Autocrine CCL2, CXCL4, CXCL9 and CXCL10 signal in retinal endothelial cells and are enhanced in diabetic retinopathy

Experimental Eye Research

Volumn 109, Issue , 2013, Pages 67-76

  Nawaz, M I ^a   Van Raemdonck, K ^b   Mohammad, G ^a   Kangave, D ^a   Van Damme, J ^b   Abu El Asrar, A M ^a   Struyf, S ^b  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Chemokines; Interferon inducible protein 10; Monocyte chemoattractant protein 1; Monokine induced by interferon ; Platelet factor 4; Proliferative diabetic retinopathy; Vascular endothelial growth factor

Indexed keywords

CHEMOKINE; CXCL4 CHEMOKINE; CXCL9 CHEMOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; CELL MIGRATION; CELL STIMULATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINE PRODUCTION; DIABETIC RETINOPATHY; DISEASE ACTIVITY; ENZYME PHOSPHORYLATION; HOMEOSTASIS; HUMAN; HUMAN CELL; MALE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; RETINA BLOOD VESSEL; RETINA CELL; RETINA DETACHMENT; RETINAL ENDOTHELIAL CELL; SIGNAL TRANSDUCTION; TRACTION RETINAL DETACHMENT; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION; VITREOUS BODY; WESTERN BLOTTING;

ANIMALS; AUTOCRINE COMMUNICATION; CELL MOVEMENT; CELLS, CULTURED; CHEMOKINE CCL2; CHEMOKINE CXCL10; CHEMOKINE CXCL9; DIABETIC RETINOPATHY; ENDOTHELIAL CELLS; HUMANS; MALE; MICROVESSELS; NEOVASCULARIZATION, PATHOLOGIC; PLATELET FACTOR 4; RATS; RATS, SPRAGUE-DAWLEY; RETINAL VESSELS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VITREOUS BODY;

EID: 84874787015     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2013.01.008     Document Type: Article

References (38)

