson JK, Beppu K, Woo CW, et al. (2006) Brain-derived neurotrophic factor activation of TrkB induces vascular endothelial growth factor expression via hypoxia-inducible factor-1 alpha in neuroblastoma cells. Cancer Res 66: 4249-4255.
15. Nico B, Mangieri D, Benagiano V, Crivellato E, Ribatti D, (2008) Nerve growth factor as an angiogenic factor. Microvasc Res 75: 135-141.
16. Emanueli C, Salis MB, Pinna A, Graiani G, Manni L, et al. (2002) Nerve growth factor promotes angiogenesis and arteriogenesis in ischemic hindlimbs. Circulation 106: 2257-2262.
17. Birnbaum T, Roider J, Schankin CJ, Padovan CS, Schichor C, et al. (2007) Malignant gliomas actively recruit bone marrow stromal cells by secreting angiogenic cytokines. J Neurooncol 83: 241-247.
18. Kohyama T, Liu X, Wen FQ, Kobayashi T, Abe S, et al. (2002) Nerve growth factor stimulates fibronectin-induced fibroblast migration. J Lab Clin Med 140: 329-335.
19. Aiello LP, Avery RL, Arrigg PG, Keyt BA, Jampel HD, et al. (1994) Vascular endothelial growth factor in ocular fluid in patients with diabetic retinopathy and other retinal disorders. N Engl J Med 331: 1480-1487.
20. Nawaz MI, Van Raemdonck K, Mohammad G, Kangave D, Van Damme J, et al. (2013) Autocrine CCL2, CXCL4, CXCL9 and CXCL10 signal in retinal endothelial cells and are enhanced in diabetic retinopathy. Exp Eye Res 109C: 67-76.
21. Iannetti L, Accorinti M, Malagola R, Bozzoni-Pantaleoni F, Da Dalt S, et al. (2011) Role of intravitreal growth factors in the pathogenesis of idiopathic epiretinal membrane. Invest Ophthalmol Vis Sci 52: 5786-5789.
22. Cai F, Tomlinson DR, Fernyhough P, (1999) Elevated expression of neurotrophin-3 mRNA in sensory nerve of streptozotocin-diabetic rats. Neurosci Lett 263: 81-84.
23. Kennedy AJ, Wellmer A, Facer P, Saldanaha G, Kopelman P, et al. (1998) Neurotrophin-3 is increased in skin in human diabetic neuropathy. J Neurol Nuerosurg Psychiatry 65: 393-395.
24. Chen Y, Yang R, Yao L, Sun Z, Wang R, et al. (2007) Differential expression of neurotrophins in penises of streptozotocin-induced diabetic rats. J Androl 28: 306-312.
25. Park KS, Kim SS, Kim JC, Kim HC, Im YS, et al. (2008) Serum and tear levels of nerve growth factor in diabetic retinopathy patients. Am J Ophthalmol 145: 432-437.
26. Hammes HP, Federoff HJ, Brownlee M, (1995) Nerve growth factor prevents both neuroretinal programmed cell death and capillary pathology in experimental diabetes. Mol Med 1: 527-534.
27. Ali TK, Matragoon S, Pillai BA, Liou GI, El-Remessy AB, (2008) Peroxynitrite mediates retinal neurodegeneration by inhibiting nerve growth factor survival signaling in experimental and human diabetes. Diabetes 57: 889-898.
28. Kim H, Li Q, Hempstead BL, Madri JA, (2004) Paracrine and autocrine functions in brain-dervied neurotrophic factor and nerve growth factor (NGF) in brain-derived endothelial cells. J Biol Chem 279: 33538-33546.
29. Lecht S, Arien-Zakay H, Kohan M, Lelkes PI, Lazarovici P, (2010) Angiostatic effects of K252a, a Trk inhibitor, in murine brain capillary endothelial cells. Mol Cell Biochem 339: 201-213.
30. Takeo C, Nakamura S, Tanaka T, Uchida D, Noguchi Y, et al. (2003) Rat cerebral endothelial cells express TarkC and are regulated by neurotrophin-3. Biochem Biophys Res Commun 305: 400-406.
31. Fragiadaki M, Hill N, Hewitt R, Bou-Gharios G, Cook T, et al. (2012) Hyperglycemia causes renal cell damage via CCN2-induced activation of the TrkA receptor: Implications for diabetic nephropathy. Diabetes 61: 2280-2288.
32. Terenghi G, Mann D, Kopelman PG, Anand P, (1997) TrkA and TrkC expression is increased in human diabetic skin. Neurosci Lett 228: 33-36.
33. Diaz-Rodriguez E, Cabrera N, Esparis-Ogando A, Montero JC, Pandiella A, (1999) Cleavage of the TrkA neutrophin receptor by multiple metalloproteases generates signaling-competent truncated forms. Eur J Neurosci 11: 1421-1430.
34. Lagadec C, Meignan S, Adriaenssens E, Foveau B, Vanhecke E, et al. (2009) TrkA overexpression enhances growth and metastasis of breast cancer cells. Oncogene 28: 1960-1970.