Polyunsaturated fatty acids affect the localization and signaling of PIP3/AKT in prostate cancer cells

Carcinogenesis

Volumn 34, Issue 9, 2013, Pages 1968-1975

  Gu, Zhennan ^a,b   Wu, Jiansheng ^b   Wang, Shihua ^b   Suburu, Janel ^b   Chen, Haiqin ^a   Thomas, Michael J ^b   Shi, Lihong ^b   Edwards, Iris J ^b   Berquin, Isabelle M ^b   Chen, Yong Q ^a,b  

^a JIANGNAN UNIVERSITY   (China)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; DOCOSAHEXAENOIC ACID; GLYCEROL; ICOSAPENTAENOIC ACID; LINOLEIC ACID; OMEGA 3 FATTY ACID; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PHOSPHOLIPID; POLYPHOSPHOINOSITIDE; POLYUNSATURATED FATTY ACID; PROTEIN BAD; PROTEIN KINASE B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL STRAIN LNCAP; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; LIPID DIET; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE TUMOR; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; FATTY ACIDS, OMEGA-3; FATTY ACIDS, UNSATURATED; HUMANS; MALE; MICE; MICE, TRANSGENIC; PHOSPHATIDYLINOSITOL 3-KINASES; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION;

EID: 84878745139     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgt147     Document Type: Article

References (48)