1. Abu El-Asrar A.M., Struyf S., Kangave D., Geboes K., Van Damme J. Chemokines in proliferative diabetic retinopathy and proliferative vitreoretinopathy. Eur. Cytokine Netw. 2006, 17:155-165.
2. Abu El-Asrar A.M., Missotten L., Geboes K. Expression of hypoxia-inducible factor-1alpha and the protein products of its target genes in diabetic fibrovascular epiretinal membranes. Br. J. Ophthalmol. 2007, 91:822-826.
3. Abu El-Asrar A.M., Missotten L., Geboes K. Expression of cyclo-oxygenase-2 and downstream enzymes in diabetic fibrovascular epiretinal membranes. Br. J. Ophthalmol. 2008, 92:1534-1539.
4. Abu El-Asrar A.M., Missotten L., Geboes K. Expression of high-mobility groups box-1/receptor for advanced glycation end products/osteopontin/early growth response-1 pathway in proliferative vitreoretinal epiretinal membranes. Mol. Vis. 2011, 17:508-518.
5. Abu El-Asrar A.M., Nawaz M.I., Kangave D., Siddiquei M.M., Ola M.S., Opdenakker G. Angiogenesis regulatory factors in the vitreous from patients with proliferative diabetic retinopathy. Acta Diabetol. 2011.
6. Aidoudi S., Bikfalvi A. Interaction of PF4 (CXCL4) with the vasculature: a role in atherosclerosis and angiogenesis. Thromb. Haemost. 2010, 104:941-948.
7. Aiello L.P., Avery R.L., Arrigg P.G., Keyt B.A., Jampel H.D., Shah S.T., Pasquale L.R., Thieme H., Iwamoto M.A., Park J.E. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N. Engl. J. Med. 1994, 331:1480-1487.
8. Berres M.L., Trautwein C., Schmeding M., Eurich D., Tacke F., Bahra M., Neuhaus P., Neumann U.P., Wasmuth H.E. Serum chemokine CXC ligand 10 (CXCL10) predicts fibrosis progression after liver transplantation for hepatitis C infection. Hepatology 2011, 53:596-603.
9. Bodnar R.J., Yates C.C., Wells A. IP-10 blocks vascular endothelial growth factor-induced endothelial cell motility and tube formation via inhibition of calpain. Circ. Res. 2006, 98:617-625.
10. Bodnar R.J., Yates C.C., Rodgers M.E., Du X., Wells A. IP-10 induces dissociation of newly formed blood vessels. J. Cell. Sci. 2009, 122:2064-2077.
11. Boulday G., Haskova Z., Reinders M.E., Pal S., Briscoe D.M. Vascular endothelial growth factor-induced signaling pathways in endothelial cells that mediate overexpression of the chemokine IFN-gamma-inducible protein of 10 kDa in vitro and in vivo. J. Immunol. 2006, 176:3098-3107.
12. Bullard L.E., Qi X., Penn J.S. Role for extracellular signal-responsive kinase-1 and -2 in retinal angiogenesis. Invest. Ophthalmol. Vis. Sci. 2003, 44:1722-1731.
13. Crane I.J., Wallace C.A., McKillop-Smith S., Forrester J.V. Control of chemokine production at the blood-retina barrier. Immunology 2000, 101:426-433.
14. Funatsu H., Yamashita H., Noma H., Shimizu E., Yamashita T., Hori S. Stimulation and inhibition of angiogenesis in diabetic retinopathy. Jpn. J. Ophthalmol. 2001, 45:577-584.
15. Gijsbers K., Gouwy M., Struyf S., Wuyts A., Proost P., Opdenakker G., Penninckx F., Ectors N., Geboes K., Van Damme J. GCP-2/CXCL6 synergizes with other endothelial cell-derived chemokines in neutrophil mobilization and is associated with angiogenesis in gastrointestinal tumors. Exp. Cell Res. 2005, 303:331-342.
16. Hanahan D., Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996, 86:353-364.
17. Hong K.H., Ryu J., Han K.H. Monocyte chemoattractant protein-1-induced angiogenesis is mediated by vascular endothelial growth factor-A. Blood 2005, 105:1405-1407.
18. Keeley E.C., Mehrad B., Strieter R.M. Chemokines as mediators of tumor angiogenesis and neovascularization. Exp. Cell Res. 2011, 317:685-690.
19. Lasagni L., Francalanci M., Annunziato F., Lazzeri E., Giannini S., Cosmi L., Sagrinati C., Mazzinghi B., Orlando C., Maggi E., Marra F., Romagnani S., Serio M., Romagnani P. An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4. J. Exp. Med. 2003, 197:1537-1549.
20. Loos T., Dekeyzer L., Struyf S., Schutyser E., Gijsbers K., Gouwy M., Fraeyman A., Put W., Ronsse I., Grillet B., Opdenakker G., Van Damme J., Proost P. TLR ligands and cytokines induce CXCR3 ligands in endothelial cells: enhanced CXCL9 in autoimmune arthritis. Lab. Invest. 2006, 86:902-916.
21. Maier R., Weger M., Haller-Schober E.M., El-Shabrawi Y., Wedrich A., Theisl A., Aigner R., Barth A., Haas A. Multiplex bead analysis of vitreous and serum concentrations of inflammatory and proangiogenic factors in diabetic patients. Mol. Vis. 2008, 14:637-643.
22. Maione T.E., Gray G.S., Petro J., Hunt A.J., Donner A.L., Bauer S.I., Carson H.F., Sharpe R.J. Inhibition of angiogenesis by recombinant human platelet factor-4 and related peptides. Science 1990, 247:77-79.
23. Marumo T., Schini-Kerth V.B., Busse R. Vascular endothelial growth factor activates nuclear factor-kappaB and induces monocyte chemoattractant protein-1 in bovine retinal endothelial cells. Diabetes 1999, 48:1131-1137.
24. Ravanat C., Gachet C., Herbert J.M., Schuhler S., Guillemot J.C., Uzabiaga F., Picard C., Ferrara P., Freund M., Cazenave J.P. Rat platelets contain glycosylated and non-glycosylated forms of platelet factor 4. Identification and characterization by mass spectrometry. Eur. J. Biochem. 1994, 223:203-210.
25. Romagnani P., Annunziato F., Lasagni L., Lazzeri E., Beltrame C., Francalanci M., Uguccioni M., Galli G., Cosmi L., Maurenzig L., Baggiolini M., Maggi E., Romagnani S., Serio M. Cell cycle-dependent expression of CXC chemokine receptor 3 by endothelial cells mediates angiostatic activity. J. Clin. Invest. 2001, 107:53-63.
26. Sato E., Fujimoto J., Tamaya T. Expression of interferon-gamma-inducible protein 10 related to angiogenesis in uterine endometrial cancers. Oncology 2007, 73:246-251.
27. Schäfer A., Schulz C., Eigenthaler M., Fraccarollo D., Kobsar A., Gawaz M., Ertl G., Walter U., Bauersachs J. Novel role of the membrane-bound chemokine fractalkine in platelet activation and adhesion. Blood 2004, 103:407-412.
28. Sica A., Wang J.M., Colotta F., Dejana E., Mantovani A., Oppenheim J.J., Larsen C.G., Zachariae C.O., Matsushima K. Monocyte chemotactic and activating factor gene expression induced in endothelial cells by IL-1 and tumor necrosis factor. J. Immunol. 1990, 144:3034-3038.
29. Spranger J., Pfeiffer A.F. New concepts in pathogenesis and treatment of diabetic retinopathy. Exp. Clin. Endocrinol. Diabetes 2001, 109(Suppl. 2):S438-S450.
30. Struyf S., Burdick M.D., Proost P., Van Damme J., Strieter R.M. Platelets release CXCL4L1, a nonallelic variant of the chemokine platelet factor-4/CXCL4 and potent inhibitor of angiogenesis. Circ. Res. 2004, 95:855-857.
31. Struyf S., Burdick M.D., Peeters E., Van den B.K., Dillen C., Proost P., Van Damme J., Strieter R.M. Platelet factor-4 variant chemokine CXCL4L1 inhibits melanoma and lung carcinoma growth and metastasis by preventing angiogenesis. Cancer Res. 2007, 67:5940-5948.
32. Struyf S., Salogni L., Burdick M.D., Vandercappellen J., Gouwy M., Noppen S., Proost P., Opdenakker G., Parmentier M., Gerard C., Sozzani S., Strieter R.M., Van Damme J. Angiostatic and chemotactic activities of the CXC chemokine CXCL4L1 (platelet factor-4 variant) are mediated by CXCR3. Blood 2011, 117:480-488.
33. Vandercappellen J., Van Damme J., Struyf S. The role of CXC chemokines and their receptors in cancer. Cancer Lett. 2008, 267:226-244.
34. Vandercappellen J., Van Damme J., Struyf S. The role of the CXC chemokines platelet factor-4 (CXCL4/PF-4) and its variant (CXCL4L1/PF-4var) in inflammation, angiogenesis and cancer. Cytokine Growth Factor Rev. 2011, 22:1-18.
35. Wakabayashi Y., Usui Y., Okunuki Y., Kezuka T., Takeuchi M., Goto H., Iwasaki T. Correlation of vascular endothelial growth factor with chemokines in the vitreous in diabetic retinopathy. Retina 2010, 30:339-344.
36. Yamada M., Kim S., Egashira K., Takeya M., Ikeda T., Mimura O., Iwao H. Molecular mechanism and role of endothelial monocyte chemoattractant protein-1 induction by vascular endothelial growth factor. Arterioscler. Thromb. Vasc. Biol. 2003, 23:1996-2001.
37. Yamashiro K., Tsujikawa A., Ishida S., Usui T., Kaji Y., Honda Y., Ogura Y., Adamis A.P. Platelets accumulate in the diabetic retinal vasculature following endothelial death and suppress blood-retinal barrier breakdown. Am. J. Pathol. 2003, 163:253-259.
38. Zeremski M., Dimova R., Brown Q., Jacobson I.M., Markatou M., Talal A.H. Peripheral CXCR3-associated chemokines as biomarkers of fibrosis in chronic hepatitis C virus infection. J. Infect. Dis. 2009, 200:1774-1780.