1. Cantley, L.C. (2002) The phosphoinositide 3-kinase pathway. Science, 296, 1655-1657.
2. Stokoe, D. (2001) PTEN. Curr. Biol., 11, R502.
3. Comer, F.I. et al. (2002) PI 3-kinases and PTEN: how opposites chemoattract. Cell, 109, 541-544.
4. Samuels, Y. et al. (2004) High frequency of mutations of the PIK3CA gene in human cancers. Science, 304, 554.
5. Chalhoub, N. et al. (2009) PTEN and the PI3-kinase pathway in cancer. Annu. Rev. Pathol., 4, 127-150.
6. Hollander, M.C. et al. (2011) PTEN loss in the continuum of common cancers, rare syndromes and mouse models. Nat. Rev. Cancer, 11, 289-301.
7. Yuan, T.L. et al. (2008) PI3K pathway alterations in cancer: variations on a theme. Oncogene, 27, 5497-5510.
8. Cully, M. et al. (2006) Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat. Rev. Cancer, 6, 184-192.
9. Manning, B.D. et al. (2007) AKT/PKB signaling: navigating downstream. Cell, 129, 1261-1274.
10. Franke, T.F. et al. (1997) Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science, 275, 665-668.
11. Scheid, M.P. et al. (2002) Phosphatidylinositol (3,4,5)P3 is essential but not sufficient for protein kinase B (PKB) activation; phosphatidylinositol (3,4) P2 is required for PKB phosphorylation at Ser-473: studies using cells from SH2-containing inositol-5-phosphatase knockout mice. J. Biol. Chem., 277, 9027-9035.
12. Stokoe, D. et al. (1997) Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. Science, 277, 567-570.
13. Willett, W. (1989) The search for the causes of breast and colon cancer. Nature, 338, 389-394.
14. Lee, M.M. et al. (2000) Dietary fat and breast cancer. Annu. Rev. Nutr., 20, 221-248.
15. Kolonel, L.N. (2001) Fat, meat, and prostate cancer. Epidemiol. Rev., 23, 72-81.
16. Berquin, I.M. et al. (2011) Polyunsaturated fatty acid metabolism in prostate cancer. Cancer Metastasis Rev., 30, 295-309.
17. Berquin, I.M. et al. (2008) Multi-targeted therapy of cancer by omega-3 fatty acids. Cancer Lett., 269, 363-377.
18. Chen, Y.Q. et al. (2007) Dietary fat-gene interactions in cancer. Cancer Metastasis Rev., 26, 535-551.
19. Hu, Y. et al. (2010) Syndecan-1-dependent suppression of PDK1/Akt/bad signaling by docosahexaenoic acid induces apoptosis in prostate cancer. Neoplasia, 12, 826-836.
20. Schley, P.D. et al. (2005) Mechanisms of omega-3 fatty acid-induced growth inhibition in MDA-MB-231 human breast cancer cells. Breast Cancer Res. Treat., 92, 187-195.
21. Friedrichs, W. et al. (2011) Omega-3 fatty acid inhibition of prostate cancer progression to hormone independence is associated with suppression of mTOR signaling and androgen receptor expression. Nutr. Cancer, 63, 771-777.
22. Toit-Kohn, J.L. et al. (2009) Docosahexaenoic acid induces apoptosis in colorectal carcinoma cells by modulating the PI3 kinase and p38 MAPK pathways. J. Nutr. Biochem., 20, 106-114.
23. Wang, S. et al. (2012) Effect of dietary polyunsaturated fatty acids on castration-resistant Pten-null prostate cancer. Carcinogenesis, 33, 404-412.
24. Berquin, I.M. et al. (2007) Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids. J. Clin. Invest., 117, 1866-1875.
25. Guillou, H. et al. (2007) Quantitative measurement of phosphatidylinositol 3,4,5-trisphosphate. Methods Enzymol., 434, 117-130.
26. Pettitt, T.R. (2009) Lipidomic analysis of phospholipids and related structures by liquid chromatography-mass spectrometry. Methods Mol. Biol., 462, 25-41.
27. Pettitt, T.R. et al. (2006) Analysis of intact phosphoinositides in biological samples. J. Lipid Res., 47, 1588-1596.
28. Brodersen, R. et al. (1990) Multiple fatty acid binding to albumin in human blood plasma. Eur. J. Biochem., 189, 343-349.
29. Soma, M.R. et al. (1992) Triglyceride metabolism in 3T3-L1 cells. An in vivo 13C NMR study. J. Biol. Chem., 267, 11168-11175.
30. Bernhard, W. et al. (1995) Composition of phospholipid classes and phosphatidylcholine molecular species of gastric mucosa and mucus. Biochim. Biophys. Acta, 1255, 99-104.
31. Beermann, C. et al. (2005) sn-position determination of phospholipidlinked fatty acids derived from erythrocytes by liquid chromatography electrospray ionization ion-trap mass spectrometry. Lipids, 40, 211-218.
32. Blero, D. et al. (2001) The SH2 domain containing inositol 5-phosphatase SHIP2 controls phosphatidylinositol 3,4,5-trisphosphate levels in CHO-IR cells stimulated by insulin. Biochem. Biophys. Res. Commun., 282, 839-843.
33. Ekinci, F.J. et al. (1999) Hyperactivation of mitogen-activated protein kinase increases phospho-tau immunoreactivity within human neuroblastoma: additive and synergistic influence of alteration of additional kinase activities. Cell. Mol. Neurobiol., 19, 249-260.
34. Stoll, L.L. et al. (1984) Changes in serum influence the fatty acid composition of established cell lines. In Vitro, 20, 732-738.
35. Chen, R. et al. (2002) A monoclonal antibody to visualize PtdIns(3,4,5)P(3) in cells. J. Histochem. Cytochem., 50, 697-708.
36. Várnai, P. et al. (1999) Phosphatidylinositol 3-kinase-dependent membrane association of the Bruton's tyrosine kinase pleckstrin homology domain visualized in single living cells. J. Biol. Chem., 274, 10983-10989.
37. Balla, T. et al. (2002) Visualizing cellular phosphoinositide pools with GFP-fused protein-modules. Sci. STKE, 2002, pl3.
38. Stephens, L. et al. (1998) Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science, 279, 710-714.
39. Sarbassov, D.D. et al. (2005) Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science, 307, 1098-1101.
40. Casamayor, A. et al. (1999) Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo. Biochem. J., 342 (Pt 2), 287-292.
41. Hart, J.R. et al. (2011) Phosphorylation of AKT: a mutational analysis. Oncotarget, 2, 467-476.
42. Akbar, M. et al. (2002) Protective effects of docosahexaenoic acid in staurosporine-induced apoptosis: involvement of phosphatidylinositol-3 kinase pathway. J. Neurochem., 82, 655-665.
43. Akbar, M. et al. (2005) Docosahexaenoic acid: a positive modulator of Akt signaling in neuronal survival. Proc. Natl Acad. Sci. USA, 102, 10858-10863.
44. Figueroa, J.D. et al. (2012) Docosahexaenoic acid pretreatment confers protection and functional improvements after acute spinal cord injury in adult rats. J. Neurotrauma, 29, 551-566.
45. Breckenridge, W.C. et al. (1972) The lipid composition of adult rat brain synaptosomal plasma membranes. Biochim. Biophys. Acta, 266, 695-707.
46. Sun, G.Y. et al. (1972) Phospholipids and acyl groups of synaptosomal and myelin membranes isolated from the cerebral cortex of squirrel monkey (Saimiri sciureus). Biochim. Biophys. Acta, 280, 306-315.
47. Ikemoto, A. et al. (2000) Effect of n-3 fatty acid deficiency on fatty acid composition and metabolism of aminophospholipids in rat brain synaptosomes. Lipids, 35, 1107-1115.
48. Glomset, J.A. (2006) Role of docosahexaenoic acid in neuronal plasma membranes. Sci. STKE, 2006, pe6.